Social and neural determinants of aggressive behavior: Pharmacotherapeutic targets at serotonin, dopamine and γ-aminobutyric acid systems

Psychopharmacology

Volumn 163, Issue 3-4, 2002, Pages 434-458

  Miczek, Klaus A ^a,b,c   Fish, Eric W ^a,b,c   De Bold, Joseph F ^a,b,c   De Almeida, Rosa M ^a,b,c  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSIDADE DO VALE DO RIO DOS SINOS   (Brazil)

Author keywords

5 HT receptor; Aggression; Alcohol; Benzodiazepines; Dopamine; GABA; GABAA receptor; Serotonin; SSRI

Indexed keywords

2 DIPROPYLAMINO 5,6 DIMETHOXYINDAN; 2 DIPROPYLAMINO 7 HYDROXYTETRALIN; 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 3,4,4A,10B TETRAHYDRO 4 PROPYL 2H,5H [1]BENZOPYRANO[4,3 B][1,4]OXAZIN 9 OL; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; AMPHETAMINE; BENZODIAZEPINE DERIVATIVE; CARBAMAZEPINE; CHLORDIAZEPOXIDE; CLOZAPINE; DIAZEPAM; DIHYDREXIDINE; DOPAMINE; DOPAMINE RECEPTOR; MUSCIMOL; NEUROLEPTIC AGENT; OLANZAPINE; PHENYTOIN; QUINPIROLE; RACLOPRIDE; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; UNINDEXED DRUG; VALPROIC ACID;

AGGRESSION; BEHAVIOR; HUMAN; MALADJUSTMENT; MOLECULAR BIOLOGY; NEUROBIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SOCIAL ASPECT;

ADAPTATION, PSYCHOLOGICAL; AGGRESSION; ANIMALS; BRAIN; DOPAMINE; ETHANOL; GAMMA-AMINOBUTYRIC ACID; GONADAL STEROID HORMONES; HUMANS; OXAZOLIDINONES; PIPERIDINES; PREGNANOLONE; PYRIDINES; RECEPTORS, DOPAMINE; RECEPTORS, GABA; RECEPTORS, SEROTONIN; REINFORCEMENT SCHEDULE; SEROTONIN; SEROTONIN AGONISTS; SOCIAL ENVIRONMENT; TRYPTAMINES;

EID: 0036392466     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-002-1139-6     Document Type: Review

References (366)

1. Aguilar MA, Minarro J, Perez-Iranzo N, Simon VM (1994) Behavioral profile of raclopride in agonistic encounters between male mice. Pharmacol Biochem Behav 47:753-756
2. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders IV. American Psychiatric Association, Washington
3. Amsel A, Roussel J (1952) Motivational properties of frustration. 1. Effect on a running response of the addition of frustration to the motivational complex. J Exp Psychol 43:363-368
4. Ando A, Yamasaki K, Shimai S, Shimada H, Utsuki N, Oashi O, Sakai A (1999) Development of the Japanese version of the Buss-Perry Aggression Questionnaire (BAQ). Jpn J Psychol 70:384-392
5. Archer J (1988) The behavioural biology of aggression. Cambridge University Press, Cambridge
6. Arnone M, Dantzer R (1980a) Does frustration induce aggression in pigs? Appl Anim Ethol 6:351-362
7. Arnone M, Dantzer R (1980b) Effects of diazepam on extinction induced aggression in pigs. Pharmacol Biochem Behav 13:27-30
8. Azrin NH, Hutchinson RR, Hake DF (1966) Extinction-induced aggression. J Exp Anal Behav 9:191-204
9. Baggio G, Ferrari F (1980) Role of brain dopaminergic mechanisms in rodent aggressive behavior: influence of (+,-)N-n-propylnorapomorphine on three experimental models. Psychopharmacology 70:63-68
10. Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-1152
11. Barratt ES (1993) The use of anticonvulsants in aggression and violence. Psychopharmacol Bull 29:75-81
12. Barratt ES, Stanford MS, Felthous AR, Kent TA (1997a) The effects of phenytoin on impulsive and premeditated aggression: a controlled study. J Clin Psychopharmacol 17:341-349
13. Barratt ES, Stanford MS, Kent TA, Felthous A (1997b) Neuropsychological and cognitive psychophysiological substrates of impulsive aggression. Biol Psychiatry 41:1045-1061
14. 2 receptor subtypes - a family re-united. Trends Pharmacol Sci 16:105-110
15. Beck AT, Erbaugh J, Ward CA, Mock J, Mendelsohn M (1961) An inventory for measuring depression. Study and course of the psychological profile in 77 patients experiencing panic disorder with agoraphobia after cognitive behaviour therapy with or without buspirone. Arch Gen Psychiatry 4:561-571
16. 1A receptor influences on rodent social and agonistic behavior: a review and empirical study. Neurosci Biobehav Rev 18:325-338
17. Bell R, Donaldson C, Gracey D (1995) Differential effects of CGS 12066B and CP-94,253 on murine social and agonistic behavior. Pharmacol Biochem Behav 52:7-16
18. Bennett RM, Buss AH, Carpenter JA (1969) Alcohol and human physical aggression. Quart J Stud Alcohol 30:870-876
19. Berkowitz L (1993) Aggression. Its causes, consequences and control. Mc Graw Hill, New York
20. Berman M, Gladue B, Taylor S (1993) The effects of hormones, type A behavior pattern, and provocation on aggression in men. Motivation Emotion 17:125-138
21. Bernstein S, Richardson D, Hammock G (1987) Convergent and discriminant validity of the Taylor and Buss measures of physical aggression. Aggress Behav 13:15-24
22. Bhana N, Foster RH, Olney R, Plosker GL (2001) Olanzapine: an updated review of its use in the management of schizophrenia. Drugs 61:111-161
23. Bjork JM, Dougherty DM (1998) Differences in alcohol expectancy between aggressive and nonaggressive social drinkers. Alcohol Clin Exp Res 22:1943-1950
24. Bjork JM, Dougherty DM, Moeller FG (1996) A positive correlation between self-ratings of depression and laboratory-measured aggression. Psychiatry Res 69:33-38
25. Bjork JM, Moeller FG, Kramer GL, Kram M, Suris A, Rush AJ, Petty F (2001) Plasma GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder. Psychiatry Res 101:131-136
26. Blanchard DC, Rodgers RJ, Hendrie CA, Hori K (1988) 'Taming' of wild rats (Rattus rattus) by 5HT1A agonists buspirone and gepirone. Pharmacol Biochem Behav 31:269-278
27. Blanchard DC, Griebel G, Blanchard RJ (2001) Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic. Neurosci Biobehav Rev 25:205-218
28. Blanchard RJ, Blanchard DC, Takahashi LK (1978) Pain and aggression in the rat. Behav Biol 23:291-305
29. Blanchard RJ, Hori K, Flannelly K, Blanchard DC (1987) The effects of ethanol on the offense and defensive behaviors of male and female rats during group formation. Pharmacol Biochem Behav 26:61-64
30. Bolin P, DaVanzo JP (1982) The influence of isolation and aminooxyacetic acid (AOAA) on GABA in muricidal rats. Psychopharmacology 76:367-370
31. Bond A, Lader M (1988) Differential effects of oxazepam and lorazepam on aggressive responding. Psychopharmacology 95:369-373
32. Bond AJ (1998) Drug-induced behavioural disinhibition: incidence, mechanisms and therapeutic implications. CNS Drugs 9:41-57
33. Bond AJ, Curran HV, Bruce MS, O'Sullivan G, Shine P (1995) Behavioural aggression in panic disorder after 8 weeks' treatment with alprazolam. J Affect Disord 35:117-123
34. Bonson KR, Johnson RG, Fiorella D, Rabin RA, Winter JC (1994) Serotonergic control of androgen-induced dominance. Pharmacol Biochem Behav 49:313-322
35. Bouvard M, Mollard E, Guerin J, Cottraux J (1997) Study and course of the psychological profile in 77 patients experiencing panic disorder with agoraphobia after cognitive behaviour therapy with or without buspirone. Psychother Psychosom 66:27-32
36. 1B knockout mice
37. Brizer DA (1988) Psychopharmacology and the management of violent patients. Psychiatr Clin North Am 11:551-568
38. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF (1979) Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res 1:131-139
39. Brunner D, Hen R (1997) Insights into the neurology of impulsive behavior from serotonin receptor knockout mice. Anal NY Acad Sci 836:81-105
