Role of urotensin II and its receptor in health and disease

Journal of Anesthesia

Volumn 21, Issue 3, 2007, Pages 378-389

  McDonald, John ^a   Batuwangala, Madura ^a   Lambert, David G ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Diabetes; Heart disease; Pharmacology; Renal failure; Urotensin II

Indexed keywords

AC 79541; ALBUMIN; CALCIUM ION; G PROTEIN COUPLED RECEPTOR; GSK 248451; INOSITOL PHOSPHATE; NITRIC OXIDE; PALOSURAN; PEPTIDE DERIVATIVE; PLACEBO; RECOMBINANT HUMAN UROTENSIN II; RECOMBINANT HUMAN UROTENSIN II RECEPTOR; SB 706375; UFP 803; UNCLASSIFIED DRUG; URANTIDE; UROTENSIN; UROTENSIN II; UROTENSIN II[4-11]; UROTENSIN RECEPTOR;

ANESTHESIST; CALCIUM CELL LEVEL; CLINICAL TRIAL; DIABETES MELLITUS; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIUM CELL; HEART FAILURE; HUMAN; HYPERTENSION; INTENSIVE CARE UNIT; IONTOPHORESIS; KIDNEY BLOOD FLOW; KIDNEY FAILURE; LIGAND BINDING; LIVER DISEASE; MICROALBUMINURIA; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION;

ANIMALS; CALCIUM; CRICETINAE; CRICETULUS; DIABETES MELLITUS; HEART FAILURE, CONGESTIVE; HUMANS; HYPERTENSION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY FAILURE; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; QUINOLINES; RATS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; UREA; UROTENSINS; VASOCONSTRICTION;

EID: 34547870172     PISSN: 09138668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00540-007-0524-z     Document Type: Review

References (97)

1. D Onan RD Hannan WG Thomas 2004 Urotensin II: The old kid in town Trends Endocrinol Metab 15 175-182 15109617 10.1016/j.tem.2004.03.007 1:CAS:528:DC%2BD2cXjsVegurg%3D
2. RS Ames HM Sarau JK Chambers RN Willette NV Aiyar AM Romanic CS Louden JJ Foley CF Sauermelch RW Coatney Z Ao J Disa SD Holmes JM Stadel JD Martin WS Liu GI Glover S Wilson DE McNulty CE Ellis NA Elshourbagy U Shabon JJ Trill DW Hay SA Douglas 1999 Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 Nature 401 282-286 10499587 10.1038/45809 1:CAS:528:DyaK1MXmt1yku7k%3D
3. A Stirrat M Gallagher SA Douglas EH Ohlstein C Berry A Kirk M Richardson MR MacLean 2001 Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries Am J Physiol Heart Circ Physiol 280 H925-928 11158995 1:CAS:528:DC%2BD3MXjtVWks78%3D
4. FD Russell P Molenaar DM O'Brien 2001 Cardiostimulant effects of urotensin-II in human heart in vitro Br J Pharmacol 132 5-9 11156554 10.1038/sj.bjp.0703811 1:CAS:528:DC%2BD3MXhtFCisLw%3D
5. M Matsushita M Shichiri T Imai M Iwashina H Tanaka N Takasu Y Hirata 2001 Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues J Hypertens 19 2185-2190 11725162 10.1097/00004872-200112000-00011 1:CAS:528:DC%2BD3MXpt1Cms7k%3D
6. S Jegou D Cartier C Dubessy BJ Gonzalez D Chatenet H Tostivint E Scalbert J LePrince H Vaudry I Lihrmann 2006 Localization of the urotensin II receptor in the rat central nervous system J Comp Neurol 495 21-36 16432902 10.1002/cne.20845 1:CAS:528:DC%2BD28XitFSlurg%3D
7. AP Davenport JJ Maguire 2000 Urotensin II: Fish neuropeptide catches orphan receptor Trends Pharmacol Sci 21 80-82 10689357 10.1016/ S0165-6147(00)01449-8 1:CAS:528:DC%2BD3cXhsFOisbo%3D
8. KL Ong KS Lam BM Cheung 2005 Urotensin II: Its function in health and its role in disease Cardiovasc Drugs Ther 19 65-75 15883758 10.1007/ s10557-005-6899-x 1:CAS:528:DC%2BD2MXjvF2mu7c%3D
