-
1
-
-
0030512608
-
Transgenic mouse models of tumour angiogenesis: The angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models
-
Hanahan D et al. (1996)Transgenic mouse models of tumour angiogenesis: The angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models. Eur J Cancer 32A 2386-2393
-
(1996)
Eur J Cancer
, vol.32 A
, pp. 2386-2393
-
-
Hanahan, D.1
-
2
-
-
0030701960
-
Halting angiogenesis suppresses carcinoma cell invasion
-
Skobe M et al. (1997) Halting angiogenesis suppresses carcinoma cell invasion. Nat Med 3: 1222-1227
-
(1997)
Nat Med
, vol.3
, pp. 1222-1227
-
-
Skobe, M.1
-
3
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J (1971) Tumor angiogenesis: Therapeutic implications. N Engl J Med 285: 1182-1186
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
4
-
-
33344468704
-
Pericytes and vascular stability
-
von Tell D et al. (2006) Pericytes and vascular stability. Exp Cell Res 312: 623-629
-
(2006)
Exp Cell Res
, vol.312
, pp. 623-629
-
-
von Tell, D.1
-
5
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ and Ellis LM (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23: 1011-1027
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
6
-
-
0036831559
-
Vascular and haematopoietic stem cells: Novel targets for anti-angiogenesis therapy?
-
Rafii S et al. (2002) Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nat Rev Cancer 2 826-835
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 826-835
-
-
Rafii, S.1
-
7
-
-
0037967272
-
Tumorigenesis and the angiogenic switch
-
Bergers G and Benjamin LE (2003) Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3: 401-410
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 401-410
-
-
Bergers, G.1
Benjamin, L.E.2
-
8
-
-
0032907687
-
Vascular endothelial growth factor (VEGF) and its receptors
-
Neufeld G et al. (1999) Vascular endothelial growth factor (VEGF) and its receptors. Faseb J 13: 9-22
-
(1999)
Faseb J
, vol.13
, pp. 9-22
-
-
Neufeld, G.1
-
9
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara N et al. (2003) The biology of VEGF and its receptors. Nat Med 9: 669-676
-
(2003)
Nat Med
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
-
10
-
-
0031038068
-
Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
-
Relf M et al. (1997) Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 57 963-969
-
(1997)
Cancer Res
, vol.57
, pp. 963-969
-
-
Relf, M.1
-
11
-
-
0025999033
-
The human gene for vascular endothelial growth factor: Multiple protein forms are encoded through alternative exon splicing
-
Tischer E et al. (1991) The human gene for vascular endothelial growth factor: Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266: 11947-11954
-
(1991)
J Biol Chem
, vol.266
, pp. 11947-11954
-
-
Tischer, E.1
-
12
-
-
0028968307
-
Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells
-
Mandriota SJ et al. (1995) Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J Biol Chem 270: 9709-9716
-
(1995)
J Biol Chem
, vol.270
, pp. 9709-9716
-
-
Mandriota, S.J.1
-
13
-
-
0026321129
-
Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
-
Pepper MS et al. (1991) Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 181 902-906
-
(1991)
Biochem Biophys Res Commun
, vol.181
, pp. 902-906
-
-
Pepper, M.S.1
-
14
-
-
0032515047
-
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway: Requirement for Flk-1/KDR activation
-
Gerber HP et al. (1998) Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway: Requirement for Flk-1/KDR activation. J Biol Chem 273: 30336-30343
-
(1998)
J Biol Chem
, vol.273
, pp. 30336-30343
-
-
Gerber, H.P.1
-
15
-
-
0036006171
-
Vascular endothelial growth factor (VEGF), a survival factor for tumour cells: Implications for anti-angiogenic therapy
-
Harmey JH and Bouchier-Hayes D (2002) Vascular endothelial growth factor (VEGF), a survival factor for tumour cells: Implications for anti-angiogenic therapy. Bioessays 24: 280-283
-
(2002)
Bioessays
, vol.24
, pp. 280-283
-
-
Harmey, J.H.1
Bouchier-Hayes, D.2
-
16
-
-
0037007037
-
A role for survivin in chemoresistance of endothelial cells mediated by VEGF
-
Tran J et al. (2002) A role for survivin in chemoresistance of endothelial cells mediated by VEGF. Proc Natl Acad Sci USA 99 4349-4354
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 4349-4354
-
-
Tran, J.1
-
17
-
-
0033708398
-
Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor
-
Gerber HP et al. (2000) Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor. Cancer Res 60: 6253-6258
-
(2000)
Cancer Res
, vol.60
