Development of a skin-based metabolic sink for phenylalanine by overexpression of phenylalanine hydroxylase and GTP cyclohydrolase in primary human keratinocytes

Gene Therapy

Volumn 7, Issue 23, 2000, Pages 1971-1978

  Christensen, R ^a   Kolvraa, S ^a   Blaese, R M ^b   Jensen, T G ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b ValiGen Corporation   (United States)

Author keywords

Metabolic co operation; Metabolic diseases; PKU; Skin

Indexed keywords

GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; SAPROPTERIN; TYROSINE; VIRUS VECTOR;

AMINO ACID METABOLISM; ARTICLE; CELL ACTIVITY; CELL CULTURE; CELL STRAIN HEPG2; CLEARANCE; COCULTURE; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; PRIORITY JOURNAL; RETROVIRUS; SKIN; TRANSGENE;

BIOPTERIN; CELL LINE; COCULTURE TECHNIQUES; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; GTP CYCLOHYDROLASE; HUMANS; KERATINOCYTES; LIVER; METABOLIC CLEARANCE RATE; PHENYLALANINE; PHENYLALANINE HYDROXYLASE; PHENYLKETONURIAS; RETROVIRIDAE; TRANSFECTION;

EID: 0034501382     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301337     Document Type: Article

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