9. YC Zhu YZ Zhu PK Moore 2006 The role of urotensin II in cardiovascular and renal physiology and diseases Br J Pharmacol 148 884-901 16783414 10.1038/sj.bjp.0706800 1:CAS:528:DC%2BD28XnsFWrtbc%3D
10. SA Douglas D Dhanak DG Johns 2004 From "gills to pills": urotensin-II as a regulator of mammalian cardiorenal function Trends Pharmacol Sci 25 76-85 15102493 10.1016/j.tips.2003.12.005 1:CAS:528:DC%2BD2cXhtVOrt78%3D
11. SA Douglas 2003 Human urotensin-II as a novel cardiovascular target: "heart" of the matter or simply a fishy "tail Curr Opin Pharmacol 3 159-167 12681238 10.1016/S1471-4892(03)00012-2 1:CAS:528:DC%2BD3sXis1GltLY%3D
12. AM Watson CN May 2004 Urotensin II, a novel peptide in central and peripheral cardiovascular control Peptides 25 1759-1766 15476943 10.1016/ j.peptides.2004.04.016 1:CAS:528:DC%2BD2cXotlWgtL8%3D
13. SA Douglas EH Ohlstein 2000 Human urotensin-II, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardiovascular disease Trends Cardiovasc Med 10 229-237 11282300 10.1016/S1050-1738(00)00069-4 1:CAS:528:DC%2BD3MXitF2ktrw%3D
14. SA Douglas EH Ohlstein 2000 Urotensin receptors D Girdlestone The IUPHAR compendium of receptor characterisation and classification IUPHAR Media London 365-372
15. V Camarda R Guerrini E Kostenis A Rizzi G Calo A Hattenberger M Zucchini S Salvadori D Regoli 2002 A new ligand for the urotensin II receptor Br J Pharmacol 137 311-314 12237249 10.1038/sj.bjp.0704895 1:CAS:528:DC%2BD38Xns1Ciuro%3D
16. SA Douglas D Naselsky Z Ao J Disa CL Herold F Lynch NV Aiyar 2004 Identification and pharmacological characterization of native, functional human urotensin-II receptors in rhabdomyosarcoma cell lines Br J Pharmacol 142 921-932 15210573 10.1038/sj.bjp.0705743 1:CAS:528:DC%2BD2cXmtlymtbk%3D
17. W Song J McDonald V Camarda G Calo R Guerrini E Marzola JP Thompson DJ Rowbotham DG Lambert 2006 Cell and tissue responses of a range of urotensin II analogs at cloned and native urotensin II receptors. Evidence for coupling promiscuity Naunyn Schmiedebergs Arch Pharmacol 373 148-157 16596397 10.1007/s00210-006-0057-2 1:CAS:528:DC%2BD28Xks1els74%3D
18. CM Filipeanu E Brailoiu S Le Dun NJ Dun 2002 Urotensin-II regulates intracellular calcium in dissociated rat spinal cord neurons J Neurochem 83 879-884 12421360 10.1046/j.1471-4159.2002.01196.x 1:CAS:528:DC%2BD38XovFOisLs%3D
19. M Mori T Sugo M Abe Y Shimomura M Kurihara C Kitada K Kikuchi Y Shintani T Kurokawa H Onda O Nishimura M Fujino 1999 Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14) Biochem Biophys Res Commun 265 123-129 10548501 10.1006/bbrc.1999.1640 1:CAS:528:DyaK1MXntVCms7s%3D
20. Y Coulouarn I Lihrmann S Jegou Y Anouar H Tostivint JC Beauvillain JM Conlon HA Bern H Vaudry 1998 Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord Proc Natl Acad Sci USA 95 15803-15808 9861051 10.1073/pnas.95.26.15803 1:CAS:528:DyaK1MXhvFensw%3D%3D
21. HA Bern D Pearson BA Larson RS Nishioka 1985 Neurohormones from fish tails: The caudal neurosecretory system. I. "Urophysiology" and the caudal neurosecretory system of fishes Recent Prog Horm Res 41 533-552 2864726 1:CAS:528:DyaL2MXlslGltLY%3D