, pp. 6253-6258
-
-
Gerber, H.P.1
-
18
-
-
0025259592
-
Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family
-
Shibuya M et al. (1990) Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 5: 519-524
-
(1990)
Oncogene
, vol.5
, pp. 519-524
-
-
Shibuya, M.1
-
19
-
-
0027421333
-
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
-
Kendall RL and Thomas KA (1993) Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA 90: 10705-10709
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 10705-10709
-
-
Kendall, R.L.1
Thomas, K.A.2
-
20
-
-
3543131382
-
A naturally occurring soluble form of vascular endothelial growth factor receptor 2 detected in mouse and human plasma
-
Ebos JM et al. (2004) A naturally occurring soluble form of vascular endothelial growth factor receptor 2 detected in mouse and human plasma. Mol Cancer Res 2: 315-326
-
(2004)
Mol Cancer Res
, vol.2
, pp. 315-326
-
-
Ebos, J.M.1
-
21
-
-
33845991161
-
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
-
Pan Q et al. (2007) Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell 11 53-67
-
(2007)
Cancer Cell
, vol.11
, pp. 53-67
-
-
Pan, Q.1
-
22
-
-
17744396472
-
Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice
-
Veikkola T et al. (2001) Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J 20: 1223-1231
-
(2001)
EMBO J
, vol.20
, pp. 1223-1231
-
-
Veikkola, T.1
-
23
-
-
33646835413
-
Targeting lymphangiogenesis to prevent tumour metastasis
-
Achen MG et al. (2006) Targeting lymphangiogenesis to prevent tumour metastasis. Br J Cancer 94: 1355-1360
-
(2006)
Br J Cancer
, vol.94
, pp. 1355-1360
-
-
Achen, M.G.1
-
24
-
-
0034650744
-
Oncogenes and tumor angiogenesis: Differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts
-
Rak J et al. (2000) Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts. Cancer Res 60: 490-498
-
(2000)
Cancer Res
, vol.60
, pp. 490-498
-
-
Rak, J.1
-
25
-
-
33751074452
-
Hypoxia-inducible factor-1 in human breast and prostate cancer
-
Kimbro KS and Simons JW (2006) Hypoxia-inducible factor-1 in human breast and prostate cancer. Endocr Relat Cancer 13: 739-749
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 739-749
-
-
Kimbro, K.S.1
Simons, J.W.2
-
26
-
-
0036359548
-
Hypoxia - a key regulatory factor in tumour growth
-
Harris AL (2002) Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
27
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssegur J et al. (2006) Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssegur, J.1
-
28
-
-
0034759792
-
Hypoxia reduces hormone responsiveness of human breast cancer cells
-
Kurebayashi J et al. (2001) Hypoxia reduces hormone responsiveness of human breast cancer cells. Jpn J Cancer Res 92: 1093-1101
-
(2001)
Jpn J Cancer Res
, vol.92
, pp. 1093-1101
-
-
Kurebayashi, J.1
-
29
-
-
0032005986
-
Progestin regulation of vascular endothelial growth factor in human breast cancer cells
-
Hyder SM et al. (1998) Progestin regulation of vascular endothelial growth factor in human breast cancer cells. Cancer Res 58: 392-395
-
(1998)
Cancer Res
, vol.58
, pp. 392-395
-
-
Hyder, S.M.1
-
30
-
-
0033602501
-
Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells
-
Ruohola JK et al. (1999) Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells. Mol Cell Endocrinol 149: 29-40
-
(1999)
Mol Cell Endocrinol
, vol.149
, pp. 29-40
-
-
Ruohola, J.K.1
-
31
-
-
0030472169
-
Estrogen regulates vascular endothelial growth/permeability factor expression in 7, 12-dimethylbenz(a)anthracene-induced rat mammary tumors
-
Nakamura J et al. (1996) Estrogen regulates vascular endothelial growth/permeability factor expression in 7, 12-dimethylbenz(a)anthracene-induced rat mammary tumors. Endocrinology 137: 5589-5596
-
(1996)
Endocrinology
, vol.137
, pp. 5589-5596
-
-
Nakamura, J.1
-
32
-
-
0034718502
-
Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta
-
Mueller MD et al. (2000) Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta. Proc Natl Acad Sci USA 97: 10972-10977
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10972-10977
-
-
Mueller, M.D.1
-
33
-
-
0036731988
-
Transcriptional regulation of vascular endothelial growth factor by estradiol and tamoxifen in breast cancer cells: A complex interplay between estrogen receptors alpha and beta
-
Buteau-Lozano H et al. (2002) Transcriptional regulation of vascular endothelial growth factor by estradiol and tamoxifen in breast cancer cells: A complex interplay between estrogen receptors alpha and beta. Cancer Res 62: 4977-4984
-
(2002)
Cancer Res
, vol.62
, pp. 4977-4984
-
-
Buteau-Lozano, H.1
-
34
-
-
1442278675
-
Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins
-
Stoner M et al. (2004) Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins. Oncogene 23: 1052-1063
-
(2004)
Oncogene
, vol.23
, pp. 1052-1063
-
-
Stoner, M.1
-
35
-
-
0346059598
-
Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo
-
Garvin S and Dabrosin C (2003) Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo. Cancer Res 63: 8742-8748
-
(2003)
Cancer Res
, vol.63
, pp. 8742-8748
-
-
Garvin, S.1
Dabrosin, C.2
-
36
-
-
0029900401
-
Antiestrogens inhibit endothelial cell growth stimulated by angiogenic growth factors
-
Gagliardi AR et al. (1996) Antiestrogens inhibit endothelial cell growth stimulated by angiogenic growth factors. Anticancer Res 16: 1101-1106
-
(1996)
Anticancer Res
, vol.16
, pp. 1101-1106
-
-
Gagliardi, A.R.1
-
37
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ et al. (1987) Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177-182
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
-
38
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ et al. (2005) Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 353 1659-1672
-
(2005)
N Engl J Med
, vol.353
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
-
39
-
-
33750584030
-
HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: Implications for HER2-targeted antibody therapy
-
Wen XF et al. (2006) HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy. Oncogene 25 6986-6996
-
(2006)
Oncogene
, vol.25
, pp. 6986-6996
-
-
Wen, X.F.1
-
40
-
-
33644529055
-
ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/ p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells
-
Klos KS et al. (2006) ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/ p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells. Cancer Res 66: 2028-2037
-
(2006)
Cancer Res
, vol.66
, pp. 2028-2037
-
-
Klos, K.S.1
-
41
-
-
0001223491
-
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
-
Petit AM et al. (1997) Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 151: 1523-1530
-
(1997)
Am J Pathol
, vol.151
, pp. 1523-1530
-
-
Petit, A.M.1
-
42
-
-
0036316476
-
Combined biological therapy of breast cancer using monoclonal antibodies directed against HER2/neu protein and vascular endothelial growth factor
-
Pegram MD and Reese DM (2002) Combined biological therapy of breast cancer using monoclonal antibodies directed against HER2/neu protein and vascular endothelial growth factor. Semin Oncol 29: 29-37
-
(2002)
Semin Oncol
, vol.29
, pp. 29-37
-
-
Pegram, M.D.1
Reese, D.M.2
-
43
-
-
0034691674
-
Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis
-
Yen L et al. (2000) Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis. Oncogene 19: 3460-3469
-
(2000)
Oncogene
, vol.19
, pp. 3460-3469
-
-
Yen, L.1
-
44
-
-
0037036451
-
Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: Their implication in vascular endothelial growth factor gene transcription
-
Milanini-Mongiat J et al. (2002) Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. J Biol Chem 277: 20631-20639
-
(2002)
J Biol Chem
, vol.277
, pp. 20631-20639
-
-
Milanini-Mongiat, J.1
-
45
-
-
0032725554
-
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1 alpha) and enhance the transcriptional activity of HIF-1
-
Richard DE et al. (1999) p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1 alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem 274: 32631-32637
-
(1999)
J Biol Chem
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
-
46
-
-
0034714265
-
Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability
-
Pages G et al. (2000) Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability. J Biol Chem 275: 26484-26491
-
(2000)
J Biol Chem
, vol.275
, pp. 26484-26491
-
-
Pages, G.1
-
47
-
-
17844398046
-
Molecular changes in tamoxifen-resistant breast cancer: Relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase
-
Gutierrez MC et al. (2005) Molecular changes in tamoxifen-resistant breast cancer: Relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase. J Clin Oncol 23: 2469-2476
-
(2005)
J Clin Oncol
, vol.23
, pp. 2469-2476
-
-
Gutierrez, M.C.1
-
48
-
-
0031741862
-
Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA
-
Huez I et al. (1998) Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA. Mol Cell Biol 18: 6178-6190
-
(1998)
Mol Cell Biol
, vol.18
, pp. 6178-6190
-
-
Huez, I.1
-
49
-
-
0036000028
-
Hypoxia-inducible factor-1α mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia
-
Lang KJ et al. (2002) Hypoxia-inducible factor-1α mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell 13: 1792-1801
-
(2002)
Mol Biol Cell
, vol.13
, pp. 1792-1801
-
-
Lang, K.J.1
-
50
-
-
0034896362
-
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
-
Ciardiello F et al. (2001) Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res 7: 1459-1465
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1459-1465
-
-
Ciardiello, F.1
-
51
-
-
20444431504
-
The antitumor and antiangiogenic activity of vascular endothelial growth factor receptor inhibition is potentiated by ErbB1 blockade
-
Sini P et al. (2005) The antitumor and antiangiogenic activity of vascular endothelial growth factor receptor inhibition is potentiated by ErbB1 blockade. Clin Cancer Res 11: 4521-4532
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4521-4532
-
-
Sini, P.1
-
52
-
-
0037149539
-
Tumour biology: Herceptin acts as an anti-angiogenic cocktail
-
Izumi Y et al. (2002) Tumour biology: Herceptin acts as an anti-angiogenic cocktail. Nature 416: 279-280
-
(2002)
Nature
, vol.416
, pp. 279-280
-
-
Izumi, Y.1
-
53
-
-
0027043136
-
Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma
-
Weidner N et al. (1992) Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst 84: 1875-1887
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 1875-1887
-
-
Weidner, N.1
-
54
-
-
0026497186
-
Angiogenesis, assessed by platelet/ endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer
-
Horak ER et al. (1992) Angiogenesis, assessed by platelet/ endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet 340: 1120-1124
-
(1992)
Lancet
, vol.340
, pp. 1120-1124
-
-
Horak, E.R.1
-
55
-
-
0029830557
-
Angiogenesis as a predictor of long-term survival for patients with node-negative breast cancer
-
Heimann R et al. (1996) Angiogenesis as a predictor of long-term survival for patients with node-negative breast cancer. J Natl Cancer Inst 88: 1764-1769
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 1764-1769
-
-
Heimann, R.1
-
56
-
-
3042672914
-
HER-2 gene amplification correlates with higher levels of angiogenesis and lower levels of hypoxia in primary breast tumors
-
Blackwell KL et al. (2004) HER-2 gene amplification correlates with higher levels of angiogenesis and lower levels of hypoxia in primary breast tumors. Clin Cancer Res 10: 4083-4088
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4083-4088
-
-
Blackwell, K.L.1
-
57
-
-
0001194118
-
Tumor angiogenesis predicts clinical outcome of node-positive breast cancer patients treated with adjuvant hormone therapy or chemotherapy
-
Gasparini G et al. (1995) Tumor angiogenesis predicts clinical outcome of node-positive breast cancer patients treated with adjuvant hormone therapy or chemotherapy. Cancer J Sci Am 1: 131-141
-
(1995)
Cancer J Sci Am
, vol.1
, pp. 131-141
-
-
Gasparini, G.1
-
58
-
-
0031032073
-
Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma
-
Gasparini G et al. (1997) Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J Natl Cancer Inst 89: 139-147
-
(1997)
J Natl Cancer Inst
, vol.89
, pp. 139-147
-
-
Gasparini, G.1
-
59
-
-
0344109584
-
Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients
-
Eppenberger U et al. (1998) Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients. J Clin Oncol 16: 3129-3136
-
(1998)
J Clin Oncol
, vol.16
, pp. 3129-3136
-
-
Eppenberger, U.1
-
60
-
-
0028115003
-
Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer
-
Toi M et al. (1994) Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn J Cancer Res 85: 1045-1049
-
(1994)
Jpn J Cancer Res
, vol.85
, pp. 1045-1049
-
-
Toi, M.1
-
61
-
-
0031671095
-
Vascular endothelial growth actor is of high prognostic value in node-negative breast carcinoma
-
Linderholm B et al. (1998) Vascular endothelial growth actor is of high prognostic value in node-negative breast carcinoma. J Clin Oncol 16: 3121-3128
-
(1998)
J Clin Oncol
, vol.16
, pp. 3121-3128
-
-
Linderholm, B.1
-
62
-
-
0035878753
-
High tumor levels of vascular endothelial growth factor predict poor response to systemic therapy in advanced breast cancer
-
Foekens JA et al. (2001) High tumor levels of vascular endothelial growth factor predict poor response to systemic therapy in advanced breast cancer. Cancer Res 61: 5407-5414
-
(2001)
Cancer Res
, vol.61
, pp. 5407-5414
-
-
Foekens, J.A.1
-
63
-
-
0032888058
-
Does vascular endothelial growth factor (VEGF) predict local relapse and survival in radiotherapy-treated node-negative breast cancer?
