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Volumn 8, Issue 11, 2007, Pages 1743-1755

Imiquimod: An immune response modifier in the treatment of precancerous skin lesions and skin cancer

Author keywords

Actinic keratosis; Basal cell carcinoma; Imiquimod; Off label use; Precancerous lesions; Skin cancer

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; ALPHA INTERFERON; B7 ANTIGEN; BACTERIUM LYSATE; BCG VACCINE; CD40 ANTIGEN; CD86 ANTIGEN; DIPHENCYPRONE; FLUOROURACIL; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMIQUIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MYCOBACTERIUM VACCINE; MYELOID DIFFERENTIATION FACTOR 88; PLACEBO; SQUARIC ACID DIBUTYL ESTER; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

EID: 34548137761     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.8.11.1743     Document Type: Article
Times cited : (35)

References (101)
  • 1
    • 33747596885 scopus 로고    scopus 로고
    • Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: Critical review and meta-analysis of efficacy studies
    • GUPTA AK, DAVEY V, MCPHAIL H: Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: critical review and meta-analysis of efficacy studies. J. Cutan. Med. Surg. (2005) 9(5):209-214.
    • (2005) J. Cutan. Med. Surg , vol.9 , Issue.5 , pp. 209-214
    • GUPTA, A.K.1    DAVEY, V.2    MCPHAIL, H.3
  • 2
    • 34249701713 scopus 로고    scopus 로고
    • Comparison of 5% 5-fluorouracil cream and 5% imiquimod cream in the management of actinic keratosis on the face and scalp
    • TANGHETTI W, WERSCHKER P: Comparison of 5% 5-fluorouracil cream and 5% imiquimod cream in the management of actinic keratosis on the face and scalp. J. Drugs Dermatol. (2007) 6(2):144-147.
    • (2007) J. Drugs Dermatol , vol.6 , Issue.2 , pp. 144-147
    • TANGHETTI, W.1    WERSCHKER, P.2
  • 3
    • 27144522254 scopus 로고    scopus 로고
    • Imiquimod and superficial skin cancers
    • NAYLOR M: Imiquimod and superficial skin cancers. J. Drugs Dermatol. (2005) 4(5):598-606.
    • (2005) J. Drugs Dermatol , vol.4 , Issue.5 , pp. 598-606
    • NAYLOR, M.1
  • 4
    • 33748900927 scopus 로고    scopus 로고
    • The role of topical immune response modifiers in skin cancer
    • WOODMANSEE C, PILLOW J, SKINNER RB Jr: The role of topical immune response modifiers in skin cancer. Drugs (2006) 66(13):1657-1664.
    • (2006) Drugs , vol.66 , Issue.13 , pp. 1657-1664
    • WOODMANSEE, C.1    PILLOW, J.2    SKINNER Jr, R.B.3
  • 5
    • 33144479922 scopus 로고    scopus 로고
    • The small-molecule immune response modifier imiquimod - its mode of action and clinical use in the treatment of skin cancer
    • SCHON MP, SCHON M: The small-molecule immune response modifier imiquimod - its mode of action and clinical use in the treatment of skin cancer. Expert Opin. Ther. Targets (2006) 10(1):69-76.
    • (2006) Expert Opin. Ther. Targets , vol.10 , Issue.1 , pp. 69-76
    • SCHON, M.P.1    SCHON, M.2
  • 6
    • 33646177310 scopus 로고    scopus 로고
    • Mechanisms of action of new treatment modalities for actinic keratosis
    • BERMAN B, VILLA AM, RAMIREZ CC: Mechanisms of action of new treatment modalities for actinic keratosis. J. Drugs Dermatol. (2006) 5(2):167-173.
    • (2006) J. Drugs Dermatol , vol.5 , Issue.2 , pp. 167-173
    • BERMAN, B.1    VILLA, A.M.2    RAMIREZ, C.C.3
  • 7
    • 0034037744 scopus 로고    scopus 로고
    • Immunomodulatory agents for prophylaxis and therapy of infections
    • MASIHI KN: Immunomodulatory agents for prophylaxis and therapy of infections. Int. J. Antimicrob. Agents (2000) 14(3):181-191.
    • (2000) Int. J. Antimicrob. Agents , vol.14 , Issue.3 , pp. 181-191
    • MASIHI, K.N.1
  • 8
    • 0034797071 scopus 로고    scopus 로고
    • The therapeutic use of topical contact sensitizers in benign dermatoses
    • BUCKLEY DA, DU VIVIER AW: The therapeutic use of topical contact sensitizers in benign dermatoses. Br. J. Dermatol. (2001) 145(3):385-405.
    • (2001) Br. J. Dermatol , vol.145 , Issue.3 , pp. 385-405
    • BUCKLEY, D.A.1    DU VIVIER, A.W.2
  • 9
    • 0035495948 scopus 로고    scopus 로고
    • Topical immunomodulators-progress towards treating inflammation, infection, and cancer
    • HENGGE UR, BENNINGHOFF B, RUZICKA T, GOOS M: Topical immunomodulators-progress towards treating inflammation, infection, and cancer. Lancet Infect. Dis. (2001) 1(3):189-198.
    • (2001) Lancet Infect. Dis , vol.1 , Issue.3 , pp. 189-198
    • HENGGE, U.R.1    BENNINGHOFF, B.2    RUZICKA, T.3    GOOS, M.4
  • 10
    • 4344560477 scopus 로고    scopus 로고
    • Topical immunomodulation in dermatology: Potential of Toll-like receptor agonists
    • HENGGE UR, RUZICKA T: Topical immunomodulation in dermatology: potential of Toll-like receptor agonists. Dermatol. Surg. (2004) 30(8):1101-1112.
    • (2004) Dermatol. Surg , vol.30 , Issue.8 , pp. 1101-1112
    • HENGGE, U.R.1    RUZICKA, T.2
  • 12
    • 33646586031 scopus 로고    scopus 로고
    • Topical imiquimod: Mechanism of action and clinical applications
    • VIDAL D: Topical imiquimod: mechanism of action and clinical applications. Mini. Rev. Med. Chem. (2006) 6(5):499-503.
    • (2006) Mini. Rev. Med. Chem , vol.6 , Issue.5 , pp. 499-503
    • VIDAL, D.1
  • 13
    • 0036456708 scopus 로고    scopus 로고
    • Imiquimod and the imidazoquinolones: Mechanism of action and therapeutic potential
    • STANLEY MA: Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential. Clin. Exp. Dermatol. (2002) 27(7):571-577.