22. WA Kinney HR Almond Jr J Qi CE Smith RJ Santulli L de Garavilla P Andrade-Gordon DS Cho AM Everson MA Feinstein PA Leung BE Maryanoff 2002 Structure-function analysis of urotensin II and its use in the construction of a ligand-receptor working model Angew Chem Int Ed Engl 41 2940-2944 12203418 10.1002/ 1521-3773(20020816)41:16<2940::AID-ANIE2940>3.0.CO;2-M 1:CAS:528:DC%2BD38XmslSrsbw%3D
23. M Mori M Fujino 2004 Urotensin II-related peptide, the endogenous ligand for the urotensin II receptor in the rat brain Peptides 25 1815-1818 15476951 10.1016/j.peptides.2004.06.025 1:CAS:528:DC%2BD2cXotlWgtLc%3D
24. T Sugo Y Murakami Y Shimomura M Harada M Abe Y Ishibashi C Kitada N Miyajima N Suzuki M Mori M Fujino 2003 Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain Biochem Biophys Res Commun 310 860-868 14550283 10.1016/ j.bbrc.2003.09.102 1:CAS:528:DC%2BD3sXnvVyltbg%3D
25. S Flohr M Kurz E Kostenis A Brkovich A Fournier T Klabunde 2002 Identification of nonpeptidic urotensin II receptor antagonists by virtual screening based on a pharmacophore model derived from structure-activity relationships and nuclear magnetic resonance studies on urotensin II J Med Chem 45 1799-1805 11960491 10.1021/jm0111043 1:CAS:528:DC%2BD38XitVOjurs%3D
26. V Camarda M Spagnol W Song R Vergura AL Roth JP Thompson DJ Rowbotham R Guerrini E Marzola S Salvadori P Cavanni D Regoli SA Douglas DG Lambert G Calo 2006 In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen(5),DTrp(7),Dab(8)]urotensin II(4-11) (UFP-803) Br J Pharmacol 147 92-100 16273120 10.1038/sj.bjp.0706438 1:CAS:528:DC%2BD28XitVSltA%3D%3D
27. R Patacchini P Santicioli S Giuliani P Grieco E Novellino P Rovero CA Maggi 2003 Urantide: An ultrapotent urotensin II antagonist peptide in the rat aorta Br J Pharmacol 140 1155-1158 14645137 10.1038/ sj.bjp.0705555 1:CAS:528:DC%2BD2cXpvV2ntQ%3D%3D
28. V Camarda W Song E Marzola M Spagnol R Guerrini S Salvadori D Regoli JP Thompson DJ Rowbotham DJ Behm SA Douglas G Calo DG Lambert 2004 Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors Eur J Pharmacol 498 83-86 15363979 10.1016/ j.ejphar.2004.07.089 1:CAS:528:DC%2BD2cXnsFGks78%3D
29. M Clozel C Binkert M Birker-Robaczewska C Boukhadra SS Ding W Fischli P Hess B Mathys K Morrison C Muller C Muller O Nayler C Qiu M Rey MW Scherz J Velker T Weller JF Xi P Ziltener 2004 Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4 -hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System J Pharmacol Exp Ther 311 204-212 15146030 10.1124/jpet.104.068320 1:CAS:528: DC%2BD2cXosVKrt70%3D
30. GE Croston R Olsson EA Currier ES Burstein D Weiner N Nash D Severance SG Allenmark L Thunberg JN Ma N Mohell B O'Dowd MR Brann U Hacksell 2002 Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954) J Med Chem 45 4950-4953 12408704 10.1021/jm025551+ 1:CAS:528:DC%2BD38Xns1GhsL0%3D
31. SA Douglas DJ Behm NV Aiyar D Naselsky J Disa DP Brooks EH Ohlstein JG Gleason HM Sarau JJ Foley PT Buckley DB Schmidt WE Wixted K Widdowson G Riley J Jin TF Gallagher SJ Schmidt L Ridgers LT Christmann RM Keenan SD Knight D Dhanak 2005 Nonpeptidic urotensin-II receptor antagonists I: In vitro pharmacological characterization of SB-706375. Br J Pharmacol 145 620-635 1:CAS:528:DC%2BD2MXlslWhsb4%3D