40. Buckley PF (1999) The role of typical and atypical antipsychotic medications in the management of agitation and aggression. J Clin Psychiatry 60[Suppl 10]:52-60
41. Buckley PF, Ibrahim ZY, Singer B, Orr B, Donenwirth K, Brar PS (1997) Aggression and schizophrenia: Efficacy of risperidone. J Am Acad Psychiatry Law 25:173-181
42. Buitelaar JK, van der Gaag RJ, Cohen-Kettenis P, Melman CTM (2001) A randomized controlled trial of risperidone in the treatment of aggression in hospitalized adolescents with subaverage cognitive abilities. J Clin Psychiatry 62:239-248
43. Buss AH (1961) The psychology of aggression. Wiley, New York
44. Buss AH, Durkee A (1957) An inventory for assessing different kinds of hostility. J Consult Psychol 21:343-349
45. Buss AH, Perry M (1992) The aggression questionnaire. J Pers Soc Psychol 63:452-459
46. Chalasani L, Kant R, Chengappa R (2001) Clozapine impact on clinical outcomes and aggression in severely ill adolescents with childhood onset schizophrenia. Can J Psychiatry 46:965-968
47. Chance MRA, Mackintosh JH, Dixon AK (1973) The effects of ethyl alcohol on social encounters between mice. J Alcoholism 8:90-93
48. Cherek DR (1984) Effects of cigarette smoking on human aggressive behavior. In: Flannelly KJ (ed) Biological perspectives on aggression. Liss, New York, pp 333-344
49. Cherek DR, Heistad GT (1971) Fixed-interval induced aggression. Psychonomic Sci 25:7-8
50. Cherek DR, Lane SD (1999) Laboratory and psychometric measurements of impulsivity among violent and nonviolent female parolees. Biol Psychiatry 46:273-280
51. Cherek DR, Steinberg JL (1987) Effects of drugs on human aggressive behavior. In: Burrows GD (ed) Advances in human psychopharmacology. JAI Press, Greenwich, pp 239-290
52. Cherek DR, Steinberg JL, Vines RV (1984) Low doses of alcohol affect human aggressive responses. Biol Psychiatry 19:263-267
53. Cherek DR, Steinberg JL, Manno BR (1985) Effects of alcohol on human aggressive behavior. J Stud Alcohol 46:321-328
54. Cherek DR, Moeller FG, Schnapp W, Dougherty DM (1997) Studies of violent and nonviolent male parolees. 1. Laboratory and psychometric measurements of aggression. Biol Psychiatry 41:514-522
55. Cherek DR, Lane SD, Pietras CJ, Steinberg JL (2002) Effects of chronic paroxetine administration on measures of aggressive and impulsive responses of adult males with a history of conduct disorder. Psychopharmacology 159:266-274
56. Cheu JW, Siegel A (1998) GABA receptor mediated suppression of defensive rage behavior elicited from the medial hypothalamus of the cat: role of the lateral hypothalamus. Brain Res 783:293-304
57. Chiavegatto S, Dawson VL, Mamounas LA, Koliatsos VE, Dawson TM, Nelson RJ (2001) Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase. Proc Natl Acad Sci USA 98:1277-1281
58. Christmas AJ, Maxwell DR (1970) A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats. Neuropharmacology 9:17-29
59. Citrome L, Volavka J (1997a) Psychopharmacology of violence - part II. Beyond the acute episode. Psychiatr Ann 10:696-703
60. Citrome L, Volavka J (1997b) Psychopharmacology of violence: part I. Assessment and acute treatment. Psychiatr Ann 27:691-695
61. Clement J, Simler S, Ciesielski L, Mandel P, Cabib S, Puglisi-Allegra S (1987) Age-dependent changes of brain GABA levels, turnover rates and shock-induced aggressive behavior in inbred strains of mice. Pharmacol Biochem Behav 26:83-88
62. Coccaro EF (1989) Central serotonin and impulsive aggression. Br J Psychiatry 155:52-62
63. Coccaro EF, Kavoussi RJ (1997) Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch Gen Psychiatry 54:1081-1088
64. Coccaro EF, Siever LJ, Klar HM, Maurer G, Cochrane K, Cooper TB, Mohs RC, Davis KL (1989) Serotonergic studies in patients with affective and personality disorders. Arch Gen Psychiatry 46:587-599
65. Coccaro EF, Kavoussi RJ, Hauger RL (1995) Physiological responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder. Int Clin Psychopharmacol 10:177-179
66. Coccaro EF, Berman ME, Kavoussi RJ (1997) Assessment of life history of aggression: development and psychometric characteristics. Psychiatry Res 73:147-157
67. Cogan R, Porcerelli JH, Dromgoole R (2001) Psychodynamics of partner, stranger, and generally violent male college students. Psychoanal Psychol 18:515-533
68. Cole HF, Wolf HH (1970) Laboratory evaluation of aggressive behavior of the grasshopper mouse (Onychomys). J Pharm Sci 59:969-971
69. Connor JL (1974) Waning and recovery of conspecific aggression in the house mouse (Mus musculus L). J Comp Physiol Psychol 87:215-227
70. Coons PM (1992) The use of carbamazepine for episodic violence in multiple personality disorder and dissociative disorder not otherwise specified: two additional cases. Biol Psychiatry 32:717-720
71. Crabbe JC, Phillips TJ, Feller DJ, Hen R, Wenger CD, Lessov CN, Schafer GL (1996) Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors. Nat Genet 14:98-101
72. Crabbe JC, Wahlsten D, Dudek BC (1999) Genetics of mouse behavior: interactions with laboratory environment. Science 284:1670-1672
73. Crawley JN, Schleidt WM, Contrera JF (1975) Does social environment decrease propensity to fight in male mice? Behav Biol 15:73-83
74. Crowcroft P (1966) Mice all over. Foulis, London
75. Crowley TJ (1972) Dose-dependent facilitation or supression of rat fighting by methamphetamine, phenobarbital, or imipramine. Psychopharmacologia 27:213-222
76. Cruz APM, Frei F, Graeff FG (1994) Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol Biochem Behav 49:171-176
77. Cueva JE, Overall JE, Small AM, Armenteros JL, Perry R, Campbell M (1996) Carbamazepine in aggressive children with conduct disorder: a double-blind and placebo-controlled study. J Am Acad Child Adolesc Psychiatry 35:480-490
78. Cutler MG, Rodgers RJ, Jackson JE (1997) Behavioural effects in mice of subchronic buspirone, ondansetron, and tianeptine. I. Social interactions. Pharmacol Biochem Behav 56:287-293
79. Czobor P, Volavka J, Meibach RC (1995) Effect of risperidone on hostility in schizophrenia. J Clin Psychopharmacol 15:243-249
80. DaVanzo JP, Sydow M (1979) Inhibition of isolation-induced aggressive behavior with GABA transaminase inhibitors. Psychopharmacology 62:23-27
81. de Almeida RMM, Lucion A (1994) Effects of intracerebroventricular administration of 5-HT receptor agonists on the maternal aggression of rats. Eur J Neurosci 264:445-448
82. de Almeida RMM, Lucion AB (1997) 8-OH-DPAT in the median raphe, dorsal periaqueductal gray and corticomedial amygdala nucleus decreases, but the medial septal area it can increase maternal aggressive behavior in rats. Psychopharmacology 134:392-400
83. 1B receptor agonist. Neuropsychopharmacology 272:171-181
84. 2A receptor agonist in the dorsal periaqueductal gray and medial septal areas on maternal aggressive behavior in female Wistar rats. Aggress Behav 27:236
85. 1B/D receptor agonist, alcohol, and aggression in male mice. Psychopharmacology 157:131-141
86. de Boer SF, Lesourd M, Mocaer E, Koolhaas JM (1999) Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via (5-hydroxytryptamine) 1A receptors: a comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. J Pharmacol Exp Ther 288:1125-1133