    • (2002) Clin. Exp. Dermatol , vol.27 , Issue.7 , pp. 571-577
    • STANLEY, M.A.1
  • 14
    • 0033937767 scopus 로고    scopus 로고
    • Immunomodulatory and pharmacologic properties of imiquimod
    • SAUDER DN: Immunomodulatory and pharmacologic properties of imiquimod. J. Am. Acad. Dermatol. (2000) 43(1 Part 2):S6-S11.
    • (2000) J. Am. Acad. Dermatol , vol.43 , Issue.1 PART 2
    • SAUDER, D.N.1
  • 15
    • 0026717120 scopus 로고
    • Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine
    • SIDKY YA, BORDEN EC, WEEKS CE, REITER MJ, HATCHER JF, BRYAN GT: Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine. Cancer Res. (1992) 52(13):3528-3533.
    • (1992) Cancer Res , vol.52 , Issue.13 , pp. 3528-3533
    • SIDKY, Y.A.1    BORDEN, E.C.2    WEEKS, C.E.3    REITER, M.J.4    HATCHER, J.F.5    BRYAN, G.T.6
  • 16
    • 33746850238 scopus 로고    scopus 로고
    • Immunological strategies to fight skin cancer
    • BERMAN B, PEREZ OA, ZELL D: Immunological strategies to fight skin cancer. Skin Ther. Lett. (2006) 11(5):1-7.
    • (2006) Skin Ther. Lett , vol.11 , Issue.5 , pp. 1-7
    • BERMAN, B.1    PEREZ, O.A.2    ZELL, D.3
  • 18
    • 0029099053 scopus 로고
    • Cytokine induction by the immunomodulators imiquimod and S-27609
    • TESTERMAN TL, GERSTER JF, IMBERTSON LM et al.: Cytokine induction by the immunomodulators imiquimod and S-27609. J. Leukoc. Biol. (1995) 58(3):365-372.
    • (1995) J. Leukoc. Biol , vol.58 , Issue.3 , pp. 365-372
    • TESTERMAN, T.L.1    GERSTER, J.F.2    IMBERTSON, L.M.3
  • 19
    • 0034120295 scopus 로고    scopus 로고
    • Imiquimod, a topical immune response modifier, induces migration of Langerhans cells
    • SUZUKI H, WANG B, SHIVJI GM et al.: Imiquimod, a topical immune response modifier, induces migration of Langerhans cells. J. Invest. Dermatol. (2000) 114(1):135-141.
    • (2000) J. Invest. Dermatol , vol.114 , Issue.1 , pp. 135-141
    • SUZUKI, H.1    WANG, B.2    SHIVJI, G.M.3
  • 20
    • 0031900829 scopus 로고    scopus 로고
    • Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463
    • IMBERTSON LM, BEAURLINE JM, COUTURE AM et al.: Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463. J. Invest. Dermatol. (1998) 110(5):734-739.
    • (1998) J. Invest. Dermatol , vol.110 , Issue.5 , pp. 734-739
    • IMBERTSON, L.M.1    BEAURLINE, J.M.2    COUTURE, A.M.3
  • 21
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • LEMAITRE B, NICOLAS E, MICHAUT L, REICHHART JM, HOFFMANN JA: The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell (1996) 86(6):973-983.
    • (1996) Cell , vol.86 , Issue.6 , pp. 973-983
    • LEMAITRE, B.1    NICOLAS, E.2    MICHAUT, L.3    REICHHART, J.M.4    HOFFMANN, J.A.5
  • 22
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • MEDZHITOV R, PRESTON-HURLBURT P, JANEWAY CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature (1997) 388(6640):394-397.
    • (1997) Nature , vol.388 , Issue.6640 , pp. 394-397
    • MEDZHITOV, R.1    PRESTON-HURLBURT, P.2    JANEWAY Jr, C.A.3
  • 23
    • 0037013830 scopus 로고    scopus 로고
    • Intefferon-α and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets
    • ITO T, AMAKAWA R, KAISHO T et al.: Intefferon-α and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J. Exp. Med. (2002) 195(11):1507-1512.
    • (2002) J. Exp. Med , vol.195 , Issue.11 , pp. 1507-1512
    • ITO, T.1    AMAKAWA, R.2    KAISHO, T.3
  • 24
    • 12444341806 scopus 로고    scopus 로고
    • Synthetic TLR agonists reveal functional differences between human TLR7 and TLRS
    • GORDEN KB, GORSKI KS, GIBSON SJ et al.: Synthetic TLR agonists reveal functional differences between human TLR7 and TLRS. J. Immunol. (2005) 174(3):1259-1268.
    • (2005) J. Immunol , vol.174 , Issue.3 , pp. 1259-1268
    • GORDEN, K.B.1    GORSKI, K.S.2    GIBSON, S.J.3
  • 25
    • 0033540341 scopus 로고    scopus 로고
    • Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod
    • WAGNER TL, AHONEN CL, COUTURE AM et al.: Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod. Cell Immunol. (1999) 191(1):10-19.
    • (1999) Cell Immunol , vol.191 , Issue.1 , pp. 10-19
    • WAGNER, T.L.1    AHONEN, C.L.2    COUTURE, A.M.3
  • 26
    • 0343485063 scopus 로고    scopus 로고
    • The imidazoquinolines, imiquimod and R-848, induce functional, but not phenotypic, maturation of human epidermal Langerhans' cells
    • BURNS RP Jr, FERBEL B, TOMAI M, MILLER R, GASPARI AA: The imidazoquinolines, imiquimod and R-848, induce functional, but not phenotypic, maturation of human epidermal Langerhans' cells. Clin. Immunol. (2000) 94(1):13-23.
    • (2000) Clin. Immunol , vol.94 , Issue.1 , pp. 13-23
    • BURNS Jr, R.P.1    FERBEL, B.2    TOMAI, M.3    MILLER, R.4    GASPARI, A.A.5
  • 27
    • 0141926501 scopus 로고    scopus 로고
    • Mechanisms underlying imiquimod-induced regression of basal cell carcinoma in vivo
    • UROSEVIC M, MAIER T, BENNINGHOFF B, SLADE H, BURG G, DUMMER R: Mechanisms underlying imiquimod-induced regression of basal cell carcinoma in vivo. Arch. Dermatol. (2003) 139(10):1325-1332.
