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Volumn 21, Issue 3, 1996, Pages 279-288

Processing of mutated human proinsulin to mature insulin in the non-endocrine cell line, CHO

Author keywords

Cell culture; CHO; Mutant human proinsulin; Proinsulin processing

Indexed keywords

INSULIN; MESSENGER RNA; PROINSULIN;

EID: 0030460856     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00365350     Document Type: Article
Times cited : (5)

References (48)
  • 1
    • 0028040778 scopus 로고
    • Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme
    • Authier F, Rachubinski RA, Posner BI and Bergeron JJM (1994) Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme. J Biol Chem 269: 3010-3016.
    • (1994) J Biol Chem , vol.269 , pp. 3010-3016
    • Authier, F.1    Rachubinski, R.A.2    Posner, B.I.3    Bergeron, J.J.M.4
  • 2
    • 0025105992 scopus 로고
    • The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells
    • Backer JM, Kahn CR and White MF (1990) The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells. J Biol Chem 265: 14828-14835.
    • (1990) J Biol Chem , vol.265 , pp. 14828-14835
    • Backer, J.M.1    Kahn, C.R.2    White, M.F.3
  • 3
    • 0028144531 scopus 로고
    • Insulin degradation in vitro and in vivo - A comparative study in men - evidence that immunoprecipitable, partially rebindable degradation products are released from cells and circulate in blood
    • Benzi L, Cecchetti P, Ciccarone A, Pilo A, Dicianni G and Navalesi R (1994) Insulin degradation in vitro and in vivo - a comparative study in men - evidence that immunoprecipitable, partially rebindable degradation products are released from cells and circulate in blood. Diabetes 43: 297-304.
    • (1994) Diabetes , vol.43 , pp. 297-304
    • Benzi, L.1    Cecchetti, P.2    Ciccarone, A.3    Pilo, A.4    Dicianni, G.5    Navalesi, R.6
  • 5
    • 0023711798 scopus 로고
    • Calcium phosphate-mediated gene transfer: A highly effective system for stably transforming cells with plasmid DNA
    • Chen C and Okayama H (1988) Calcium phosphate-mediated gene transfer: A highly effective system for stably transforming cells with plasmid DNA. Bio/Techniques 6: 632-638.
    • (1988) Bio/Techniques , vol.6 , pp. 632-638
    • Chen, C.1    Okayama, H.2
  • 7
    • 0023655547 scopus 로고
    • The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing
    • Davidson HW and Hutton JC (1987) The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. Biochem J 245: 575-582.
    • (1987) Biochem J , vol.245 , pp. 575-582
    • Davidson, H.W.1    Hutton, J.C.2
  • 8
    • 0023408598 scopus 로고
    • 2+-dependent acidic endopeptidase in isolated insulin-secretory granules
    • 2+-dependent acidic endopeptidase in isolated insulin-secretory granules. Biochem J 246: 279-286.
    • (1987) Biochem J , vol.246 , pp. 279-286
    • Davidson, H.W.1    Peshavaria, M.2    Hutton, J.C.3
  • 9
    • 0026601458 scopus 로고
    • Site-directed mutagenesis of virtually any plasmid by eliminating a unique site
    • Deng WP and Nickoloff JA (1992) Site-directed mutagenesis of virtually any plasmid by eliminating a unique site. Anal Biochem 200: 81-88.
    • (1992) Anal Biochem , vol.200 , pp. 81-88
    • Deng, W.P.1    Nickoloff, J.A.2
  • 13
    • 0023429489 scopus 로고
    • Type 1 transforming growth factor beta: Amplified expression and secretion of mature and precursor polypeptides in Chinese hamster ovary cells
    • Gentry LE, Webb NR, Lim GJ, Brunner AM, Ranchalis JE, Twardzik DR, Lioubin MN, Ma H and Purchio AF (1987) Type 1 transforming growth factor beta: amplified expression and secretion of mature and precursor polypeptides in Chinese hamster ovary cells. Mol Cell Biol 7: 3418-3427.
