메뉴 건너뛰기




Volumn 23, Issue 9, 2007, Pages 449-456

Unraveling the epigenetic code of cancer for therapy

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTINEOPLASTIC AGENT; CHOLINE; CYANOCOBALAMIN; DEMETHYLATING AGENT; DEPSIPEPTIDE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; EPIGALLOCATECHIN GALLATE; HISTONE; HISTONE DEACETYLASE INHIBITOR; HISTONE MODIFYING AGENT; IMATINIB; INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERLEUKIN 2; METHIONINE; MG 98; PROCAINE; PYRIDOXINE; UNCLASSIFIED DRUG; ZEBULARINE;

EID: 34547914473     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2007.07.005     Document Type: Review
Times cited : (59)

References (84)
  • 1
    • 33751364987 scopus 로고    scopus 로고
    • Genomic imprinting in mammals: emerging themes and established theories
    • Wood A.J., and Oakey R.J. Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet. 2 (2006) e147
    • (2006) PLoS Genet. , vol.2
    • Wood, A.J.1    Oakey, R.J.2
  • 2
    • 0031811256 scopus 로고    scopus 로고
    • Regulation of X-chromosome inactivation in development in mice and humans
    • Goto T., and Monk M. Regulation of X-chromosome inactivation in development in mice and humans. Microbiol. Mol. Biol. Rev. 62 (1998) 362-378
    • (1998) Microbiol. Mol. Biol. Rev. , vol.62 , pp. 362-378
    • Goto, T.1    Monk, M.2
  • 3
    • 0016345881 scopus 로고
    • F. 5-Methylcytosine localised in mammalian constitutive heterochromatin
    • Miller O.J., et al. F. 5-Methylcytosine localised in mammalian constitutive heterochromatin. Nature 251 (1974) 636-637
    • (1974) Nature , vol.251 , pp. 636-637
    • Miller, O.J.1
  • 4
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • Bird A.P. CpG-rich islands and the function of DNA methylation. Nature 321 (1986) 209-213
    • (1986) Nature , vol.321 , pp. 209-213
    • Bird, A.P.1
  • 5
    • 0020489781 scopus 로고
    • Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells
    • Ehrlich M., et al. Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res. 10 (1982) 2709-2721
    • (1982) Nucleic Acids Res. , vol.10 , pp. 2709-2721
    • Ehrlich, M.1
  • 6
    • 34247136384 scopus 로고    scopus 로고
    • Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases
    • Ho S.M., and Tang W.Y. Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases. Reprod. Toxicol. 23 (2007) 267-282
    • (2007) Reprod. Toxicol. , vol.23 , pp. 267-282
    • Ho, S.M.1    Tang, W.Y.2
  • 7
    • 33847261476 scopus 로고    scopus 로고
    • The application of microarray technology to the analysis of the cancer genome
    • Cowell J.K., and Hawthorn L. The application of microarray technology to the analysis of the cancer genome. Curr. Mol. Med. 7 (2007) 103-120
    • (2007) Curr. Mol. Med. , vol.7 , pp. 103-120
    • Cowell, J.K.1    Hawthorn, L.2
  • 8
    • 33748629119 scopus 로고    scopus 로고
    • Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis
    • Zhang X., et al. Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis. Cell 126 (2006) 1189-1201
    • (2006) Cell , vol.126 , pp. 1189-1201
    • Zhang, X.1
  • 9
    • 33845880624 scopus 로고    scopus 로고
    • Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription
    • Zilberman D., et al. Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription. Nat. Genet. 39 (2007) 61-69
    • (2007) Nat. Genet. , vol.39 , pp. 61-69
    • Zilberman, D.1
  • 10
    • 26444546469 scopus 로고    scopus 로고
    • Interindividual variability and parent of origin DNA methylation differences at specific human Alu elements
    • Sandovici I., et al. Interindividual variability and parent of origin DNA methylation differences at specific human Alu elements. Hum. Mol. Genet. 14 (2005) 2135-2143
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 2135-2143
    • Sandovici, I.1
  • 11
    • 33745752370 scopus 로고    scopus 로고
    • Epigenetics and twins: three variations on the theme
    • Petronis A. Epigenetics and twins: three variations on the theme. Trends Genet. 22 (2006) 347-350
    • (2006) Trends Genet. , vol.22 , pp. 347-350
    • Petronis, A.1
  • 12
    • 20044390368 scopus 로고    scopus 로고
    • DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project
    • Rakyan V.K., et al. DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project. PLoS Biol. 2 (2004) e405
    • (2004) PLoS Biol. , vol.2
    • Rakyan, V.K.1
  • 13
    • 33751505540 scopus 로고    scopus 로고
    • DNA methylation profiling of human chromosomes 6
    • Eckhardt F., et al. DNA methylation profiling of human chromosomes 6. Nat. Genet. 38 (2006) 1378-1385
    • (2006) Nat. Genet. , vol.38 , pp. 1378-1385
    • Eckhardt, F.1
  • 14
    • 33847663874 scopus 로고    scopus 로고
    • Epigenetic regulation of NANOG gene in embryonic stem and trophoblast stem cells
    • Hattori N., et al. Epigenetic regulation of NANOG gene in embryonic stem and trophoblast stem cells. Genes Cells 12 (2007) 387-396
    • (2007) Genes Cells , vol.12 , pp. 387-396
    • Hattori, N.1
  • 15
    • 14744267496 scopus 로고    scopus 로고
    • Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression
    • Song F., et al. Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 3336-3341
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 3336-3341
    • Song, F.1
  • 16
    • 0242584449 scopus 로고    scopus 로고
    • Induction of tumors in mice by genomic hypomethylation
    • Gaudet F., et al. Induction of tumors in mice by genomic hypomethylation. Science 300 (2003) 489-492
    • (2003) Science , vol.300 , pp. 489-492
    • Gaudet, F.1
  • 17
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: too much, but also too little
    • Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 21 (2002) 5400-5413
    • (2002) Oncogene , vol.21 , pp. 5400-5413
    • Ehrlich, M.1
  • 18
    • 0032528255 scopus 로고    scopus 로고
    • Chromosome methylation patterns during mammalian preimplantation development
    • Rougier N. Chromosome methylation patterns during mammalian preimplantation development. Genes Dev. 12 (1998) 2108-2113
    • (1998) Genes Dev. , vol.12 , pp. 2108-2113
    • Rougier, N.1
  • 19
    • 33846933274 scopus 로고    scopus 로고
    • Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
    • Barreto G., et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 445 (2007) 671-675
    • (2007) Nature , vol.445 , pp. 671-675
    • Barreto, G.1
  • 20
    • 33845528560 scopus 로고    scopus 로고
    • Implication of abnormal epigenetic patterns for human diseases
    • Santos-Reboucas C.B., and Pimentel M.M. Implication of abnormal epigenetic patterns for human diseases. Eur. J. Hum. Genet. 15 (2006) 10-17
    • (2006) Eur. J. Hum. Genet. , vol.15 , pp. 10-17
    • Santos-Reboucas, C.B.1    Pimentel, M.M.2
  • 21
    • 32544431582 scopus 로고    scopus 로고
    • Epigenetics and human disease: translating basic biology into clinical applications
    • Rodenhiser D., and Mann M. Epigenetics and human disease: translating basic biology into clinical applications. CMAJ 174 (2006) 341-348
    • (2006) CMAJ , vol.174 , pp. 341-348
    • Rodenhiser, D.1    Mann, M.2
  • 22
    • 0037263628 scopus 로고    scopus 로고
    • Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice
    • Trasler J., et al. Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice. Carcinogenesis 24 (2003) 39-45
    • (2003) Carcinogenesis , vol.24 , pp. 39-45
    • Trasler, J.1
  • 23
    • 85047696878 scopus 로고    scopus 로고
    • Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors
    • Smiraglia D., et al. Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors. Oncogene 21 (2002) 3909-3916
    • (2002) Oncogene , vol.21 , pp. 3909-3916
    • Smiraglia, D.1
  • 24
    • 0343621494 scopus 로고    scopus 로고
    • Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