    • (2003) Arch. Dermatol , vol.139 , Issue.10 , pp. 1325-1332
    • UROSEVIC, M.1    MAIER, T.2    BENNINGHOFF, B.3    SLADE, H.4    BURG, G.5    DUMMER, R.6
  • 28
    • 33745521238 scopus 로고    scopus 로고
    • The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion
    • SCHON MP, SCHON M, KLOTZ KN: The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J. Invest. Dermatol. (2006) 126(6):1338-1347.
    • (2006) J. Invest. Dermatol , vol.126 , Issue.6 , pp. 1338-1347
    • SCHON, M.P.1    SCHON, M.2    KLOTZ, K.N.3
  • 30
    • 2442555760 scopus 로고    scopus 로고
    • Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod
    • SCHON MP, WIENRICH BG, DREWNIOK C et al.: Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod. J. Invest. Dermatol. (2004) 122(5):1266-1276.
    • (2004) J. Invest. Dermatol , vol.122 , Issue.5 , pp. 1266-1276
    • SCHON, M.P.1    WIENRICH, B.G.2    DREWNIOK, C.3
  • 31
    • 11144287785 scopus 로고    scopus 로고
    • Gene expression in actinic keratoses: Pharmacological modulation by imiquimod
    • LYSA B, TARTLER U, WOLF R et al.: Gene expression in actinic keratoses: pharmacological modulation by imiquimod. Br. J. Dermatol. (2004) 151(6):1150-1159.
    • (2004) Br. J. Dermatol , vol.151 , Issue.6 , pp. 1150-1159
    • LYSA, B.1    TARTLER, U.2    WOLF, R.3
  • 32
    • 0347951008 scopus 로고    scopus 로고
    • Expression of Fas-receptor on basal cell carcinomas after treatment with imiquimod 5% cream or vehicle
    • BERMAN B, SULLIVAN T, DE ARAUJO T, NADJI M: Expression of Fas-receptor on basal cell carcinomas after treatment with imiquimod 5% cream or vehicle. Br. J. Dermatol. (2003) 149(66):59-61.
    • (2003) Br. J. Dermatol , vol.149 , Issue.66 , pp. 59-61
    • BERMAN, B.1    SULLIVAN, T.2    DE ARAUJO, T.3    NADJI, M.4
  • 33
    • 0041920772 scopus 로고    scopus 로고
    • Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod
    • SCHON M, BONG AB, DREWNIOK C et al.: Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod. J. Natl. Cancer Inst. (2003) 95(15):1138-1149.
    • (2003) J. Natl. Cancer Inst , vol.95 , Issue.15 , pp. 1138-1149
    • SCHON, M.1    BONG, A.B.2    DREWNIOK, C.3
  • 34
    • 18744387684 scopus 로고    scopus 로고
    • Imiquimod stimulates innate and cell mediated immunity which controls virus infections and tumors
    • MILLER R: Imiquimod stimulates innate and cell mediated immunity which controls virus infections and tumors. Int. J. Dermatol. (2002) 41(1):3-6.
    • (2002) Int. J. Dermatol , vol.41 , Issue.1 , pp. 3-6
    • MILLER, R.1
  • 35
    • 0035084237 scopus 로고    scopus 로고
    • Identification of genes induced by a macrophage activator, S-28463, using gene expression array analysis
    • BUATES S, MATLASHEWSKI G: Identification of genes induced by a macrophage activator, S-28463, using gene expression array analysis. Antimicrob. Agents Chemother. (2001) 45(4):1137-1142.
    • (2001) Antimicrob. Agents Chemother , vol.45 , Issue.4 , pp. 1137-1142
    • BUATES, S.1    MATLASHEWSKI, G.2
  • 36
    • 4143061382 scopus 로고    scopus 로고
    • Imiquimod treatment induces expression of opioid growth factor receptor: A novel tumor antigen induced by interferon-α?
    • UROSEVIC M, OBERHOLZER PA, MAIERT et al.: Imiquimod treatment induces expression of opioid growth factor receptor: a novel tumor antigen induced by interferon-α? Clin. Cancer Res. (2004) 10(15):4959-4970.
    • (2004) Clin. Cancer Res , vol.10 , Issue.15 , pp. 4959-4970
    • UROSEVIC, M.1    OBERHOLZER, P.A.2    MAIERT3
  • 38
    • 0034669965 scopus 로고    scopus 로고
    • Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848
    • BISHOP GA, HSING Y, HOSTAGER BS, JALUKAR SV, RAMIREZ LM, TOMAI MA: Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848. J. Immunol. (2000) 165(10):5552-5557.
    • (2000) J. Immunol , vol.165 , Issue.10 , pp. 5552-5557
    • BISHOP, G.A.1    HSING, Y.2    HOSTAGER, B.S.3    JALUKAR, S.V.4    RAMIREZ, L.M.5    TOMAI, M.A.6
  • 41
    • 0032802988 scopus 로고    scopus 로고
    • Enhancement of the innate and cellular immune response in patients with genital warts treated with topical imiquimod cream 5%
    • ARANY I, TYRING SK, STANLEY MA et al.: Enhancement of the innate and cellular immune response in patients with genital warts treated with topical imiquimod cream 5%. Antiviral Res. (1999) 43(1):55-63.
    • (1999) Antiviral Res , vol.43 , Issue.1 , pp. 55-63
    • ARANY, I.1    TYRING, S.K.2    STANLEY, M.A.3
  • 42
    • 0141995600 scopus 로고    scopus 로고
    • Imiquimod: A topically applied link between innate and acquired immunity
    • HURWITZ DJ, PINCUS L, KUPPER TS: Imiquimod: a topically applied link between innate and acquired immunity. Arch. Dermatol. (2003) 139(10):1347-1350.
    • (2003) Arch. Dermatol , vol.139 , Issue.10 , pp. 1347-1350
    • HURWITZ, D.J.1    PINCUS, L.2    KUPPER, T.S.3
  • 43
    • 32944462834 scopus 로고    scopus 로고
    • Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    • KANNEGANTI TD, OZOREN N, BODY-MALAPEL M et al.: Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 440(7081):233-236.