    • (1987) Mol Cell Biol , vol.7 , pp. 3418-3427
    • Gentry, L.E.1    Webb, N.R.2    Lim, G.J.3    Brunner, A.M.4    Ranchalis, J.E.5    Twardzik, D.R.6    Lioubin, M.N.7    Ma, H.8    Purchio, A.F.9
  • 14
    • 0000404279 scopus 로고
    • The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection
    • Gorman CM, Merlino GT, Willingham MC, Pastan I and Howard BH (1982) The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proc Natl Acad Sci U.S.A. 79: 6777-6781.
    • (1982) Proc Natl Acad Sci U.S.A. , vol.79 , pp. 6777-6781
    • Gorman, C.M.1    Merlino, G.T.2    Willingham, M.C.3    Pastan, I.4    Howard, B.H.5
  • 15
    • 0023751336 scopus 로고
    • Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells
    • Gough NM (1988) Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells. Anal Biochem 173: 93-95.
    • (1988) Anal Biochem , vol.173 , pp. 93-95
    • Gough, N.M.1
  • 16
    • 0028064783 scopus 로고
    • Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin
    • Groskreutz DJ, Sliwkowski MX and Gorman CM (1994) Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin. J Biol Chem 269: 6241-6245.
    • (1994) J Biol Chem , vol.269 , pp. 6241-6245
    • Groskreutz, D.J.1    Sliwkowski, M.X.2    Gorman, C.M.3
  • 17
    • 0024849679 scopus 로고
    • Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells
    • Gross DJ, Villa KL, Kahn CR, Weir GC and Halban PA (1989) Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells. J Biol Chem 264: 21486-21490.
    • (1989) J Biol Chem , vol.264 , pp. 21486-21490
    • Gross, D.J.1    Villa, K.L.2    Kahn, C.R.3    Weir, G.C.4    Halban, P.A.5
  • 18
    • 0019497089 scopus 로고
    • Expression of simian virus 40-rat preproinsulin recombinants in monkey kidney cells: Use of preproinsulin RNA processing signals
    • Gruss P and Khoury G (1981) Expression of simian virus 40-rat preproinsulin recombinants in monkey kidney cells: Use of preproinsulin RNA processing signals. Proc Natl Acad Sci U.S.A. 78: 133-137.
    • (1981) Proc Natl Acad Sci U.S.A. , vol.78 , pp. 133-137
    • Gruss, P.1    Khoury, G.2
  • 19
    • 0025339084 scopus 로고
    • Proinsulin trafficking and processing in the pancreatic B cell
    • Halban PA (1990) Proinsulin trafficking and processing in the pancreatic B cell. Trends Endocrinol Metab 1: 261-265.
    • (1990) Trends Endocrinol Metab , vol.1 , pp. 261-265
    • Halban, P.A.1
  • 20
    • 0025635768 scopus 로고
    • Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells
    • Hatsuzawa K, Hosaka M, Nakagawa T, Nagase M, Shoda A, Murakami K and Nakayama K (1990) Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells. J Biol Chem 265: 22075-22078.
    • (1990) J Biol Chem , vol.265 , pp. 22075-22078
    • Hatsuzawa, K.1    Hosaka, M.2    Nakagawa, T.3    Nagase, M.4    Shoda, A.5    Murakami, K.6    Nakayama, K.7
  • 21
    • 0026742960 scopus 로고
    • Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells
    • Hatsuzawa K, Nagahama M, Takahashi S, Takada K, Murakami K and Nakayama K (1992) Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells. J Biol Chem 267: 16094-16099.