87. de Boer SF, Lesourd M, Mocaer E, Koolhaas JM (2000) Somatodendritic 5-HT1A autoreceptors mediate the anti-aggressive actions of 5-HT(1A) receptor agonists in rats: an ethopharmacological study with S-15535, alnespirone, and WAY-100635. Neuropsychopharmacology 23:20-33
88. De Deyn PP, Rabheru K, Rasmussen A, Bocksberger JP, Dautzenberg PL, Eriksson S, Lawlor BA (1999) A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia. Neurology 53:946-955
89. 1A receptor agonists: recent developments and controversial issues. Psychopharmacology 121:1-26
90. Delini-Stula A, Vassout A (1978) Influence of baclofen and GABA-mimetic agents of spontaneous and olfactory-bulb-ablation-induced muricidal behaviour in the rat. Arzneim Forsch 28:1508-1509
91. Delini-Stula A, Vassout A (1981) The effects of antidepressants on aggressiveness induced by social deprivation in mice. Pharmacol Biochem Behav 14[Suppl 1]:33-41
92. Delville Y, Mansour KM, Ferris CF (1996) Serotonin blocks vasopressin-facilitated offensive aggression: interactions within the ventrolateral hypothalamus of golden hamsters. Physiol Behav 59:813-816
93. DeMoja CA, Spielberger CD (1997) Anger and drug addiction. Psychol Rep 81:152-154
94. Depaulis A, Vergnes M (1983) Induction of mouse-killing in the rat by intraventricular injection of a GABA-agonist. Physiol Behav 30:383-388
95. Dews PB (1970) The theory of fixed-interval responding. In: Schoenfeld WN (ed) The theory of reinforcement schedules. Appleton-Century-Crofts, New York, pp 43-61
96. Dietch JT, Jennings RK (1988) Aggressive dyscontrol in patients treated with benzodiazepines. J Clin Psychiatry 49:184-188
97. DiMascio A (1973) The effects of benzodiazepines on aggression: reduced or increased? Psychopharmacologia 30:95-102
98. DiMascio A, Shader RI, Harmatz J (1969) Psychotropic drugs and induced hostility. Psychosomatics 10:46-47
99. Dollard J, Doob L, Miller N, Mowrer O, Sears R (1939) Frustration and aggression. Yale University Press, New Haven
100. 1 binding sites as target for a novel putative anxiolytic. Naunyn-Schmiedeberg's Arch Pharmacol 328:467-470
101. Doudet D, Hommer D, Higley JD, Andreason PJ, Moneman R, Suomi SJ, Linnoila M (1995) Cerebral glucose metabolism, CSF 5-HIAA levels, and aggressive behavior in rhesus monkeys. Am J Psychiatry 152:1782-1787
102. Early CJ, Leonard BE (1980) The effect of testosterone and cyproterone acetate on the concentration of γ-aminobutyric acid in brain areas of aggressive and non-aggressive mice. Pharmacol Biochem Behav 12:189-193
103. Eibl-Eibesfeldt I (1950) Beiträge zur Biologie der Haus- und Ährenmaus nebst einigen Beobachtungen an anderen Nagern. Zeitschrift für Tierpsychologie 7:558-587
104. Eibl-Eibesfeldt I (1961) The fighting behavior of animals. Sci Am 203:112-120
105. Eichelman BSJ, Thoa NB, Ng KY (1972) Facilitated aggression in the rat following 6-hydroxydopamine administration. Physiol Behav 8:1-3
106. Ellison G (1976) Monoamine neurotoxins: selective and delayed effects on behavior in colonies of laboratory rats. Brain Res 103:81-92
107. Fagen RM, Young DY (1978) Temporal patterns of behaviors: durations, intervals, latencies, and sequences. In: Colgan PW (ed) Quantitative ethology. Wiley, New York, pp 79-114
108. Fairbanks LA, Fontenot MB, Phillips-Conroy JE, Jolly CJ, Kaplan JR, Mann JJ (1999) CSF monoamines, age and impulsivity in wild grivet monkeys (Cercopithecus aethiops aethiops). Brain Behav Evol 53:305-312
109. Fairbanks LA, Melega WP, Jorgensen MJ, Kaplan JR, McGuire MT (2001) Social impulsivity inversely associated with CSF 5-HIAA and fluoxetine exposure in vervet monkeys. Neuropsychopharmacology 24:370-378
110. Fava M (1997) Psychopharmacologic treatment of pathologic aggression. Psychiatr Clin North Am 20:427-451
111. Ferrari PF, Parmigiani S, Rodgers RJ, Palanza P (1997) Differential effects of chlordiazepoxide on aggressive behavior in male mice: the influence of social factors. Psychopharmacology 134:258-265
112. Ferris CF, Melloni RH, Koppel G, Perry KW, Fuller RW, Delville Y (1997) Vasopressin/serotonin interactions in the anterior hypothalamus control aggressive behavior in golden hamsters. J Neurosci 17:4331-4340
113. Fichtner CG, Kuhlman DT, Gruenfeld MJ, Hughes JR (1990) Decreased episodic violence and increased control of dissociation in a carbamazepine-treated case of multiple personality. Biol Psychiatry 27:1045-1052
114. 1B receptor agonist CP-94,253. Psychopharmacology 146:391-399
115. Fish EW, De Bold JF, Miczek KA (2001a) Repeated alcohol: behavioral sensitization and alcohol-heightened aggression in mice. Psychopharmacology 160:39-48
116. Fish EW, Faccidomo S, DeBold JF, Miczek KA (2001b) Alcohol, allopregnanolone and aggression in mice. Psychopharmacology 153:473-483
117. Fish EW, DeBold JF, Miczek KA (2002) Aggressive behavior as a reinforcer in mice: activation by allopregnanolone. Psychoharmacology DOI 10.1007/s00213-002-1211-2
118. Forgays KD, Spielberg CD, Ottaway SA, Forgays DG (1998) Factor structure of the State-Trait Anger Expression Inventory for middle-aged men and women. Assessment 5:141-155
119. Fossati AD (2001) Psychometric properties of an Italian version of the Barratt impulsiveness scale-11 (BIS-11) in nonclinical subjects. J Clin Psychol 57:815-828
120. Fuller RW (1996) The influence of fluoxetine on aggressive behavior. Neuropsychopharmacology 14:77-81
121. Gardos G, DiMascio A, Salzman C, Shader RI (1968) Differential actions of chlordiazepoxide and oxazepam on hostility. Arch Gen Psychiatry 18:757-760
122. Gendreau PL, Petitto JM, Petrova A, Gariepy J, Lewis MH (2000) D3 and D2 dopamine receptor agonists differentially modulate isolation-induced social-emotional reactivity in mice. Behav Brain Res 114:107-117
123. Gerra G, Fertonani G, Zaimovic A, Rotagraziosi I, Avanzini P, Caccavari R, Delsignore R, Lucchini A (1995) Hostility in heroin abusers subtypes: fluoxetine and naltrexone treatment. Prog Neuropsychopharmacol Biol Psychiatry 19:1225-1237
124. Geyer MA, Segal DS (1974) Shock-induced aggression: opposite effects of intraventricularly infused dopamine and norepinephrine. Behav Biol 10:99-104
125. Giacalone E, Tansella M, Valzelli L, Garattini S (1968) Brain serotonin metabolism in isolated aggressive mice. Biochem Pharmacol 17:1315-1327
126. Giancola PR, Chermack ST (1998) Construct validity of laboratory aggression paradigms: a response to Tedeschi and Quigley (1996). Aggress Violent Behav 3:237-253
127. Giancola PR, Zeichner A (1995) Alcohol-related aggression in males and females: effects of blood alcohol concentration, subjective intoxication, personality, and provocation. Alcohol Clin Exp Res 19:130-134
128. Gianutsos G, Lal H (1978) Narcotic analgesics and aggression. In: Valzelli L (ed) Modern problems of pharmopsychiatry: psychopharmacology of aggression. Karger, New York, pp 114-138
129. Gidron Y, Davidson K, Ilia R (2001) Development and cross-cultural and clinical validation of a brief comprehensive scale for assessing hostility in medical settings. J Behav Med 24:1-15
130. Ginsburg B, Allee WC (1942) Some effects of conditioning on social dominance and subordination in inbred strains of mice. Physiol Zool 15:485-506
131. Glazer WM, Dickson RA (1998) Clozapine reduces violence and persistent aggression in schizophrenia. J Clin Psychiatry 59[Suppl 3]:8-14