    • (2006) Nature , vol.440 , Issue.7081 , pp. 233-236
    • KANNEGANTI, T.D.1    OZOREN, N.2    BODY-MALAPEL, M.3
  • 45
    • 3042539632 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of imiquimod 5% cream in the treatment of actinic keratoses of the face, scalp, or hands and arms
    • HARRISON LI, SKINNER SL, MARBURY TC et al.: Pharmacokinetics and safety of imiquimod 5% cream in the treatment of actinic keratoses of the face, scalp, or hands and arms. Arch. Dermatol. Res. (2004) 296(1):6-11.
    • (2004) Arch. Dermatol. Res , vol.296 , Issue.1 , pp. 6-11
    • HARRISON, L.I.1    SKINNER, S.L.2    MARBURY, T.C.3
  • 47
    • 0342771237 scopus 로고
    • α-interferon induction in human blood cell culture by immunomodulator candidate R-837
    • Abstract
    • WEEKS CE, GIBSON SJ: α-interferon induction in human blood cell culture by immunomodulator candidate R-837. J. Interferon Res. (1989) 9(Suppl. 2):S215 (Abstract).
    • (1989) J. Interferon Res , vol.9 , Issue.SUPPL. 2
    • WEEKS, C.E.1    GIBSON, S.J.2
  • 48
    • 0028330004 scopus 로고
    • Effects of a novel topical immunomodulator, imiquimod, on keratinocyte cytokine gene expression
    • KONO T, KONDO S, PASTORE S et al.: Effects of a novel topical immunomodulator, imiquimod, on keratinocyte cytokine gene expression. Lymphokine Cytokine Res. (1994) 13(2):71-76.
    • (1994) Lymphokine Cytokine Res , vol.13 , Issue.2 , pp. 71-76
    • KONO, T.1    KONDO, S.2    PASTORE, S.3
  • 49
    • 0031473031 scopus 로고    scopus 로고
    • Imiquimod - an immune response modifier for the treatment of genital warts
    • BEUTNER KR, GEISSE JK: Imiquimod - an immune response modifier for the treatment of genital warts. Today's Ther. Trends (1997) 15(3):165-178.
    • (1997) Today's Ther. Trends , vol.15 , Issue.3 , pp. 165-178
    • BEUTNER, K.R.1    GEISSE, J.K.2
  • 50
    • 0031853904 scopus 로고    scopus 로고
    • A randomized, controlled, molecular study of condylomata acuminata clearance during treatment with imiquimod
    • TYRING SK, ARANY I, STANLEY MA et al.: A randomized, controlled, molecular study of condylomata acuminata clearance during treatment with imiquimod. J. Infect. Dis. (1998) 178(2):551-555.
    • (1998) J. Infect. Dis , vol.178 , Issue.2 , pp. 551-555
    • TYRING, S.K.1    ARANY, I.2    STANLEY, M.A.3
  • 51
    • 0037009268 scopus 로고    scopus 로고
    • Related articles, links safety studies of topical imiquimod 5% cream on normal skin exposed to ultraviolet radiation
    • KAIDBEY K, OWENS M, LIBERDA M, SMITH M: Related articles, links safety studies of topical imiquimod 5% cream on normal skin exposed to ultraviolet radiation. Toxicology (2002) 178(2):175-182.
    • (2002) Toxicology , vol.178 , Issue.2 , pp. 175-182
    • KAIDBEY, K.1    OWENS, M.2    LIBERDA, M.3    SMITH, M.4
  • 52
    • 2342450044 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of actinic keratosis: Results from two Phase III, randomized, double-blind, parallel group, vehicle-controlled trials
    • LEBWOHL M, DINEHART S, WHITING D et al.: Imiquimod 5% cream for the treatment of actinic keratosis: results from two Phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J. Am. Acad. Dermatol. (2004) 50(5):714-721.
    • (2004) J. Am. Acad. Dermatol , vol.50 , Issue.5 , pp. 714-721
    • LEBWOHL, M.1    DINEHART, S.2    WHITING, D.3
  • 53
    • 17444394323 scopus 로고    scopus 로고
    • Dosing with imiquimod 5% cream 3 times per week for the treatment of actinic keratosis: Results of two Phase III, randomised, double blind, parallel group, vehicle controlled trials
    • KORMAN N, MOY R, LING M et al.: Dosing with imiquimod 5% cream 3 times per week for the treatment of actinic keratosis: results of two Phase III, randomised, double blind, parallel group, vehicle controlled trials. Arch. Dermatol. (2005) 141(4):467-473.
    • (2005) Arch. Dermatol , vol.141 , Issue.4 , pp. 467-473
    • KORMAN, N.1    MOY, R.2    LING, M.3
  • 54
    • 0036845121 scopus 로고    scopus 로고
    • A randomized, double-blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses
    • STOCKFLETH E, MEYER T, BENNINGHOFF B et al.: A randomized, double-blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses. Arch. Dermatol. (2002) 138(11):1498-1502.
    • (2002) Arch. Dermatol , vol.138 , Issue.11 , pp. 1498-1502
    • STOCKFLETH, E.1    MEYER, T.2    BENNINGHOFF, B.3
  • 55
    • 4644304377 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of actinic keratosis: Results from a Phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology
    • SZEIMIES RM, GERRITSEN MJ, GUPTA G et al.: Imiquimod 5% cream for the treatment of actinic keratosis: results from a Phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. J. Am. Acad. Dermatol. (2004) 51(4):547-555.
    • (2004) J. Am. Acad. Dermatol , vol.51 , Issue.4 , pp. 547-555
    • SZEIMIES, R.M.1    GERRITSEN, M.J.2    GUPTA, G.3
  • 56
    • 33746888686 scopus 로고    scopus 로고
    • Imiquimod for the treatment of actinic keratosis: A meta-analysis of randomized controlied trials
    • FALAGAS M, ANGELOUSI A, PEPPAS G: Imiquimod for the treatment of actinic keratosis: a meta-analysis of randomized controlied trials. J. Am. Acad. Dermatol. (2006):537-538.
    • (2006) J. Am. Acad. Dermatol , pp. 537-538
    • FALAGAS, M.1    ANGELOUSI, A.2    PEPPAS, G.3
  • 57
    • 0344687222 scopus 로고    scopus 로고
    • Short course therapy with 5% imiquimod cream for solar keratoses: A randomized controlled trial
    • CHEN K, YAP LM, MARKS R et al.: Short course therapy with 5% imiquimod cream for solar keratoses: a randomized controlled trial. Aust. J. Dermatol. (2003) 44(4):250-255.