32. A Carotenuto P Grieco P Rovero E Novellino 2006 Urotensin-II receptor antagonists Curr Med Chem 13 267-275 16475936 10.2174/092986706775476061 1:CAS:528:DC%2BD28XhtVequrk%3D
33. A Gibson S Conyers HA Bern 1988 The influence of urotensin II on calcium flux in rat aorta J Pharm Pharmacol 40 893-895 2907588 1:CAS:528:DyaL1MXhvFSgtg%3D%3D
34. V Camarda A Rizzi G Calo G Gendron SI Perron E Kostenis P Zamboni F Mascoli D Regoli 2002 Effects of human urotensin II in isolated vessels of various species; comparison with other vasoactive agents Naunyn Schmiedebergs Arch Pharmacol 365 141-149 11819032 10.1007/ s00210-001-0503-0 1:CAS:528:DC%2BD38Xls1CqsA%3D%3D
35. O Saetrum Opgaard H Nothacker FJ Ehlert DN Krause 2000 Human urotensin II mediates vasoconstriction via an increase in inositol phosphates Eur J Pharmacol 406 265-271 11020490 10.1016/S0014-2999(00)00672-5 1:STN:280:DC%2BD3M%2Fls1WgsQ%3D%3D
36. JJ Maguire AP Davenport 2002 Is urotensin-II the new endothelin? Br J Pharmacol 137 579-588 12381671 10.1038/sj.bjp.0704924 1:CAS:528:DC%2BD38XosF2htrg%3D
37. M Batuwangala J McDonald G Calo LL Ng DG Lambert 2006 Characterization of native urotensin II receptors expressed in SJCRH30 rhabdomyosarcoma cells Br J Anaesth 97 440
38. D Onan L Pipolo E Yang RD Hannan WG Thomas 2004 Urotensin II promotes hypertrophy of cardiac myocytes via mitogen-activated protein kinases Mol Endocrinol 18 2344-2354 15205471 10.1210/me.2003-0309 1:CAS:528:DC%2BD2cXnsVKgtbk%3D
39. PH Sugden A Clerk 1998 Cellular mechanisms of cardiac hypertrophy J Mol Med 76 725-746 9826118 10.1007/s001090050275 1:STN:280:DyaK1M%2FktFCqsw%3D%3D
40. A Clerk PH Sugden 1999 Activation of protein kinase cascades in the heart by hypertrophic G protein-coupled receptor agonists Am J Cardiol 83 64H-69H 10750590 10.1016/S0002-9149(99)00261-1 1:CAS:528:DyaK1MXks1Gltr0%3D
41. P Ziltener C Mueller B Haenig MW Scherz O Nayler 2002 Urotensin II mediates ERK1/2 phosphorylation and proliferation in GPR14-transfected cell lines J Recept Signal Transduct Res 22 155-168 12503613 10.1081/ RRS-120014593 1:CAS:528:DC%2BD38Xps1ejs7w%3D
42. TF Luscher 1991 Endothelium-derived nitric oxide: The endogenous nitrovasodilator in the human cardiovascular system Eur Heart J 12 Suppl E 2-11 1790780
43. Moncada S, Higgs EA (2006) Nitric oxide and the vascular endothelium. Handb Exp Pharmacol 213-254
44. V Camarda A Rizzi G Calo G Gendron SI Perron E Kostenis P Zamboni F Mascoli D Regoli 2002 Effects of human urotensin II in isolated vessels of various species; comparison with other vasoactive agents Naunyn Schmiedebergs Arch Pharmacol 365 141-149 11819032 10.1007/ s00210-001-0503-0 1:CAS:528:DC%2BD38Xls1CqsA%3D%3D
45. SA Douglas AC Sulpizio V Piercy HM Sarau RS Ames NV Aiyar EH Ohlstein RN Willette 2000 Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey Br J Pharmacol 131 1262-1274 11090097 10.1038/sj.bjp.0703690 1:CAS:528:DC%2BD3cXovFygt7g%3D
46. H Itoh D McMaster K Lederis 1988 Functional receptors for fish neuropeptide urotensin II in major rat arteries Eur J Pharmacol 149 61-66 3396626 10.1016/0014-2999(88)90042-8 1:STN:280:BieB1czotF0%3D
47. A Ishihata M Sakai Y Katano 2006 Vascular contractile effect of urotensin II in young and aged rats: Influence of aging and contribution of endothelial nitric oxide Peptides 27 80-86 16159683 10.1016/ j.peptides.2005.07.012 1:CAS:528:DC%2BD28Xktl2ntQ%3D%3D
