Increased urinary level of oxidized nucleosides in patients with mild-to-moderate Alzheimer's disease

Clinical Biochemistry

Volumn 40, Issue 13-14, 2007, Pages 936-938

  Hee Lee, Sang ^a,b   Kim, Inseong ^c   Chul Chung, Bong ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Kyung Hee University   (South Korea)

^c Gongju Geriatric Hospital   (South Korea)

Author keywords

Alzheimer's disease; Liquid chromatography mass spectrometry; Oxidized nucleosides; Urine

Indexed keywords

1 METHYLADENOSINE; 2 DEOXYGUANOSINE; 3 METHYLURIDINE; 5 DEOXYADENOSINE; 5 METHYLCYTIDINE; 5 METHYLDEOXYCYTIDINE; 8 HYDROXYDEOXYGUANOSINE; CYTIDINE DERIVATIVE; N2,N2 DIMETHYLGUANOSINE; NUCLEOSIDE DERIVATIVE; PSEUDOURIDINE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CHROMATOGRAPHY, LIQUID; DEOXYRIBONUCLEOSIDES; FEMALE; HUMANS; NUCLEOSIDES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 34548162663     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2006.11.021     Document Type: Article

References (28)

1. Harman D. The free radical theory of aging. Antioxid. Redox Signal. 5 (2003) 557-561
2. Schoneich C., Pogocki D., Hug G.L., and Bobrowski K. Free radical reactions of methionine in peptides: mechanisms relevant to beta-amyloid oxidation and Alzheimer's disease. J. Am. Chem. Soc. 125 (2003) 13700-13713
3. Varadarajan S., Yatin S., Aksenova M., and Butterfield D.A. Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J. Struct. Biol. 130 (2000) 184-208
4. Timothy J.O., Janice F.W., and Carl L.K. Chronic consumption of flavanol- and procyanindin-rich diet is associated with reduced levels of 8-hydroxy-2′-deoxyguanosine in rat testes. J. Nutr. Biochem. 14 (2003) 104-110
5. Lyras L.N., Cairns J., Jenner A., Jenner P., and Halliwell B. An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J. Nerochem. 68 (1997) 2061-2069
6. Morocz M., Kalman J., Juhasz A., Sinko I., McGlynn A.P., Downes C.S., et al. Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease. Neurobiol. Aging 23 (2002) 47-53
7. Mecocci P., Polidori M.C., Cherubini A., Ingegni T., Mattioli P., Catani M., et al. Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease. Arch. Neurol. 59 (2002) 794-798
8. Nunomura A., Perry G., Aliev G., Hirai K., Takeda A., Balraj E.K., et al. Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60 (2001) 759-767
9. Gabbita S.P., Lovell M.A., and Markesbery W.R. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. J. Neurochem. 71 (1998) 2034-2040
10. Lovell M.A., and Markesbery W.R. Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid. Arch. Neurol. 58 (2001) 392-396
11. McGrath L.T., McGleenon B.M., Brennan S., McColl D., MclLroy S., and Passmore A.P. Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde. QJM 94 (2001) 485-490
12. Montine T.J., Neely M.D., Quinn J.F., Beal M.F., Markesbery W.R., Roberts L.J., et al. Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic. Biol. Med. 33 (2002) 620-626
13. Aksenov M.Y., Aksenova M.V., Butterfield D.A., Geddes J.W., and Markesbery W.R. Protein oxidation in the brain in Alzheimer's disease. Neuroscience 103 (2001) 373-383
14. Butterfield D.A., and Kanski J. Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins. Mech. Ageing Dev. 122 (2001) 945-962
15. Prasad M.R., Lovell M.A., Yatin M., Dhillon H., and Markesbery W.R. Regional membrane phospholipid alterations in Alzheimer's disease. Neurochem. Res. 23 (1998) 81-88
16. Mecocci P., Polidori M.C., Cherubini A., Ingegni T., Mattiolo P., Catani M., et al. Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease. Arch. Neurol. 59 (2002) 794-798
17. Lee S.H., Jung B.H., Kim S.Y., and Chung B.C. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid. Commun. Mass Spectrom 18 (2004) 1-6
18. McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 (1984) 939-944
19. Bai S.W., Jung B.H., Chung B.C., Kim S.U., Kim J.Y., Rha K.H., et al. Relationship between urinary profile of the endogenous steroids and postmenopausal women with stress urinary incontinence. Neurourol. Urodyn. 22 (2003) 198-205
20. Butterfield D.A., Castegna A., Lauderback C.M., and Drake J. Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death. Neurobiol. Aging 23 (2002) 655-664
21. Butterfield D.A., and Lauderback C.M. Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic. Biol. Med. 32 (2002) 1050-1060
22. Di Luca M., Pastorino L., Bianchetti A., Perez J., Vignolo L.A., Lenzi G.L., et al. Differential level of platelet amyloid beta precursor protein isoforms: an early marker for Alzheimer disease. Arch. Neurol. 55 (1998) 1195-11200
23. Ferrarese C., Begni B.M., Canevari C., Zoia C., Piolti R., Frigo M., et al. Glutamate uptake is decreased in platelets from Alzheimer's disease patients. Ann. Neurol. 47 (2000) 641-643
24. Pratico D., Clark C.M., Lee V.M., Trojanowski J.Q., RokachFit J., and Gerald G.A. Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity. Ann. Neurol. 48 (2000) 809-812
25. Roth A., Schaffner W., and Hertel C. Phytoestrogen kaempferol (3,4′,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity. J. Neurosci. Res. 57 (1999) 399-404
26. Branca F., and Lorenzetti S. Health effects of phytoestrogens. Forum Nutr. 57 (2005) 100-111
27. Mizutani K., Ikeda K., Kawai Y., and Yamori Y. Protective effect of resveratrol on oxidative damage in male and female stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 28 (2001) 55-59
28. Lee S.H., Jung B.H., Kim S.Y., and Chung B.C. Determination of phytoestrogens in traditional medicinal herbs using gas chromatography-mass spectrometry. J. Nutr. Biochem. 15 (2004) 452-460