    • (2003) Aust. J. Dermatol , vol.44 , Issue.4 , pp. 250-255
    • CHEN, K.1    YAP, L.M.2    MARKS, R.3
  • 58
    • 0036788815 scopus 로고    scopus 로고
    • Cycle therapy of actinic kerarosis of the face and scalp with 5% topical imiquimod cream: An open label trial
    • SALASCHE SJ, LEVINE N, MORRISON L: Cycle therapy of actinic kerarosis of the face and scalp with 5% topical imiquimod cream: an open label trial. J. Am. Acad. Dermatol. (2002) 47(4):571-577.
    • (2002) J. Am. Acad. Dermatol , vol.47 , Issue.4 , pp. 571-577
    • SALASCHE, S.J.1    LEVINE, N.2    MORRISON, L.3
  • 59
    • 22844432861 scopus 로고    scopus 로고
    • Long term clinical outcomes following treatment of actinic keratosis with imiquimod 5% cream
    • LEE PK, HARWELL WB, LOVEN KH et al.: Long term clinical outcomes following treatment of actinic keratosis with imiquimod 5% cream. Dermatol. Surg. (2005) 31(6):659-664.
    • (2005) Dermatol. Surg , vol.31 , Issue.6 , pp. 659-664
    • LEE, P.K.1    HARWELL, W.B.2    LOVEN, K.H.3
  • 60
    • 10344253361 scopus 로고    scopus 로고
    • Low incidence of new actinic keratoses after topical 5% imiquimod cream treatment: A long-term follow-up study
    • STOCKFLETH E, CHRISTOPHERS E, BENNINGHOFF B, STERRY W: Low incidence of new actinic keratoses after topical 5% imiquimod cream treatment: a long-term follow-up study. Arch. Dermatol. (2004) 140(12):1542.
    • (2004) Arch. Dermatol , vol.140 , Issue.12 , pp. 1542
    • STOCKFLETH, E.1    CHRISTOPHERS, E.2    BENNINGHOFF, B.3    STERRY, W.4
  • 61
    • 33644904180 scopus 로고    scopus 로고
    • Successful treatment of multiple actinic keratosis in organ transplant patients with topical imiquimod 5% cream
    • ULRICH C, BUSCH JO, MEYER T et al.: Successful treatment of multiple actinic keratosis in organ transplant patients with topical imiquimod 5% cream. Br. J. Dermatol. (2006) 155(2):451-454.
    • (2006) Br. J. Dermatol , vol.155 , Issue.2 , pp. 451-454
    • ULRICH, C.1    BUSCH, J.O.2    MEYER, T.3
  • 62
    • 0032694077 scopus 로고    scopus 로고
    • Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream
    • BEUTNER KR, GEISSE JK, HELMAN D et al.: Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream. J. Am. Acad. Dermatol. (1999) 416:1002-1007.
    • (1999) J. Am. Acad. Dermatol , vol.416 , pp. 1002-1007
    • BEUTNER, K.R.1    GEISSE, J.K.2    HELMAN, D.3
  • 63
    • 0036737628 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of superficial basal cell cardnoma: A double-blind, randomized, vehicle-controlled study
    • GEISSE JK, RICH P, PANDYA A et al.: Imiquimod 5% cream for the treatment of superficial basal cell cardnoma: a double-blind, randomized, vehicle-controlled study. J. Am. Acad. Dermatol. (2002) 47(3):390-398.
    • (2002) J. Am. Acad. Dermatol , vol.47 , Issue.3 , pp. 390-398
    • GEISSE, J.K.1    RICH, P.2    PANDYA, A.3
  • 64
    • 2342473348 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: Results form two Phase III, randomized, vehicle-controlled studies
    • GEISSE J, CARO I, LINDHOLM J, GOLITZ L, STAMPONE P, OWENS M: Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results form two Phase III, randomized, vehicle-controlled studies. J. Am. Acad. Dermatol. (2004) 50:722-733.
    • (2004) J. Am. Acad. Dermatol , vol.50 , pp. 722-733
    • GEISSE, J.1    CARO, I.2    LINDHOLM, J.3    GOLITZ, L.4    STAMPONE, P.5    OWENS, M.6
  • 65
    • 0035028717 scopus 로고    scopus 로고
    • AUSTRALASIAN MULTICENTRE TRIAL GROUP: Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-wcek dose-response trial
    • MARKS R, GEBAUER K, SHUMACK S et al.; AUSTRALASIAN MULTICENTRE TRIAL GROUP: Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-wcek dose-response trial. J. Am. Acad. Dermatol. (2001) 44(5):807-813.
    • (2001) J. Am. Acad. Dermatol , vol.44 , Issue.5 , pp. 807-813
    • MARKS, R.1    GEBAUER, K.2    SHUMACK, S.3
  • 66
    • 18944395052 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: Results from a randomized vehicle-controlled Phase III study in Europe
    • SCHULZE HJ, CRIBIER B, REQUENA J et al.: Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from a randomized vehicle-controlled Phase III study in Europe. Br. J. Dermatol. (2005) 152:939-947.
    • (2005) Br. J. Dermatol , vol.152 , pp. 939-947
    • SCHULZE, H.J.1    CRIBIER, B.2    REQUENA, J.3
  • 67
    • 25144522269 scopus 로고    scopus 로고
    • Recurrence rate of superficial BCC following successful treatment with imiquimod 5% cream: Interim 2 year results from an on going 5 year follow up study
    • GOLLNICK H, BARONA CG, FRANK RGJ et al.: Recurrence rate of superficial BCC following successful treatment with imiquimod 5% cream: interim 2 year results from an on going 5 year follow up study. Eur. J. Dermatol. (2005) 15(5):374-381.
    • (2005) Eur. J. Dermatol , vol.15 , Issue.5 , pp. 374-381
    • GOLLNICK, H.1    BARONA, C.G.2    FRANK, R.G.J.3
  • 68
    • 0036886426 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: Randomized studies comparing low-frequency dosing with and without occlusion
    • STERRY W, RUZICKA T, HERRERA E et al.: Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: randomized studies comparing low-frequency dosing with and without occlusion Br. J. Dermatol. (2002) 147(6):1227-1236.
