Complete remission of multiple satellite and in-transit melanoma metastases after sequential treatment with isolated limb perfusion and topical imiquimod [9]

British Journal of Dermatology

Volumn 155, Issue 2, 2006, Pages 488-491

  Utikal, J ^a   Zimpfer, A ^b   Thoelke, A ^b   Figl, R ^b   Hildenbrand, R ^b   Kettelhack, C ^c   Goerdt, S ^a   Schadendorf, D ^b   Ugurel, S ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMIQUIMOD; MELPHALAN; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TASONERMIN;

ADULT; BRAIN METASTASIS; CANCER CHEMOTHERAPY; CANCER INVASION; CANCER REGRESSION; CANCER SURGERY; CASE REPORT; CAUSE OF DEATH; CRYOSURGERY; DRUG RESPONSE; FEMALE; HUMAN; HUMAN TISSUE; LASER SURGERY; LEG; LETTER; LIMB PERFUSION; LYMPH NODE BIOPSY; LYMPH NODE METASTASIS; MELANOMA; METASTASIS; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; TOPICAL TREATMENT; TUMOR LOCALIZATION;

AMINOQUINOLINES; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, CANCER, REGIONAL PERFUSION; FATAL OUTCOME; FEMALE; HUMANS; MELANOMA; MIDDLE AGED; REMISSION INDUCTION; SKIN NEOPLASMS;

EID: 33745915868     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2006.07333.x     Document Type: Letter

References (11)

1. Hayes AJ, Clark MA, Harries M, Thomas JM. Management of in-transit metastases from cutaneous malignant melanoma. Br J Surg 2004; 91:673-82.
2. Kettelhack C, Hohenberger P, Schlag PM. Isolated hyperthermic perfusion of extremities in malignant melanoma with melphalan and tumor necrosis factor. Langenbecks Arch Chir Suppl Kongressbd 1996; 113:127-9.
3. Kettelhack C, Hohenberger P, Schlag PM. Isolated hyperthermic limb perfusion with melphalan and tumor necrosis factor in malignant melanoma. Dtsch Med Wochenschr 1997; 122:177-81.
4. Fajardo LF, Prionas SD, Kowalski J, Kwan HH. Hyperthermia inhibits angiogenesis. Radiat Res 1988; 114:297-306.
5. Pelz J, Mollwitz M, Stremmel C et al. The impact of surgery and mild hyperthermia on tumor response and angioneogenesis of malignant melanoma in a rat perfusion model. BMC Cancer 2004; 4:53.
6. Nooijen PT, Eggermont AM, Schalkwijk L et al. Complete response of melanoma-in-transit metastasis after isolated limb perfusion with tumor necrosis factor alpha and melphalan without massive tumor necrosis: a clinical and histopathological study of the delayed-type reaction pattern. Cancer Res 1998; 58:4880-7.
7. Ugurel S, Wagner A, Pfohler C et al. Topical imiquimod eradicates skin metastases of malignant melanoma but fails to prevent rapid lymphogenous metastatic spread. Br J Dermatol 2002; 147:621-4.
8. Wolf IH, Smolle J, Binder B et al. Topical imiquimod in the treatment of metastatic melanoma to skin. Arch Dermatol 2003; 139:273-6.
9. Skinner RB Jr. Imiquimod. Dermatol Clin 2003; 21:291-300.
10. Navi D, Huntley A. Imiquimod 5 percent cream and the treatment of cutaneous malignancy. Dermatol Online J 2004; 10:4.
11. Stanley MA. Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential. Clin Exp Dermatol 2002; 27:571-7.