48. FE Bottrill SA Douglas CR Hiley R White 2000 Human urotensin-II is an endothelium-dependent vasodilator in rat small arteries Br J Pharmacol 130 1865-1870 10952676 10.1038/sj.bjp.0703513 1:CAS:528:DC%2BD3cXmtFenu7c%3D
49. MR MacLean D Alexander A Stirrat M Gallagher SA Douglas EH Ohlstein I Morecroft K Polland 2000 Contractile responses to human urotensin-II in rat and human pulmonary arteries: Effect of endothelial factors and chronic hypoxia in the rat Br J Pharmacol 130 201-204 10807654 10.1038/ sj.bjp.0703314 1:CAS:528:DC%2BD3cXjsl2mtLg%3D
50. I Muramatsu M Fujiwara H Hidaka H Akutagawa 1979 Pharmacological analysis of urotensin-induced contraction and relaxation in isolated rabbit aortas K Yamamoto The caudal neurosecretory system of fishes (16th Gunma Symposium in Endocrinology) Gunma University Maebashi, Japan 39-47
51. SM Gardiner JE March PA Kemp AP Davenport T Bennett 2001 Depressor and regionally-selective vasodilator effects of human and rat urotensin II in conscious rats Br J Pharmacol 132 1625-1629 11309232 10.1038/ sj.bjp.0704051 1:CAS:528:DC%2BD3MXjt1arsL0%3D
52. SM Gardiner JE March PA Kemp JJ Maguire RE Kuc AP Davenport T Bennett 2006 Regional heterogeneity in the haemodynamic responses to urotensin II infusion in relation to UT receptor localisation Br J Pharmacol 147 612-621 16314853 10.1038/sj.bjp.0706503 1:CAS:528:DC%2BD28XisFOntrw%3D
53. GA Gray MR Jones I Sharif 2001 Human urotensin II increases coronary perfusion pressure in the isolated rat heart: Potentiation by nitric oxide synthase and cyclooxygenase inhibition Life Sci 69 175-180 11441907 10.1016/S0024-3205(01)01101-8 1:CAS:528:DC%2BD3MXkt1Cgtbk%3D
54. DJ Behm SM Harrison Z Ao K Maniscalco SJ Pickering EV Grau TN Woods RW Coatney CP Doe RN Willette DG Johns SA Douglas 2003 Deletion of the UT receptor gene results in the selective loss of urotensin-II contractile activity in aortae isolated from UT receptor knockout mice Br J Pharmacol 139 464-472 12770952 10.1038/sj.bjp.0705254 1:CAS:528:DC%2BD3sXkvFClt7Y%3D
55. ZJ Wang LB Shi ZW Xiong LF Zhang L Meng DF Bu CS Tang WH Ding 2006 Alteration of vascular urotensin II receptor in mice with apolipoprotein E gene knockout Peptides 27 858-863 16325305 10.1016/ j.peptides.2005.08.028 1:CAS:528:DC%2BD28XjtFWqs7g%3D
56. Y Coulouarn C Fernex S Jegou CE Henderson H Vaudry I Lihrmann 2001 Specific expression of the urotensin II gene in sacral motoneurons of developing rat spinal cord Mech Dev 101 187-190 11231072 10.1016/ S0925-4773(00)00548-7 1:CAS:528:DC%2BD3MXhsFShtbw%3D
57. SL Dun GC Brailoiu J Yang JK Chang NJ Dun 2001 Urotensin II-immunoreactivity in the brainstem and spinal cord of the rat Neurosci Lett 305 9-12 11356295 10.1016/S0304-3940(01)01804-3 1:CAS:528:DC%2BD3MXjsFeisbo%3D
58. Y Lin T Tsuchihashi K Matsumura I Abe M Iida 2003 Central cardiovascular action of urotensin II in conscious rats J Hypertens 21 159-165 12544448 10.1097/00004872-200301000-00026 1:CAS:528:DC%2BD3sXlsV2iuw%3D%3D
59. AM Watson GW Lambert KJ Smith CN May 2003 Urotensin II acts centrally to increase epinephrine and ACTH release and cause potent inotropic and chronotropic actions Hypertension 42 373-379 12885791 10.1161/ 01.HYP.0000084633.85427.E6 1:CAS:528:DC%2BD3sXmslSjurk%3D
