Porous silicon protein microarray technology and ultra-/superhydrophobic states for improved bioanalytical readout

Biotechnology Annual Review

Volumn 13, Issue , 2007, Pages 149-200

  Ressine, Anton ^a   Marko Varga, György ^b   Laurell, Thomas ^a  

^a LUND INSTITUTE OF TECHNOLOGY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

antibody microarrays; biomarker discovery; high speed biomarker identification; lysate microarrays; MALDI TOF MS; porous silicon; protein microarray technology; superhydrophobic; superhydrophobic target anchor chips.; ultrahydrophobic; water repellency

Indexed keywords

CYCLIN E; FLUORESCEIN ISOTHIOCYANATE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; PHOSPHATE BUFFERED SALINE; POLITEF; POLYSTYRENE; SILICON; SODIUM CHLORIDE;

BIOSENSOR; BIOTECHNOLOGY; BREAST CANCER; CELL LYSATE; CRYSTALLIZATION; DNA MICROARRAY; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; IMMUNOASSAY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR IMAGING; MOLECULAR INTERACTION; POROSITY; PROCESS DEVELOPMENT; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN IMMOBILIZATION; PROTEIN MICROARRAY; QUALITY CONTROL; REPRODUCIBILITY; REVIEW; SURFACE PROPERTY; THREE DIMENSIONAL IMAGING; WETTABILITY;

BIOLOGICAL ASSAY; DATA DISPLAY; HYDROPHOBICITY; PEPTIDE MAPPING; POROSITY; PROTEIN ARRAY ANALYSIS; SILICON; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 34548580703     PISSN: 13872656     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1387-2656(07)13007-6     Document Type: Review

References (214)

1. Dufva M., and Christensen C.B.V. Diagnostic and analytical applications of protein microarrays. Exp Rev Proteomics 2 1 (2005) 41-48
2. MacBeath G. Protein microarrays and proteomics. Nat Genet 32 Suppl. (2002) 526-532
3. O'Connor C.D., and Pickard K. Protein chips and microarrays. In: Day I.N.M. (Ed). Microarrays & Microplates: Applications in Biomedical Sciences (2003), BIOS Scientific Publ 61-88
4. Templin M.F., Stoll D., Schwenk J.M., Potz O., Kramer S., and Joos T.O. Protein microarrays: Promising tools for proteomic research. Proteomics 3 11 (2003) 2155-2166
5. Wilson D.S., and Nock S. Recent developments in protein microarray technology. Angew Chem Int Ed 42 5 (2003) 494-500
6. Zhou F.X., Bonin J., and Predki P.F. Development of functional protein microarrays for drug discovery: progress and challenges. Comb Chem. High Th. Screen 7 6 (2004) 539-546
7. Zhu H., and Snyder M. Protein arrays and microarrays. Curr Opin Chem Biol 5 1 (2001) 40-45
8. Zhu H., and Snyder M. Protein chip technology. Curr Opin Chem Biol 7 1 (2003) 55-63
9. Kambhampati D (ed). Protein microarray technology, Wiley, 2004, 276 pp.
10. Schena M (ed). Protein microarrays. Jones and Bartlett Pub., 2005, 469 pp.
11. MacBeath G., and Schreiber S.L. Printing proteins as microarrays for high-throughput function determination. Science 289 5485 (2000) 1760-1763
12. Zhu H., Bilgin M., Bangham R., Hall D., Casamayor A., Bertone P., Lan N., Jansen R., Bidlingmaier S., Houfek T., Mitchell T., Miller P., Dean R.A., Gerstein M., and Snyder M. Global analysis of protein activities using proteome chips. Science 293 5537 (2001) 2101-2105
13. Chen G.Y.J., Uttamchandani M., Zhu Q., Wang G., and Yao S.Q. Developing a strategy for activity-based detection of enzymes in a protein microarray. ChemBiochem 4 4 (2003) 336-339
14. Espina V., Mehta A.I., Winters M.E., Calvert V., Wulfkuhle J., Petricoin E.F., and Liotta L.A. Protein microarrays: molecular profiling technologies for clinical specimens. Proteomics 3 11 (2003) 2091-2100
15. Gulmann C., Espina V., Petricoin III E., Longo D.L., Santi M., Knutsen T., Raffeld M., Jaffe E.S., Liotta L.A., and Feldman A.L. Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphoma. Clin Cancer Res 11 16 (2005) 5847-5855
16. Hanash S. Diagnostic applications of protein microarrays. Medical Biomethods Handbook 2005: 583-592.
17. Harwanegg C., and Hiller R. Protein microarrays for the diagnosis of allergic diseases: state-of-the-art and future development. Laboratoriumsmedizin 29 4 (2005) 272-277
18. Hudelist G., Singer C.F., Kubista E., and Czerwenka K. Use of high-throughput arrays for profiling differentially expressed proteins in normal and malignant tissues. Anticancer Drugs 16 7 (2005) 683-689
19. Koopmann JO, McAndrew MB and Blackburn JM. Development of protein microarrays for drug discovery. In: Protein Microarrays, Schena M (ed), Chapter 22, Jones & Bartlett Pub., 2005, pp. 401-420.
20. Korf U., and Wiemann S. Protein microarrays as a discovery tool for studying protein-protein interactions. Exp Rev Proteom 2 1 (2005) 13-26
21. Kumble K.D. Protein microarrays: new tools for pharmaceutical development. Anal Bioanal Chem 377 5 (2003) 812-819
22. LaBaer J., and Ramachandran N. Protein microarrays as tools for functional proteomics. Curr Opin Chem Biol 9 1 (2005) 14-19
23. Nishizuka S., Chen S.T., Gwadry F.G., Alexander J., Major S.M., Scherf U., Reinhold W.C., Waltham M., Charboneau L., Young L., Bussey K.J., Kim S.Y., Lababidi S., Lee J.K., Pittaluga S., Scudiero D.A., Sausville E.A., Munson P.J., Petricoin E.F., Liotta L.A., Hewitt S.M., Raffeld M., and Weinstein J.N. Diagnostic markers that distinguish colon and ovarian adenocarcinomas: identification by genomic, proteomic, and tissue array profiling. Cancer Res 63 17 (2003) 5243-5250
24. Paweletz C.P., Charboneau L., Bichsel V.E., Simone N.L., Chen T., Gillespie J.W., Emmert-Buck M.R., Roth M.J., Petricoin E.F., and Liotta L.A. Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene 20 16 (2001) 1981-1989
25. Poetz O., Ostendorp R., Brocks B., Schwenk J.M., Stoll D., Joos T.O., and Templin M.F. Protein microarrays for antibody profiling: specificity and affinity determination on a chip. Proteomics 5 9 (2005) 2402-2411
26. Schneiderhan-Marra N., Kirn A., Doettinger A., Templin M., Sauer G., Deissler H., and Joos T.O. Protein microarrays - a promising tool for cancer diagnosis. Cancer Genom Proteom 2 1 (2005) 37-42
27. Sreekumar A., Nyati M.K., Varambally S., Barrette T.R., Ghosh D., Lawrence T.S., and Chinnaiyan A.M. Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteins. Cancer Res 61 20 (2001) 7585-7593
28. Steller S., Angenendt P., Cahill D.J., Heuberger S., Lehrach H., and Kreutzberger J. Bacterial protein microarrays for identification of new potential diagnostic markers for Neisseria meningitidis infections. Proteomics 5 8 (2005) 2048-2055
29. Stoll D., Templin M.F., Bachmann J., and Joos T.O. Protein microarrays: applications and future challenges. Curr Opin Drug Discov Dev 8 2 (2005) 239-252
30. Cowherd S.M., Espina V.A., Petricoin III E.F., and Liotta L.A. Proteomic analysis of human breast cancer tissue with laser-capture microdissection and reverse-phase protein microarrays. Clin Breast Cancer 5 5 (2004) 385-392
31. Davies D.H., Liang X., Hernandez J.E., Randall A., Hirst S., Mu Y., Romero K.M., Nguyen T.T., Kalantari-Dehaghi M., Crotty S., Baldi P., Villarreal L.P., and Felgner P.L. Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery. Proc Natl Acad Sci USA 102 3 (2005) 547-552
32. James P. Chips for proteomics: a new tool or just hype?. BioTechniques Suppl 4-10 (2002) 12-13
33. Kricka L.J., and Master S.R. Validation and quality control of protein microarray-based analytical methods. Methods Mol Med 114 Microarrays in Clinical Diagnostics (2005) 233-255
34. Kusnezow W., and Hoheisel J.D. Antibody microarrays: promises and problems. BioTechniques 33 (2002) S14-S23
35. Kusnezow W., and Hoheisel J.D. Solid supports for microarray immunoassays. J Mol Recog 16 4 (2003) 165-176
36. Ressine A., Ekstrom S., Marko-Varga G., and Laurell T. Macro-/nanoporous silicon as a support for high-performance protein microarrays. Anal Chem 75 24 (2003) 6968-6974
37. Ressine A., Finnskog D., Malm J., Becker C., Lilja H., Varga G.M., and Laurell T. Macro/nano-structured silicon as solid support for antibody arrays. Surface design, reproducibility, and assay characteristics enabling discovery of kallikrein gene products for prostate disease diagnostics. NanoBiotechnology 1 1 (2005) 93-104
38. Steinhauer C., Ressine A., Marko-Varga G., Laurell T., Borrebaeck C.A.K., and Wingren C. Biocompatibility of surfaces for antibody microarrays: design of macroporous silicon substrates. Anal Biochem 341 2 (2005) 204-213
39. Ressine A, Corin I, Jaras K, Guant G, Simone C, Marko-Varga G and Laurell T. Porous silicon surfaces - a candidate substrate for reverse protein arrays in cancer biomarker detection. Electrophoresis 2007; in press.
40. Finnskog D., Ressine A., Laurell T., and Marko-Varga G. Protein microchip bioassay with dual fluorescent - and maldi read-out. J Proteome Res 3 5 (2004) 988-994
41. Ressine A., Auzelyte V., Kristiansson P., Marko-Varga G., and Laurell T. Fabrication of sample target plate for MALDI MS using proton beam writing. Nucl Inst Meth B 249 (2006) 715-718
42. Finnskog D., Jaras K., Ressine A., Malm J., Marko-Varga G., Lilja H., and Laurell T. High-speed biomarker identification utilizing porous silicon nanovial arrays and MALDI-TOF mass spectrometry. Electrophoresis 27 5-6 (2006) 1093-1103
43. Ressine A, Finnskog D, Marko-Varga G and Laurell T. Superhydrophobic and hydrophilic states on porous silicon. Proceedings of microTAS 2005 Conference, 2005b, vol. 1, pp. 256-258.
44. Morozov VN. Protein microarrays: principles and limitations. In: Protein Microarrays, Schena M (ed), Chapter 5, Jones & Bartlett Pub., 2005, pp. 71-105.
45. Schäferling M and Kambhampati D. Protein microarray surface chemistry and coupling schemes. In: Protein Microarray Technology, Kambhampati D (ed), Chapter 2, John Wiley & Sons, 2004, pp. 11-38.
46. Turner D.R. Electropolishing silicon in in HF acid solutions. J Electrochem Soc 105 (1958) 402-408
47. Ulhir A. Electrolytic shaping of germanium and silicon. Bell SystTech J 35 (1956) 333
48. Bell T.E., Gennissen P.T.J., Demunter D., and Kuhl M. Porous silicon as a sacrificial material. J Micromech Microeng 6 4 (1996) 361-369
49. Splinter A., Bartels O., and Benecke W. Thick porous silicon formation using implanted mask technology. Sens Actuators B B76 1-3 (2001) 354-360
50. Steiner P., Richter A., and Lang W. Using porous silicon as a sacrificial layer. J Micromech Microeng 3 1 (1993) 32-36
51. Colinge JP. Silicon-on-insulator and porous silicon. In: Silicon: Evolution and Future of a Technology, Siffert P and Krimmel E (eds), Springer, 2005, pp. 139-167.
52. Takai H., and Itoh T. Porous silicon layers and its oxide for the silicon-on-insulator structure. J Appl Phys 60 1 (1986) 222-225
53. Bisi O., Ossicini S., and Pavesi L. Porous silicon: a quantum sponge structure for silicon based optoelectronics. Surf Sci Rep 38 1-3 (2000) 1-126
54. Cullis A.G., Canham L.T., and Calcott P.D.J. The structural and luminescence properties of porous silicon. J Appl Phys 82 3 (1997) 909-965
55. Herino R. Porous silicon for microelectronics and optoelectronics. Mater Sci Technol 13 11 (1997) 965-970
56. Menna P., Di Francia G., and La Ferrara V. Porous silicon in solar cells: a review and a description of its application as an AR coating. Sol Energy Mater Sol Cells 37 1 (1995) 13-24
57. Saadoun M., Ezzaouia H., Bessais B., Boujmil M.F., and Bennaceur R. Formation of porous silicon for large-area silicon solar cells: a new method. Sol Energy Mater Sol Cells 59 4 (1999) 377-385
58. Solanki C.S., Bilyalov R.R., Poortmans J., Beaucarne G., Van Nieuwenhuysen K., Nijs J., and Mertens R. Characterization of free-standing thin crystalline films on porous silicon for solar cells. Thin Solid Films 451-452 (2004) 649-654
59. Berger M.G., Dieker C., Thoenissen M., Vescan L., Lueth H., Muender H., Theiss W., Wernke M., and Grosse P. Porosity superlattices: a new class of Si heterostructures. J Phys D 27 6 (1994) 1333-1336
60. Vincent G. Optical properties of porous silicon superlattices. Appl Phys Lett 64 18 (1994) 2367-2369
61. Aravamudhan S., Rahman A.R.A., and Bhansali S. Porous silicon based orientation independent, self-priming micro direct ethanol fuel cell. Sens Actuat A A123-A124 (2005) 497-504
62. Presting H., Konle J., Starkov V., Vyatkin A., and Konig U. Porous silicon for micro-sized fuel cell reformer units. Mater Sci Eng B B108 1-2 (2004) 162-165
63. Aston R, and Canham LT. A porous and/or polycrystalline silicon orthopedic implant, PCT Int Appl 2001; 48 pp. Wo: (Secretary of State for Defence, UK).
64. Pramatarova L., Pecheva E., Dimova-Malinovska D., Pramatarova R., Bismayer U., Petrov T., and Minkovski N. Porous silicon as a substrate for hydroxyapatite growth. Vacuum 76 2-3 (2004) 135-138
65. Rajaraman S., and Henderson H.T. A unique fabrication approach for microneedles using coherent porous silicon technology. Sens Actuators B B105 2 (2005) 443-448
66. Salonen J., Paski J., Vaehae-Heikkilae K., Heikkilae T., Bjoerkqvist M., and Lehto V.P. Determination of drug load in porous silicon microparticles by calorimetry. Phys Stat Sol A 202 8 (2005) 1629-1633
67. Sailor M.J. Sensor applications of porous silicon. EMIS Datareviews Ser 18 Properties of Porous Silicon (1997) 364-370
68. Mathew F.P., and Alocilja E.C. Porous silicon-based biosensor for pathogen detection. Biosens Bioelectron 20 8 (2005) 1656-1661
69. Tinsley-Bown A.M., Canham L.T., Hollings M., Anderson M.H., Reeves C.L., Cox T.I., Nicklin S., Squirrell D.J., Perkins E., Hutchinson A., Sailor M.J., and Wun A. Tuning the pore size and surface chemistry of porous silicon for immunoassays. Phys Stat Sol A 182 1 (2000) 547-553
70. Anon. Characterizing a porous silicon optical biosensor. Anal Chem 71 21 (1999) 727A
71. Lehmann V. Biosensors: barcoded molecules. Nat Mater 1 1 (2002) 12-13
72. Martin-Palma R.J., Torres-Costa V., Arroyo-Hernandez M., Manso M., Perez-Rigueiro J., and Martinez-Duart J.M. Porous silicon multilayer stacks for optical biosensing applications. Microelectron J 35 1 (2004) 45-48
73. Pacholski C., Sartor M., Sailor M.J., Cunin F., and Miskelly G.M. Biosensing using porous silicon double-layer interferometers: reflective interferometric fourier transform spectroscopy. J Am Chem Soc 127 33 (2005) 11636-11645
74. Schoning M.J., Kurowski A., Thust M., Kordos P., Schultze J.W., and Luth H. Capacitive microsensors for biochemical sensing based on porous silicon technology. Sens Actuators B B64 1-3 (2000) 59-64
75. Starodub N.F., Rebriev A.V., and Starodub V.M. Biosensors and express biochemical diagnostics of some diseases. NATO Sci Ser I: Life Behavioural Sci 346 Disease Markers in Exhaled Breath (2002) 391-394
