Genetic ablation of parathyroid glands reveals another source of parathyroid hormone

Nature

Volumn 406, Issue 6792, 2000, Pages 199-203

  Günther, Thomas ^a   Chen, Zhou Feng ^b   Kim, Jaesang ^c   Priemel, Matthias ^d   Rueger, Johannes M ^d   Amling, Michael ^d   Moseley, Jane M ^e   Martin, T John ^e   Anderson, David J ^c   Karsenty, Gerard ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF HAMBURG   (Germany)

^e ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; PARATHYROID HORMONE;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; DOWN REGULATION; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENE TARGETING; GENETIC ANALYSIS; HORMONAL REGULATION; MOUSE; NONHUMAN; PARATHYROID GLAND; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; REGULATOR GENE; THYMUS;

ANIMALS; BONE AND BONES; CALCIUM; CROSSES, GENETIC; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; MICE; MICE, INBRED C57BL; NEUROPEPTIDES; PARATHYROID GLANDS; PARATHYROID HORMONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; THYMUS GLAND; TRANS-ACTIVATORS;

ANIMALIA;

EID: 0034644149     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35018111     Document Type: Article

References (28)

1. Potts, J. T. & Jüppner, H. in Metabolic Bone Disease and Clinically Related Disorders: Parathyroid Hormone and Parathyroid Hormone-Related Peptide in Calcium Homeostasis, Bone Metabolism and Bone Development: The Proteins, their Genes, and Receptors (eds Avioli, L. V. & Krane, S. M.) 52-94 (Academic, San Diego, 1998).
2. Hosoya, T., Takizawa, K., Nitta, K. & Hotta, Y. Glial cells missing: A binary switch between neuronal and glial determination in Drosophila. Cell 82, 1025-1036 (1995).
3. Jones, B. W., Fetter, R. D., Tear, G. & Goodman, C. S. Glial cells missing: A genetic switch that controls glial versus neuronal fate. Cell 82, 1013-1023 (1995).
4. Akiyama, Y., Hosoya, T., Poole, A. & Hotta, Y. The gcm-motif: A novel DNA-binding motif conserved in Drosophila and mammals. Proc. Natl Acad. Sci. USA 93, 14912-14916 (1996).
5. Kim, J. et al. Isolation and characterization of mammalian homologs of the Drosophila gene glial cells mining. Proc. Natl Acad. Sci. USA 95, 12364-12369 (1998).
6. Bronner, F. in Mineral Metabolism: Dynamics in Function of Calcium (eds Comar, L. C. & Bronner, F.) 342-447 (Academic, New York, 1964).
7. Cowie, A. T. & Folley, S. J. Parathyroidectomy and lactation in the rat. Nature 156, 19-720 (1945).
8. Dusso, A. S. & Brown, A. J. Mechanism of vitamin D action and its regulation. Am. J. Kidney Dis. 32, (Suppl. 2) S13-24 (1998).
9. Selye, H. On the stimulation of new bone-formation with parathyroid extract and irradiated ergosterol. Endocrinology 16, 547-558 (1932).
10. Kalu, D. N., Doyle, F. H., Pennock, J. & Foster, G. V. Parathyroid hormone and experimental osteosclerosis. Lancet 1, 1363-1366 (1970).
11. Hammett, F. S. Studies of the thyroid apparatus J. Biol. Chem. 72, 505-525 (1927).
12. Loshkajian, A. et al. Familial Blomstrand chondrodysplasia with advanced skeletal maturation: further delineation. Am. J. Med. Genet. 71, 283-288 (1997).
13. Jobert, A. S. et al. Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia. J. Clin. Invest. 102, 34-40 (1998).
14. Lanske, B. et al. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273, 663-666 (1996).
15. Li, Y. C. et al. Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia. Proc. Natl Acad. Sci. USA 94, 9831-9835 (1997).
16. Suva, L. J. et al. A parathyroid hormone-related protein implicated in malignant hypercalcemia. Science 237, 893-896 (1987).
17. Fraser, R. A., Kronenberg, H. M., Pang, P. K. & Harvey, S. Parathyroid hormone messenger ribunucleic acid in the rat hypothalamus. Endocrinology 127, 2517-2522 (1990).
18. Chisaka, O. & Capecchi, M. R. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1. 5. Nature 350, 473-479 (1991).
19. Kovacs, C. S., Manley, N. R & Kronenberg, H. M. Hoxa3 knockout mice are hypocalcemic and have reduced placental calcium transfer. 80th meeting of the Endocrine Society, 91 (Endocrine Society Press, Bethesda, Maryland, 1998).
20. Silver, J., Russel, J. & Sherwood, L. M. Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc. Natl Acad. Sci. USA 82, 4270-4273 (1985).
21. Naveh-Many, T., Friedlaender, M. M., Mayer, H. & Silver, J. Calcium regulates parathyroid hormone messenger ribonucleic acid (mRNA), but not calcitonin mRNA in vivo in the rat. Dominant role of 1,25-Dihydroxyvitamin D. Endocrinology 125, 275-280 (1989).
22. Amiel, C., Kuntziger, H., Couette, S., Coureau, C. & Bergounioux, N. Evidence for a parathyroid hormone-independent calcium modulation of phosphate transport along the nephron. J. Clin. Invest. 57, 256-263 (1976).
23. Jaffe, R. B. in Reproductive Endocrinology: The Menopause and Perimenopausal Period (eds Samuel, S., Yen, C. & Jaffe, R. B.) 389-408 (W. B. Saunders Company, Philadelphia, 1991).
24. Ma, Q., Chen, Z., del Barco Barrantes, I., de la Pompa, J. L. & Anderson, D. J. Neurogeninl is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20, 469-482 (1998).
25. Grill, V. et al. Parathyroid hormone-related protein: elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer. J. Clin. Endocrinol. Metab. 73, 1309-1315 (1991).
26. Neubüser, A., Koseki, H. & Balling, R. Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1. Dev. Biol. 170, 701-716 (1995).
27. Emanuel, R. L. et al. Calcium-sensing receptor expression and regulation by extracellular calcium in the AtT-20 pituitary cell line. Mol. Endocrinol. 10, 555-565 (1996).
28. Ducy, P. et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100, 197-207 (2000).