132. Goodall J (1986) The chimpanzees of Gombe: patterns of behavior. Belknap Press of Harvard University Press, Cambridge
133. Gourley SL, Sekinda M, De Bold JF, Miczek KA (2002) Heightened aggression after self-administered alcohol in rats: reduction by 5-HT1A and 5-HT1B agonists. Psychopharmacology (in press)
134. Grant KA (1994) Emerging neurochemical concepts in the actions of ethanol at ligand-gated ion channels. Behav Pharmacol 5:383-404
135. Grobin AC, Matthews DB, Devaud LL, Morrow AL (1998) The role of GABAA receptors in the acute and chronic effects of ethanol. Psychopharmacology 139:2-19
136. Guillot PV, Chapoutier G (1996) Intermale aggression and dark preference in ten inbred mouse strains. Behav Brain Res 77:211-213
137. Guillot PV, Chapouthier G (1998) Intermale aggression, GAD activity in the olfactory bulbs and Y chromosome effect in seven inbred mouse strains. Behav Brain Res 90:203-206
138. Gustafson R (1992) Alcohol and aggression: a replication study controlling for potential confounding variables. Aggress Behav 18:21-28
139. Hadfield MG (1983) Dopamine: mesocortical versus nigrostriatal uptake in isolated fighting mice and controls. Behav Brain Res 7:269-281
140. Haney M, Noda K, Kream R, Miczek KA (1990) Regional serotonin and dopamine activity: sensitivity to amphetamine and aggressive behavior in mice. Aggress Behav 16:259-270
141. Hasselager E, Rolinski Z, Randrup A (1972) Specific antagonism by dopamine inhibitors of items of amphetamine induced aggressive behaviour. Psychopharmacologia 24:485-495
142. Haug M, Simler S, Ciesielski L, Mandel P, Moutier R (1984) Influence of castration and brain GABA levels in three strains of mice on aggression towards lactating intruders. Physiol Behav 32:767-770
143. Haug M, Wallian L, Brain PF (1990) Effects of 8-OH-DPAT and fluoxetine on activity and attack by female mice towards lactating intruders. Gen Pharmacol 21:845-849
144. Hebert MA, Potegal M, Moore T, Evenson AR, Meyerhoff JL (1996) Diazepam enhances conditioned defeat in hamsters (mesocricetus auratus). Pharmacol Biochem Behav 55:405-413
145. Hector RI (1998) The use of clozapine in the treatment of aggressive schizophrenia. Can J Psychiatry 43:466-472
146. Heiligenberg W (1974) Processing governing behavioral states of readiness. Adv Stud Behav 5:173-200
147. Heiligenstein JH, Beasley CM Jr, Potvin JH (1993) Fluoxetine not associated with increased aggression in controlled clinical trials. Int Clin Psychopharmacol 8:277-280
148. Hen R (1996) Mean genes. Neuron 16:17-21
149. Hendley ED, Moisset B, Welch BL (1973) Catecholamine uptake in cerebral cortex: adaptive change induced by fighting. Science 180:1050-1052
150. Hernandez L, Hoebel BG (1988) Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life Sci 42:1705-1712
151. Higley JD (2001) Individual differences in alcohol-induced aggression: a nonhuman-primate model. Alcohol Res Health 25:12-19
152. Higley JD, Bennett AJ (1999) Central nervous system serotonin and personality as variables contributing to excessive alcohol consumption in non-human primates. Alcohol Alcohol 34:402-418
153. Ho HP, Olsson M, Westberg L, Melke J, Eriksson E (2001) The serotonin reuptake inhibitor fluoxetine reduces sex steroid-related aggression in female rats: an animal model of premenstrual irritability? Neuropsychopharmacology 24:502-510
154. Hodge GK, Butcher LL (1975) Catecholamine correlates of isolation-induced aggression in mice. Eur J Pharmacol 31:81-93
155. Holland TR, Holt N, Levi M, Beckett S (1983) Comparison and combination of clinical and statistical predictions of recidivism among adult offenders. J Appl Psychol 68:203-211
156. Hollander E (1999) Managing aggressive behavior in patients with obsessive-compulsive disorder and borderline personality disorder. J Clin Psychiatry 60[Suppl 15]:38-44
157. Holmes A, Murphy DL, Crawley JN (2002) Reduced aggression in mice lacking the serotonin transporter. Psychopharmacology 161:160-167
158. Huber R, Kravitz EA (1995) A quantitative analysis of agonistic behavior in juvenile American lobsters (Homarus americanus L.). Brain Behav Evol 46:72-83
159. Huntingford FA (1984) Some ethical issues raised by studies of predation and aggression. Anim Behav 32:210-215
160. Huntingford FA, Turner AK (1987) Animal conflict. Chapman and Hall, London
161. Ingle D (2002) Recreational aggression: cultural and biological dimensions. Aggress Behav (in press)
162. Jacobs BL, Fornal CA (1999) Activity of serotonergic neurons in behaving animals. Neuropsychopharmacology 21:9S-15S
163. Janssen PAG, Jageneau AH, Niemegeers CJE (1960) Effects of various drugs on isolation-induced fighting behavior in male mice. J Pharmacol Exp Ther 129:471-475
164. Johnstone RA (2001) Eavesdropping and animal conflict. Proc Natl Acad Sci USA 98:9177-9180
165. Joppa MA, Rowe RK, Meisel RL (1997) Effects of serotonin 1A or 1B receptor agonists on social aggression in male and female Syrian hamsters. Pharmacol Biochem Behav 58:349-353
166. Kaiser H (1968) Periodic territorial behavior in the dragon-fly Aeschna cyanea. Naturwissenschaften 55:657
167. Kantak KM, Miczek KA (1988) Social, motor, and autonomic signs of morphine withdrawal: differential sensitivities to catecholaminergic drugs in mice. Psychopharmacology 96:468-476
168. Kavoussi R, Armstead P, Coccaro E (1997) The neurobiology of impulsive aggression. Psychiatr Clin North Am 20:395-403
169. Keck PE Jr, Strakowski SM, McElroy SL (2000) The efficacy of atypical antipsychotics in the treatment of depressive symptoms, hostility, and suicidality in patients with schizophrenia. J Clin Psychiatry 61[Suppl 3]:4-9
170. Kelleher RT, Morse WH (1968) Determinants of the specificity of behavioral effects of drugs. Ergeb Physiol Biol Chem Exp Pharmakol 60:1-56
171. Kelly DD (1974) The experimental imperative: laboratory analyses of aggressive behaviors. In: Frazier SH (ed) Aggression. Research publications of the Association for Research in Nervous and Mental Diseases. Williams and Wilkins, Baltimore, pp 21-41
172. Kelsey JE, Cassidy D (1976) The reinforcing properties of aggressive vs. nonaggressive social interactions in isolated male ICR mice (Mus musculus). Aggress Behav 2:275-284
173. Kennedy JS, Bymaster FP, Schuh L, Calligaro DO, Nomikos G, Felder CC, Bernauer M, Kinon BJ, Baker RW, Hay D, Roth HJ, Dossenbach M, Kaiser C, Beasley CM, Holcombe JH, Effron MB, Breier A (2001) A current review of olanzapine's safety in the geriatric patient: from pre-clinical pharmacology to clinical data. Int J Geriatr Psychiatry 16:S33-S61
174. Knight RA, Cerce DD (1999) Validation and revision of the multidimensional assessment of sex and aggression. Psychologica Belgica 39:135-161
175. Knight RA, Prentky RA, Cerce DD (1994) The development, reliability, and validity of an inventory for the multidimensional assessment of sex and aggression. Criminal Justice Behav 21:72-94
176. Knutson B, Wolkowitz OM, Cole SW, Chan T, Moore EA, Johnson RC, Terpstra J, Turner RA, Reus VI (1998) Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry 155:373-379
177. Kollack-Walker S, Watson SJ, Akil H (1997) Social stress in hamsters: defeat activates specific neurocircuits within the brain. J Neurosci 17:8842-8855