60. JJ Maguire RE Kuc AP Davenport 2000 Orphan-receptor ligand human urotensin II: Receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1. Br J Pharmacol 131 441-446 1:CAS:528:DC%2BD3cXnsVygt7g%3D
61. K Totsune K Takahashi Z Arihara M Sone S Ito O Murakami 2003 Increased plasma urotensin II levels in patients with diabetes mellitus Clin Sci (Lond) 104 1-5 1:CAS:528:DC%2BD3sXitVOruw%3D%3D
62. J Heller M Schepke M Neef R Woitas C Rabe T Sauerbruch 2002 Increased urotensin II plasma levels in patients with cirrhosis and portal hypertension J Hepatol 37 767-772 12445417 10.1016/S0168-8278(02)00295-7 1:CAS:528:DC%2BD38XoslCjtLc%3D
63. N Aiyar B Guida Z Ao J Disa D Naselsky DJ Behm JL Su FC Kull SA Douglas Jr 2004 Differential levels of "urotensin-II-like" activity determined by radio-receptor and radioimmuno-assays Peptides 25 1339-1347 15350702 10.1016/j.peptides.2004.05.015 1:CAS:528:DC%2BD2cXntlelsr0%3D
64. SA Douglas L Tayara EH Ohlstein N Halawa A Giaid 2002 Congestive heart failure and expression of myocardial urotensin II Lancet 359 1990-1997 12076554 10.1016/S0140-6736(02)08831-1 1:CAS:528:DC%2BD38XksFKkt7o%3D
65. M Lim S Honisett CD Sparkes P Komesaroff A Kompa H Krum 2004 Differential effect of urotensin II on vascular tone in normal subjects and patients with chronic heart failure Circulation 109 1212-1214 15007012 10.1161/01.CIR.0000121326.69153.98 1:CAS:528:DC%2BD2cXhvFakt70%3D
66. JP Thompson P Watt S Sanghavi JW Strupish DG Lambert 2003 A comparison of cerebrospinal fluid and plasma urotensin II concentrations in normotensive and hypertensive patients undergoing urological surgery during spinal anesthesia: A pilot study Anesth Analg 97 1501-1503 14570674 10.1213/01.ANE.0000086723.97421.BC 1:CAS:528:DC%2BD3sXptlCisrg%3D
67. E Cowley JP Thompson P Sharpe J Waugh N Ali DG Lambert 2005 Effects of pre-eclampsia on maternal plasma, cerebrospinal fluid, and umbilical cord urotensin II concentrations: A pilot study Br J Anaesth 95 495-499 16126783 10.1093/bja/aei222 1:CAS:528:DC%2BD2MXpvFGqtLk%3D
68. O Balat F Aksoy I Kutlar MG Ugur H Iyikosker A Balat R Anarat 2005 Increased plasma levels of urotensin-II in preeclampsia-eclampsia: A new mediator in pathogenesis? Eur J Obstet Gynecol Reprod Biol 120 33-38 15866083 10.1016/j.ejogrb.2004.07.029 1:CAS:528:DC%2BD2MXjslKgsro%3D
69. B Sondermeijer A Kompa P Komesaroff H Krum 2005 Effect of exogenous urotensin-II on vascular tone in skin microcirculation of patients with essential hypertension Am J Hypertens 18 1195-1199 16182109 10.1016/ j.amjhyper.2005.03.748 1:CAS:528:DC%2BD2MXhtVegurbI
70. K Totsune K Takahashi Z Arihara M Sone F Satoh S Ito Y Kimura H Sasano O Murakami 2001 Role of urotensin II in patients on dialysis Lancet 358 810-811 11564491 10.1016/S0140-6736(01)06002-0 1:CAS:528:DC%2BD3MXmvVKmsbg%3D
71. K Totsune K Takahashi Z Arihara M Sone O Murakami S Ito M Kikuya T Ohkubo J Hashimoto Y Imai 2004 Elevated plasma levels of immunoreactive urotensin II and its increased urinary excretion in patients with Type 2 diabetes mellitus: Association with progress of diabetic nephropathy Peptides 25 1809-1814 15476950 10.1016/j.peptides.2004.06.024 1:CAS:528:DC%2BD2cXotlWgtLY%3D
