Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase

Nucleic Acids Research

Volumn 35, Issue 1, 2007, Pages 186-192

  Sabini, Elisabetta ^c   Hazra, Saugata ^c   Konrad, Manfred ^a   Burley, Stephen K ^b   Lavie, Arnon ^c  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b SGX Pharmaceuticals Inc   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYCYTIDINE KINASE; LAMIVUDINE; NUCLEOSIDE; NUCLEOSIDE ANALOG; TROXACITABINE;

ARTICLE; BINDING SITE; CATALYSIS; CHIRALITY; CONFORMATIONAL TRANSITION; DRUG ACTIVATION; DRUG CONFORMATION; DRUG DETERMINATION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ANALYSIS;

ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; CYTOSINE; DEOXYCYTIDINE KINASE; DIOXOLANES; HUMANS; LAMIVUDINE; MODELS, MOLECULAR; PRODRUGS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 33846661140     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl1038     Document Type: Article

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