    • (1992) J Biol Chem , vol.267 , pp. 16094-16099
    • Hatsuzawa, K.1    Nagahama, M.2    Takahashi, S.3    Takada, K.4    Murakami, K.5    Nakayama, K.6
  • 22
    • 0028117410 scopus 로고
    • Production of bioactive gastrin from the Non-Endocrine cell lines CHO and COS-7
    • Hayashi N, Kayo T, Sugano K and Takeuchi T (1994) Production of bioactive gastrin from the Non-Endocrine cell lines CHO and COS-7. FEBS Lett 337: 27-32.
    • (1994) FEBS Lett , vol.337 , pp. 27-32
    • Hayashi, N.1    Kayo, T.2    Sugano, K.3    Takeuchi, T.4
  • 23
    • 0025916877 scopus 로고
    • Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway
    • Hosaka M, Nagahama M, Kim WS, Watanabe T, Hatsuzawa K, Ikemizu J, Murakami K and Nakayama K (1991) Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway. J Biol Chem 266: 12127-12130.
    • (1991) J Biol Chem , vol.266 , pp. 12127-12130
    • Hosaka, M.1    Nagahama, M.2    Kim, W.S.3    Watanabe, T.4    Hatsuzawa, K.5    Ikemizu, J.6    Murakami, K.7    Nakayama, K.8
  • 24
    • 0024307859 scopus 로고
    • The insulin secretory granule
    • Hutton JC (1989) The insulin secretory granule. Diabetologia 32: 271-281.
    • (1989) Diabetologia , vol.32 , pp. 271-281
    • Hutton, J.C.1
  • 25
    • 0025646802 scopus 로고
    • Subtilisin-like proteinases involved in the activation of proproteins of the eukaryotic secretory pathway
    • Hutton JC (1990) Subtilisin-like proteinases involved in the activation of proproteins of the eukaryotic secretory pathway. Curr Opin Cell Biol 2: 1131-1142.
    • (1990) Curr Opin Cell Biol , vol.2 , pp. 1131-1142
    • Hutton, J.C.1
  • 26
    • 0027166876 scopus 로고
    • Accumulation of PDGFB and cell-binding forms of PDGF a in the extracellular matrix
    • Kelly JL, Sanchez A, Brown GS, Chesterman CN and Sleigh MJ (1993) Accumulation of PDGFB and cell-binding forms of PDGF A in the extracellular matrix. J Cell Biol 121: 1153-1163.
    • (1993) J Cell Biol , vol.121 , pp. 1153-1163
    • Kelly, J.L.1    Sanchez, A.2    Brown, G.S.3    Chesterman, C.N.4    Sleigh, M.J.5
  • 27
    • 0022402201 scopus 로고
    • Pathways of protein secretion in eukaryotes
    • Kelly RB (1985) Pathways of protein secretion in eukaryotes. Science 230: 25-32.
    • (1985) Science , vol.230 , pp. 25-32
    • Kelly, R.B.1
  • 28
    • 0020633329 scopus 로고
    • Expression of the human insulin gene and cDNA in a heterologous mammalian system
    • Laub O and Rutler WJ (1983) Expression of the human insulin gene and cDNA in a heterologous mammalian system. J Biol Chem 258: 6043-6050.
    • (1983) J Biol Chem , vol.258 , pp. 6043-6050
    • Laub, O.1    Rutler, W.J.2
  • 29
    • 0025852474 scopus 로고
    • Separation and quantitation of serum proinsulin and proinsulin intermediates in humans
    • Linde S, Roder ME, Hartling SG, Binder C and Welinder BS (1991) Separation and quantitation of serum proinsulin and proinsulin intermediates in humans. J Chromatogr 548: 371-380.
    • (1991) J Chromatogr , vol.548 , pp. 371-380
    • Linde, S.1    Roder, M.E.2    Hartling, S.G.3    Binder, C.4    Welinder, B.S.5
  • 30
    • 0027225379 scopus 로고
    • Analysis of proinsulin and its conversion products by Reversed-Phase High-Performance liquid chromatography
    • Linde S, Welinder BS and Nielsen JH (1993) Analysis of proinsulin and its conversion products by Reversed-Phase High-Performance liquid chromatography. J Chromatogr 614: 185-204.