72. Z Wenyi S Suzuki M Hirai Y Hinokio Y Tanizawa A Matsutani J Satoh Y Oka 2003 Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects Diabetologia 46 972-976 12830381 10.1007/s00125-003-1145-1 1:CAS:528:DC%2BD3sXls1yns7o%3D
73. S Suzuki Z Wenyi M Hirai Y Hinokio C Suzuki T Yamada S Yoshizumi M Suzuki Y Tanizawa A Matsutani Y Oka 2004 Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese Peptides 25 1803-1808 15476949 10.1016/ j.peptides.2004.03.030 1:CAS:528:DC%2BD2cXotlWgtLk%3D
74. KL Ong LY Wong YB Man RY Leung YQ Song KS Lam BM Cheung 2006 Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance Peptides 27 1659-1667 16597476 10.1016/j.peptides.2006.02.008 1:CAS:528:DC%2BD28XlsFCjurc%3D
75. IB Wilkinson JT Affolter SL de Haas MP Pellegrini J Boyd MJ Winter RJ Balment DJ Webb 2002 High plasma concentrations of human urotensin II do not alter local or systemic hemodynamics in man Cardiovasc Res 53 341-347 11827684 10.1016/S0008-6363(01)00485-0 1:CAS:528:DC%2BD38XhtVKks7s%3D
76. JT Affolter DE Newby IB Wilkinson MJ Winter RJ Balment DJ Webb 2002 No effect on central or peripheral blood pressure of systemic urotensin II infusion in humans Br J Clin Pharmacol 54 617-621 12492609 10.1046/ j.1365-2125.2002.t01-1-01704.x 1:CAS:528:DC%2BD3sXnvVansA%3D%3D
77. M Clozel P Hess C Qiu SS Ding M Rey 2006 The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats J Pharmacol Exp Ther 316 1115-1121 16267137 10.1124/jpet.105.094821 1:CAS:528:DC%2BD28Xit1Sgsro%3D
78. PN Sidharta FD Wagner H Bohnemeier A Jungnik A Halabi S Krahenbuhl H Chadha-Boreham J Dingemanse 2006 Pharmacodynamics and pharmacokinetics of the urotensin II receptor antagonist palosuran in macroalbuminuric, diabetic patients Clin Pharmacol Ther 80 246-256 16952491 10.1016/ j.clpt.2006.05.013 1:CAS:528:DC%2BD28XptFCgu7g%3D
79. P Grieco A Carotenuto P Campiglia E Zampelli R Patacchini CA Maggi E Novellino P Rovero 2002 A new, potent urotensin II receptor peptide agonist containing a Pen residue at the disulfide bridge J Med Chem 45 4391-4394 12238917 10.1021/jm025549i 1:CAS:528:DC%2BD38Xms1CksbY%3D
80. DJ Behm G Stankus CP Doe RN Willette HM Sarau JJ Foley DB Schmidt P Nuthulaganti JA Fornwald RS Ames DG Lambert G Calo V Camarda NV Aiyar SA Douglas 2006 The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems Br J Pharmacol 148 173-190 16547525 10.1038/sj.bjp.0706716 1:CAS:528:DC%2BD28XksFSgurk%3D
81. LL Ng I Loke RJ O'Brien IB Squire JE Davies 2002 Plasma urotensin in human systolic heart failure Circulation 106 2877-2880 12460864 10.1161/ 01.CIR.0000044388.19119.02 1:CAS:528:DC%2BD38XovVelt7c%3D
82. SQ Khan SS Bhandari P Quinn JE Davies LL Ng 2007 Urotensin II is raised in acute myocardial infarction and low levels predict risk of adverse clinical outcome in humans Int J Cardiol 117 323-328 16887216 10.1016/ j.ijcard.2006.05.016
83. T Dschietzig C Bartsch R Pregla HR Zurbrugg FP Armbruster C Richter M Laule E Romeyke C Neubert W Voelter G Baumann K Stangl 2002 Plasma levels and cardiovascular gene expression of urotensin-II in human heart failure Regul Pept 110 33-38 12468107 10.1016/S0167-0115(02)00158-1 1:CAS:528:DC%2BD38XptFelt74%3D