    • (2002) Br. J. Dermatol , vol.147 , Issue.6 , pp. 1227-1236
    • STERRY, W.1    RUZICKA, T.2    HERRERA, E.3
  • 69
    • 9344235468 scopus 로고    scopus 로고
    • Treatment of bowenoid and basaloid vulvar intraepithelial neoplasia 2/3 with imiquimod 5% cream
    • MARCHITELLI C, SECCO G, PERROTTA M, LUGONES L, PESCE R, TESTA R: Treatment of bowenoid and basaloid vulvar intraepithelial neoplasia 2/3 with imiquimod 5% cream. J. Reprod. Med. (2004) 49(11):876-882.
    • (2004) J. Reprod. Med , vol.49 , Issue.11 , pp. 876-882
    • MARCHITELLI, C.1    SECCO, G.2    PERROTTA, M.3    LUGONES, L.4    PESCE, R.5    TESTA, R.6
  • 70
    • 0036746671 scopus 로고    scopus 로고
    • Imiquimod in the treatment of multifocal vulvar intraepithelial neoplasia 2/3. Results ora Pilot Study
    • VAN SETERS M, FONS G, VAN BEURDEN M: Imiquimod in the treatment of multifocal vulvar intraepithelial neoplasia 2/3. Results ora Pilot Study. J. Reprod. Med. (2002) 47(9):701-705.
    • (2002) J. Reprod. Med , vol.47 , Issue.9 , pp. 701-705
    • VAN SETERS, M.1    FONS, G.2    VAN BEURDEN, M.3
  • 71
    • 31844455686 scopus 로고    scopus 로고
    • Preliminary results of 5% imiquimod cream in the primary treatment of vulva intraepithelial neoplasia grade 2/3
    • LE T, HIVKD W, MENARD C, HOPKINS L, FUNG MF: Preliminary results of 5% imiquimod cream in the primary treatment of vulva intraepithelial neoplasia grade 2/3. Am. J. Obstet. Gynecol. (2006) 194(2):377-380.
    • (2006) Am. J. Obstet. Gynecol , vol.194 , Issue.2 , pp. 377-380
    • LE, T.1    HIVKD, W.2    MENARD, C.3    HOPKINS, L.4    FUNG, M.F.5
  • 72
    • 0242351962 scopus 로고    scopus 로고
    • Treatment of vaginal intraepithelial neoplasia (primarily low grade) with imiquimod 5% cream
    • BUCK HW, GUTH KJ: Treatment of vaginal intraepithelial neoplasia (primarily low grade) with imiquimod 5% cream. J. Low Genit. Tract Dis. (2003) 7(4):290-293.
    • (2003) J. Low Genit. Tract Dis , vol.7 , Issue.4 , pp. 290-293
    • BUCK, H.W.1    GUTH, K.J.2
  • 73
    • 28944449883 scopus 로고    scopus 로고
    • Can local application of imiquimod cream be an alternative mode of therapy for patients with high-grade intraepithelial lesions of the vagina?
    • HAIDOPOULOS D, DIAKOMANOLIS E, RODOLAKIS A, VOULGARIS Z, VLACHOS G, INTSAKLIS A: Can local application of imiquimod cream be an alternative mode of therapy for patients with high-grade intraepithelial lesions of the vagina? Int. J. Gynecol. Cancer (2005) 15(5):898-902.
    • (2005) Int. J. Gynecol. Cancer , vol.15 , Issue.5 , pp. 898-902
    • HAIDOPOULOS, D.1    DIAKOMANOLIS, E.2    RODOLAKIS, A.3    VOULGARIS, Z.4    VLACHOS, G.5    INTSAKLIS, A.6
  • 74
    • 0034800165 scopus 로고    scopus 로고
    • Clinical and molecular responses in high-grade intraepithelial neoplasia treated with topical imiquimod 5%
    • DIAZ-ARRASTIA C, ARANY I, ROBAZETTI SC et al.: Clinical and molecular responses in high-grade intraepithelial neoplasia treated with topical imiquimod 5%. Clin. Cancer Res. (2001) 7(10):3031-3033.
    • (2001) Clin. Cancer Res , vol.7 , Issue.10 , pp. 3031-3033
    • DIAZ-ARRASTIA, C.1    ARANY, I.2    ROBAZETTI, S.C.3
  • 75
    • 0035726451 scopus 로고    scopus 로고
    • Successful topical immunotherapy of bowenoid papulosis with imiquimod
    • PETROW W, GERSDEN R, URELICH M, RICHTER O, BIEBER T: Successful topical immunotherapy of bowenoid papulosis with imiquimod. Br. J. Dermatol. (2001) 145(6):1022-1023.
    • (2001) Br. J. Dermatol , vol.145 , Issue.6 , pp. 1022-1023
    • PETROW, W.1    GERSDEN, R.2    URELICH, M.3    RICHTER, O.4    BIEBER, T.5
  • 76
    • 0036788796 scopus 로고    scopus 로고
    • Topical 5% imiquimod for the treatment of actinic cheilitis
    • SMITH KJ, GERMAIN M, YEAGER J, SKELTON H: Topical 5% imiquimod for the treatment of actinic cheilitis. J. Am. Acad. Dermatol. (2002) 47(4):497-501.
    • (2002) J. Am. Acad. Dermatol , vol.47 , Issue.4 , pp. 497-501
    • SMITH, K.J.1    GERMAIN, M.2    YEAGER, J.3    SKELTON, H.4
  • 78
    • 1242303458 scopus 로고    scopus 로고
    • Treatment of Bowen's disease using a cycle regimen of imiquimod 5% cream
    • CHEN K, SHUMACK S: Treatment of Bowen's disease using a cycle regimen of imiquimod 5% cream. Clin. Exp. Dermatol. (2003) 28(Suppl. 1):10-12.
    • (2003) Clin. Exp. Dermatol , vol.28 , Issue.SUPPL. 1 , pp. 10-12
    • CHEN, K.1    SHUMACK, S.2
  • 79
    • 0034973036 scopus 로고    scopus 로고
    • Squamous cell carcinoma in situ (Bowen's disease) in renal transplant recipients treated with 5% imiquimod and 5% 5-fluorouracil therapy
    • SMITH KJ, GERMAIN M, SKELTON H: Squamous cell carcinoma in situ (Bowen's disease) in renal transplant recipients treated with 5% imiquimod and 5% 5-fluorouracil therapy. Dermatol. Surg. (2001) 27(6):561-564.
    • (2001) Dermatol. Surg , vol.27 , Issue.6 , pp. 561-564
    • SMITH, K.J.1    GERMAIN, M.2    SKELTON, H.3
  • 80
    • 33646531439 scopus 로고    scopus 로고
    • Imiquimod 5% cream monotherapy for cutaneous squamous cell carcinoma in situ (Bowen's disease): A randomized, double-blind, placebo-controlled trial
    • PATEL GK, GOODWIN R, CHAWLA M et al.: Imiquimod 5% cream monotherapy for cutaneous squamous cell carcinoma in situ (Bowen's disease): a randomized, double-blind, placebo-controlled trial. J. Am. Acad. Dermatol. (2006) 54(6):1025-1032.
    • (2006) J. Am. Acad. Dermatol , vol.54 , Issue.6 , pp. 1025-1032
    • PATEL, G.K.1    GOODWIN, R.2    CHAWLA, M.3
  • 81
    • 33745843689 scopus 로고    scopus 로고
    • Imiquimod 5% cream in the treatment of Bowen's disease and invasive squamous cell carcinoma
    • PERIS K, MICANTONIOT, FARGNOLI MC, LOZZI GP, CHIMENTI S: Imiquimod 5% cream in the treatment of Bowen's disease and invasive squamous cell carcinoma. J. Am. Acad. Dermatol. (2006) 55(2):324-327.
    • (2006) J. Am. Acad. Dermatol , vol.55 , Issue.2 , pp. 324-327
    • PERIS, K.1    MICANTONIOT2    FARGNOLI, M.C.3    LOZZI, G.P.4    CHIMENTI, S.5
  • 83
    • 0036715342 scopus 로고    scopus 로고
    • Efficacy of topical 5% imiquimod cream for the treatment of nodular basal cell carcinoma: Comparison of dosing regimens
    • SHUMACK S, ROBINSON J, KOSSARD S: Efficacy of topical 5% imiquimod cream for the treatment of nodular basal cell carcinoma: comparison of dosing regimens. Arch. Dermatol. (2002) 138(9):1165-1171.
    • (2002) Arch. Dermatol , vol.138 , Issue.9 , pp. 1165-1171
    • SHUMACK, S.1    ROBINSON, J.2    KOSSARD, S.3
  • 84
    • 34447122462 scopus 로고    scopus 로고
    • Treatment of basal cell carcinoma of the eyelids with 5% topical imiquimod: A 3-year follow-up study
    • Epub head of print
    • CHOONTANOM R, THANOS S, BUSSE H, STUPP T: Treatment of basal cell carcinoma of the eyelids with 5% topical imiquimod: a 3-year follow-up study. Graefe's Arch. Clin. Exp. Ophthalmol. (2007) [Epub head of print].
    • (2007) Graefe's Arch. Clin. Exp. Ophthalmol
    • CHOONTANOM, R.1    THANOS, S.2    BUSSE, H.3    STUPP, T.4
  • 85
    • 33745931967 scopus 로고    scopus 로고
    • Local immune modulator (imiquimod 5% cream) as adjuvant treatment after incomplete Mohs micrographic surgery for large, mixed type basal cell carcinoma: A report of 3 cases
    • THISSEN MR, KUIJPERS DI, KREKELS GA: Local immune modulator (imiquimod 5% cream) as adjuvant treatment after incomplete Mohs micrographic surgery for large, mixed type basal cell carcinoma: a report of 3 cases. J. Drugs Dermatol. (2006) 5(5):461-464.
    • (2006) J. Drugs Dermatol , vol.5 , Issue.5 , pp. 461-464
    • THISSEN, M.R.1    KUIJPERS, D.I.2    KREKELS, G.A.3
  • 86
    • 33645802442 scopus 로고    scopus 로고
    • Pilot study of imiquimod 5% cream as adjunctive therapy to curettage and electrodesiccation for nodular basal cell carcinoma
    • SPENCER JM: Pilot study of imiquimod 5% cream as adjunctive therapy to curettage and electrodesiccation for nodular basal cell carcinoma. Dermatol. Surg. (2006) 32(1):63-69.
    • (2006) Dermatol. Surg , vol.32 , Issue.1 , pp. 63-69
    • SPENCER, J.M.1
  • 87
    • 33645011912 scopus 로고    scopus 로고
    • An open-label, pilot study examining the efficacy of curettage followed by imiquimod 5% cream for the treatment of primary nodular basal cell carcinoma
    • WU JK, OH C, STRUTTON G, SILLER G: An open-label, pilot study examining the efficacy of curettage followed by imiquimod 5% cream for the treatment of primary nodular basal cell carcinoma. Aust. J. Dermatol. (2006) 47(1):46-48.
    • (2006) Aust. J. Dermatol , vol.47 , Issue.1 , pp. 46-48
    • WU, J.K.1    OH, C.2    STRUTTON, G.3    SILLER, G.4
  • 88
    • 0033743997 scopus 로고    scopus 로고
    • Imiquimod: A novel treatment for lentigo maligna
    • AHMED I, BERTH JONES J: Imiquimod: a novel treatment for lentigo maligna. Br. J. Dermatol. (2000) 143(4):843-845.
    • (2000) Br. J. Dermatol , vol.143 , Issue.4 , pp. 843-845
    • AHMED, I.1    BERTH, J.J.2
  • 89
    • 9144253900 scopus 로고    scopus 로고
    • Treatment of lentigo maligna with topical imiquimod
    • NAYLOR MF, CROWSON N, KUWAHARA R et al.: Treatment of lentigo maligna with topical imiquimod. Br. J. Dermatol. (2003) 149(Suppl. 66):66-70.
    • (2003) Br. J. Dermatol , vol.149 , Issue.SUPPL. 66 , pp. 66-70
    • NAYLOR, M.F.1    CROWSON, N.2    KUWAHARA, R.3
  • 90
    • 0842330526 scopus 로고    scopus 로고
    • Topical imiquimod immunotherapy in the management of lentigo maligna
    • POWELL AM, RUSSELL-JONES R, BARLOW RJ: Topical imiquimod immunotherapy in the management of lentigo maligna. Clin. Exp. Dermatol. (2004) 29:15-21.