178. Kouri EM, Pope HGJ, Lukas SE (1999) Changes in aggressive behavior during withdrawal from long-term marijuana use. Psychopharmacology 143:302-308
179. Krsiak M (1974) Isolation-induced timidity in mice as a measure of anxiolytic activity of drugs. Activitas Nervosa Superior 16:241-142
180. Krsiak M, Sulcova A, Tomasikova Z, Dlohozkova N, Kosar E, Masek K (1981) Drug effects on attack, defense and escape in mice. Pharmacol Biochem Behav 14:47-52
181. Kruesi MJP, Rapoport JL, Hamburger S, Hibbs E, Potter WZ, Lenane M, Brown GR (1990) Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Arch Gen Psychiatry 47:419-426
182. Lachowicz JE, Sibley DR (1997) Molecular characteristics of mammalian dopamine receptors. Pharmacol Toxicol 81:105-113
183. Lange A, Pahlich A, Sarucco M, Smits G, Dehghani B, Hanewald G (1995) Psychometric chracteristics and validity of the the dutch adaptation of the Buss-Durkee hostility inventory (the BDHI-D). Behav Res Ther 33:223-227
184. Lau MA, Pihl RO (1994) Alcohol and the Taylor aggression paradigm - repeated-measures study. J Stud Alcohol 55:701-706
185. Lavine R (1997) Psychopharmacological treatment of aggression and violence in the substance using population. J Psychoactive Drugs 29:321-329
186. Lesch KP, Merschdorf U (2000) Impulsivity, aggression, and serotonin: a molecular psychobiological perspective. Behav Sci Law 18:581-604
187. Lewis MH, Gariepy JL, Gendreau P, Nichols DE, Mailman RB (1994) Social reactivity and D1 dopamine receptors: studies in mice selectively bred for high and low levels of aggression. Neuropsychopharmacology 10:115-122
188. Licata A, Taylor S, Cranston J (1993) Effects of cocaine on human-aggression. Pharmacol Biochem Behav 45:549-552
189. Lindenmayer JP, Kotsaftis A (2000) Use of sodium valproate in violent and aggressive behaviors: a critical review. J Clin Psychiatry 61:123-128
190. Lindgren T, Kantak KM (1987) Effects of serotonin receptor agonists and antagonists on offensive aggression in mice. Aggress Behav 13:87-96
191. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK (1983) Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci 33:2609-2614
192. Linnoila M, De Jong J, Virkkunen M (1989) Family history of alcoholism in violent offenders and impulsive fire setters. Arch Gen Psychiatry 46:613-616
193. Lonergan E, Luxenberg J, Colford J (2001) Haloperidol for agitation in dementia (Cochrane Review). Cochrane Database Syst Rev 4:CD002852
194. Lorenz K (1966) On aggression. Methuen, London
195. Löw K, Crestani F, Keist R, Benke D, Brünig I, Benson JA, Fritschy JM, Rülicke T, Bluethmann H, Möhler H, Rudolph U (2000) Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290:131-134
196. Lucki I, Wieland S (1990) 5-Hydroxytryptamine-1A receptors and behavioral responses. Neuropsychopharmacology 3:481-493
197. Mackintosh JH (1970) Territory formation by laboratory mice. Anim Behav 18:177-183
198. Maes M, Cosyns P, Meltzer HY, De Meyer F, Peeters D (1993) Seasonality in violent suicide but not in nonviolent suicide or homicide. Am J Psychiatry 150:1380-1385
199. Maes M, Scharpe S, Verkerk R, Dhondt P, Peeters D, Cosyns P, Thompson P, Demeyer F, Wauters A, Neels H (1995) Seasonal variation in plasma L-tryptophan availability in healthy volunteers - relationships to violent suicide occurrence. Arch Gen Psychiatry 52:937-946
200. Maletzky BM (1973) The episodic dyscontrol syndrome. Dis Nerv Syst 34:178-185
201. Martinez M, Guillen-Salazar F, Salvador A, Simon VM (1995) Successful intermale aggression and conditioned place preference in mice. Physiol Behav 58:323-328
202. Martinez M, Phillips PJ, Herbert J (1998) Adaptation in patterns of c-fos expression in the brain associated with exposure to either single or repeated social stress in male rats. Eur J Neurosci 10:20-33
203. Matsumoto K, Ojima K, Watanabe H (1995) Noradrenergic denervation attenuates desipramine enhancement of aggressive behavior in isolated mice. Pharmacol Biochem Behav 50:481-484
204. McCormick RA, Smith M (1995) Aggression and hostility in substance-abusers - the relationship to abuse patterns, coping style, and relapse triggers. Addict Behav 20:555-562
205. McKinley JC, Hathaway SR, Meehl PE (1948) The Minesota Multiphasic Personality Inventory: the k-scale. J Consult Psychol 12:20-31
206. McMillen BA, DaVanzo EA, Scott SM, Song AH (1988) N-alkyl-substituted aryl-piperazine drugs: relationship between affinity for serotonin receptors and inhibition of aggression. Drug Dev Res 12:53-62
207. McMillen BA, DaVanzo EA, Song AH, Scott SM, Rodriguez ME (1989) Effects of classical and atypical antipsychotic drugs on isolation-induced aggression in male mice. Eur J Pharmacol 160:149-153
208. Mehlman PT, Higley JD, Faucher I, Lilly AA, Taub DM, Vickers J, Suomi SJ, Linnoila M (1994) Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. Am J Psychiatry 151:1485-1491
209. A-gated chloride channels. J Pharmacol Exp Ther 246:558-564
210. Meisel RL, Joppa MA (1994) Conditioned place preference in female hamsters following aggressive or sexual encounters. Physiol Behav 56:1115-1118
211. Mendoza DL, Bravo HA, Swanson HH (1999) Antiaggresive and anxiolytic effects of gepirone in mice, and their attenuation by WAY 100635. Pharmacol Biochem Behav 62:499-509
212. Michael RP, Zumpe D (1981) Relation between the seasonal changes in aggression, plasma testosterone and the photoperiod in male rhesus monkeys. Psychoneuroendocrinology 6:145-158
213. Miczek KA (1974) Intraspecies aggression in rats: effects of D-amphetamine and chlordiazepoxide. Psychopharmacologia 39:275-301
214. Miczek KA (1999) Aggressive and social stress responses in genetically modified mice: from horizontal to vertical strategy. Psychopharmacology 147:17-19
215. Miczek KA (2001) Research on animal aggression: emerging successes for understanding determinants of human violence. In: Carrol ME, Overmier JB (eds) Animal research and human health: advancing human welfare through behavioral science. American Psychological Association, Washington
216. Miczek KA, Barry H III (1977) Effects of alcohol on attack and defensive-submissive reactions in rats. Psychopharmacology 52:231-237
217. 1B agonist anpirtoline. Psychopharmacology 157:421-429
218. Miczek KA, Haney M (1994) Psychomotor stimulant effects of D-amphetamine, MDMA and PCP: aggressive and schedule-controlled behavior in mice. Psychopharmacology 115:358-365
219. Miczek KA, Krsiak M (1979) Drug effects on agonistic behavior. In: Thompson T, Dews PB (eds) Advances in behavioral pharmacology. Academic Press, New York, pp 87-162
220. Miczek KA, O'Donnell JM (1978) Intruder-evoked aggression in isolated and nonisolated mice: effects of psychomotor stimulants and L-dopa. Psychopharmacology 57:47-55
221. Miczek KA, O'Donnell JM (1980) Alcohol and chlordiazepoxide increase suppressed aggression in mice. Psychopharmacology 69:39-44
222. Miczek KA, Yoshimura H (1982) Disruption of primate social behavior by D-amphetamine and cocaine: differential antagonism by antipsychotics. Psychopharmacology 76:163-171
223. Miczek KA, Weerts EM, Tornatzky W, De Bold JF, Vatne TM (1992) Alcohol and "bursts" of aggressive behavior: ethological analysis of individual differences in rats. Psychopharmacology 107:551-563
224. Miczek KA, Haney M, Tidey J, Vivian J, Weerts E (1994a) Neurochemistry and pharmacotherapeutic management of violence and aggression. In: Reiss AJ (ed) Understanding and preventing violence: biobehavioral influences on violence. National Academy Press, Washington, pp 244-514
225. Miczek KA, Weerts EM, Haney M, Tidey J (1994b) Neurobiological mechanisms controlling aggression: preclinical developments for pharmacotherapeutic interventions. Neurosci Biobehav Rev 18:97-110
226. Miczek KA, Barros HM, Sakoda L, Weerts EM (1998a) Alcohol and heightened aggression in individual mice. Alcohol Clin Exp Res 22:1698-1705
227. 1A receptor agonists. Psychopharmacology 139:160-168
228. A receptor agonists, self-administered alcohol and aggression in mice. Soc Neurosci Abstr 31:225.8
229. Miczek KA, Maxson SC, Fish EW, Faccidomo S (2001b) Aggressive behavioral phenotypes in mice. Behav Brain Res 125:167-181
230. 1A receptor antagonist, WAY-100635. Behav Pharmacol 8:585-606
231. Mitchell PJ, Fletcher A, Redfern PH (1991) Is antidepressant efficacy revealed by drug-induced changes in rat behaviour exhibited during social interaction? Neurosci Biobehav Rev 15:539-544
232. Moeller FG, Dougherty DM, Rustin T, Swann AC, Allen TJ, Shah N, Cherek DR (1997) Antisocial personality disorder and aggression in recently abstinent cocaine dependent subjects. Drug Alcohol Depend 44:175-182
233. Moeller FG, Allen T, Cherek DR, Dougherty DM, Lane S, Swann AC (1998) Ipsapirone neuroendocrine challenge: relationship to aggression as measured in the human laboratory. Psychiatry Res 81:31-38
234. Molina V, Ciesielsski L, Gobaille S, Mandel P (1986) Effects of the potentiation of the GABAergic neurotransmission in the olfactory bulbs on mouse-killing behavior. Pharmacol Biochem Behav 24:657-664
235. Mos J, Vanaken HHM, Vanoorschot R, Olivier B (1996) Chronic treatment with eltoprazine does not lead to tolerance in its antiaggressive action, in contrast to haloperidol. Eur Neuropsychopharmacol 6:1-7
236. Muehlenkamp F, Lucion A, Vogel WH (1995) Effects of selective serotonergic agonists on aggressive behavior in rats. Pharmacol Biochem Behav 50:671-674
237. Neppe VM (1988) Carbamazepine in nonresponsive psychosis. J Clin Psychiatry 49[Suppl]:22-30
238. Nestoros JN (1980) Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex. Science 209:708-710
239. Niehoff DL (1998) The biology of violence. The Free Press, New York
240. 1B receptor agonists in regulation of mouse aggressive behavior. Behav Pharmacol 10:S67
241. 1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man. Aggress Behav 18:357-364
242. Nikulina EM, Marchand JE, Kream R, Miczek KA (1998) Fos expression in murine brain stem nuclei after a brief social stress: behavioral sensitization to cocaine. Brain Res 810:200-210
243. Nishida T, Haraiwa-Hasegawa M, Takahata Y (1985) Group extinction and female transfer in wild chimpanzees in the Mahale National Park, Tanzania. Z Tierpsychol 67:284-301
244. Nogueira RL, Graeff FG (1995) Role of 5HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion. Pharmacol Biochem Behav 52:1-6
245. Olivier B, van Dalen D (1982) Social behaviour in rats and mice: an ethologically based model for differentiating psychoactive drugs. Aggress Behav 8:163-168
246. Olivier B, Mos J, Miczek KA (1991) Ethopharmacological studies of anxiolytics and aggression. Eur Neuropsychopharmacol 1:97-100
247. Olivier B, Mos J, de Koning P, Mak M (1994) Serenics. Prog Drug Res 42:167-302
248. Olivier B, Mos J, Van Oorschot R, Hen R (1995) Serotonin receptors and animal models of aggressive behavior. Pharmacopsychiatry 28:80-90
249. Olvera RL, Pliszka SR, Konyecsni WM, Hernandez Y, Farnum S, Tripp RF (2001) Validation of the interview module for intermittent explosive disorder (M-IED) in children and adolescents: a pilot study. Psychiatry Res 101:259-267
250. Oquendo MA (2001) Spanish adaptation of the Barratt impulsiveness scale (BIS-11). Eur J Psychiatry 15:147-155
251. Pabis DJ, Stanislav SW (1996) Pharmacotherapy of aggressive behavior. Ann Pharmacother 30:278-287
252. Peeke HVS, Figler MH (1981) Modulation of aggressive behavior in fish by alcohol and congeners. Pharmacol Biochem Behav 14[Suppl]:79-84
253. Petry NM (2001) Reliability of drug users' self-reported HIV risk behaviors using a brief, 11-item scale. Subst Use Misuse 36:1731-1747
254. Pfaus JG, Damsma G, Nomikos GG, Wenkstern DG, Blaha CD, Phillips AG, Fibiger HC (1990) Sexual behavior enhances central dopamine transmission in the male rat. Brain Res 530:345-348
255. Pfaus JG, Damsma G, Wenkerstern D, Fibiger HC (1995) Sexual activity increases dopamine transmission in the nucleus accumbens and striatum of female rats. Brain Res 693:21-30
256. Pihl RO, Peterson JB (1993) Alcohol, serotonin, and aggression. Alcohol Health Res World 17:113-116
257. Pihl RO, Young SN, Harden P, Plotnick S, Chamberlain B, Ervin FR (1995) Acute effect of altered tryptophan levels and alcohol on aggression in normal human males. Psychopharmacology 119:353-360
258. Placidi GPA, Oquendo MA, Malone KM, Huang YY, Ellis SP, Mann JJ (2001) Aggressivity, suicide attempts, and depression: relationship to cerebrospinal fluid monoamine metabolite levels. Biol Psychiatry 50:783-791
259. Poshivalov VP (1981) Pharmaco-ethological analysis of social behaviour of isolated mice. Pharmacol Biochem Behav 14[Suppl 1]:53-59
260. Potegal M (1979) The reinforcing value of several types of aggressive behavior: a review. Aggress Behav 5:353-373
261. Potegal M (1984) The persistence of attack satiation in female golden hamsters. Aggress Behav 10:303-307
262. Potegal M (1991) Attack priming and satiation in female golden hamsters: tests of some alternatives to the aggression arousal interpretation. Aggress Behav 17:327-335
263. Potegal M (1992) Time course of aggressive arousal in female hamsters and male rats. Behav Neural Biol 58:120-124
264. Potegal M, Perumal AS, Barkai AI, Cannova GE, Blau AD (1982) GABA binding in the brains of aggressive and non-aggressive female hamsters. Brain Res 247:315-324
265. Potegal M, Yoburn B, Glusman M (1983) Disinhibition of muricide and irritability by intraseptal muscimol. Pharmacol Biochem Behav 19:663-669
266. Puech AJ, Simon P, Chermat R, Boisseir JR (1974) Profil neuropsychopharmacologique de l'apomorphine. J Pharmacol 5:241-254
267. Puglisi-Allegra S, Cabib S (1990) Effects of defeat experiences on dopamine metabolism in different brain areas of the mouse. Aggress Behav 16:271-284
268. Puglisi-Allegra S, Mandel P (1980) Effects of sodium N-dipropylacetate, muscimol hydrobromide and (R, S)nipecotic acid amide on isolation-induced aggressive behavior in mice. Psychopharmacology 70:287-290
269. Puglisi-Allegra S, Mack G, Oliverio A, Mandel P (1979) Effects of apomorphine and sodium di-N-propylacetate on the aggressive behaviour of three strains of mice. Prog Neuropsychopharmacol 3:491-502
270. Puglisi-Allegra S, Simler S, Kempf E, Mandel P (1981) Involvement of the GABAergic system on shock-induced aggressive behavior in two strains of mice. Pharmacol Biochem Behav 14[Suppl 1]:13-18
271. Rabinowitz J, Avnon M, Rosenberg V (1996) Effect of clozapine on physical and verbal aggression. Schizophr Res 22:249-255
272. 1B receptor knock out - behavioral consequences. Behav Brain Res 73:305-312