76. Starodub V.M. Porous silicon as transducer for immune sensors: from theory to practice. NATO Sci Ser II: Math, Phy Chem 57 Frontiers of Multifunctional Nanosystems (2002) 383-398
77. Tinsley-Bown A., Smith R.G., Hayward S., Anderson M.H., Koker L., Green A., Torrens R., Wilkinson A.S., Perkins E.A., Squirrell D.J., Nicklin S., Hutchinson A., Simons A.J., and Cox T.I. Immunoassays in a porous silicon interferometric biosensor combined with sensitive signal processing. Phys Stat Sol A 202 8 (2005) 1347-1356
78. Zairi S., Martelet C., Jaffrezic-Renault N., M'Gaieth R., Maaref H., and Lamartine R. Porous silicon. A transducer material for a high-sensitive (bio)chemical sensor: effect of a porosity, pores morphologies and a large surface area on a sensitivity. Thin Solid Films 383 1,2 (2001) 325-327
79. Foll H., Christophersen M., Carstensen J., and Hasse G. Formation and application of porous silicon. Mater Sci Eng R: Rep R39 4 (2002) 93-141
80. Drott J., Rosengren L., Lindstrom K., and Laurell T. Pore morphology influence on catalytic turn-over for enzyme activated porous silicon matrices. Thin Solid Films 330 2 (1998) 161-166
81. Bengtsson M., Drott J., and Laurell T. Tailoring of porous silicon morphology in chip integrated bioreactors. Phys Stat Sol A 182 1 (2000) 533-539
82. Collins A., Mikeladze E., Bengtsson M., Kokaia M., Laurell T., and Csoregi E. Interference elimination in glutamate monitoring with chip integrated enzyme microreactors. Electroanalysis 13 6 (2001) 425-431
83. Davidsson R., Genin F., Bengtsson M., Laurell T., and Emneus J. Microfluidic biosensing systems. Part I. Development and optimisation of enzymatic chemiluminescent m-biosensors based on silicon microchips. Lab on a Chip 4 5 (2004) 481-487
84. Drott J., Lindstroem K., Rosengren L., and Laurell T. Porous silicon as the carrier matrix in microstructured enzyme reactors yielding high enzyme activities. J Micromech Microeng 7 1 (1997) 14-23
85. Ekstrom S., Ericsson D., Onnerfjord P., Bengtsson M., Nilsson J., Marko-Varga G., and Laurell T. Signal amplification using "spot-on-a-chip" technology for the identification of proteins via MALDI-TOF MS. Anal Chem 73 2 (2001) 214-219
86. Lendl B., Schindler R., Frank J., Kellner R., Drott J., and Laurell T. Fourier transform infrared detection in miniaturized total analysis systems for sucrose analysis. Anal Chem 69 15 (1997) 2877-2881
87. Melander C., Momcilovic D., Nilsson C., Bengtsson M., Schagerloef H., Tjerneld F., Laurell T., Reimann C.T., and Gorton L. Microchip immobilized enzyme reactors for hydrolysis of methyl cellulose. Anal Chem 77 10 (2005) 3284-3291
88. Yakovleva J., Davidsson R., Lobanova A., Bengtsson M., Eremin S., Laurell T., and Emneus J. Microfluidic enzyme immunoassay using silicon microchip with immobilized antibodies and chemiluminescence detection. Anal Chem 74 13 (2002) 2994-3004
89. Schoning M.J., Ronkel F., Crott M., Thust M., Schultze J.W., Kordos P., and Luth H. Miniaturization of potentiometric sensors using porous silicon microtechnology. Electrochim Acta 42 20-22 (1997) 3185-3193
90. Thust M., Schoening M.J., Frohnhoff S., Arens-Fischer R., Kordos P., and Lueth H. Porous silicon as a substrate material for potentiometric biosensors. Measure Sci Technol 7 1 (1996) 26-29
91. Bayliss S.C., Ashraf I., and Sapelkin A.V. Concerning signaling in in vitro neural arrays using porous silicon. NATO Sci Ser II: Mathe, Phys Chem 152 (2004) 467-471
92. Buckberry L., and Bayliss S. Semiconducting biomaterials: current status and future perspectives. Med Device Technol 12 5 (2001) 14-20
93. de-Leon S.B.-T., Oren R., Spira M.E., Korbakov N., Yitzchaik S., and Sa'ar A. Porous silicon substrates for neurons culturing and bio-photonic sensing. Phys Stat Sol A 202 8 (2005) 1456-1461
94. Mayne A.H., Bayliss S.C., Barr P., Tobin M., and Buckberry L.D. Biologically interfaced porous silicon devices. Phys Stat Sol A 182 1 (2000) 505-513
95. Lehmann V., and Gösele U. Porous silicon formation: a quantum wire effect. Appl Phys Lett 58 8 (1991) 856-858
96. Zhang X.G. Morphology and formation mechanisms of porous silicon. J Electrochem Soc 151 1 (2004) C69-C80
97. Carstensen J., Christophersen M., Loelkes S., Ossei-Wusu E., Bahr J., Langa S., Popkirov G., and Foell H. Large area etching for porous semiconductors. Phys Stat Sol C 2 9 (2005) 3339-3343
98. Ouyang H., Christophersen M., and Fauchet P.M. Enhanced control of porous silicon morphology from macropore to mesopore formation. Phys Stat Sol A 202 8 (2005) 1396-1401
99. Vadjikar R.M., and Nandedkar R.V. Pore size dependence on doping concentration in porous silicon. Curr Sci 64 3 (1993) 180-182
100. Christophersen M., Carstensen J., Voigt K., and Foll H. Organic and aqueous electrolytes used for etching macro- and mesoporous silicon. Phys Stat Sol A 197 1 (2003) 34-38
101. Christophersen M., Langa S., Carstensen J., Tiginyanu I.M., and Foll H. A comparison of pores in silicon and pores in III-V compound materials. Phys Stat Sol A 197 1 (2003) 197-203
