Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue

Journal of Lipid Research

Volumn 48, Issue 6, 2007, Pages 1273-1279

  Souza, Sandra C ^a   Christoffolete, Marcelo A ^b   Ribeiro, Miriam O ^c   Miyoshi, Hideaki ^a,d   Strissel, Katherine J ^a   Stancheva, Zlatina S ^a   Rogers, Nicole H ^a   D'Eon, Tara M ^a,e   Perfield II, James W ^a   Imachi, Hitomi ^a,f   Obin, Martin S ^a   Bianco, Antonio C ^b   Greenberg, Andrew S ^a  

^a TUFTS UNIVERSITY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MACKENZIE PRESBYTERIAN UNIVERSITY   (Brazil)

^d HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e Elixir Pharmaceuticals Inc   (United States)

^f KAGAWA UNIVERSITY   (Japan)

Author keywords

Brown adipocytes; Norepinephrine induced thermal response; Protein kinase A stimulated lipolysis

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; NORADRENALIN; PERILIPIN;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CELL ISOLATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; LIPOLYSIS; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERMOGENESIS; THERMOREGULATION; WESTERN BLOTTING;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; ANIMALS; BLOTTING, WESTERN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION; ION CHANNELS; LIPOLYSIS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION; NOREPINEPHRINE; OXYGEN CONSUMPTION; PHOSPHOPROTEINS; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; THERMOGENESIS;

EID: 34548160963     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M700047-JLR200     Document Type: Article

References (30)

1. Mokdad, A., E. Ford, B. Bowman, W. Dietz, F. Vinicor, V. Bales, and J. Marks. 2003. Prevalence of obesity, diabetes, and obesity-related health-risk factors, 2001. J. Am. Med. Assoc. 289: 76-79.
2. Roden, M., T. Price, G. Perseghin, K. Petersen, D. Rothman, G. Cline, and G. Shulman. 1996. Mechanism of free fatty acid-induced insulin resistance in humans. J. Clin. Invest. 97: 2859-2865.
3. Robidoux, J., T. L. Martin, and S. Collins. 2004. Beta-adrenergic receptors and regulation of energy expenditure: a family affair. Annu. Rev. Pharmacol. Toxicol. 44: 297-323.
4. Thomas, S., and R. Palmitier. 1997. Thermoregulatory metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature. 287: 94-97.
5. Bachman, E., H. Dhillon, C. Zhang, S. Cinit, A. Bianco, B. Koblka, and B. Lowell. 2002. Beta AR signaling required for diet-induced thermogenesis and obesity resistance. Science. 297: 843-845.
6. Kozak, L., and M-E. Harper. 2000. Mitochondrial uncoupling proteins in energy expenditure. Annu. Rev. Nutr. 20: 339-363.
7. Nicholls, D. G., and R. M. Locke. 1984. Thermogenic mechanisms in brown fat. Physiol. Rev. 64: 1-64.
8. Cannon, B., and J. Nedergaard. 2004. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84: 277-359.
9. Belfrage, P., G. Fredrikson, H. Olsson, and P. Stralfors. 1982. Hormonal regulation of adipose tissue lipolysis by reversible phosphorylation of hormone-sensitive lipase. Prog. Clin. Biol. Res. 102: 213-223.
10. Greenberg, A. S., J. J. Egan, S. A. Wek, N. B. Garty, E. J. Blanchette-Mackie, and C. Londos. 1991. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 266: 11341-11346.
11. Brasaemle, D., B. Rubin, I. Harten, J. Gruia-Gray, A. Kimmel, and C. Londos. 2000. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J. Biol. Chem. 275: 38486-38493.
12. Souza, S., L. Moitoso de Vargas, M. Yamamato, P. Line, M. Franciosa, L. Moss, and A. Greenberg. 1998. Overexpression of perilipin A and B blocks the ability of tumor necrosis factor to increase adipocyte lipolysis in 3T3-L1 adipocytes. J. Biol. Chem. 273: 24665-24669.
13. Souza, S., K. Muliro, L. Liscum, P. Lien, Y. Yamamoto, J. Schaffer, G. Dallal, X. Wang, F. Kraemer, M. Obin, et al. 2002. Modulation of hormone-sensitive lipase and protein kinase-A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. J. Biol. Chem. 277: 8267-8272.
14. Miyoshi, H., J. W. Perfield, II, S. C. Souza, W-J. Shen, H-H. Zhang, Z. S. Stancheva, F. B. Kraemer, M. S. Obin, and A. S. Greenberg. 2007. Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes. J. Biol. Chem. 282: 996-1002.
15. Zimmermann, R., J. G. Strauss, G. Haemmerle, G. Schoiswohl, R. Birner-Gruenberger, M. Riederer, A. Lass, G. Neuberger, F. Eisenhaber, A. Hermetter, et al. 2004. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science. 306: 1383-1386.
16. Zhang, H. H., S. C. Souza, K. V. Muliro, F. B. Kraemer, M. S. Obin, and A. S. Greenberg. 2003. Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis. J. Biol. Chem. 278: 51535-51542.
17. Miyoshi, H., S. C. Souza, H. H. Zhang, K. J. Strissel, M. A. Christoffolete, J. Kovsan, A. Rudich, F. B. Kraemer, A. C. Bianco, M. S. Obin, et al. 2006. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J. Biol. Chem. 281: 15837-15844.
18. Tansey, J. T., A. M. Huml, R. Vogt, K. E. Davis, J. M. Jones, K. A. Fraser, D. L. Brasaemle, A. R. Kimmel, and C. Londos. 2003. Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols. J. Biol. Chem. 278: 8401-8406.
19. Garcia, A., V. Subramanian, A. Sekowski, S. Bhattacharyya, M. W. Love, and D. L. Brasaemle. 2004. The amino and carboxyl termini of perilipin A facilitate the storage of triacylglycerols. J. Biol. Chem. 279: 8409-8416.
20. Subramanian, V., A. Garcia, A. Sekowski, and D. L. Brasaemle. 2004. Hydrophobic sequences target and anchor perilipin A to lipid droplets. J. Lipid Res. 45: 1983-1991.
21. Subramanian, V., A. Rothenberg, C. Gomez, A. W. Cohen, A. Garcia, S. Bhattacharyya, L. Shapiro, G. Dolios, R. Wang, M. P. Lisanti, et al. 2004. Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J. Biol. Chem. 279: 42062-42071.
22. Soloveva, V., R. A. Graves, M. M. Rasenick, B. M. Spiegelman, and S. R. Ross. 1997. Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity. Mol. Endocrinol. 11: 27-38.
23. Rickwood, D., M.T. Wilson, and V. M. Darley-Usmar. 1988. Isolation and characteristics of intact mitochondria. In Mitochondria: A Practical Approach. IRL Press, Oxford, UK. 1-16.
24. Ribeiro, M. O., S. D. Carvalho, J. J. Schultz, G. Chiellini, T. S. Scanlan, A. C. Bianco, and G. A. Brent. 2001. Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific. J. Clin. Invest. 108: 97-105.
25. Souza, S. C., M. Yamamoto, M. Franciosa, P. Lien, and A. Greenberg. 1998. BRL blocks the lipolytic actions of tumor necrosis factor-alpha (TNF-α): a potential new insulin-sensitizing mechanism for the thiazolidinediones. Diabetes. 47: 691-695.
26. de Jesus, L. A., S. D. Carvalho, M. O. Ribeiro, M. Schneider, S. W. Kim, J. W. Harney, P. R. Larsen, and A. C. Bianco. 2001. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J. Clin. Invest. 108: 1379-1385.
27. Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25: 402-408.
28. Tansey, J., C. Sztalryd, J. Gruia-Gray, D. Roush, J. Zeo, O. Gavrilova, M. Reitman, C-X. Deng, C. Ki, A. Kimmel, and C. Londos. 2001. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. USA. 98: 6494-6499.
29. Krauss, S., C. Y. Zhang, and B. B. Lowell. 2005. The mitochondrial uncoupling-protein homologues. Nat. Rev. Mol. Cell Biol. 6: 248-261.
30. Martinez-Botas, J., J. Andreson, D. Tessler, A. Lapillojnne, B. H-J. Chang, M. Quast, D. Gorenstein, K-H. Chen, and L. Chan. 2000. Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice. Nat. Genet. 26: 474-479.