-
Linderholm B et al. (1999) Does vascular endothelial growth factor (VEGF) predict local relapse and survival in radiotherapy-treated node-negative breast cancer? Br J Cancer 81: 727-732
-
(1999)
Br J Cancer
, vol.81
, pp. 727-732
-
-
Linderholm, B.1
-
64
-
-
0032943036
-
Clinical relevance of vascular endothelial growth factor and thymidine phosphorylase in patients with node-positive breast cancer treated with either adjuvant chemotherapy or hormone therapy
-
Gasparini G et al. (1999) Clinical relevance of vascular endothelial growth factor and thymidine phosphorylase in patients with node-positive breast cancer treated with either adjuvant chemotherapy or hormone therapy. Cancer J Sci Am 5: 101-111
-
(1999)
Cancer J Sci Am
, vol.5
, pp. 101-111
-
-
Gasparini, G.1
-
65
-
-
0034034667
-
Correlation of vascular endothelial growth factor content with recurrences, survival, and first relapse site in primary node-positive breast carcinoma after adjuvant treatment
-
Linderholm B et al. (2000) Correlation of vascular endothelial growth factor content with recurrences, survival, and first relapse site in primary node-positive breast carcinoma after adjuvant treatment. J Clin Oncol 18: 1423-1431
-
(2000)
J Clin Oncol
, vol.18
, pp. 1423-1431
-
-
Linderholm, B.1
-
66
-
-
23044463773
-
Tumor-specific expression of vascular endothelial growth factor receptor 2 but not vascular endothelial growth factor or human epidermal growth factor receptor 2 is associated with impaired response to adjuvant tamoxifen in premenopausal breast cancer
-
Ryden L et al. (2005) Tumor-specific expression of vascular endothelial growth factor receptor 2 but not vascular endothelial growth factor or human epidermal growth factor receptor 2 is associated with impaired response to adjuvant tamoxifen in premenopausal breast cancer. J Clin Oncol 23: 4695-4704
-
(2005)
J Clin Oncol
, vol.23
, pp. 4695-4704
-
-
Ryden, L.1
-
67
-
-
13844296572
-
Tumor-specific VEGF-A and VEGFR2 in postmenopausal breast cancer patients with long-term follow-up: Implication of a link between VEGF pathway and tamoxifen response
-
Ryden L et al. (2005) Tumor-specific VEGF-A and VEGFR2 in postmenopausal breast cancer patients with long-term follow-up: implication of a link between VEGF pathway and tamoxifen response. Breast Cancer Res Treat 89: 135-143
-
(2005)
Breast Cancer Res Treat
, vol.89
, pp. 135-143
-
-
Ryden, L.1
-
68
-
-
12144291334
-
Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients
-
Konecny GE et al. (2004) Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients. Clin Cancer Res 10: 1706-1716
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1706-1716
-
-
Konecny, G.E.1
-
69
-
-
21744453318
-
ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis
-
Svensson S et al. (2005) ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis. Oncogene 24: 4370-4379
-
(2005)
Oncogene
, vol.24
, pp. 4370-4379
-
-
Svensson, S.1
-
70
-
-
15244362063
-
Association between intratumoral free and total VEGF, soluble VEGFR-1, VEGFR-2 and prognosis in breast cancer
-
Bando H et al. (2005) Association between intratumoral free and total VEGF, soluble VEGFR-1, VEGFR-2 and prognosis in breast cancer. Br J Cancer 92: 553-561
-
(2005)
Br J Cancer
, vol.92
, pp. 553-561
-
-
Bando, H.1
-
71
-
-
23244463512
-
Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: Retrospective study in a series of 745 patients
-
Dales JP et al. (2005) Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: Retrospective study in a series of 745 patients. Int J Cancer 116: 734-739
-
(2005)
Int J Cancer
, vol.116
, pp. 734-739
-
-
Dales, J.P.1
-
72
-
-
0037443587
-
Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma
-
Bos R et al. (2003) Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 97: 1573-1581
-
(2003)
Cancer
, vol.97
, pp. 1573-1581
-
-
Bos, R.1
-
73
-
-
33748037026
-
Hypoxia-inducible factor-1α expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer
-
Generali D et al. (2006) Hypoxia-inducible factor-1α expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. Clin Cancer Res 12: 4562-4568
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4562-4568
-
-
Generali, D.1
-
74
-
-
33646423829
-
Hypoxia inducible factor-1α is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response
-
Kronblad A et al. (2006) Hypoxia inducible factor-1α is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response. Int J Cancer 118: 2609-2616
-
(2006)
Int J Cancer
, vol.118
, pp. 2609-2616
-
-
Kronblad, A.1
-
75
-
-
0346694519
-
The role of VEGF expression in response to bevacizumab plus capecitabine in metastatic breast cancer (MBC) [abstract #766]
-
Hillan KJ et al. (2003) The role of VEGF expression in response to bevacizumab plus capecitabine in metastatic breast cancer (MBC) [abstract #766]. Proc Am Soc Clin Oncol 22
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Hillan, K.J.1
-
76
-
-
34548421475
-