102. Butler J.E. Solid supports in enzyme-linked immunosorbent assay and other solid-phase immunoassays. Methods 22 1 (2000) 4-23
103. Vermeer A.W.P., Giacomelli C.E., and Norde W. Adsorption of IgG onto hydrophobic teflon. Differences between the Fab and Fc domains. Biochim Biophys Acta, General Subjects 1526 1 (2001) 61-69
104. Butler J.E. Solid supports in enzyme-linked immunosorbent assay and other solid-phase immunoassays. Methods Mol Med 94 (2004) 333-372
105. Piehler J., Brecht A., Geckeler K.E., and Gauglitz G. Surface modification for direct immunoprobes. Biosen Bioelectron 11 6/7 (1996) 579-590
106. Piehler J., Brecht A., Valiokas R., Liedberg B., and Gauglitz G. A high-density poly(ethylene glycol) polymer brush for immobilization on glass-type surfaces. Biosens Bioelectron 15 9-10 (2000) 473-481
107. Lilja H., Christensson A., Dahlen U., Matikainen M.T., Nilsson O., K. P., and Lovgren T. Prostate-specific antigen in serum occurs predominantly in complex with alpha-1-antichymotrypsin. Clin Chem 37 9 (1991) 1618-1625
108. Oesterling J.E., Jacobsen S.J., Klee G.G., Pettersson K., Piironen T., Abrahamsson P.A., Stenman U.H., Dowell B., Lovgren T., and Lilja H. Free, complexed and total serum prostate-specific antigen - the establishment of appropriate reference ranges for their concentrations and ratios. J Urol 154 3 (1995) 1090-1095
109. Calvert V.S., Tang Y., Boveia V., Wulfkuhle J., Schutz-Geschwender A., Olive D.M., Liotta L.A., and Petricoin III E.F. Development of multiplexed protein profiling and detection using near infrared detection of reverse-phase protein microarrays. Clin Proteom 1 1 (2004) 81-89
110. Espina V., Woodhouse E.C., Wulfkuhle J., Asmussen H.D., Petricoin E.F., and Liotta L.A. Protein microarray detection strategies: focus on direct detection technologies. J Immunol Methods 290 1-2 (2004) 121-133
111. Grubb R.L., Calvert V.S., Wulkuhle J.D., Paweletz C.P., Linehan W.M., Phillips J.L., Chuaqui R., Valasco A., Gillespie J., Emmert-buck M., Liotta L.A., and Petricoin E.F. Signal pathway profiling of prostate cancer using reverse phase protein arrays. Proteomics 3 11 (2003) 2142-2146
112. Borg A., Ferno M., and Peterson C. Predicting the future of breast cancer. Nat Med 9 1 (2003) 16-18
113. Keyomarsi K., Tucker Susan L., Buchholz Thomas A., Callister M., Ding Y., Hortobagyi Gabriel N., Bedrosian I., Knickerbocker C., Toyofuku W., Lowe M., Herliczek Thaddeus W., and Bacus Sarah S. Cyclin E and survival in patients with breast cancer. New Engl J Med 347 20 (2002) 1566-1575
114. Lindahl T., Landberg G., Ahlgren J., Nordgren H., Norberg T., Klaar S., Holmberg L., and Bergh J. Overexpression of cyclin E protein is associated with specific mutation types in the p53 gene and poor survival in human breast cancer. Carcinogenesis 25 3 (2004) 375-380
115. Cheek B.J., Steel A.B., Torres M.P., Yu Y.-Y., and Yang H. Chemiluminescence detection for hybridization assays on the flow-thru chip, a three-dimensional microchannel biochip. Anal Chem 73 24 (2001) 5777-5783
116. Tseng FG, Lin SC, Yao DJ, Huang H and Chieng CC. Technological aspects of protein microarrays and nanoarrays. In: Protein Microarrays, Schena M (ed), Chapter 16, Jones & Bartlett Pub., 2005, pp. 305-337.
117. Dugas V., Broutin J., and Souteyrand E. Droplet evaporation study applied to DNA chip manufacturing. Langmuir 21 20 (2005) 9130-9136
118. Blossey R and Lorke A. Wetting droplet instability and quantum ring formation. Phys Rev E 2002;65(2-1):021603/021601-021603/021603.
119. Deegan R.D., Bakajin O., Dupont T.F., Huber G., Nagel S.R., and Witten T.A. Capillary flow as the cause of ring stains from dried liquid drops. Nature 389 6653 (1997) 827-829
120. Heim T., Preuss S., Gerstmayer B., Bosio A., and Blossey R. Deposition from a drop: morphologies of unspecifically bound DNA. J Phys: Condens Matter 17 9 (2005) S703-S716
121. Hu H., and Larson R. Analysis of the microfluid flow in an evaporating sessile droplet. Langmuir 21 (2005) 3963-3971
122. McQuain M.K., Seale K., Peek J., Levy S., and Haselton F.R. Effects of relative humidity and buffer additives on the contact printing of microarrays by quill pins. Anal Biochem 320 2 (2003) 281-291
123. Blossey R., and Bosio A. Contact line deposits on cDNA microarrays: A "Twin-Spot Effect". Langmuir 18 7 (2002) 2952-2954
124. Deegan R.D., Bakajin O., Dupont T.F., Huber G., Nagel S.R., and Witten T.A. Contact line deposits in an evaporating drop. Phys Rev E 62 (2000) 756-765
125. Tekin E., de Gans B.-J., and Schubert U.S. Ink-jet printing of polymers - from single dots to thin film libraries. J Mater Chem 14 17 (2004) 2627-2632
126. Ko SH, Chung J, Choi Y, Grigoropoulos CP, Bieri NR, Choi T-y, Dockendorf C and Poulikakos D. Laser based hybrid inkjet printing of nanoink for flexible electronics. Proceedings of SPIE-The International Society for Optical Engineering 5713 (Photon Processing in Microelectronics and Photonics IV) 2005, pp. 97-104.
