GABA transporters in Drosophila melanogaster: Molecular cloning, behavior, and physiology

Invertebrate Neuroscience

Volumn 3, Issue 4, 1998, Pages 279-294

  Neckameyer, W S ^a   Cooper, R L ^b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Behavior; Electrophysiology; GABA; Reuptake mechanisms; Southern

Indexed keywords

4 AMINOBUTYRIC ACID; ANTIBODY; CARRIER PROTEIN; COMPLEMENTARY DNA; NIPECOTIC ACID; RESTRICTION ENDONUCLEASE;

ALTERNATIVE RNA SPLICING; ARTICLE; BEHAVIOR; DEVELOPMENT; DNA LIBRARY; DNA SEQUENCE; DOSE RESPONSE; DROSOPHILA MELANOGASTER; GABAERGIC TRANSMISSION; GENE LOCUS; LATENT PERIOD; MOLECULAR CLONING; NERVOUS TISSUE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY;

EID: 0032452211     PISSN: 13542516     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02577688     Document Type: Article

References (47)

1. Atwood, H. L., Govind, C. K. and Wu, C.-F. (1993) Differential ultrastructure of synaptic terminals on ventral longitudinal abdominal muscles in Drosophila larvae. J. Neurobiol., 24, 1008-1024.
2. Atwood, H. L. and Cooper, R. L. (1995) Functional and structural parallels in crustaceans and Drosophila neuromuscular systems. American Zool., 35, 556-565.
3. Atwood, H. L. and Cooper, R. L. (1996a) Ultrastructure of crustacean and insect neuromuscular junctions. J. Neurosci. Methods, 69, 51-58.
4. Atwood, H. L. and Cooper, R. L. (1996b) Synaptic diversity and differentiation: crustacean neuromuscular junctions. Invertebrate Neuroscience, 1, 291-307.
5. Blakely, R., Berson, H., Fremeau, R., Caron, M., Peek, M., Prince, H. and Bradley, C. (1991) Cloning and expression of a functional serotonin transporter from rat brain. Nature, 354, 66-70.
6. Buchner, E., Bader, R., Buchner, S. and Cox, J. (1988) Cell specific immuno-probes for the brain of normal and mutant Drosophila melanogaster. I. Wildtype visual system. Cell and Tiss. Res., 253, 357-370.
7. Campos-Ortega, J. and Hartenstein, V. (1985) The Embryonic Development of Drosophila melanogaster. Springer Verlag, Berlin.
8. Chen, P. and Widmer, B. (1968) Content and synthesis of γ-aminobutyric acid in the larval brain of Drosophila melanogaster. Experientia, 24, 516-517.
9. Cherubini, E., Gaiarsa, J. L. and Ben-Ari, Y. (1991) GABA: an excitatory transmitter in early postnatal life. Trends Neurosci., 14, 515-519.
10. Clark, J. A., and Amara, S. G. (1994) Stable expression of a neuronal γ-aminobutyric acid transporter, GAT-3, in mammalian cells demonstrates unique pharmacological properties and ion dependence. Mol. Pharmacol., 46, 550-557.
11. Clark, J. A., Deutch, A. Y-, Gallipoli, P. Z. and Amara, S. G. (1992) Functional expression and CNS distribution of β-alanine sensitive neuronal GABA transporter. Neuron, 9, 337-347.
12. Cobb, M., Bruneau, S. and Jallon, J.-M. (1992) Genetic and developmental factors in the olfactory response of Drosophila melanogaster larvae to alcohols. Proc. R. Soc. London B., 248, 103-109.
13. Cooper, R. L., Stewart, B. A., Wojtowicz, J. M., Wang, S. and Atwood, H. L. (1995a) Quantal measurement and analysis methods compared for crayfish and Drosophila neuromuscular junctions and rat hippocampus. J. Neurosci. Methods, 61, 67-79.
14. Cooper, R. L., Marin, L. and Atwood, H. L. (1995b). Synaptic differentiation of a single motor neuron: conjoint definition of transmitter release, presynaptic calcium signals, and ultrastructure. J. Neuroscience, 15, 4209-4222.
15. Cooper, R. L., Hampson, D. and Atwood, H. L. (1996a) Synaptotagmin-like expression in the motor nerve terminals of crayfish. Brain Res., 703, 214-216.
16. Cooper, R. L., Harrington, C. C. Marin, L. and Atwood, H. L. (1996b) Quantal release at visualized terminals of a crayfish motor axon: intraterminal and regional differences. J. Comp. Neurol., 375, 583-600
17. Cooper, R. L., Winslow, J., Govind, C. K. and Atwood, H. L. (1996c) Synaptic structural complexity as a factor enhancing probability of calcium-mediated transmitter release. J. Neurophysiol., 75, 2451-2466.
18. DeFeudis, F. (1982) GABA binding processes and behavior. Gen. Pharmacol., 14, 313-319.
19. Dodge, F. A. and Rahamimoff, R. (1967) Cooperative action of calcium ions in transmitter release at the neuromuscular junction. J. Physiol., 193, 419-432.
20. Engels, W., Preston, C., Thompson, P. and Eggelston, W. (1986) In situ hybridization to Drosophila salivary chromosomes with biotinylated DNA probes and alkaline pohosphatase. BRL Focus, 8, 6-8.
