Protective role of heme oxygenase-1 on trinitrobenzene sulfonic acid-induced colitis in rats

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 281, Issue 2 44-2, 2001, Pages

  Wang, W P ^a   Guo, X ^a   Koo, M W L ^a   Wong, B C Y ^b   Lam, S K ^b   Ye, Y N ^a   Cho, C H ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Inducible nitric oxide synthase; Reactive oxygen species

Indexed keywords

ARGININE; HEME OXYGENASE; MESOPORPHYRIN TIN; MESSENGER RNA; MYELOPEROXIDASE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; TRINITROBENZENESULFONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COLON INJURY; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0034880733     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.281.2.g586     Document Type: Article

References (47)

1. Inhibition of iNOS in human intestinal epithelial cells by agents that can induce heme oxygenase-1 (HO-1) expression
2. Expression of inducible nitric oxide synthase mRNA in rat digestive tissue after endotoxin and its role in intestinal mucosal injury
3. Effect of cigarette smoking on ethanol-induced gastric mucosal lesion: The role of nitric oxide and neutrophils
4. Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis
5. Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells
6. Oxidants and free radicals in inflammatory bowel disease
7. Metabolism of trinitrobenzene sulfonic acid by the rat colon produces reactive oxygen species
8. Involvement of neutrophils and free radicals in the potentiating effects of passive cigarette smoking on inflammatory bowel disease in rats
9. Unconjugated bilirubin inhibits in vitro major histocompatibility complex-unrestricted cytotoxicity of human lymphocytes
10. Unconjugated bilirubin inhibits in vitro cytotoxic T lymphocyte activity of human lymphocytes
11. Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: Role of bilirubin generated by the enzyme
12. Gene regulation of heme oxygenase-1 as a therapeutic target
13. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite
14. Iron attenuates nitric oxide level and iNOS expression in endotoxin-treated mice
15. Heme oxygenase induction with attenuation of experimentally induced corneal inflammation
16. Direct evidence of oxidative damage in acute and chronic phases of experimental colitis in rats
17. The role of nitric oxide in inflammation
18. Heme oxygenase: Function, multiplicity, regulatory mechanism, and clinical application
19. Prematurely evoked synthesis and induction of δ-aminolevulinate synthetase in neonatal liver
20. Characterization of two constitutive forms of heme oxygenase: Only one molecular species of the enzyme is inducible
21. Does carbon monoxide have a physiological function?
22. Nitric oxide synthase structure and mechanism
23. Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide
24. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis
25. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP
26. Hapten-induced model of chronic inflammation and ulceration in rat colon
27. A beneficial role of bile pigments as an endogenous tissue protector: Anti-complement effects of biliverdin and conjugated bilirubin
28. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
29. Effects of chronic nitric oxide synthase inhibition on TNBS-induced colitis in rats
30. Reduced stress defense in heme oxygenase 1-deficient cells
31. Inflammatory mediators of experimental colitis in rats
32. Peroxynitrite-induced rat colitis: A new model of colonic inflammation
33. Molecular and metabolic evidence for the restricted expression of inducible nitric oxide synthase in healing wounds
34. Suppression of TNF-α gene expression by hemin: Implications for the role of iron homeostasis in host inflammatory responses
35. Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease
36. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease
37. Bilirubin is an antioxidant of possible physiological importance
38. The heme oxygenase-carbon monoxide system: A regulator of hepatobiliary function
39. Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron
40. Assay method for myeloperoxidase in human polymorphonuclear leukocytes
41. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
42. Multiplicity of heme oxygenase isozymes: HO-1 and HO-2 are different molecular species in rat and rabbit
43. Glomerular inflammation induces resistance to tubular injury in the rat. A novel form of acquired, heme oxygenase-dependent resistance to renal injury
44. Iron regulates nitric oxide synthase activity by controlling nuclear transcription
45. Nitric oxide synthase is a cytochrome P-450-type hemoprotein
46. Heme oxygenase: A novel target for the modulation of the inflammatory response
47. Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock