Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Cell

Volumn 78, Issue 5, 1994, Pages 761-771

  Rock, Kenneth L ^a,b   Gramm, Colette ^a   Rothstein, Lisa ^a   Clark, Karen ^a   Stein, Ross ^b   Dick, Lawrence ^b   Hwang, Daniel ^c   Goldberg, Alfred L ^b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Department of Cellular Molecular Physiology Harvard Medical School Boston ^*

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME; UBIQUITIN;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CYTOSOL; LYMPHOBLAST; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; ANIMAL; ANTIGEN PRESENTATION; B-LYMPHOCYTES; COMPARATIVE STUDY; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; LEUPEPTINS; LYMPHOCYTES; MICE; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; OVALBUMIN; PROTEASE INHIBITORS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES; UBIQUITINS;

ANIMALIA;

EID: 0027980319     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(94)90462-6     Document Type: Article

References (45)

1. Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules
2. T cellrecognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions
3. Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes
4. Efficient expression of tum-antigen P91A by transfected subgenic fragments
5. Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85
6. Molecular determinants of protein half-lives in eukaryotic cells
7. The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins
8. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome
9. 2 terminus of the nucleoprotein gene does not affect generation of cytotoxic T lymphocyte epitopes
10. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes
11. The biochemistry and cell biology of antigen processing and presentation
12. The mechanism and functions of ATP-dependent proteases in bacterial and animal cells
13. Proteolysis proteosomes and antigen presentation
14. Intracellular protein degradation in mammalian and bacterial cells
15. The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts
16. The ubiquitin-activating enzyme E1 is required for stress-induced lysosomal degradation of cellular proteins
17. Isolation of twelve monoclonal antibodies against Ia and H-2 antigens
18. The ubiquitin system for protein degradation
19. Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts
20. Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted
21. Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas
22. Selective rejection of H-2 deficient lymphoma variants suggests alternative immune defense strategy
23. A role for the ubiquitin-dependent proteolytic pathway in MHC class Irestricted antigen presentation
24. A molecular model of MHC class-I-restricted antigen processing
25. Introduction of soluble protein into the class I pathway of antigen processing and presentation
26. ATP-dependent reversible association of proteasomes with multiple protein components to form 26S complexes that degrade ubiquitinated proteins in human HL-60 cells
27. The multicatalytic proteinase complex a major extralysosomal proteolytic system
28. b haplotype reveal genetic control of isotype expression
29. Ubiquitin-mediated pathways for intracellular proteolysis
30. The multicatalytic and 26 S proteases
31. Proteasomes multicatalytic proteinase complexes
32. Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene controlled polymers evidence of specific competition for accessory cell antigen-presentation
33. Generation of class I MHC-restricted T-T hybridomas
34. 2-microglobulin leads to the accumulation of a substantial pool of inactive class I MHC heavy chains on the cell surface
35. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins
36. Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins
37. In vivo function of the proteasome in the ubiquitin pathway
38. In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal
39. The conformational flexibility of class I H-2 molecules as revealed by anti-peptide antibodies specific for intracytoplasmic determinants differential reactivity of beta-2 microblobulin “bound” and “free” heavy chains
40. Improved method for preparation of ubiquitin-ligated lysoszyme as substrate of ATP-dependent proteolysis
41. Dietary protein deficiency reduces lysosomal and nonlysosomal ATP-dependent proteolysis in muscle
42. The transporters associated with antigen presentation
43. Assembly of MHC class I molecules analyzed in vitro
44. Purification and characterization of a ZLeuLeuLeupMCA degrading protease expected to regulate neurite formation a novel catalytic activity in proteasome
45. Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex