Invertebrate Glia

Myelin Biology and Disorders

Volumn 1, Issue , 2004, Pages 199-222

  Bellen, Hugo J ^a   Schulze, Karen L ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34547699699     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012439510-7/50061-9     Document Type: Chapter

References (128)

1. Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., et al. The genome sequence of Drosophila melanogaster. Science 2000, 287:2185-2195.
2. Akiyama Y., Hosoya T., Poole A.M., Hotta Y. The gem-motif: A novel DNA-binding motif conserved in Drosophila and mammals. Proc Natl Acad Sci USA 1996, 93:14912-14916.
3. Anderson M.G., Perkins G.L., Chittick P., Shrigley R.J., Johnson W.A. drifter, a Drosophila POU-domain transcription factor, is required for correct differentiation and migration of tracheal cells and midline glia. Genes Dev 1995, 9:123-137.
4. Artavanis-Tsakonas S., Rand M.D., Lake R.J. Notch signaling: Cell fate control and signal integration in development. Science 1999, 284:770-776.
5. Auld V.J., Fetter R.D., Broadie K., Goodman C.S. Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila. Cell 1995, 81:757-767.
6. Baumgartner S., Littleton J.T., Broadie K., Bhat M.A., Harbecke R., Lengyel J.A., Chiquet-Ehrismann R., Prokop A., Bellen H.J. A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. Cell 1996, 87:1059-1068.
7. Bellen H.J., Lu Y., Beckstead R., Bhat M.A. Neurexin IV, caspr and paranodin-novel members of the neurexin family: Encounters of axons and glia. Trends Neurosci 1998, 21:444-449.
8. Berdnik D., Torok T., Gonzalez-Gaitan M., Knoblich J.A. The endocrytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell 2002, 3:221-231.
9. Bergmann A., Tugentman M., Shilo B.Z., Steller H. Regulation of cell number by MAPK-dependent control of apoptosis: A mechanism for trophic survival signaling. Dev Cell 2002, 2:159-170.
10. Bhat M.A. The neurexin gene. Myelin Biology and Disorders 2004, Elsevier San Diego, Oxford. R. Lazzarini, J. Griffin, H. Lassman, K.-A. Nave, R. Miller, B. Trapp (Eds.).
11. Bhat M.A., Rios J.C., Lu Y., Garcia-Fresco G.P., Ching W., St Martin M., Li J., Einheber S., Chesler M., Rosenbluth J., Salzer J.L., Bellen H.J. Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron 2001, 30:369-383.
12. Bier E., Jan L.Y., Jan Y.N. Rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Genes Dev 1990, 4:190-203.
13. Booth G.E., Kinrade E.F., Hidalgo A. Glia maintain follower neuron survival during Drosophila CNS development. Development 2000, 127:237-244.
14. Bossing T., Technau G.M. The fate of the CNS midline progenitors in Drosophila as revealed by a new method for single cell labelling. Development 1994, 120:1895-1906.
15. Buchanan R.L., Benzer S. Defective glia in the Drosophila brain degeneration mutant drop-dead. Neuron 1993, 10:839-850.
16. Campbell G., Goring H., Lin T., Spana E., Andersson S., Doe C.Q., Tomlinson A. RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila. Development 1994, 120:2957-2966.
17. 3H-gamma-aminobutyric acid uptake in the lamina ganglionaris of Musca and Drosophila. Z Zellforsch Mikrosk Anat 1974, 147:415-431.
18. Carlson S.D., Saint Marie R.L. Structure and function of insect glia. Annu Rev Entomol 1990, 35:597-621.
19. Carpenter E.M., Hollyday M. The location and distribution of neural crest-derived Schwann cells in developing peripheral nerves in the chick forelimb. Dev Biol 1992, 150:144-159.
20. Cavodeassi F., Modolell J., Gomez-Skarmeta J.L. The Iroquois family of genes: From body building to neural patterning. Development 2001, 128:2847-2855.
21. Chanal P., Labouesse M. A screen for genetic loci required for hypodermal cell and glial-like cell development during Caenorhabditis elegans embryogenesis. Genetics 1997, 146:207-226.
22. Chi C., Carlson S.D. The perineurium of the adult housefly: Ultrastructure and permeability to lanthanum. Cell Tissues Res 1981, 217:373-386.
23. Choi K.W., Benzer S. Migration of glia along photoreceptor axons in the developing Drosophila eye. Neuron 1994, 12:423-431.
24. Crews S.T., Thomas J.B., Goodman C.S. The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product. Cell 1988, 52:143-151.
25. Cui X., Doe C.Q. ming is expressed in neuroblast sublineages and regulates gene expression in the Drosophila central nervous system. Development 1992, 116:943-952.
26. Dong R., Jacobs J.R. Origin and differentiation of supernumerary midline glia in Drosophila embryos deficient for apoptosis. Dev Biol 1997, 190:165-177.
27. Ebens A.J., Garren H., Cheyette B.N., Zipursky S.L. The Drosophila anachronism locus: A glycoprotein secreted by glia inhibits neuroblast proliferation. Cell 1993, 74:15-27.
28. Edwards J.S., Swales L.S., Bate M. The differentiation between neuroglia and connective tissue sheath in insect ganglia revisited: The neural lamella and perineurial sheath cells are absent in a mesodermless mutant of Drosophila. J Comp Neurol 1993, 333:301-308.
29. Eng L.F., DeArmond S.J. Immunocytochemical studies of astrocytes in normal development and disease. Adv Cell Neurobiol 1982, 3:145-171.
30. Erwin D.H., Davidson E.H. The last common bilaterian ancestor. Development 2002, 129:3021-3032.
31. Faeder I.R., Salpeter M.M. Glutamate uptake by a stimulated insect nerve muscle preparation. J. Cell. Biol. 1970, 46:300-307.
32. Fernandez P.A., Tang D.G., Cheng L., Prochiantz A., Mudge A.W., Raff M.C. Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve. Neuron. 2000, 28:81-90.
33. Flower N.E. Septate and gap junctions between the epithelial cells of an invertebrate, the mollusc Cominella maculosa. J Ultrastruct Res 1971, 37:259-268.
34. Gaiano N., Fishell G. The role of Notch in promoting glial and neural stem cell fates. Annu Rev Neurosci 2002, 25:471-490.
35. Galli A., Petersen C.I., deBlaquiere M., Blakely R.D., DeFelice L.J. Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel. J Neurosci 1997, 17:3401-3411.
36. Georgiou M., Tear G. Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline. Development 2002, 129:2947-2956.
37. Gho M., Bellaiche Y., Schweisguth F. Revisiting the Drosophila microchaete lineage: A novel intrinsically asymmetric cell division generates a glial cell. Development 1999, 126:3573-3584.
38. Gho M., McDonald K., Ganetzky B., Saxton W.M. Effects of kinesin mutations on neuronal functions. Science 1992, 258:313-316.
39. Giangrande A. Glia in the fly wing are clonally related to epithelial cells and use the nerve as a pathway for migration. Development 1994, 120:523-534.
40. Giangrande A. Proneural genes influence gliogenesis in Drosophila. Development 1995, 121:429-438.
41. Giangrande A., Murray M.A., Palka J. Development and organization of glial cells in the peripheral nervous system of Drosophila melanogaster. Development 1993, 117:895-904.
42. Giesen K., Hummel T., Stollewerk A., Harrison S., Travers A., Klambt C. Glial development in the Drosophila CNS requires concomitant activation of glial and repression of neuronal differentiation genes. Development 1997, 124:2307-2316.
43. Goodman C.S. Mechanisms and molecules that control growth cone guidance. Annu Rev Neurosci 1996, 19:341-377.
44. Granderath S., Bunse I., Klambt C. gcm and pointed synergistically control glial transcription of the Drosophila gene loco. Mech Dev 2000, 91:197-208.
45. Granderath S., Stollewerk A., Greig S., Goodman C.S., O'Kane C.J., Klambt C. loco encodes an RGS protein required for Drosophila glial differentiation. Development 1999, 126:1781-1791.
46. Gunther T., Chen Z.F., Kim J., Priemel M., Rueger J.M., Amling M., Moseley J.M., Martin T.J., Anderson D.J., Karsenty G. Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. Nature 2000, 406:199-203.
47. Halter D.A., Urban J., Rickert C., Ner S.S., Ito K., Travers A.A., Technau G.M. The homeobox gene repo is required for the differentiation and maintenance of glia function in the embryonic nervous system of Drosophila melanogaster. Development 1995, 121:317-332.
48. Hassan B.A., Bellen H.J. Doing the MATH: Is the mouse a good model for fly development?. Genes Dev 2000, 14:1852-1865.
49. Hertweck H. Anatomie und Variabilitat des Nervensystems und der Sinnesorgane von Drosophila melanogaster (Meigen). Z Wiss Zool 1931, 139:559-663.
50. Hidalgo A. Interactive nervous system development: Control of cell survival in Drosophila. Trends Neurosci 2002, 25:365-370.
51. Hidalgo A., Booth G.E. Glia dictate pioneer axon trajectories in the Drosophila embryonic CNS. Development 2000, 127:393-402.
52. Hidalgo A., Kinrade E.F., Georgiou M. The Drosophila neuregulin vein maintains glial survival during axon guidance in the CNS. Dev Cell 2001, 1:679-690.
53. Hinz U., Giebel B., Campos-Ortega J.A. The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 1994, 76:77-87.
54. Hirata J., Nakagoshi H., Nabeshima Y., Matsuzaki F. Asymmetric segregation of the homeodomain protein Prospero during Drosophila development. Nature 1995, 377:627-630.
55. Hosoya T., Takizawa K., Nitta K., Hotta Y. glial cells missing: A binary switch between neuronal and glial determination in Drosophila. Cell 1995, 82:1025-1036.
56. Hoyle G. High blood potassium in insects in relation to nerve conduction. Nature 1952, 169:281-282.
57. Hoyle G. Glial cells of an insect ganglion. J Comp Neurol 1986, 246:85-103.
58. Huang Y., Stern M. In vivo properties of the Drosophila inebriated-encoded neurotransmitter transporter. J Neurosci 2002, 22:1698-1708.
59. Ito K., Urban J., Technau G.M. Distribution, classification, and development of Drosophila glial cells in the late embryonic and early larval ventral nerve cord. Roux Arch Dev Biol 1995, 204:284-307.
60. Jaaro H., Beck G., Conticello S.G., Fainzilber M. Evolving better brains: A need for neurotrophins?. Trends Neurosci 2001, 24:79-85.
61. Jacobs J.R. The midline glia of Drosophila: A molecular genetic model for the developmental functions of glia. Prog Neurobiol 2000, 62:475-508.
62. Jafar-Nejad H., Norga K., Bellen H. Numb: "Adapting" notch for endocytosis. Dev Cell 2002, 3:155-156.
63. Jan Y.N., Jan L.Y. The peripheral nervous system. The Development of Drosophila melanogaster 1993, 1207-1244. Plainview, Cold Spring Harbor Laboratory Press. M. Bate, A. Martinez Arias (Eds.).
64. Jennings B., Preiss A., Delidakis C., Bray S. The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development 1994, 120:3537-3548.
65. Jones B.W. Glial cell development in the Drosophila embryo. Bioessays 2001, 23:877-887.
66. Jones B.W., Fetter R.D., Tear G., Goodman C.S. glial cells missing: A genetic switch that controls glial versus neuronal fate. Cell 1995, 82:1013-1023.
67. Kambadur R., Koizumi K., Stivers C., Nagle J., Poole S.J., Odenwald W.F. Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNS. Genes Dev 1998, 12:246-260.
68. Kania A., Salzberg A., Bhat M., D'Evelyn D., He Y., Kiss I., Bellen H.J. P-element mutations affecting embryonic peripheral nervous system development in Drosophila melanogaster. Genetics 1995, 139:1663-1678.
69. Kaplan M.R., Meyer-Franke A., Lambert S., Bennett V., Duncan I.D., Levinson S.R., Barres B.A. Induction of sodium channel clustering by oligodendrocytes. Nature 1997, 386:724-728.
70. Keleman K., Rajagopalan S., Cleppien D., Teis D., Paiha K., Huber L.A., Technau G.M., Dickson B.J. Comm sorts robo to control axon guidance at the Drosophila midline. Cell 2002, 110:415-427.
71. Kim J., Jones B.W., Zock C., Chen Z., Wang H., Goodman C.S., Anderson D.J. Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing. Proc. Natl Acad Sci USA 1998, 95:12364-12369.
72. Klambt C., Jacobs J.R., Goodman C.S. The midline of the Drosophila central nervous system: A model for the genetic analysis of cell fate, cell migration, and growth cone guidance. Cell 1991, 64:801-815.
73. Knoblich J.A., Jan L.Y., Jan Y.N. Asymmetric segregation of Numb and Prospero during cell division. Nature 1995, 377:624-627.
74. Kosman D., Ip Y.T., Levine M., Arora K. Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo. Science 1991, 254:118-122.
75. Lane N.J. Invertebrate neuroglia: Junctional structure and development. J Exp Biol 1981, 95:7-33.
76. Leiserson W.M., Harkins E.W., Keshishian H. Fray, a Drosophila serine/threonine kinase homologous to mammalian PASK, is required for axonal ensheathment. Neuron 2000, 28:793-806.
77. Loughney K., Kreber R., Ganetzky B. Molecular analysis of the para locus, a sodium channel gene in Drosophila. Cell 1989, 58:1143-1154.
78. Mayer U., Nusslein-Volhard C. A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo. Genes Dev 1988, 2:1496-1511.
79. Menne T.V., Luer K., Technau G.M., Klambt C. CNS midline cells in Drosophila induce the differentiation of lateral neural cells. Development 1997, 124:4949-4958.
80. Miller A.A., Bernardoni R., Giangrande A. Positive autoregulation of the glial promoting factor glide/gcm. Embo J 1998, 17:6316-6326.
81. Morel V., Schweisguth F. Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev 2000, 14:377-388.
82. Nambu J.R., Lewis J.O., Wharton K.A., Crews S.T. The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development. Cell 1991, 67:1157-1167.
83. Neckameyer W.S., Cooper R.L. GABA transporters in Drosophila melanogaster: Molecular cloning, behavior, and physiology. Invert Neurosci 1998, 3:279-294.
84. Nolo R., Abbott L.A., Bellen H.J. Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 2000, 102:349-362.
85. Noordermeer J.N., Kopczynski C.C., Fetter R.D., Bland K.S., Chen W.Y., Goodman C.S. Wrapper, a novel member of the Ig superfamily, is expressed by midline glia and is required for them to ensheath commissural axons in Drosophila. Neuron 1998, 21:991-1001.
86. Peles E., Salzer J.L. Molecular domains of myelinated axons. Curr Opin Neurobiol 2000, 10:558-565.
87. Pentreath V. Invertebrate glial cells. Comp Biochem Physiol C 1989, 93A:77-83.
88. Pfrieger F.W., Barres B.A. Synaptic efficacy enhanced by glial cells in vitro. Science 1997, 277:1684-1687.
89. Ramón Cajal S., Sanchez D. Contribución al conocimiento de los centros nerviosos de los insectos. Trab Lab Invertebr Biol Univ Madrid 1915, 13:1-168.
90. Rao Y., Vaessin H., Jan L.Y., Jan Y.N. Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation. Genes Dev 1991, 5:1577-1588.
91. Rothberg J.M., Hartley D.A., Walther Z., Artavanis-Tsakonas S. slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system. Cell 1988, 55:1047-1059.
92. Saint Marie R.L., Carlson S.D. Glial membrane specializations and the compartmentalization of the lamina ganglionaris of the housefly compound eye. J Neurocytol 1983, 12:243-275.
93. Saint Marie R.L., Carlson S.D. Interneuronal and glial-neuronal gap junctions in the lamina ganglionaris of the compound eye of the housefly. Musca domestica. Cell Tissue Res 1985, 241:43-52.
94. Scharrer B.C.J. The differentiation between neuroglia and connective tissue sheath in the cockroach (Periplaneta americana). J Comp Neurol 1939, 70:77-78.
95. Scherer S.S., Arroyo E.J. Recent progress on the molecular organization of myelinated axons. J Peripher Nerv Syst 2002, 7:1-12.
96. Schindelholz B., Knirr M., Warrior R., Zinn K. Regulation of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F. Development 2001, 128:4371-4382.
97. Schmidt H., Rickert C., Bossing T., Vef O., Urban J., Technau G.M. The embryonic central nervous system lineages of Drosophila melanogaster. II. Neuroblast lineages derived from the dorsal part of the neuroectoderm. Dev Biol 1997, 189:186-204.
98. Schreiber J., Riethmacher-Sonnenberg E., Riethmacher D., Tuerk E.E., Enderich J., Bosl M.R., Wegner M. Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa. Mol Cell Biol 2000, 20:2466-2474.
99. Schweisguth F., Posakony J.W. Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Cell 1992, 69:1199-1212.
100. Sepp K.J., Schulte J., Auld V.J. Developmental dynamics of peripheral glia in Drosophila melanogaster. Glia 2000, 30:122-133.
101. Shishido E., Ono N., Kojima T., Saigo K. Requirements of DFR1/Heartless, a mesoderm-specific Drosophila FGF-receptor, for the formation of heart, visceral and somatic muscles, and ensheathing of longitudinal axon tracts in CNS. Development 1997, 124:2119-2128.
102. Skeath J.B. The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo. Development 1998, 125:3301-3312.
103. Skeath J.B. At the nexus between pattern formation and cell-type specification: The generation of individual neuroblast fates in the Drosophila embryonic central nervous system. Bioessays 1999, 21:922-931.
104. Smith D.S., Treherne J.E. The electron microscopic localization of cholinesterase activity in the central nervous system of an insect, Periplaneta americana 1. J Cell Biol 1965, 26:445-465.
105. Sonnenfeld M., Ward M., Nystrom G., Mosher J., Stahl S., Crews S. The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development. Development 1997, 124:4571-4582.
106. Sonnenfeld M.J., Jacobs J.R. Apoptosis of the midline glia during Drosophila embryogenesis: A correlation with axon contact. Development 1995, 121:569-578.
107. Soriano N.S., Russell S. The Drosophila SOX-domain protein Dichaete is required for the development of the central nervous system midline. Development 1998, 125:3989-3996.
108. Soustelle L., Besson M.T., Rival T., Birman S. Terminal glial differentiation involves regulated expression of the excitatory amino acid transporters in the Drosophila embryonic CNS. Dev Biol 2002, 248:294-306.
109. Stein E., Tessier-Lavigne M. Hierarchical organization of guidance receptors: Silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science 2001, 291:1928-1938.
110. Strausfeld N.J. Atlas of an Insect Brain 1976, Springer-Verlag, Berlin, New York.
111. Sun Q., Schindelholz B., Knirr M., Schmid A., Zinn K. Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Mol Cell Neurosci 2001, 17:274-291.
112. Tepass U., Hartenstein V. The development of cellular junctions in the Drosophila embryo. Dev Biol 1994, 161:563-596.
113. Thomas J.B., Crews S.T., Goodman C.S. Molecular genetics of the single-minded locus: A gene involved in the development of the Drosophila nervous system. Cell 1988, 52:133-141.
114. Tix S., Eule E., Fischbach K.F., Benzer S., Benzer S. Glia in the chiasms and medulla of the Drosophila melanogaster optic lobes. Cell Tissue Res 1997, 289:397-409.
115. Tsruya R., Schlesinger A., Reich A., Gabay L., Sapir A., Shilo B.Z. Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz. Genes Dev 2002, 16:222-234.
116. Udolph G., Rath P., Chia W. A requirement for Notch in the genesis of a subset of glial cells in the Drosophila embryonic central nervous system which arise through asymmetric divisions. Development 2001, 128:1457-1466.
117. Udolph G., Urban J., Rusing G., Luer K., Technau G.M. Differential effects of EGF receptor signalling on neuroblast lineages along the dorsoventral axis of the Drosophila CNS. Development 1998, 125:3291-3299.
118. Umesono Y., Hiromi Y., Hotta Y. Context-dependent utilization of Notch activity in Drosophila glial determination. Development 2002, 129:2391-2399.
119. Urban S., Lee J.R., Freeman M. Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 2001, 107:173-182.
120. Vaessin H., Greel E., Wolff E., Bier E., Jan L.Y., Jan Y.N. prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell 1991, 67:941-953.
121. Van de Bor V., Heitzler P., Leger S., Plessy C., Giangrande A. Precocious expression of the Glide/Gcm glial-promoting factor in Drosophila induces neurogenesis. Genetics 2002, 160:1095-1106.
122. Van de Bor V., Walther R., Giangrande A. Some fly sensory organs are gliogenic and require glide/gcm in a precursor that divides symmetrically and produces glial cells. Development 2000, 127:3735-3743.
123. Vincent S., Vonesch J.L., Giangrande A. Glide directs glial fate commitment and cell fate switch between neurones and glia. Development 1996, 122:131-139.
124. Wharton K.A., Franks R.G., Kasai Y., Crews S.T. Control of CNS midline transcription by asymmetric E-box-like elements: Similarity to xenobiotic responsive regulation. Development 1994, 120:3563-3569.
125. Winberg M.L., Perez S.E., Steller H. Generation and early differentiation of glial cells in the first optic ganglion of Drosophila melanogaster. Development 1992, 115:903-911.
126. Xiong W.C., Montell C. Defective glia induce neuronal apoptosis in the repo visual system of Drosophila. Neuron 1995, 14:581-590.
127. Yager J., Richards S., Hekmat-Scafe D.S., Hurd D.D., Sundaresan V., Caprette D.R., Saxton W.M., Carlson J.R., Stern M. Control of Drosophila perineurial glial growth by interacting neurotrans-mitter-mediated signaling pathways. Proc Natl Acad Sci USA 2001, 98:10445-10450.
128. Yuan L.L., Ganetzky B. A glial-neuronal signaling pathway revealed by mutations in a neurexinrelated protein. Science 1999, 283:1343-1345.