21. Guastella, J., Nelson, H., Cayzyk, L., Keynan, S., Miedel, M., Davidson, N., Lester, H. and Kanner, B. (1990) Cloning and expression of a rat GABA transporter. Science, 249, 1303-1306.
22. Guimbal, C., Klostermann, A. and Kilimann, M. (1995) Phylogeneyic conservation of 4-aminobutyric acid (GABA) transporter isoforms: cloning and pharmacological characterization of a GABA/β-alanine transporter from Torpedo. Eur. J. Biochem., 234, 794-800.
23. Honda, S., Yamamoto, M. and Salto, N. (1995) Immunocytochemical localization of 3 subtypes of GABA transporter isoforms. Mol. Brain Res., 33, 319-325.
24. Ikegaki, N., Saito, N., Hashima, M. and Tanaka, C. (1994) Production of specific antibodies against GABA transporter subtypes (GAT-1, GAT-2, GAT-3) and their application to immunocytochemistry. Mol. Brain Res., 26, 47-54.
25. Itoh, N., Salvaterra, P. and Itakura, K. (1985) Construction of an adult Drosophila head cDNA expression library with λgt11. Dros. Inf. Serv., 61, 89.
26. Iverson, L. and Kravitz, E. (1968) The metabolism of GABA in the lobster nervous system. Uptake of GABA the nerve-muscle preparations. J. Neurochem., 15, 1141-1149.
27. Jursky, F. and Nelson, N. (1994) Developmental expression of GABA transporters GAT-1 and GAT-4 suggests involvement in brain maturation. J. Neurochem., 67, 857-867.
28. Katz, B. and Miledi, R. (1968) The role of calcium in neuromuscular facilitation.;. J. Physiol, 195, 481-492.
29. Krause, D., Ikeda, K. and Roberts, E. (1981) Dose-conductance relationships for GABA agonists and the effect of uptake inhibitors in crayfish stretch receptor neurons. Brain Res., 225, 319-332.
30. Kurdyak, P., Atwood, H. L., Stewart, B. A. and Wu, C.-F. (1994) Differential physiology and morphology of motor axons to ventral longitudinal muscles in larval Drosophila. J. Comp. Neurol., 350, 463-472.
31. Lilly, M. and Carlson, J. (1990). smellblind, a gene required for Drosophila olfaction. Genetics, 124, 293-302.
32. Liu, Q., Mandiyan, S., Lopez-Corcuera, B., Nelson, H. and Nelson, N. (1993) A rat brain cDNA encoding the neurotransmitter transporter with an unusual structure. FEBS Lett., 315, 114-118.
33. Mbungu, D., Ross, L. and Gill, (1995) Cloning, functional expression and pharmacology of a GABA transporter from Manduca sexta. Arch. Biochem. Biophys., 318, 489-497.
34. Meier, E., Hertz, L. and Schousboe, A. (1991) Neurotransmitters as developmental signals. Neurochem. Int., 19, 99-102.
35. Minelli, A., Brecha, N., Karschin, C., DeBiasi, S. and Conti, F. (1995) GAT-1, a high-affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex. J. Neurosci., 15, 7754-7736.
36. Muller, K. J., Nicholls, J. G. and Stent, G. S. (1981) Neurobiology of the Leech, p. 254. New York: Cold Spring Harbor Laboratory.
37. Neckameyer, W. (1996) Multiple roles for dopamine in Drosophila development. Dev. Biol., 176, 209-219.
38. Paredes, R. and Agmo, A. (1992) GABA and behavior: the role of receptor subtypes. Neuroscience and Biobehavioral Rev., 16, 145-170.
39. Sanger, F., Nicklen, S. and Coulson, A. (1977) DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA, 74, 5463-5467.
40. Sewell, D., Burnet, B. and Connolly, K. (1975) Genetic analysis of larval feeding behavior in Drosophila melanogaster. Genet. Res. Camb., 24, 163-173.
41. Shepherd, D. and Tyrer, N. (1985) Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle. Comp. Biochem. Physiol., 82C, 315-321.
42. Shimada, S., Kitayama, S., Lin, C., Patel, A., Nanthakumar, E., Gregor, P., Kuhar, M. and UhI, G. (1991) Cloning and expression of a cocaine-sensitive dopamine transporter complementary cDNA. Science, 254, 576-578.
43. Southern, E. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol., 98, 503-517.
44. Stewart, B. A., Atwood, H. L., Renger, J. J., Wang, J. and Wu, C.-F. (1994) Improved stability of Drosophila larval neuromuscular preparation in haemolymph-like physiological solutions. J. Comp. Physiol A, 175, 179-191.
45. Stewart, B. A., Schuster, C. M., Goodman, C. S. and Atwood, H. L. (1996) Homeostasis of synaptic transmission in Drosophila with genetically altered nerve terminal morphology. J. Neurosci., 16, 3877-3886.
46. Takahashi, K.-I., Miyoshi, S.-I., Kaneko, A. and Copenhagen, D. (1995) Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina. Jap. J. Physiol., 45, 457-473.
47. Zucker, R. S. and Lara-Estrella, L. O. (1983) Post-tetanic decay of evoked and spontaneous transmitter release and a residual calcium model of synaptic facilitation at crayfish neuromuscular junctions. J. Gen. Physiol., 81, 355-372.