Quantification of neuroreceptors in the living human brain: III. D2- like dopamine receptors: Theory, validation, and changes during normal aging

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 3, 1997, Pages 316-330

  Wong, Dean F ^a,b   Young, David ^c   Wilson, P David ^a   Meltzer, Carolyn Cidis ^a   Gjedde, Albert ^d  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Dopamine receptors; Positron emission tomography; Receptor quantification; Schizophrenia

Indexed keywords

3 METHYLSPIPERONE; BRAIN RECEPTOR; DOPAMINE 2 RECEPTOR; HALOPERIDOL; TRACER;

AGING; ARTICLE; BRAIN; CALCULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR DENSITY; TECHNIQUE;

EID: 0030889597     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199703000-00009     Document Type: Article

References (31)

1. 2 receptors in the human striatum. Schizophr Bull 14:471-484
2. 76Br]bromospiperone binding sites demonstrated by positron tomography in progressive supranuclear palsy. J Cereb Blood Flow Metab 6:131-136
3. Cressie NAC, Keightly DD (1981) Analyzing data from hormone-receptor assays. Biometrics 37:235-249
4. Crone C (1963) The permeability of capillaries in various organs as determined by use of the 'indicator diffusion' method. Acta Physiol Scand 58:292-305
5. 11C]methyl)spiperone. Int J Appl Radiat Isot 37:433
6. DeKeyser J, Ebinger G, Vauquelin G (1990) Age-related changes in the human nigrostriatal dopaminergic system. Ann Neurol 27:157-161
7. Dixon M (1953) The determination of enzyme inhibitor constants. J Biochem 55:170-171
8. 2 receptor increase in PET study of schizophrenia. Arch Gen Psychiatry 44:671-672
9. 2 dopamine receptors in neuroleptic-naive schizophrenic patients. Arch Gen Psychiatry 47:213-219
10. Gjedde A (1981) High- and Low-affinity transport of D-glucose from blood to brain. J Neurochem 36:1463-1471
11. Gjedde A (1982) Calculation of glucose phosphorylation from brain uptake of glucose analogs in vivo: a re-examination. Brain Res Rev 4:237-274
12. Gjedde A, Wong DF, Wagner HN Jr (1986) Transient analysis of irreversible and reversible tracer binding in human brain in vivo. In: PET and NMR New Perspectives in Neuroimaging and in Clinical Neurochemistry. (L. Battistin and F. Gerstenbrand, eds), New York, Alan R. Liss, Inc 223-235
13. 2 dopamine receptors in caudate nucleus. Neurosurg Rev 10:9-17
14. 11C-N-methylspiperone in vivo binding to human striatum detected by PET. Jpn J Nucl Med 26:213-220
15. 2 dopamine binding sites in human brain during aging human brain. Brain Res 508:349-352
16. Patlak C, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1-7
17. Patlak C, Blasberg RG (1985) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab 5:584-590
18. 2 Dopamine Receptor PET and Structural MRI Changes in Late Onset Schizophrenia. Schizophr Bull 19:783-795
19. Rinne JO (1987) Muscarinic and dopaminergic receptors in the aging human brain. Brain Res 404:162-168
20. 11C]raclopride. J Cereb Blood Flow Metab 13:310-314
21. Seeman P, Bzowej NH, Guan H-G, et al. (1987) Human brain dopamine receptors in children and aging adults. Synapse 1:399-404
22. 2 receptor reveals difference densities for dopamine receptor antagonist ligands. Implications for human brain positron emission tomography. Eur J Pharmacol 227:139-146
23. 18F-haloperidol. J Labelled Compounds Radiopharmaceuticals 26:386
24. Singer HS, Wong DF, Brown JE, et al. (1992) Positron emission tomography evaluation of dopamine D-2 receptors in adults with Tourette syndrome. Adv Neurol 58:233-239
25. 2 receptors by irreversible tracer binding in the living human brain: The model-dependent correction of metabolites. J Cereb Blood Flow Metab 9:906-913
26. 11C-N-methylspiperone. Psychiatry Res 49:219-237
27. Wong DF, Wagner HN Jr, Dannals RF, et al. (1984) Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain. Science 226:1,393-1,396
28. Wong DF, Gjedde A, Wagner HN Jr (1986a) Quantification of neuroreceptors in the living human brain. Part I. Association rate of irreversibly bound ligands. J Cereb Blood Flow Metab 6:137-146
29. Wong DF, Gjedde A, Wagner HN Jr, et al. (1986b) Quantification of neuroreceptors in living human brain. Part II. Inhibition studies of receptor density and affinity. J Cereb Blood Flow Metab 6:147-153
30. 2 dopamine receptors in drug-naive schizophrenics. Science 234:1558-1563
31. Wong DF, Gjedde A, Young D (1989) Reply to Swart and Korf. J Cereb Blood Flow Metab 9(6):908-910