127. Rickman D.S., Herbert C.J., and Aggerbeck L.P. Optimizing spotting solutions for increased reproducibility of cDNA microarrays. Nucl Acids Res 31 18 (2003) e109
128. Sefiane K. Effect of nonionic surfactant on wetting behavior of an evaporating drop under a reduced pressure environment. J Colloid Interface Sci 272 2 (2004) 411-419
129. Neogi P. Tears-of-wine and related phenomena. J Colloid Int Sci 105 1 (1985) 94-101
130. Vuilleumier R., Ego V., Neltner L., and Cazabat A.M. Tears of wine: the stationary state. Langmuir 11 10 (1995) 4117-4121
131. Hu H., and Larson R. Analysis of the effect of Marangoni stresses on the microflow in an evaporating sessile droplet. Langmuir 21 (2005) 3972-3980
132. Savino R., Paterna D., and Favaloro N. Buoyancy and Marangoni effects in an evaporating drop. J Thermophys Heat Trans 16 4 (2002) 562-574
133. Artus G.R.J., Jung S., Zimmermann J., Gautschi H.-P., Marquardt K., and Seeger S. Silicone nanofilaments and their application as superhydrophobic coatings. Adv Mater 18 20 (2006) 2758-2762
134. Baldacchini T., Carey J.E., Zhou M., and Mazur E. Superhydrophobic surfaces prepared by microstructuring of silicon using a femtosecond laser. Langmuir 22 11 (2006) 4917-4919
135. Callies M., and Quere D. On water repellency. Soft Matter 1 1 (2005) 55-61
136. Coffinier Y., Janel S., Addad A., Blossey R., Gengembre L., Payen E., and Boukherroub R. Preparation of superhydrophobic silicon oxide nanowire surfaces. Langmuir 23 4 (2007) 1608-1611
137. Feng X., and Jiang L. Design and creation of superwetting/antiwetting surfaces. Adv Mater 18 23 (2006) 3063-3078
138. Gao L., and McCarthy T.J. Artificial lotus leaf Prepared using a 1945 patent and a commercial textile. Langmuir 22 14 (2006) 5998-6000
139. Han J T, Kim S and Karim A. UVO-tunable superhydrophobic to superhydrophilic wetting transition on biomimetic nanostructured surfaces. Langmuir 2007, ACS ASAP.
140. Li Y., Huang X.J., Heo S.H., Li C.C., Choi Y.K., Cai W.P., and Cho S.O. Superhydrophobic bionic surfaces with hierarchical microsphere/SWCNT composite arrays. Langmuir 23 4 (2007) 2169-2174
141. Ma M., and Hill R.M. Superhydrophobic surfaces. Curr Opin Colloid Interface Sci 11 4 (2006) 193-202
142. Xiu Y., Zhu L., Hess D.W., and Wong C.P. Biomimetic creation of hierarchical surface structures by combining colloidal self-assembly and au sputter deposition. Langmuir 22 23 (2006) 9676-9681
143. Zhai L., Berg M.C., Cebeci F.C., Kim Y., Milwid J.M., Rubner M.F., and Cohen R.E. Patterned superhydrophobic surfaces: toward a synthetic mimic of the Namib desert beetle. NanoLetters 6 6 (2006) 1213-1217
144. Zhang J., Huang W., and Han Y. A composite polymer film with both superhydrophobicity and superoleophilicity. Macromol Rapid Commun 27 10 (2006) 804-808
145. Egatz-Gomez A, Melle S, Garcia AA, Lindsay SA, Marquez M, Dominguez-Garcia P, Rubio MA, Picraux ST, Taraci JL, Clement T, Yang D, Hayes MA and Gust D. Discrete magnetic microfluidics. Appl Phys Lett 2006;89(3):034106/034101-034106/034103.
146. Herbertson D.L., Evans C.R., Shirtcliffe N.J., McHale G., and Newton M.I. Electrowetting on superhydrophobic SU-8 patterned surfaces. Sens Actuators A A130-A131 (2006) 189-193
147. Hong X., Gao X., and Jiang L. Application of superhydrophobic surface with high adhesive force in no lost transport of superparamagnetic microdroplet. J Am Chem Soc 129 6 (2007) 1478-1479
148. Lu C, Juang YJ, Koh CG and Lee LJ. Superhydrophobic valve for microfluidics. In: Proceedings of the 64th Annual Technical Conference & Exhibition, Charlotte, NC (ed), May 7-11, Society of Plastics Engineers, 2006, pp. 2566-2570.