    • Costello J.F., et al. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat. Genet. 24 (2000) 132-138
    • (2000) Nat. Genet. , vol.24 , pp. 132-138
    • Costello, J.F.1
  • 25
    • 0035870248 scopus 로고    scopus 로고
    • A gene hypermethylation profile of human cancer
    • Esteller M., et al. A gene hypermethylation profile of human cancer. Cancer Res. 61 (2001) 3225-3229
    • (2001) Cancer Res. , vol.61 , pp. 3225-3229
    • Esteller, M.1
  • 26
    • 0033153303 scopus 로고    scopus 로고
    • The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors
    • Robertson K.D., et al. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 27 (1999) 2291-2298
    • (1999) Nucleic Acids Res. , vol.27 , pp. 2291-2298
    • Robertson, K.D.1
  • 27
    • 0034658196 scopus 로고    scopus 로고
    • Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells
    • Robertson K.D., et al. Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. Nucleic Acids Res. 28 (2000) 2108-2113
    • (2000) Nucleic Acids Res. , vol.28 , pp. 2108-2113
    • Robertson, K.D.1
  • 28
    • 0038527642 scopus 로고    scopus 로고
    • Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor
    • Di Croce L., et al. Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science 295 (2002) 1079-1082
    • (2002) Science , vol.295 , pp. 1079-1082
    • Di Croce, L.1
  • 29
    • 13444270415 scopus 로고    scopus 로고
    • Myc represses transcription through recruitment of DNA methyltransferase corepressor
    • Brenner C., et al. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 24 (2005) 336-346
    • (2005) EMBO J. , vol.24 , pp. 336-346
    • Brenner, C.1
  • 30
    • 33747429765 scopus 로고    scopus 로고
    • PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter
    • Tabe Y., et al. PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter. Ann. Hematol. 85 (2006) 689-704
    • (2006) Ann. Hematol. , vol.85 , pp. 689-704
    • Tabe, Y.1
  • 31
    • 0142059820 scopus 로고    scopus 로고
    • Predicting aberrant CpG island methylation
    • Feltus F.A., et al. Predicting aberrant CpG island methylation. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 12253-12258
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 12253-12258
    • Feltus, F.A.1
  • 32
    • 33645132331 scopus 로고    scopus 로고
    • G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis
    • Feldman N., et al. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat. Cell Biol. 8 (2006) 188-194
    • (2006) Nat. Cell Biol. , vol.8 , pp. 188-194
    • Feldman, N.1
  • 33
    • 33644861719 scopus 로고    scopus 로고
    • The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction
    • Tagoh H., et al. The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction. EMBO J. 25 (2006) 1070-1080
    • (2006) EMBO J. , vol.25 , pp. 1070-1080
    • Tagoh, H.1
  • 34
    • 2542545717 scopus 로고    scopus 로고
    • Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells
    • Stirzaker C., et al. Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells. Cancer Res. 64 (2004) 3871-3877
    • (2004) Cancer Res. , vol.64 , pp. 3871-3877
    • Stirzaker, C.1
  • 35
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • Berger S.L. The complex language of chromatin regulation during transcription. Nature 447 (2007) 407-412
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 36
    • 14844307097 scopus 로고    scopus 로고
    • Epigenetic regulation by histone methylation and histone variants
    • Cheung P., and Lau P. Epigenetic regulation by histone methylation and histone variants. Mol. Endocrinol. 19 (2005) 563-573
    • (2005) Mol. Endocrinol. , vol.19 , pp. 563-573
    • Cheung, P.1    Lau, P.2
  • 37
    • 3242657117 scopus 로고    scopus 로고
    • The clinical application of targeting cancer through histone acetylation and hypomethylation
    • Gilbert J., et al. The clinical application of targeting cancer through histone acetylation and hypomethylation. Clin. Cancer Res. 10 (2004) 4589-4596
    • (2004) Clin. Cancer Res. , vol.10 , pp. 4589-4596
    • Gilbert, J.1
  • 38
    • 34247109637 scopus 로고    scopus 로고
    • Epigenetic gene regulation: linking early developmental environment to adult disease
    • Dolinoy D.C., et al. Epigenetic gene regulation: linking early developmental environment to adult disease. Reprod. Toxicol. 23 (2006) 297-307
    • (2006) Reprod. Toxicol. , vol.23 , pp. 297-307
    • Dolinoy, D.C.1
  • 39
    • 33745632390 scopus 로고    scopus 로고
    • The epigenetic magic of histone lysine methylation
    • Jenuwein T. The epigenetic magic of histone lysine methylation. FEBS J. 273 (2006) 3121-3135
    • (2006) FEBS J. , vol.273 , pp. 3121-3135
    • Jenuwein, T.1
  • 40
    • 17944380227 scopus 로고    scopus 로고
    • Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
    • Peters A.H., et al. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 107 (2001) 323-337
    • (2001) Cell , vol.107 , pp. 323-337
    • Peters, A.H.1
  • 41
    • 0035282458 scopus 로고    scopus 로고
    • Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    • Bannister A.J., et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410 (2001) 120-124
    • (2001) Nature , vol.410 , pp. 120-124
    • Bannister, A.J.1
  • 42
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    • Fraga M.F., et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet. 37 (2005) 391-400
    • (2005) Nat. Genet. , vol.37 , pp. 391-400
    • Fraga, M.F.1
  • 43
    • 33847768829 scopus 로고    scopus 로고
    • Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini
    • Taverna S.D., et al. Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 2086-2091
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 2086-2091
    • Taverna, S.D.1
  • 44
    • 33744963540 scopus 로고    scopus 로고
    • A trans-tail histone code defined by monomethylated H4 Lys-20 and H3 Lys-9 demarcates distinct regions of silent chromatin
    • Sims J.K., et al. A trans-tail histone code defined by monomethylated H4 Lys-20 and H3 Lys-9 demarcates distinct regions of silent chromatin. J. Biol. Chem. 281 (2006) 12760-12766
    • (2006) J. Biol. Chem. , vol.281 , pp. 12760-12766
    • Sims, J.K.1
  • 45
    • 0033988813 scopus 로고    scopus 로고
    • DNA methyltransferase Dnmt1 associates with histone deacetylase activity
    • Fuks F., et al. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat. Genet. 24 (2000) 88-91
    • (2000) Nat. Genet. , vol.24 , pp. 88-91
    • Fuks, F.1
  • 46
    • 8544226964 scopus 로고    scopus 로고
    • Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer
    • Leu Y.W., et al. Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer. Cancer Res. 64 (2004) 8184-8192
    • (2004) Cancer Res. , vol.64 , pp. 8184-8192
    • Leu, Y.W.1
  • 47
    • 0037041422 scopus 로고    scopus 로고
    • Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase
    • Jackson J.P., et al. Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature 416 (2002) 556-560
    • (2002) Nature , vol.416 , pp. 556-560
    • Jackson, J.P.1
  • 48
    • 0035891265 scopus 로고    scopus 로고
    • A histone H3 methyltransferase controls DNA methylation in Neurospora crassa
    • Tamaru H., and Selker E.U. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414 (2001) 277-283
    • (2001) Nature , vol.414 , pp. 277-283
    • Tamaru, H.1    Selker, E.U.2
  • 49
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron E.E., et al. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat. Genet. 21 (1999) 103-107
    • (1999) Nat. Genet. , vol.21 , pp. 103-107
    • Cameron, E.E.1
  • 50
    • 33845874371 scopus 로고    scopus 로고
    • Methylation-dependent transition rates are dependent on local sequence lengths and genomic regions
    • Zhao Z., and Jiang C. Methylation-dependent transition rates are dependent on local sequence lengths and genomic regions. Mol. Biol. Evol. 24 (2006) 23-25