Effect of treatment with sunitinib malate, a multitargeted tyrosine kinase inhibitor, on circulating plasma levels of VEGF, soluble VEGF receptors 2 and 3, and soluble KIT in patients with metastatic breast cancer [abstract #578]
-
Deprimo SE et al. (2006) Effect of treatment with sunitinib malate, a multitargeted tyrosine kinase inhibitor, on circulating plasma levels of VEGF, soluble VEGF receptors 2 and 3, and soluble KIT in patients with metastatic breast cancer [abstract #578]. J Clin Oncol 24 (Suppl 18)
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL. 18
-
-
Deprimo, S.E.1
-
77
-
-
33144475980
-
E2100: A randomized phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer [abstract]
-
Presented at the
-
Miller KD et al. (2005) E2100: A randomized phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer [abstract]. Presented at the 41st Annual Meeting of the American Society of Clinical Oncology
-
(2005)
41st Annual Meeting of the American Society of Clinical Oncology
-
-
Miller, K.D.1
-
78
-
-
33644863001
-
Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer
-
Wedam SB et al. (2006) Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer. J Clin Oncol 24: 769-777
-
(2006)
J Clin Oncol
, vol.24
, pp. 769-777
-
-
Wedam, S.B.1
-
79
-
-
33750286135
-
The multifaceted circulating endothelial cell in cancer: Towards marker and target identification
-
Bertolini F et al. (2006) The multifaceted circulating endothelial cell in cancer: Towards marker and target identification. Nat Rev Cancer 6: 835-845
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 835-845
-
-
Bertolini, F.1
-
80
-
-
34248588177
-
Change in circulating endothelial cells (CEC) predicts progression free survival (PFS) in patients (pts) with hormone receptor positive metastatic breast cancer (MBC) receiving letrozole (L) and bevacizumab (B) [abstract #3039]
-
Rugo HS et al. (2006) Change in circulating endothelial cells (CEC) predicts progression free survival (PFS) in patients (pts) with hormone receptor positive metastatic breast cancer (MBC) receiving letrozole (L) and bevacizumab (B) [abstract #3039]. J Clin Oncol 24 (Suppl 18)
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL. 18
-
-
Rugo, H.S.1
-
81
-
-
20444433587
-
Association of genetic polymorphisms in the VEGF gene with breast cancer survival
-
Lu H et al. (2005) Association of genetic polymorphisms in the VEGF gene with breast cancer survival. Cancer Res 65: 5015-5019
-
(2005)
Cancer Res
, vol.65
, pp. 5015-5019
-
-
Lu, H.1
-
82
-
-
21044453002
-
Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis
-
Jin Q et al. (2005) Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis. Clin Cancer Res 11: 3647-3653
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3647-3653
-
-
Jin, Q.1
-
83
-
-
0035870297
-
The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors
-
Sweeney CJ et al. (2001) The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. Cancer Res 61: 3369-3372
-
(2001)
Cancer Res
, vol.61
, pp. 3369-3372
-
-
Sweeney, C.J.1
-
84
-
-
0034032882
-
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
-
Browder T et al. (2000) Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 60: 1878-1886
-
(2000)
Cancer Res
, vol.60
, pp. 1878-1886
-
-
Browder, T.1
-
85
-
-
0035865363
-
Redefining the target: Chemotherapeutics as antiangiogenics
-
Miller KD et al. (2001) Redefining the target: Chemotherapeutics as antiangiogenics. J Clin Oncol 19: 1195-1206
-
(2001)
J Clin Oncol
, vol.19
, pp. 1195-1206
-
-
Miller, K.D.1
-
86
-
-
1642368865
-
Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression
-
Hamano Y et al. (2004) Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res 64: 1570-1574
-
(2004)
Cancer Res
, vol.64
, pp. 1570-1574
-
-
Hamano, Y.1
-
87
-
-
0242331613
-
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
-
Bocci G et al. (2003) Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci USA 100: 12917-12922
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 12917-12922
-
-
Bocci, G.1
-
88
-
-
27144465977
-
Phase I and pharmacokinetic study of VEGF Trap administered subcutaneously to patients with advanced solid malignancies
-
June 5-8; New Orleans
-
Dupont J et al. (2004) Phase I and pharmacokinetic study of VEGF Trap administered subcutaneously to patients with advanced solid malignancies. In Proceedings of the American Society of Clinical Oncology: 2004 June 5-8; New Orleans
-
(2004)
Proceedings of the American Society of Clinical Oncology
-
-
Dupont, J.1
-
89
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK (2005) Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 307: 58-62
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
90
-
-
20344379950
-
Disrupting tumour blood vessels
-
Tozer GM et al. (2005) Disrupting tumour blood vessels. Nat Rev Cancer 5: 423-435
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 423-435
-
-
Tozer, G.M.1
-
91
-
-
13844262926
-
Cyclooxygenase-2 inhibition in colorectal cancer: Boom or bust?