    • (2004) Clin. Exp. Dermatol , vol.29 , pp. 15-21
    • POWELL, A.M.1    RUSSELL-JONES, R.2    BARLOW, R.J.3
  • 91
    • 0041307296 scopus 로고    scopus 로고
    • Treatment of melanoma in situ on sun-damaged skin with topical 5% imiquimod cream complicated by the development of invasive disease
    • FISHER GH, LANG PG: Treatment of melanoma in situ on sun-damaged skin with topical 5% imiquimod cream complicated by the development of invasive disease. Arch. Dermatol. (2003) 139(7):945-947.
    • (2003) Arch. Dermatol , vol.139 , Issue.7 , pp. 945-947
    • FISHER, G.H.1    LANG, P.G.2
  • 92
    • 33748454894 scopus 로고    scopus 로고
    • Imiquimod in the treatment of lentigo maligna
    • RAJPAR SF, MARSDEN JR: Imiquimod in the treatment of lentigo maligna. Br. J. Dermatol. (2006) 155(2):653-656.
    • (2006) Br. J. Dermatol , vol.155 , Issue.2 , pp. 653-656
    • RAJPAR, S.F.1    MARSDEN, J.R.2
  • 93
    • 33745915868 scopus 로고    scopus 로고
    • Complete remission of multiple satellite and in-transit melanoma metastases after sequential treatment with isolated limb perfusion and topical imiquimod
    • UTIKAL J, ZIMPFER A, THOELKE A et al.: Complete remission of multiple satellite and in-transit melanoma metastases after sequential treatment with isolated limb perfusion and topical imiquimod. Br. J. Dermatol. (2006) 155(2):488-489.
    • (2006) Br. J. Dermatol , vol.155 , Issue.2 , pp. 488-489
    • UTIKAL, J.1    ZIMPFER, A.2    THOELKE, A.3
  • 94
    • 33846212288 scopus 로고    scopus 로고
    • Phase I/II study of topical imiquimod and intralesional interleukin-2 in the treatment of accessible metastases in malignant melanoma
    • GREEN DS, BODMAN-SMITH MD, DALGLEISH AG, FISCHER MD: Phase I/II study of topical imiquimod and intralesional interleukin-2 in the treatment of accessible metastases in malignant melanoma. Br. J. Dermatol. (2007) 156(2):337-345.
    • (2007) Br. J. Dermatol , vol.156 , Issue.2 , pp. 337-345
    • GREEN, D.S.1    BODMAN-SMITH, M.D.2    DALGLEISH, A.G.3    FISCHER, M.D.4
  • 95
    • 33748334284 scopus 로고    scopus 로고
    • Topical imiquimod as treatment of various kinds of cutaneous lymphomas
    • COORS EA, SCHULER G, VON DER DRIESCH P: Topical imiquimod as treatment of various kinds of cutaneous lymphomas. Eur. J. Dermatol. (2006) 16(4):391-393.
    • (2006) Eur. J. Dermatol , vol.16 , Issue.4 , pp. 391-393
    • COORS, E.A.1    SCHULER, G.2    VON DER DRIESCH, P.3
  • 96
    • 26244456936 scopus 로고    scopus 로고
    • Topical imiquimod to treat recurrent breast cancer
    • HENGGE UR, ROTH S, TANNAPFEL A: Topical imiquimod to treat recurrent breast cancer. Breast Cancer Res. Treat. (2005) 94(1):93-94.
    • (2005) Breast Cancer Res. Treat , vol.94 , Issue.1 , pp. 93-94
    • HENGGE, U.R.1    ROTH, S.2    TANNAPFEL, A.3
  • 97
    • 34548112336 scopus 로고    scopus 로고
    • Localized pemphigus foliaceus induced by topical imiquimod treatment
    • LIN R, LADD DJ Jr, POWELL DJ, WAY BV: Localized pemphigus foliaceus induced by topical imiquimod treatment. Arch. Dermatol. (2005) 141(7):908-909.
    • (2005) Arch. Dermatol , vol.141 , Issue.7 , pp. 908-909
    • LIN, R.1    LADD Jr, D.J.2    POWELL, D.J.3    WAY, B.V.4
  • 98
    • 33645547271 scopus 로고    scopus 로고
    • Generalized exacerbation of psoriasis associated with imiquimod cream treatment of superficial basal cell carcinomas
    • RAJAN N, LANGTRY JA: Generalized exacerbation of psoriasis associated with imiquimod cream treatment of superficial basal cell carcinomas. Clin. Exp. Dermatol. (2006) 31(1):140-141.
    • (2006) Clin. Exp. Dermatol , vol.31 , Issue.1 , pp. 140-141
    • RAJAN, N.1    LANGTRY, J.A.2
  • 99
    • 33845296923 scopus 로고    scopus 로고
    • Generalized psoriasis induced by topical treatment of actinic keratosis with imiquimod
    • FANTI PA, DIKA E, VACCARI S, MISCIAL C, VAROTTI C: Generalized psoriasis induced by topical treatment of actinic keratosis with imiquimod. Int. J. Dermatol. (2006) 45(12):1464-1465.
    • (2006) Int. J. Dermatol , vol.45 , Issue.12 , pp. 1464-1465
    • FANTI, P.A.1    DIKA, E.2    VACCARI, S.3    MISCIAL, C.4    VAROTTI, C.5
  • 100
    • 17844410072 scopus 로고    scopus 로고
    • Vitiligo like hypopigmentation associated with imiquimod treatment of genital warts
    • BROWN T, ZIRVI M, COTSARELIS G, GELFAND JM: Vitiligo like hypopigmentation associated with imiquimod treatment of genital warts. J. Am. Acad. Dermatol. (2005) 52(4):715-716.
    • (2005) J. Am. Acad. Dermatol , vol.52 , Issue.4 , pp. 715-716
    • BROWN, T.1    ZIRVI, M.2    COTSARELIS, G.3    GELFAND, J.M.4
  • 101
    • 33745132145 scopus 로고    scopus 로고
    • A case of severe eczema following use of imiquimod 5% cream
    • TAYLOR GL, MASLEN M, KAPEMBWA A: A case of severe eczema following use of imiquimod 5% cream. Sex Transm. Infect. (2006) 82(3):227-228.
    • (2006) Sex Transm. Infect , vol.82 , Issue.3 , pp. 227-228
    • TAYLOR, G.L.1    MASLEN, M.2    KAPEMBWA, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.