    • (2006) Mol. Biol. Evol. , vol.24 , pp. 23-25
    • Zhao, Z.1    Jiang, C.2
  • 51
    • 33750465872 scopus 로고    scopus 로고
    • SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes
    • Cai S., et al. SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat. Genet. 38 (2006) 1278-1288
    • (2006) Nat. Genet. , vol.38 , pp. 1278-1288
    • Cai, S.1
  • 52
    • 33947638345 scopus 로고    scopus 로고
    • DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC
    • Zhang Y., et al. DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Mol. Cell 24 (2006) 559-568
    • (2006) Mol. Cell , vol.24 , pp. 559-568
    • Zhang, Y.1
  • 53
    • 5444227862 scopus 로고    scopus 로고
    • Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach
    • Gius D., et al. Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell 6 (2004) 361-371
    • (2004) Cancer Cell , vol.6 , pp. 361-371
    • Gius, D.1
  • 54
    • 0034883005 scopus 로고    scopus 로고
    • Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2′-deoxycytidine
    • Lubbert M., et al. Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2′-deoxycytidine. Br. J. Haematol. 114 (2001) 349-357
    • (2001) Br. J. Haematol. , vol.114 , pp. 349-357
    • Lubbert, M.1
  • 55
    • 31344450167 scopus 로고    scopus 로고
    • Methylation inhibitor therapy in the treatment of myelodysplastic syndrome
    • Silverman L.R., and Mufti G.J. Methylation inhibitor therapy in the treatment of myelodysplastic syndrome. Nat. Clin. Pract. Oncol. 2 Suppl 1 (2005) S12-S23
    • (2005) Nat. Clin. Pract. Oncol. , vol.2 , Issue.SUPPL. 1
    • Silverman, L.R.1    Mufti, G.J.2
  • 56
    • 0030974771 scopus 로고    scopus 로고
    • Pilot phase I-II study on 5-aza-2′-deoxycytidine (Decitabine) in patients with metastatic lung cancer
    • Momparler R.L., et al. Pilot phase I-II study on 5-aza-2′-deoxycytidine (Decitabine) in patients with metastatic lung cancer. Anticancer Drugs 8 (1997) 358-368
    • (1997) Anticancer Drugs , vol.8 , pp. 358-368
    • Momparler, R.L.1
  • 57
    • 0031945210 scopus 로고    scopus 로고
    • A phase II study of 5-aza-2′deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer
    • Thibault A., et al. A phase II study of 5-aza-2′deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer. Tumori 84 (1998) 87-89
    • (1998) Tumori , vol.84 , pp. 87-89
    • Thibault, A.1
  • 58
    • 33750326078 scopus 로고    scopus 로고
    • Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura
    • Schrump D.S., et al. Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura. Clin. Cancer Res. 12 (2006) 5777-5785
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5777-5785
    • Schrump, D.S.1
  • 59
    • 0028151343 scopus 로고
    • Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
    • Juttermann R., et al. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 11797-11801
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 11797-11801
    • Juttermann, R.1
  • 60
    • 12444297637 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks
    • Davis A.J., et al. Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks. Invest. New Drugs 21 (2003) 85-97
    • (2003) Invest. New Drugs , vol.21 , pp. 85-97
    • Davis, A.J.1
  • 61
    • 33645086120 scopus 로고    scopus 로고
    • Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines
    • Stresemann C., et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66 (2006) 2794-2800
    • (2006) Cancer Res. , vol.66 , pp. 2794-2800
    • Stresemann, C.1
  • 62
    • 0041302197 scopus 로고    scopus 로고
    • Histone deacetylases
    • Marks P.A., et al. Histone deacetylases. Curr. Opin. Pharmacol. 3 (2003) 344-351
    • (2003) Curr. Opin. Pharmacol. , vol.3 , pp. 344-351
    • Marks, P.A.1
  • 63
    • 33845440390 scopus 로고    scopus 로고
    • Dual targeting of epigenetic therapy in cancer