84. P Zhong ZL Li HC Wu CS Tang Q Lu 2003 Clinical study of changes of urotensin II in patients with congestive heart failure (in Chinese) Di Yi Jun Yi Da Xue Xue Bao (Academic journal of the first medical college of PLA) 23 121-123
85. FD Russell D Meyers AJ Galbraith N Bett I Toth P Kearns P Molenaar 2003 Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure Am J Physiol Heart Circ Physiol 285 H1576-1581 12791592 1:CAS:528:DC%2BD3sXosVKjt7c%3D
86. SH Fang ZL Li HC Wu CS Tang Q Lu HC Liu QN Yan 2004 Clinical study of plasma urotensin II in patients with coronary heart disease (in Chinese) Di Yi Jun Yi Da Xue Xue Bao (Academic journal of the first medical college of PLA) 24 563-565 1:CAS:528:DC%2BD2cXlt1Ciu7k%3D
87. S Kruger J Graf D Kunz T Stickel MW Merx P Hanrath U Janssens 2005 Urotensin II in patients with chronic heart failure Eur J Heart Fail 7 475-478 15921782 10.1016/S1388-9842(03)00106-5 1:CAS:528:DC%2BD2MXks1emtL4%3D
88. D Gruson MF Rousseau SA Ahn F van Linden JM Ketelslegers 2005 Circulating urotensin II levels in moderate to severe congestive heart failure: Its relations with myocardial function and well established neurohormonal markers Peptides 27 1527-1531 16364499 10.1016/ j.peptides.2005.11.019 1:CAS:528:DC%2BD28XltFOnsro%3D
89. D Joyal T Huynh N Aiyar B Guida S Douglas A Giaid 2006 Urotensin-II levels in acute coronary syndromes Int J Cardiol 108 31-35 16516696 10.1016/j.ijcard.2005.04.001
90. M Heringlake T Kox O Uzun B Will L Bahlmann S Klaus S Eleftheriadis FP Armbruster N Franz E Kraatz 2004 The relationship between urotensin II plasma immunoreactivity and left ventricular filling pressures in coronary artery disease Regul Pept 121 129-136 15256283 10.1016/ j.regpep.2004.04.012 1:CAS:528:DC%2BD2cXlsl2jsLw%3D
91. H Lapp G Boerrigter LC Costello-Boerrigter K Jaekel T Scheffold I Krakau M Schramm H Guelker J-P Stasch 2004 Elevated plasma human urotensin-II-like immunoreactivity in ischemic cardiomyopathy Int J Cardiol 94 93-97 14996481 10.1016/j.ijcard.2003.05.008
92. AM Richards MG Nicholls JG Lainchbury S Fisher TG Yandle 2002 Plasma urotensin II in heart failure Lancet 360 545-546 12241661 10.1016/ S0140-6736(02)09709-X 1:CAS:528:DC%2BD38XmtlelsrY%3D
93. CM Simpson DJ Penny CF Stocker LS Shekerdemian 2006 Urotensin II is raised in children with congenital heart disease Heart 92 983-984 16308415 10.1136/hrt.2005.074039 1:CAS:528:DC%2BD28Xntl2ltLk%3D
94. BM Cheung R Leung YB Man LY Wong 2004 Plasma concentration of urotensin II is raised in hypertension J Hypertens 22 1341-1344 15201550 10.1097/ 01.hjh.0000125452.28861.f1 1:CAS:528:DC%2BD2cXkvVGisr4%3D
95. A Balat IH Pakir F Gok R Anarat S Sahinoz 2005 Urotensin-II levels in children with minimal change nephrotic syndrome Pediatr Nephrol 20 42-45 15602665 10.1007/s00467-004-1716-5
96. F Mallamaci S Cutrupi P Pizzini G Tripepi C Zoccali 2005 Urotensin II in end-stage renal disease: An inverse correlate of sympathetic function and cardiac natriuretic peptides J Nephrol 18 727-732 16358231 1:CAS:528:DC%2BD28XhsFGmsbs%3D
97. C Zoccali F Mallamaci G Tripepi S Cutrupi P Pizzini L Malatino 2006 Urotensin II is an inverse predictor of incident cardiovascular events in end-stage renal disease Kidney Int 69 1253-1258 16508659 10.1038/ sj.ki.5000114 1:CAS:528:DC%2BD28XivFOmsb8%3D