    • (1993) J Chromatogr , vol.614 , pp. 185-204
    • Linde, S.1    Welinder, B.S.2    Nielsen, J.H.3
  • 32
    • 0026775916 scopus 로고
    • Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen
    • Molloy SS, Bresnahan PA, Leppla SH, Klimpel KR and Thomas G (1992) Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J Biol Chem 267: 16396-16402.
    • (1992) J Biol Chem , vol.267 , pp. 16396-16402
    • Molloy, S.S.1    Bresnahan, P.A.2    Leppla, S.H.3    Klimpel, K.R.4    Thomas, G.5
  • 33
    • 0021024216 scopus 로고
    • Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation
    • Moore HP, Walker MD, Lee F and Kelly RB (1983) Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation. Cell 35: 531-538.
    • (1983) Cell , vol.35 , pp. 531-538
    • Moore, H.P.1    Walker, M.D.2    Lee, F.3    Kelly, R.B.4
  • 34
    • 0023760126 scopus 로고
    • Efficient targeting to storage granules of human proinsulins with altered propeptide domain
    • Powell SK, Orci L, Craik CS and Moore HP (1988) Efficient targeting to storage granules of human proinsulins with altered propeptide domain. J Cell Biol 106: 1843-1851.
    • (1988) J Cell Biol , vol.106 , pp. 1843-1851
    • Powell, S.K.1    Orci, L.2    Craik, C.S.3    Moore, H.P.4
  • 35
    • 0025786795 scopus 로고
    • Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers
    • Quinn D, Orci L, Ravazzola M and Moore HP (1991) Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers. J Cell Biol 113: 987-996.
    • (1991) J Cell Biol , vol.113 , pp. 987-996
    • Quinn, D.1    Orci, L.2    Ravazzola, M.3    Moore, H.P.4
  • 36
    • 0027362049 scopus 로고
    • Defective processing of the insulin receptor in an endoprotease-deficient Chinese hamster cell strain is corrected by expression of mouse furin
    • Robertson BJ, Moehring JM and Moehring TJ (1993) Defective processing of the insulin receptor in an endoprotease-deficient Chinese hamster cell strain is corrected by expression of mouse furin. J Biol Chem 268: 24274-24277.
    • (1993) J Biol Chem , vol.268 , pp. 24274-24277
    • Robertson, B.J.1    Moehring, J.M.2    Moehring, T.J.3
  • 38
    • 0027078415 scopus 로고
    • The new enzymology of precursor processing endoproteases
    • Steiner DF, Smeekens SP, Ohagi S and Chan SJ (1992) The new enzymology of precursor processing endoproteases. J Biol Chem 267: 23435-23438.
    • (1992) J Biol Chem , vol.267 , pp. 23435-23438
    • Steiner, D.F.1    Smeekens, S.P.2    Ohagi, S.3    Chan, S.J.4
  • 39
    • 0026502553 scopus 로고
    • Release of proinsulin from the human fetal β cell
    • Tuch BE, Roberts EC and Darby KB (1992) Release of proinsulin from the human fetal β cell. J. Endocrinol. 132: 159-167.
    • (1992) J. Endocrinol. , vol.132 , pp. 159-167
    • Tuch, B.E.1    Roberts, E.C.2    Darby, K.B.3
  • 41
    • 0027380787 scopus 로고
    • Substrate specificity of proinsulin conversion in the constitutive pathway of transfected FAO (hepatoma) cells
    • Vollenweider F, Irminger JC and Halban PA (1993) Substrate specificity of proinsulin conversion in the constitutive pathway of transfected FAO (hepatoma) cells. Diabetologia 36: 1322-1325.