    • Hellebrekers D.M., et al. Dual targeting of epigenetic therapy in cancer. Biochim. Biophys. Acta. 1775 (2006) 76-91
    • (2006) Biochim. Biophys. Acta. , vol.1775 , pp. 76-91
    • Hellebrekers, D.M.1
  • 64
    • 0035048449 scopus 로고    scopus 로고
    • Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
    • Kim M.S., et al. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat. Med. 7 (2001) 437-443
    • (2001) Nat. Med. , vol.7 , pp. 437-443
    • Kim, M.S.1
  • 65
    • 85047699941 scopus 로고    scopus 로고
    • Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
    • Deroanne C.F., et al. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene 21 (2002) 427-436
    • (2002) Oncogene , vol.21 , pp. 427-436
    • Deroanne, C.F.1
  • 66
    • 33644873930 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors reduce VEGF production and induce growth suppression and apoptosis in human mantle cell lymphoma
    • Heider U., et al. Histone deacetylase inhibitors reduce VEGF production and induce growth suppression and apoptosis in human mantle cell lymphoma. Eur. J. Haematol. 76 (2006) 42-50
    • (2006) Eur. J. Haematol. , vol.76 , pp. 42-50
    • Heider, U.1
  • 67
    • 0034571056 scopus 로고    scopus 로고
    • Demethylation by 5-aza-2′-deoxycytidine (5-azadC) of p16INK4A gene results in downregulation of vascular endothelial growth factor expression in human lung cancer cell lines
    • Miki K., et al. Demethylation by 5-aza-2′-deoxycytidine (5-azadC) of p16INK4A gene results in downregulation of vascular endothelial growth factor expression in human lung cancer cell lines. Oncol. Res. 12 (2001) 335-342
    • (2001) Oncol. Res. , vol.12 , pp. 335-342
    • Miki, K.1
  • 68
    • 31544464120 scopus 로고    scopus 로고
    • Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589
    • Qian D.Z., et al. Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589. Clin. Cancer Res. 12 (2006) 634-642
    • (2006) Clin. Cancer Res. , vol.12 , pp. 634-642
    • Qian, D.Z.1
  • 69
    • 33646850050 scopus 로고    scopus 로고
    • Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01
    • Yeow W.S., et al. Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01. Br. J. Cancer 94 (2006) 1436-1445
    • (2006) Br. J. Cancer , vol.94 , pp. 1436-1445
    • Yeow, W.S.1
  • 70
    • 26844505068 scopus 로고    scopus 로고
    • Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer
    • Chavez-Blanco A., et al. Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study. Mol. Cancer 4 (2005) 22
    • (2005) A phase I study. Mol. Cancer , vol.4 , pp. 22
    • Chavez-Blanco, A.1
  • 71
    • 0034885248 scopus 로고    scopus 로고
    • A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies
    • Gilbert J., et al. A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies. Clin. Cancer Res. 7 (2001) 2292-2300
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2292-2300
    • Gilbert, J.1
  • 72
    • 0038494686 scopus 로고    scopus 로고
    • Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein
    • Aron J.L., et al. Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein. Blood 102 (2003) 652-658
    • (2003) Blood , vol.102 , pp. 652-658
    • Aron, J.L.1
  • 73
    • 0036301281 scopus 로고    scopus 로고
    • Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms
    • Sandor V., et al. Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms. Clin. Cancer Res. 8 (2002) 718-728
    • (2002) Clin. Cancer Res. , vol.8 , pp. 718-728
    • Sandor, V.1
  • 74
    • 0242500847 scopus 로고    scopus 로고
    • Angiogenesis and the role of epigenetics in metastasis
    • Coomber B.L., et al. Angiogenesis and the role of epigenetics in metastasis. Clin. Exp. Metastasis 20 (2003) 215-227
    • (2003) Clin. Exp. Metastasis , vol.20 , pp. 215-227
    • Coomber, B.L.1
  • 75
    • 33747341830 scopus 로고    scopus 로고
    • Can the state of cancer chemotherapy resistance be reverted by epigenetic therapy?
