Cardiostimulant effects of urotensin-II in human heart in vitro

British Journal of Pharmacology

Volumn 132, Issue 1, 2001, Pages 5-9

  Russell, Fraser D ^a   Molenaar, Peter ^a   O'Brien, Donalee M ^a  

^a THE PRINCE CHARLES HOSPITAL   (Australia)

Author keywords

Atrium; Coronary artery; Human heart; Human urotensin II; Ventricle

Indexed keywords

CALCIUM ION; POTASSIUM CHLORIDE; UROTENSIN II;

ARTERY TONE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; DRUG EFFECT; DRUG EFFICACY; HEART ARRHYTHMIA; HEART ATRIUM MUSCLE; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; HEART STIMULATION; HEART VENTRICLE WALL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL;

EID: 0035146524     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703811     Document Type: Article

References (16)

1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
2. Contractile and arrhythmic effects of endothelin receptor agonists in human heart in vitro: Blockade with SB 209670
3. Chemical synthesis of urotensin II, a somatostatin like peptide in the caudal neurosecretory system of fishes
4. Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors
5. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord
6. Functional receptors for fish neuropeptide urotensin II in major rat arteries
7. Vasodilator effect of urotensin II, one of the most potent vasoconstricting factors, on rat coronary arteries
8. 2-adrenoceptors mediate catecholamine-evoked arrhythmias in isolated human right atrium
9. A 5-hydroxytryptamine receptor in human atrium
10. Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14
11. Contractile responses to human urotensin-II in rat and human pulmonary arteries: Effect of endothelial factors and chronic hypoxia in the rat
12. Orphan-receptor ligand human urotensin II: Receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1
13. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GRP14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors
14. Studies on molecular weights of two peptide hormones from urophysis of white sucker (Catostomus commersoni)
15. Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor. SENR (GPR14)
16. Effect of urotensin II on myocyte hypertrophy and collagen synthesis by myofibroblasts in vitro