149. Lu C., Xie Y., Yang Y., Cheng M.M.C., Koh C.-G., Bai Y., Lee L.J., and Juang Y.-J. New valve and bonding designs for microfluidic biochips containing proteins. Anal Chem 79 3 (2007) 994-1001
150. Zhang J., and Kwok D.Y. Contact line and contact angle dynamics in superhydrophobic channels. Langmuir 22 11 (2006) 4998-5004
151. Acatay K., Simsek E., Ow-Yang C., and Menceloglu Y.Z. Superhydrophobic films: tunable, superhydrophobically stable polymeric surfaces by electrospinning. Angew Chem Int Ed 43 39 (2004) 5210-5213
152. Erbil H.Y., Demirel A.L., Avci Y., and Mert O. Transformation of a simple plastic into a superhydrophobic surface. Science 299 5611 (2003) 1377-1380
153. Feng L., Song Y., Zhai J., Liu B., Xu J., Jiang L., and Zhu D. Creation of a superhydrophobic surface from an amphiphilic polymer. Angew Chem Int Ed 42 7 (2003) 800-802
154. Han J.T., Lee D.H., Ryu C.Y., and Cho K. Fabrication of superhydrophobic surface from a supramolecular organosilane with quadruple hydrogen bonding. JACS 126 15 (2004) 4796-4797
155. Jiang L., Zhao Y., and Zhai J. Superhydrophobic surface: a lotus-leaf-like superhydrophobic surface: a porous microsphere/nanofiber composite film prepared by electrohydrodynamics. Angew Chem Int Ed 43 33 (2004) 4338-4341
156. Jiang Y., Wang Z., Yu X., Shi F., Xu H., Zhang X., Smet M., and Dehaen W. Self-assembled monolayers of dendron thiols for electrodeposition of gold nanostructures: toward fabrication of superhydrophobic/superhydrophilic surfaces and pH-responsive surfaces. Langmuir 21 5 (2005) 1986-1990
157. Lau K.K.S., Bico J., Teo K.B.K., Chhowalla M., Amaratunga G.A.J., Milne W.I., McKinley G.H., and Gleason K.K. Superhydrophobic carbon nanotube forests. NanoLetters 3 12 (2003) 1701-1705
158. Shang H.M., Wang Y., Limmer S.J., Chou T.P., Takahashi K., and Cao G.Z. Optically transparent superhydrophobic silica-based films. Thin Solid Films 472 1-2 (2005) 37-43
159. Shirtcliffe N.J., McHale G., Newton M.I., and Perry C.C. Intrinsically superhydrophobic organosilica sol-gel foams. Langmuir 19 14 (2003) 5626-5631
160. Sun T, Feng L, Gao X and Jiang L. Bioinspired surfaces with special wettability. Acc. Chem. Res. 2005, ACS ASAP.
161. Tadanaga K., Kitamuro K., Matsuda A., and Minami T. Formation of superhydrophobic alumina coating films with high transparency on polymer substrates by the sol-gel method. J Sol-Gel Sci Technol 26 1/2/3 (2003) 705-708
162. Chen W., and al. e. Ultrahydrophobic and ultralyophobic surfaces: some comments and examples. Langmuir 15 (1999) 3395-3399
163. Wu Y., and al. e. Thin films with nanotextures for transparent and ultra water-repellent coatings produced from trimethylmethoxysilane by microwave plasma CVD. Chem Vap Deposition 8 (2002) 47-50
164. Youngblood J.P., and T.J. M. Polymer surfaces prepared by simultaneous ablation of polypropylene and sputtering of poly(tetrafluoroethylene) using radio frequency plasma. Macromolecules 32 (1999) 6800-6806
165. Lee CS, Lee SH, Park SS, Kim YK and Kim BG. Protein patterning on silicon-based surface using background hydrophobic thin film. Biosens Bioelectron 2003;18:437-444
166. Fuerstner R., Barthlott W., Neinhuis C., and Walzel P. Wetting and self-cleaning properties of artificial superhydrophobic surfaces. Langmuir 21 3 (2005) 956-961
167. Li Y., Cai W., Duan G., Cao B., Sun F., and Lu F. Superhydrophobicity of 2D ZnO ordered pore arrays formed by solution-dipping template method. J Colloid Interface Sci 287 2 (2005) 634-639
168. Öner D., and McCarthy T.J. Ultrahydrophobic surfaces. Effects of topography length scales on wettability. Langmuir 16 (2000) 7777-7782
169. Shiu J.-Y., Kuo C.-W., Chen P., and Mou C.-Y. Fabrication of tunable superhydrophobic surfaces by nanosphere lithography. Chem Mater 16 4 (2004) 561-564
170. Ren S., Yang S., Zhao Y., Yu T., and Xiao X. Preparation and characterization of an ultrahydrophobic surface based on a stearic acid self-assembled monolayer over polyethyleneimine thin films. Surf Sci 546 2-3 (2003) 64-74
171. Li M., Zhai J., Liu H., Song Y., Jiang L., and Zhu D. Electrochemical deposition of conductive superhydrophobic zinc oxide thin films. J Phys Chem B 107 37 (2003) 9954-9957
172. Wu Y., Sugimura H., Inoue Y., and Takai O. Thin films with nanotextures for transparent and ultra water-repellent coatings produced from trimethylmethoxysilane by microwave plasma CVD. Chem Vap Deposition 8 2 (2002) 47-50
173. Ressine A, Finnskog D, Marko-Varga G and Laurell T. Superhydrophobic properties of porous silicon improves surface based bioanalysis. NanoBiotechnology 2007; in press.
174. Cao M., Song X., Zhai J., Wang J., and Wang Y. Fabrication of highly antireflective silicon surfaces with superhydrophobicity. J Phys Chem B 110 26 (2006) 13072-13075
175. Wang M-F, Raghunathan N and Ziaie B. A nonlithographic top-down electrochemical approach for creating hierarchical (micro-nano) superhydrophobic silicon surfaces. Langmuir, 2007, ACS ASAP.
176. Boys C.V. Soap Bubbles (1902), Society for Promoting Christian Knowledge, London
177. Barthlott W., and Neinhuis C. Purity of the sacred lotus, or escape from contamination in biological surfaces. Planta 202 1 (1997) 1-8
178. Onda T., Shibuichi S., Satoh N., and Tsujii K. Super-water-repellent fractal surfaces. Langmuir 12 9 (1996) 2125-2127
179. Young T. An essay on the cohesion of fluids. Philos Trans R Soc London 95 (1805) 65-87
180. Wenzel R.N. Resistance of solid surfaces to wetting by water. Ind Eng Chem 28 (1936) 988-994
181. Cassie A.B.D., and Baxter S. Wettability of porous surfaces. Trans Faraday Soc 40 (1944) 546-551
182. Lafuma A., and Quere D. Superhydrophobic states. Nat Mater 2 7 (2003) 457-460
183. Quere D., Lafuma A., and Bico J. Slippy and sticky microtextured solids. Nanotechnology 14 10 (2003) 1109-1112
184. Carbone G., and Mangialardi L. Hydrophobic properties of a wavy rough substrate. Eur Phys J E: Soft Matter 16 1 (2005) 67-76
185. Quéré D. Non-sticking drops. Rep Progr Phys 68 (2005) 2495-2532
186. Teare D.O.H., Spanos C.G., Ridley P., Kinmond E.J., Roucoules V., Badyal J.P.S., Brewer S.A., Coulson S., and Willis C. Pulsed plasma deposition of super-hydrophobic nanospheres. Chem Mater 14 11 (2002) 4566-4571
187. Woodward I., Schofield W.C.E., Roucoules V., and Badya J.P.S. Super-hydrophobic surfaces produced by plasma fluorination of polybutadiene films. Langmuir 19 8 (2003) 3432-3438
188. Herminghaus S. Roughness-induced non-wetting. Europhys Lett 52 2 (2000) 165
189. Schibuichi S, Yamamoto T, Onda T and Tsujii K. Super water repellent surfaces resulting from fractal surfaces. J Phys Chem 1996;100:19512-19517.