    • Perez-Plasencia C., and Duenas-Gonzalez A. Can the state of cancer chemotherapy resistance be reverted by epigenetic therapy?. Mol. Cancer 5 (2006) 27
    • (2006) Mol. Cancer , vol.5 , pp. 27
    • Perez-Plasencia, C.1    Duenas-Gonzalez, A.2
  • 76
    • 33744745285 scopus 로고    scopus 로고
    • Promoter methylation and response to chemotherapy and radiation in esophageal cancer
    • Hamilton J.P., et al. Promoter methylation and response to chemotherapy and radiation in esophageal cancer. Clin. Gastroenterol. Hepatol. 4 (2006) 701-708
    • (2006) Clin. Gastroenterol. Hepatol. , vol.4 , pp. 701-708
    • Hamilton, J.P.1
  • 77
    • 33646128506 scopus 로고    scopus 로고
    • Epigenetics as a mechanism driving polygenic clinical drug resistance
    • Glasspool R., et al. Epigenetics as a mechanism driving polygenic clinical drug resistance. Br. J. Cancer 94 (2006) 1087-1092
    • (2006) Br. J. Cancer , vol.94 , pp. 1087-1092
    • Glasspool, R.1
  • 78
    • 33747339752 scopus 로고    scopus 로고
    • Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation
    • Reu F.J., et al. Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation. J. Clin. Oncol. 24 (2006) 3771-3779
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3771-3779
    • Reu, F.J.1
  • 79
    • 33747841204 scopus 로고    scopus 로고
    • 5-Aza-2′-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8
    • Fulda S., and Debatin K.M. 5-Aza-2′-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8. Oncogene 25 (2006) 5125-5133
    • (2006) Oncogene , vol.25 , pp. 5125-5133
    • Fulda, S.1    Debatin, K.M.2
  • 80
    • 33746850238 scopus 로고    scopus 로고
    • Immunological strategies to fight skin cancer
    • Berman B., et al. Immunological strategies to fight skin cancer. Skin Therapy Lett. 11 (2006) 1-7
    • (2006) Skin Therapy Lett. , vol.11 , pp. 1-7
    • Berman, B.1
  • 81
    • 34248230089 scopus 로고    scopus 로고
    • Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells
    • Yang D., et al. Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells. Cancer Res. 67 (2007) 3301-3309
    • (2007) Cancer Res. , vol.67 , pp. 3301-3309
    • Yang, D.1
  • 82
    • 33748046812 scopus 로고    scopus 로고
    • Phase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma
    • Gollob J.A., et al. Phase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma. Clin. Cancer Res. 12 (2006) 4619-4627
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4619-4627
    • Gollob, J.A.1
  • 83
    • 21244431605 scopus 로고    scopus 로고
    • Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate
    • Issa J.P., et al. Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. J. Clin. Oncol. 23 (2005) 3948-3956
    • (2005) J. Clin. Oncol. , vol.23 , pp. 3948-3956
    • Issa, J.P.1
  • 84
    • 33748360764 scopus 로고    scopus 로고
    • Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci
    • Munshi A., et al. Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol. Cancer Ther. 5 (2006) 1967-1974
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 1967-1974
    • Munshi, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.