-
Sanborn R and Blanks CD (2005) Cyclooxygenase-2 inhibition in colorectal cancer: Boom or bust? Semin Oncol 32: 69-75
-
(2005)
Semin Oncol
, vol.32
, pp. 69-75
-
-
Sanborn, R.1
Blanks, C.D.2
-
92
-
-
28444476260
-
Angiogenic inhibitors: A new therapeutic strategy in oncology
-
Gasparini G et al. (2005) Angiogenic inhibitors: A new therapeutic strategy in oncology. Nat Clin Pract Oncol 2: 562-577
-
(2005)
Nat Clin Pract Oncol
, vol.2
, pp. 562-577
-
-
Gasparini, G.1
-
93
-
-
20044364346
-
Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
-
Miller KD et al. (2005) Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 23: 792-799
-
(2005)
J Clin Oncol
, vol.23
, pp. 792-799
-
-
Miller, K.D.1
-
94
-
-
33744973643
-
Metronomic chemotherapy with and without bevacizumab for advanced breast cancer: A randomized phase II study. [abstract #4]
-
Burstein H et al. (2005) Metronomic chemotherapy with and without bevacizumab for advanced breast cancer: A randomized phase II study. [abstract #4] Breast Cancer Res Treat 94 (Suppl 1): S6
-
(2005)
Breast Cancer Res Treat
, vol.94
, Issue.SUPPL. 1
-
-
Burstein, H.1
-
95
-
-
31544441697
-
Metronomic low-dose oral cyclophosphamide and methotrexate plus or minus thalidomide in metastatic breast cancer: Antitumor activity and biological effects
-
Colleoni M et al. (2006) Metronomic low-dose oral cyclophosphamide and methotrexate plus or minus thalidomide in metastatic breast cancer: antitumor activity and biological effects. Ann Oncol 17: 232-238
-
(2006)
Ann Oncol
, vol.17
, pp. 232-238
-
-
Colleoni, M.1
-
96
-
-
0242468884
-
A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer
-
Cobleigh MA et al. (2003) A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer. Semin Oncol 30: 117-124
-
(2003)
Semin Oncol
, vol.30
, pp. 117-124
-
-
Cobleigh, M.A.1
-
97
-
-
33645364706
-
Phase II study of SU11248, a multitargeted receptor tyrosine kinase inhibitor (TKI), in patients (pts) with previously treated metastatic breast cancer (MBC) [abstract #563]
-
Miller KD et al. (2005) Phase II study of SU11248, a multitargeted receptor tyrosine kinase inhibitor (TKI), in patients (pts) with previously treated metastatic breast cancer (MBC) [abstract #563]. J Clin Oncol 23 (Suppl 16): 563
-
(2005)
J Clin Oncol
, vol.23
, Issue.SUPPL. 16
, pp. 563
-
-
Miller, K.D.1
-
98
-
-
18244387980
-
A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer
-
Miller KD et al. (2005) A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer. Clin Cancer Res 11: 3369-3376
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3369-3376
-
-
Miller, K.D.1
-
99
-
-
30944446883
-
Lessons from phase III clinical trials on anti-VEGF therapy for cancer
-
Jain RK et al. (2006) Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 3: 24-40
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 24-40
-
-
Jain, R.K.1
-
100
-
-
34548408637
-
-
Pegram MCD et al. (2006) Phase II combined biological therapy targeting the HER2 proto-oncogene and the vascular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first line treatment of HER2-amplified breast cancer. In Proceedings of the San Antonio Breast Cancer Symposium: 2006 December 14-17; San Antonio
-
Pegram MCD et al. (2006) Phase II combined biological therapy targeting the HER2 proto-oncogene and the vascular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first line treatment of HER2-amplified breast cancer. In Proceedings of the San Antonio Breast Cancer Symposium: 2006 December 14-17; San Antonio
-
-
-
-
101
-
-
21844475563
-
Phase II trial of neoadjuvant docetaxel with or without bevacizumab in patients with locally advanced breast cancer
-
December 8-11; San Antonio
-
Overmoyer B (2004) Phase II trial of neoadjuvant docetaxel with or without bevacizumab in patients with locally advanced breast cancer. In Proceedings of the San Antonio Breast Cancer Symposium: 2004 December 8-11; San Antonio
-
(2004)
Proceedings of the San Antonio Breast Cancer Symposium
-
-
Overmoyer, B.1
-
102
-
-
24944542869
-
Weekly paclitaxel improves pathologic complete remission in operable breast cancer when compared with paclitaxel once every 3 weeks
-
Green MC et al. (2005) Weekly paclitaxel improves pathologic complete remission in operable breast cancer when compared with paclitaxel once every 3 weeks. J Clin Oncol 23: 5983-5992
-
(2005)
J Clin Oncol
, vol.23
, pp. 5983-5992
-
-
Green, M.C.1
-
103
-
-
33747032320
-
Randomized phase II trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients
-
Bottini A et al. (2006) Randomized phase II trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients. J Clin Oncol 24: 3623-3628
-
(2006)
J Clin Oncol
, vol.24
, pp. 3623-3628
-
-
Bottini, A.1
-
104
-
-
0036780251
-
Clinical translation of angiogenesis inhibitors
-
Kerbel R and Folkman J (2002) Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2: 727-739
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 727-739
-
-
Kerbel, R.1
Folkman, J.2
-
105
-
-
30744477950
-
From angiogenesis to neuropathology
-
Greenberg DA and Jin K (2005) From angiogenesis to neuropathology. Nature 438: 954-959
-
(2005)
Nature
, vol.438
, pp. 954-959
-
-
Greenberg, D.A.1
Jin, K.2
-
106
-
-
0034655182
-
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
-
Wood JM et al. (2000) PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 60: 2178-2189
-
(2000)
Cancer Res
, vol.60
, pp. 2178-2189
-
-
Wood, J.M.1
-
107
-
-
2942558419
-
Maximizing the potential of bevacizumab in cancer treatment
-
Bergsland E and Dickler MN (2004) Maximizing the potential of bevacizumab in cancer treatment. Oncologist 9 (Suppl 1): S36-S42
-
(2004)
Oncologist
, vol.9
, Issue.SUPPL. 1
-
-
Bergsland, E.1
Dickler, M.N.2
-
108
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascularendothelial growth factor antibody, for metastatic renal cancer
-
Yang JC et al. (2003) A randomized trial of bevacizumab, an anti-vascularendothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 349: 427-434
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
-
109
-
-
2942657615
-
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
-
Johnson DH et al. (2004) Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 22: 2184-2191
-
(2004)
J Clin Oncol
, vol.22
, pp. 2184-2191
-
-
Johnson, D.H.1
-
110
-
-
33746548452
-
Predicting benefit from anti-angiogenic agents in malignancy
-
Jubb AM et al. (2006) Predicting benefit from anti-angiogenic agents in malignancy. Nat Rev Cancer 6: 626-635
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 626-635
-
-
Jubb, A.M.1
-
111
-
-
20944441692
-
Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials
-
Drevs J et al. (2005) Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials. Ann Oncol 16: 558-565
-
(2005)
Ann Oncol
, vol.16
, pp. 558-565
-
-
Drevs, J.1
-
112
-
-
0030823968
-
Vascular endothelial growth factor is essential for initial but not continued in vivo growth of human breast carcinoma cells
-
Yoshiji H et al. (1997) Vascular endothelial growth factor is essential for initial but not continued in vivo growth of human breast carcinoma cells. Cancer Res 57: 3924-3928
-
(1997)
Cancer Res
, vol.57
, pp. 3924-3928
-
-
Yoshiji, H.1
-
113
-
-
0034087691
-
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
-
Klement G et al. (2000) Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest 105: R15-R24
-
(2000)
J Clin Invest
, vol.105
-
-
Klement, G.1
-
114
-
-
0035884219
-
Clinical trials of antiangiogenic drugs: Opportunities, problems, and assessment of initial results
-
Kerbel RS (2001) Clinical trials of antiangiogenic drugs: Opportunities, problems, and assessment of initial results. J Clin Oncol 19 (Suppl): S45-S51
-
(2001)
J Clin Oncol
, vol.19
, Issue.SUPPL.
-
-
Kerbel, R.S.1
-
115
-
-
0842304140
-
Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis
-
Huang J et al. (2004) Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis. Mol Cancer Res 2 36-42
-
(2004)
Mol Cancer Res
, vol.2
, pp. 36-42
-
-
Huang, J.1
-
116
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O et al. (2005) Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8: 299-309
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
-
117
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers G et al. (2003) Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 111: 1287-1295
-
(2003)
J Clin Invest
, vol.111
, pp. 1287-1295
-
-
Bergers, G.1
|