190. Bico J., Thiele U., and Quere D. Wetting of textured surfaces. Coll Surf A 206 1-3 (2002) 41-46
191. Nosonovsky M., and Bhushan B. Roughness optimization for biomimetic superhydrophobic surfaces. Microsystem Technol 11 7 (2005) 535-549
192. Miwa M., Nakajima A., Fujishima A., Hashimoto K., and Watanabe T. Effects of the surface roughness on sliding angles of water droplets on superhydrophobic surfaces. Langmuir 16 13 (2000) 5754-5760
193. Gao X., and Jiang L. Biophysics: water-repellent legs of water striders. Nature 432 7013 (2004) 36
194. Bruin G.J.M. Recent developments in electrokinetically driven analysis on microfabricated devices. Electrophoresis 21 (2000) 3931-3951
195. van der Berg A., and Lammerink T.S.J. Micro total analysis systems: microfluidic aspects, integration concept and applications. Top Curr Chem 194 (1998) 21-49
196. Gao J., Xu J.D., Locascio L.E., and Lee C.S. Integrated microfluidic system enabling protein digestion, peptide separation, and protein
197. Liu Y.J., Foote R.S., Jacobsson S.C., Ramsey R.S., and Ramsey J.M. Electrophoretic separation of proteins on a microchip with noncovalentpostcolumn labeling. Anal Chem 72 (2000) 4608-4613
198. Wang J., Chatrathi M.P., Mulchandani A., and Chen W. Capillary electrophoresis microchips for separation and detection of organophosphate nerve agents. Anal Chem 73 (2001) 1804-1808
199. Ceriotti L., de Rooij N.F., and Verpoorte E. An integrated fritless column for on-chip capillary electrochromatography with conventional stationary phases. Anal Chem 74 74 (2002) 639-647
200. Ericson C., Holm J., Ericson T., and Hjertén S. Electroosmosis and pressure-driven chromatography in chip using continuous beds. Anal Chem 72 (2000) 81-87
201. Ngola S.M., Fintschenko Y., Choi W.Y., and Sheppodd T.J. Conduct-as-cast polymer monoliths as separation media for capillary electrochromatography. Anal Chem 73 (2001) 849-856
202. Throckmorton D.J., Schepodd T.J., and Singh A.K. Electrochromatography in microchips: reversed-phase separation of peptides and amino acids using photopatterned rigid polymer monoliths. Anal Chem 74 (2002) 784-789
203. Drott J., Lindstrom K., Rosengren L., and Laurell T. Porous silicon as the carrier matrix in microstructured enzyme reactors yielding high enzyme activities. J Micromech Microeng 7 (1997) 14-23
204. Laurell T., Drott J., Rosengren L., and Lindstrom K. Enhanced enzyme activity in silicon integrated enzyme reactors utilizing porous silicon as the coupling matrix. Sens Actuators 31 (1996) 161-166
205. Mao H., Yang T., and Cremer P.T. Design and characterization of immobilized enzymes in microfluidic systems. Anal Chem 74 (2002) 379-385
206. Wang J. On-chip enzymatic assays. Electrophoresis 23 (2002) 713-718
207. Wang J., Chatrathi M.P., and Tian B.M. Micromachined separation chips with a precolumn reactor and end-column electrochemical detector. Anal Chem 72 (2000) 5774-5778
208. Dodge A., Fluri K., Verpoorte E., and de Rooij N.F. Electrokinetically driven microfluidic chips with surface-modified chambers for heterogeneous immunoassays. Anal Chem 73 (2001) 3400-3409
209. Ressine A., Ekstrom S., Marko-Varga G., and Laurell T. Macro-/nanoporous silicon as a support for high-performance protein microarrays. Anal Chem 24 (2003) 6968-6974
210. Sato K., Tokeshi M., Kimura H., and Kitamori T. Determination of carcinoembryonic antigen in human sera by integrated bead-bed immunoassay in a microchip for cancer diagnosis. Anal Chem 73 (2001) 1213-1218
211. James P. Chips for proteomics: a new tool or just hype? BioTechniques 2002;33:4-13.
212. Ericsson D., Ekstrom S., Nilsson J., Bergquist J., Marko-Varga G., and Laurell T. Downsizing proteolytic digestion and analysis using dispenser-aided sample handling and nanovial matrix-assisted laser/desorption ionization-target arrays. Proteomics 1 9 (2001) 1072-1081
213. Litborn E., Emmer A., and Roeraade J. Chip-based nanovials for tryptic digest and capillary electrophoresis. Anal Chim Acta 401 1-2 (1999) 11-19
214. Ekstrom S., Ericsson D., Oennerfjord P., Bengtsson M., Nilsson J., Marko-Varga G., and Laurell T. Signal amplification using "Spot-on-a-Chip" technology for the identification of proteins via MALDI-TOF MS. Anal Chem 73 2 (2001) 214-219