    • (1993) Diabetologia , vol.36 , pp. 1322-1325
    • Vollenweider, F.1    Irminger, J.C.2    Halban, P.A.3
  • 42
    • 0027439846 scopus 로고
    • Recombinant porcine prorelaxin produced in Chinese hamster ovary cells is biologically active
    • Vu AL, Green CB, Roby KF, Soares MJ, Fei DT, Chen AB and Kwok SC (1993) Recombinant porcine prorelaxin produced in Chinese hamster ovary cells is biologically active. Life Sci 52: 1055-1061.
    • (1993) Life Sci , vol.52 , pp. 1055-1061
    • Vu, A.L.1    Green, C.B.2    Roby, K.F.3    Soares, M.J.4    Fei, D.T.5    Chen, A.B.6    Kwok, S.C.7
  • 43
    • 0027474401 scopus 로고
    • Positional and additive effects of basic amino acids on processing of precursor proteins within the constitutive secretory pathway
    • Watanabe T, Murakami K and Nakayama K (1993) Positional and additive effects of basic amino acids on processing of precursor proteins within the constitutive secretory pathway. FEBS Lett 320: 215-8.
    • (1993) FEBS Lett , vol.320 , pp. 215-218
    • Watanabe, T.1    Murakami, K.2    Nakayama, K.3
  • 44
    • 0025606360 scopus 로고
    • Expression of a human proprotein processing enzyme: Correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site
    • Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ and Kaufman RJ (1990) Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. Proc Natl Acad Sci U. S. A. 87: 9378-9382.
    • (1990) Proc Natl Acad Sci U. S. A. , vol.87 , pp. 9378-9382
    • Wise, R.J.1    Barr, P.J.2    Wong, P.A.3    Kiefer, M.C.4    Brake, A.J.5    Kaufman, R.J.6
  • 45
    • 0025125718 scopus 로고
    • Partial processing of the neuropeptide Y precursor in transfected CHO cells
    • Wulff BS, O'Hare MM, Boel E, Theill LE and Schwartz TW (1990) Partial processing of the neuropeptide Y precursor in transfected CHO cells. FEBS Lett 261: 101-105.
    • (1990) FEBS Lett , vol.261 , pp. 101-105
    • Wulff, B.S.1    O'Hare, M.M.2    Boel, E.3    Theill, L.E.4    Schwartz, T.W.5
  • 46
    • 84995842413 scopus 로고
    • Processing of mutated proinsulin with tetrabasic cleavage sites to mature insulin reflects the expression of furin in nonendocrine cell lines
    • Yanagita M, Hoshino H, Nakayama K and Takeuchi T (1993) Processing of mutated proinsulin with tetrabasic cleavage sites to mature insulin reflects the expression of furin in nonendocrine cell lines. Endocrinology 133: 639-644.
    • (1993) Endocrinology , vol.133 , pp. 639-644
    • Yanagita, M.1    Hoshino, H.2    Nakayama, K.3    Takeuchi, T.4
  • 47
    • 0026658003 scopus 로고
    • Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non-endocrine cell line, COS-7
    • Yanagita M, Nakayama K and Takeuchi T (1992) Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non-endocrine cell line, COS-7. FEBS Lett 311: 55-59.
    • (1992) FEBS Lett , vol.311 , pp. 55-59
    • Yanagita, M.1    Nakayama, K.2    Takeuchi, T.3
  • 48
    • 0025149102 scopus 로고
    • Effects of amino acid replacements within the tetrabasic cleavage site on the processing of the human insulin receptor precursor expressed in Chinese hamster ovary cells
    • Yoshimasa Y, Paul JI, Whittaker J and Steiner DF (1990) Effects of amino acid replacements within the tetrabasic cleavage site on the processing of the human insulin receptor precursor expressed in Chinese hamster ovary cells. J Biol Chem 265: 17230-17237.
    • (1990) J Biol Chem , vol.265 , pp. 17230-17237
    • Yoshimasa, Y.1    Paul, J.I.2    Whittaker, J.3    Steiner, D.F.4


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