Effect of donor age on function of isolated human islets

Diabetes

Volumn 55, Issue 5, 2006, Pages 1361-1368

  Ihm, Sung Hee ^a   Matsumoto, Ippei ^a   Sawada, Toshiya ^a   Nakano, Masahiko ^a   Zhang, Hui J ^a   Ansite, Jeffrey D ^a   Sutherland, David E R ^a   Hering, Bernhard J ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

AIR, acute insulin response; AUC, area under the curve; CIT, cold ischemia time; CPI, C peptide increment; GSIR, glucose stimulated insulin release; HPLC, high performance liquid chromatography; IRI, immunoreactive insulin

Indexed keywords

INSULIN; ADENOSINE TRIPHOSPHATE; CREATININE; GLUCOSE;

ARTICLE; CELL FUNCTION; CELL ISOLATION; CELL TRANSPLANTATION; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; PANCREAS ISLET CELL; PRIORITY JOURNAL; ADOLESCENT; ADULT; AGE; AGED; BLOOD; CADAVER; CAUSE OF DEATH; DONOR; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; METABOLISM; MIDDLE AGED; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION; PHYSIOLOGY; SECRETION;

ADENOSINE TRIPHOSPHATE; ADOLESCENT; ADULT; AGE FACTORS; AGED; BLOOD GLUCOSE; CADAVER; CAUSE OF DEATH; CREATININE; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MIDDLE AGED; TISSUE DONORS;

EID: 33745297641     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-1333     Document Type: Article

References (46)

1. Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR, Wiedmeyer HS, Byrd-Holt DD: Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U. S. adults: the third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care 21:518-524, 1998
2. DeFronzo R: Glucose intolerance and aging. Diabetes Care 4:493-501, 1981
3. Chang AM, Halter JB: Aging and insulin secretion. Am J Physiol Endocrinol Metab 284:E7-E12, 2003
4. Reaven EP, Gold G, Reaven GM: Effect of age on glucose-stimulated insulin release by the beta-cell of the rat. J Clin Invest 64:591-599, 1979
5. Reaven EP, Reaven GM: Structure and function changes in the endocrine pancreas of aging rats with reference to the modulating effects of exercise and caloric restriction. J Clin Invest 68:75-84, 1981
6. Draznin B, Steinberg JP, Leitner JW, Sussman KE: The nature of insulin secretory defect in aging rats. Diabetes 34:1168-1173, 1985
7. Reaven EP, Curry DL, Reaven M: Effect of age and sex on rat endocrine pancreas. Diabetes 36:1397-1400, 1987
8. Selawry H, Harrison J, Patipa M, Mintz DH: Pancreatic islet isotransplantation: effects of age and organ culture of donor islets on reversal of diabetes in rats. Diabetes 27:625-631, 1978
9. Keymeulen B, Anselmo J, Pipeleers D: Length of metabolic normalization after rat islet cell transplantation depends on endocrine cell composition of graft and on donor age. Diabetologia 40:1152-1158, 1997
10. Lakey JRT, Warnock GL, Rajotte RV, Suarez-Almazor ME, Ao Z, Shapiro AMJ, Kneteman NM: Variables in organ donors that affect the recovery of human islets of Langerhans. Transplantation 61:1047-1053, 1996
11. Shapiro AMJ, Lakey JRT, Ryan EA, Korbutt GS, Toth EL, Warnock GL, Kneteman NM, Rajotte RV: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230-238, 2000
12. Ryan EA, Lakey JRT, Rajotte RV, Korbutt GS, Kin T, Imes S, Rabinovitch A, Elliott JF, Bigam D, Kneteman NM, Warnock GL, Larsen I, Shapiro AMJ: Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 50:710-719, 2001
13. Ryan EA, Lakey JRT, Paty BW, Imes S, Korbutt GS, Kneteman NM, Bigam D, Rajotte RV, Shapiro AMJ: Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes 51:2148-2157, 2002
14. Zeng Y, Torre MA, Karrison T, Thistlethwaite JR: The correlation between donor characteristics and the success of human islet isolation. Transplantation 57:954-958, 1994
15. Benhamou PY, Watt PC, Mullen Y, Ingles S, Watanabe Y, Nomura Y, Hober C, Miyamoto M, Kenmochi T, Passaro EP: Human islet isolation in 104 consecutive cases: factors affecting isolation success. Transplantation 57:1804-1810, 1994
16. Odorico JS, Heisey DM, Voss BJ, Steiner DS, Knechtle SJ, D'Alessandro AM, Hoffman RM, Sollinger HW: Donor factors affecting outcome after pancreas transplantation. Transplant Proc 30:276-277, 1998
17. Krieger NR, Odorico JS, Heisey DM, D'Alessandro AM, Knechtle SJ, Pirsch JD, Sollinger HW: Underutilization of pancreas donors. Transplantation 75:1271-1276, 2003
18. Hering BJ, Matsumoto I, Sawada T, Nakano M, Sakai T, Kandaswamy R, Sutherland DE: Impact of two-layer pancreas preservation on islet isolation and transplantation. Transplantation 74:1813-1816, 2002
19. Hering BJ, Kandaswamy R, Harmon JV, Ansite JD, Clemmings SM, Sakai T, Paraskevas S, Eckman PM, Sageshima J, Nakano M, Sawada T, Matsumoto I, Zhang HJ, Sutherland DE, Bluestone JA: Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody. Am J Transplant 4:390-401, 2004
20. Ricordi C, Lacy PE, Finke EH, Olack BJ, Scharp DW: Automated method for isolation of human pancreatic islets. Diabetes 37:413-420, 1988
21. Micheli V, Simmonds HA, Bari M, Pompucci G: HPLC determination of oxidized and reduced pyridine coenzymes in human erythrocytes. Clin Chim Acta 220:1-17, 1993
22. Hering BJ, Kandaswamy R, Ansite JD, Eckman PM, Nakano M, Sawada T, Matsumoto I, Ihm SH, Zhang HJ, Parkey J, Hunter DW, Sutherland DE: Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes. JAMA 293:830-835, 2005
23. Weyer C, Bogardus C, Mott DM, Pratley RE: The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787-794, 1999
24. Kahn SE: The importance of β-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 86:4047-4058, 2001
25. Clausen JO, Borch Johnsen K, Ibsen H, Bergman RN, Hougaard P, Winther K, Pedersen O: Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians: analysis of the impact of gender, body fat, physical fitness, and life-style factors. J Clin Invest 98:1195-1209, 1996
26. Iozzo P, Beck Nielsen H, Laakso M, Smith U, Yki Jarvinen H, Ferrannini E: Independent influence of age on basal insulin secretion in nondiabetic humans: European Group for the Study of Insulin Resistance. J Clin Endocrinol Metab 84:863-868, 1999
27. DeFronzo RA: Glucose intolerance and aging: evidence for tissue insensitivity to insulin. Diabetes 28:1095-1101, 1979
28. Swenne I: Effects of aging on the regenerative capacity of the pancreatic B-cell of the rat. Diabetes 32:14-19, 1983
29. Tyrberg B, Eizirik DL, Hellerstrom C, Pipeleers DG, Andersson A: Human pancreatic β-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro. Endocrinology 137:5694-5699, 1996
30. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC: β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110, 2003
31. Scheen AJ, Sturis J, Polonsky KS, Van Cauter E: Alterations in the ultradian oscillations of insulin secretion and plasma glucose in aging. Diabetologia 39:564-572, 1996
32. Meneilly GS, Ryan AS, Veldhuis JD, Elahi D: Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals. J Clin Endocrinol Metab 82:4088-4093, 1997
33. Fritsche A, Madaus A, Stefan N, Tschritter O, Maerker E, Teigeler A, Haring H, Stumvoll M: Relationships among age, proinsulin conversion, and β-cell function in nondiabetic humans. Diabetes 51 (Suppl. 1):S234-S239, 2002
34. Blachier F, Mourtada A, Sener A, Malaisse WJ: Stimulus-secretion coupling of arginine-induced insulin release: uptake of metabolized and nonmetabolized cationic aminoacids by pancreatic islets. Endocrinology 124:134-141, 1989
35. (LEU)(UUR) gene mutation. Diabetes 45:478-487, 1996
36. LEU(UUR) gene mutation. Diabetes Care 24:1253-1258, 2001
37. Ames BN, Shigenaga MK, Hagen TM: Mitochondrial decay in aging. Biochim Biophys Acta 1271:165-170, 1995
38. Shigenaga MK, Hagen TM, Ames BN: Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A 91:10771-10778, 1994
39. Barazzoni R, Short KR, Nair KS: Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart. J Biol Chem 275:3343-3347, 2000
40. Song J, Oh JY, Sung YA, Pak YK, Park KS, Lee HK: Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients. Diabetes Care 24:865-869, 2001
41. Hagen TM, Yowe DL, Bartholomew JC, Wehr CM, Do KL, Park JY, Ames BN: Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci U S A 94:3064-3069, 1997
42. Maechler P, Jornot L, Wollheim CB: Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J Biol Chem 274:27905-27913, 1999
43. Rastellini C, Rilo HHL, Fontes P, Behboo R, Carroll P, Ricordi C, Starzl TE, Rao AS: The effect of donor age on the outcome of islets isolated from human pancreata. Transplant Proc 27:3257-3258, 1995
44. Alexander JW, Bennett LE, Breen TJ: Effect of donor age on outcome of kidney transplantation: a two-year analysis of transplants reported to the United Network for Organ Sharing Registry. Transplantation 57:871-876, 1994
45. Basar H, Soran A, Shapiro R, Vivas C, Scantlebury VP, Jordan ML, Gritsch HA, McCauley J, Randhawa P, Irish W, Hakala TR, Fung JJ: Renal transplantation in recipients over the age of 60: the impact of donor age. Transplantation 67:1191-1193, 1999
46. Mizutani K, Ono Y, Kinukawa T, Hattori R, Nishiyama N, Kamihila O, Ohshima S: Use of marginal organs from non-heart-beating cadaveric kidney donors. Transplantation 72:1376-1380, 2001