273. Ranen NG, Lipsey JR, Treisman G, Ross CA (1996) Sertraline in the treatment of severe aggressiveness in Huntington's disease. J Neuropsychiatry Clin Neurosci 8:338-340
274. Ratey J, Sovner R, Parks A, Rogentine K (1991) Buspirone treatment of aggression and anxiety in mentally retarded patients: a multiple-baseline, placebo lead-in study. J Clin Psychiatry 52:159-162
275. Ray A, Sharma KK, Alkondon M, Sen P (1983) Possible interrelationship between the biogenic amines involved in the modulation of footshock aggression in rats. Arch Int Pharmacodyn Ther 265:36-41
276. Raynes AE, Ryback RS (1970) Effect of alcohol and congeners on aggressive response in Betta splendens. Quart J Stud Alcohol 5:130-135
277. Redfern PH, Mitchell PJ (1992) Chronic treatment with clomipramine and mianserin increases the hierarchical position of subdominant rats housed in triads. Behav Pharmacol 3:239-247
278. Roberts WW, Kiess HO (1963) Positive reinforcing property of performance of attack potentiated by stimulation of cat hypothalamus. Am Psychol 18:426
279. Rocha BA, Scearce-Levie K, Lucas JJ, Hiroi N, Castanon N, Crabbe JC, Nestler EJ, Hen R (1998) Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature 393:175-178
280. Rodgers RJ, DePaulis A (1982) Gabaergic influences on defensive fighting in rats. Pharmacol Biochem Behav 17:451-456
281. Rodgers RJ, Waters AJ (1985) Benzodiazepines and their antagonists: a pharmacoethological analysis with particular reference to effects on "aggression". Neurosci Biobehav Rev 9:21-35
282. Rodriguez-Arias M, Minarro J, Aguilar MA, Pinazo J, Simon VM (1998) Effects of risperidone and SCH 23390 on isolation-induced aggression in male mice. Eur Neuropsychopharmacol 8:95-103
283. Rodriguez-Arias M, Felip CM, Broseta I, Minarro J (1999a) The dopamine D3 antagonist U-99194A maleate increases social behaviors of isolation-induced aggressive male mice. Psychopharmacology 144:90-94
284. Rodriguez-Arias M, Pinazo J, Minarro J, Stinus L (1999b) Effects of SCH 23390, raclopride, and haloperidol on morphine withdrawal-induced aggression in male mice. Pharmacol Biochem Behav 64:123-130
285. Roizen J (1996) Epidemiological issues in alcohol-related violence. In: Galanter M (ed) Recent developments in alcoholism. Plenum Press, New York, pp 7-37
286. Rolinski Z (1975) Pharmacological studies on isolation-induced aggressiveness in mice in relation to biogenic amines. Pol J Pharmacol Pharm 27:37-44
287. Rose RM, Holaday JW, Bernstein IS (1971) Plasma testosterone, dominance rank and aggressive behavior in a group of male rhesus monkeys. Nature 231:366-368
288. Rose RM, Bernstein IS, Gordon TP (1975) Consequences of social conflict on plasma testosterone levels in rhesus monkeys. Psychosom Med 37:50-61
289. A receptor subtypes. Nature 401:796-800
290. 1A receptors. Eur J Pharmacol 264:241-247
291. Sanchez C, Meier E (1997) Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Psychopharmacology 129:197-205
292. Sanchez C, Arnt J, Hyttel J, Moltzen EK (1993) The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice. Psychopharmacology 110:53-59
293. 1B receptor. Science 265:1875-1878
294. Saxena PR (1995) Serotonin receptors-subtypes, functional-responses and therapeutic relevance. Pharmacol Toxicol 66:339-368
295. Scarpa A, Raine A (1997) Psychophysiology of anger and violent behavior. Psychiatr Clin North Amer 20:375-394
296. Scheier MF, Fenigste A, Buss AH (1974) Self-awareness and physical aggression. J Exp Psychol 10:264-273
297. Schotte A, Janssen PF, Gommeren W, Luyten WH, Van Gompel P, Lesage AS, De Loore K, Leysen JE (1996) Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 124:57-73
298. Scott JP (1958) Aggression. The University of Chicago Press, Chicago
299. Scott JP, Fredericson E (1951) The causes of fighting in mice and rats. Physiol Zool 24:273-309
300. Sekinda M, Van Erp AMM, Kalsy S, Miczek KA (1999) Heightened aggression after self-administered alcohol in rats: role of 5-HT receptors. Soc Neurosci Abstr 25:58
301. Senault B (1968) Syndrome agressif induit par l'apomorphine chez le Rat. J Physiologie 60:543-544
302. Senault B (1970) Comportement d'aggresivit' intrasp'cifique induit par l'apomorphine chez la rat. Psychopharmacologia 18:271-287
303. Serova LI, Naumenko EV (1996) Involvement of the brain catecholaminergic system in the regulation of dominant behavior. Pharmacol Biochem Behav 53:285-290
304. 2/1C receptors in the midbrain periaqueductal gray differentially modulate defensive rage behavior elicited from the medial hypothalamus of the cat. Brain Res 765:198-207
305. Shih JC, Ridd MJ, Chen K, Meehan WP, Kung MP, Seif I, De Maeyer E (1999) Ketanserin and tetrabenazine aggression in mice lacking monoamine oxidase A. Brain Res 835:104-112
306. 1 receptors and offensive aggression in rats: a combined behavioural and autoradiographic study with eltoprazine. Pharmacol Biochem Behav 38:447-458
307. Silver LM (1995) Mouse genetics. Concepts and applications. Oxford University Press, New York
308. 1B agonist effects on intermale aggression. Neurosci Biobehav Rev 23:325-336
309. Sofia RD, Salama AI (1970) Circadian rhythm for experimentally-induced aggressive behavior in mice. Life Sci 9:331-338
310. Soloff PH, Lynch KG, Kelly TM, Malone KM, Mann JJ (2000) Characteristics of suicide attempts of patients with major depressive episode and borderline personality disorder: a comparative study. Am J Psychiatry 157:601-608
311. Someya TS (2001) The Japanese version of the Barratt impulsiveness scale, 11th version (BIS-11): its reliability and validity. Psychiatry Clin Neurosci 55:111-114
312. Soreni N, Apter A, Weizman A, Don-Tufeled O, Leschiner S, Karp L, Gavish M (1999) Decreased platelet peripheral-type benzodiazepine receptors in adolescent inpatients with repeated suicide attempts. Biol Psychiatry 46:484-488
313. Spielberg CD, Sharma S, Singh M (1973) Development of Hindi edition of state-trait anxiety inventory. Indian J Psychol 48:11-20
314. Spielewoy C, Roubert C, Hamon M, Nosten-Bertrand M, Betancur C, Giros B (2000) Behavioural disturbances associated with hyperdopaminergia in dopamine-transporter knockout mice. Behav Pharmacol 11:279-290
315. Spivak B, Roitman S, Vered Y, Mester R, Graff E, Talmon Y, Guy N, Gonen N, Weizman A (1998) Diminished suicidal and aggressive behavior, high plasma norepinephrine levels, and serum triglyceride levels in chronic neuroleptic-resistant schizophrenic patients maintained on clozapine. Clin Neuropharmacol 21:245-250
316. Stanford MS, Greve KW, Broudreax JK, Mathias CW, Brumbelow JL (1996) Impulsiveness and risk-taking behavior: comparison of high-school and college students using the Barratt impulsiveness scale. Pers Individ Dif 21:1073-1075
317. Stanford MS, Houston RJ, Mathias CW, Greve KW, Villemarette-Pittman NR, Adams D (2001) A double-blind placebo-controlled crossover study of phenytoin in individuals with impulsive aggression. Psychiatry Res 103:193-203
318. 65. Brain Res 865:45-58
319. Suzdak PD, Schwartz RD, Skolnick P, Paul SM (1986) Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc Natl Acad Sci USA 83:4071-4075
320. Tariot PN, Erb R, Podgorski CA, Cox C, Patel S, Jakimovich L, Irvine C (1998) Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. Am J Psychiatry 155:54-61
321. Taylor DP (1988) Buspirone, a new approach to the treatment of anxiety. FASEB J 2:2445-2452
322. Taylor SP (1967) Aggressive behavior and physiological arousal as a function of provocation and the tendency to inhibit aggression. J Pers 35:297-310
323. Taylor SP, Vardaris RM, Rawtich AB, Gammon CB, Cranston JW, Lubetkin AI (1976) The effects of alcohol and delta-9 tetrahydrocannabinol on human physical aggression. Aggress Behav 2:153-161
324. Tecott LH, Barondes SH (1996) Genes and aggressiveness. Behavioral genetics. Curr Biol 6:238-240
325. Tellegen A, Horn JM (1972) Primary aggressive motivation in three inbred strains of mice. J Comp Physiol Psychol 78:297-304
326. Tellegen A, Horn JM, Legrand RG (1969) Opportunity for aggression as a reinforcer in mice. Psychonomic Sci 14:104-105
327. Thompson T (1969) Aggressive behaviour of siamese fighting fish. In: Garattini S (ed) Aggressive behaviour. Excerpta Medica, Amsterdam, pp 15-31
328. Thompson T, Bloom W (1966) Aggressive behavior and extinction-induced response-rate increase. Psychonomic Sci 5:335-336
329. Thor DH, Ghiselli WB (1975) Suppression of mouse killing and apomorphine-induced social aggression in rats by local anesthesia of the mystacial vibrissae. J Comp Physiol Psychol 88:40-46
330. Tidey JW, Miczek KA (1992a) Effects of SKF38393 and quinpirole on patterns of aggressive, motor and schedule-controlled behaviors in mice. Behav Pharmacol 3:553-565
331. 2 receptor agonists. Psychopharmacology 108:177-184
332. Tidey JW, Miczek KA (1992c) Heightened aggressive behavior during morphine withdrawal: effects of d-amphetamine. Psychopharmacology 107:297-302
333. Tidey JW, Miczek KA (1996) Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study. Brain Res 721:140-149
334. Tompkins EC, Clemento AJ, Taylor DP, Perhach JL Jr (1980) Inhibition of aggressive behavior in rhesus monkeys by buspirone. Res Commun Psychol Psychiatr Behav 5:337-352
335. Troisi A, Vicario E, Nuccetelli F, Ciani N, Pasini A (1995) Effects of fluoxetine on aggressive behavior of adult inpatients with mental retardation and epilepsy. Pharmacopsychiatry 28:1-4
336. Valzelli L (1969) Aggressive behavior induced by isolation. In: Garattini S (ed) Aggressive behavior. Wiley, New York, pp 70-76
337. Valzelli L (1973) The "isolation syndrome" in mice. Psychopharmacologia 31:305-320
338. Van Der Vegt BJ, de Boer SF, Buwalda B, de Ruiter AJ, de Jong JG, Koolhaas JM (2001) Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression. Physiol Behav 74:205-211
339. Van Erp AMM, Miczek KA (1997) Increased aggression after ethanol self-administration in male resident rats. Psychopharmacology 131:287-295
340. Van Erp AMM, Miczek KA (2000) Aggressive behavior, increased accumbal dopamine and decreased cortical serotonin in rats. J Neurosci 15:9320-9325
341. van Hooff JARA (1982) Categories and sequences of behavior: methods of description and analysis. In: Scherer KR (ed) Handbook of methods in nonverbal behavior research. Cambridge University Press, Cambridge, pp 362-439
342. Vanderschuren LJMJ, Kalivas PW (2000) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology 151:99-120
343. Vartiainen H, Tiihonen J, Putkonen A, Koponen H, Virkkunen M, Hakola P, Lehto H (1995) Citalopram, a selective serotonin reuptake inhibitor, in the treatment of aggression in schizophrenia. Acta Psychiatr Scand 91:348-351
344. Virkkunen M (1979) Alcoholism and antisocial personality. Acta Psychiatr Scand 59:493-501
345. Virkkunen M, Linnoila M (1993) Brain serotonin, Type II alcoholism and impulsive violence. J Stud Alcohol Supp 11:163-169
346. Virkkunen M, Kallio E, Rawlings R, Tokola R, Poland RE, Guidotti A, Nemeroff C, Bissette G, Kalogeras K, Karonen SL, Linnoila M (1994) Personality profiles and state aggressiveness in Finnish alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 51:28-33
347. Vitiello B, Stoff DM (1997) Subtypes of aggression and their relevance to child psychiatry. J Am Acad Child Adolesc Psychiatry 36:307-315
348. Volavka J (1995) Neurobiology of violence. American Psychiatric Press, Washington
349. Volavka J (1999) The effects of clozapine on aggression and substance abuse in schizophrenic patients. J Clin Psychiatry 60[Suppl 12]:43-46
350. Volavka J, Citrome L (1999) Atypical antipsychotics in the treatment of the persistently aggressive psychotic patient: methodological concerns. Schizophr Res 35:S23-S33
351. Wallen K (1996) Nature needs nurture: the interaction of hormonal and social influences on the development of behavioral sex differences in rhesus monkeys. Horm Behav 30:364-378
352. Walsh MT, Dinan TG (2001) Selective serotonin reuptake inhibitors and violence: a review of the available evidence. Acta Psychiatr Scand 104:84-91
353. Weerts EM, Miczek KA (1996) Primate vocalizations during social separation and aggression: effects of alcohol and benzodiazepines. Psychopharmacology 127:255-264
354. Weerts EM, Tornatzky W, Miczek KA (1993) "Anxiolytic" and "anxiogenic" benzodiazepines and beta-carbolines: effects on aggressive and social behavior in rats and squirrel monkeys. Psychopharmacology 110:451-459
355. Weisman AM, Berman ME, Taylor SP (1998) Effects of clorazepate, diazepam, and oxazepam on a laboratory measurement of aggression in men. Int Clin Psychopharmacol 13:183-188
356. Westerink BHC, Teisman A, Devries JB (1994) Increase in dopamine release from the nucleus accumbens in response to feeding: a model to study interactions between drugs and naturally activated dopaminergic neurons in the rat brain. Naunyn-Schmiedeberg's Arch Pharmacol 349:230-235
357. World Health Organization (1992) International statistical classification of diseases and related health problems. World Health Organization, Geneva
358. Winslow JT, Miczek KA (1983) Habituation of aggression in mice: pharmacological evidence of catecholaminergic and serotonergic mediation. Psychopharmacology 81:286-291
359. Workman M, Beer J (1992) Depression, suicide ideation, and aggression among high-school students whose parents are divorced and use alcohol at home. Psychol Rep 70:503-511
360. Wroblewski BA, Joseph AB, Kupfer J, Kalliel K (1997) Effectiveness of valporic acid on destructive and agressive behaviours in patients with acquired brain injury. Brain Inj 11:37-47
361. Yen CY, Stanger RL, Millman N (1959) Ataractic suppression of isolation-induced aggressive behavior. Arch Int Pharmacodyn Ther 123:179-185
362. Yoshida M, Yokoo H, Mizoguchi K, Kawahara H, Tsuda A, Nishikawa T, Tanaka M (1992) Eating and drinking cause increased dopamine release in the nucleus accumbens and ventral tegmental area in the rat - measurement by in vivo microdialysis. Neurosci Lett 139:73-76
363. Yudofsky SC, Silver JM, Schneider SE (1987) Pharmacologic treatment of aggression. Psychiatr Ann 17:397
364. Zarcone JR, Hellings JA, Crandall K, Reese RM, Marquis J, Fleming K, Shores R, Williams D, Schroeder SR (2001) Effects of risperidone on aberrant behaviour of persons with developmental disabilities: I. A double-blind crossover study using multiple measures. Am J Ment Retard 106:525-538
365. Zeichner A, Pihl RO (1978) Effects of alcohol and behavior contingencies on human aggression. J Abnorm Psychol 88:153-160
366. 1B receptors. Neuropsychopharmacology 21:S52-S60