Basal expression rate of comK sets a 'switching-window' into the K-state of Bacillus subtilis

Molecular Microbiology

Volumn 63, Issue 6, 2007, Pages 1806-1816

  Leisner, Madeleine ^a,b   Stingl, Kerstin ^a   Rädler, Joachim O ^b   Maier, Berenike ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACILLUS SUBTILIS; CATALYSIS; FEEDBACK SYSTEM; GENE SWITCHING; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; TRANSCRIPTION FACTORS; TRANSFORMATION, BACTERIAL;

BACILLUS SUBTILIS;

EID: 33947270897     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2007.05628.x     Document Type: Article

References (31)

1. Albano, M., Hahn, J., and Dubnau, D. (1987) Expression of competence genes in Bacillus subtilis. J Bacteriol 169: 3110-3117.
2. Avery, S.V. (2006) Microbial cell individuality and the underlying sources of heterogeneity. Nat Rev Microbiol 4: 577-587.
3. Berka, R.M., Hahn, J., Albano, M., Draskovic, I., Persuh, M., Cui, X., et al. (2002) Microarray analysis of the Bacillus subtilis K-state: genome-wide expression changes dependent on ComK. Mol Microbiol 43: 1331-1345.
4. Dubnau, D., and Losick, R. (2006) Bistability in bacteria. Mol Microbiol 61: 564-572.
5. Fujita, M., Gonzalez-Pastor, J.E., and Losick, R. (2005) High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis. J Bacteriol 187: 1357-1368.
6. Hahn, J., Kong, L., and Dubnau, D. (1994) The regulation of competence transcription factor synthesis constitutes a critical control point in the regulation of competence in Bacillus subtilis. J Bacteriol 176: 5753-5761.
7. Hahn, J., Roggiani, M., and Dubnau, D. (1995) The major role of Spo0A in genetic competence is to downregulate abrB, an essential competence gene. J Bacteriol 177: 3601-3605.
8. Hahn, J., Luttinger, A., and Dubnau, D. (1996) Regulatory inputs for the synthesis of ComK, the competence transcription factor of Bacillus subtilis. Mol Microbiol 21: 763-775.
9. Hahn, J., Maier, B., Haijema, B.J., Sheetz, M., and Dubnau, D. (2005) Transformation proteins and DNA uptake localize to the cell poles in Bacillus subtilis. Cell 122: 59-71.
10. Haijema, B.J., Hahn, J., Haynes, J., and Dubnau, D. (2001) A ComGA-dependent checkpoint limits growth during the escape from competence. Mol Microbiol 40: 52-64.
11. Hamoen, L.W., Van Werkhoven, A.F., Bijlsma, J.J., Dubnau, D., and Venema, G. (1998) The competence transcription factor of Bacillus subtilis recognizes short A/T-rich sequences arranged in a unique, flexible pattern along the DNA helix. Genes Dev 12: 1539-1550.
12. Hamoen, L.W., Van Werkhoven, A.F., Venema, G., and Dubnau, D. (2000) The pleiotropic response regulator DegU functions as a priming protein in competence development in Bacillus subtilis. Proc Natl Acad Sci USA 97: 9246-9251.
13. Hamoen, L.W., Smits, W.K., de Jong, A., Holsappel, S., and Kuipers, O.P. (2002) Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach. Nucleic Acids Res 30: 5517-5528.
14. Hamoen, L.W., Kausche, D., Marahiel, M.A., van Sinderen, D., Venema, G., and Serror, P. (2003) The Bacillus subtilis transition state regulator AbrB binds to the -35 promoter region of comK. FEMS Microbiol Lett 218: 299-304.
15. Hoa, T.T., Tortosa, P., Albano, M., and Dubnau, D. (2002) Rok (YkuW) regulates genetic competence in Bacillus subtilis by directly repressing comK. Mol Microbiol 43: 15-26.
16. Liu, L., Nakano, M.M., Lee, O.H., and Zuber, P. (1996) Plasmid-amplified comS enhances genetic competence and suppresses sinR in Bacillus subtilis. J Bacteriol 178: 5144-5152.
17. Maamar, H., and Dubnau, D. (2005) Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop. Mol Microbiol 56: 615-624.
18. McKenzie, T., Hoshino, T., Tanaka, T., and Sueoka, N. (1986) The nucleotide sequence of pUB110: some salient features in relation to replication and its regulation. Plasmid 15: 93-103.
19. Magnuson, R., Solomon, J., and Grossman, A.D. (1994) Biochemical and genetic characterization of a competence pheromone from B. subtilis. Cell 77: 207-216.
20. Maier, B., Chen, I., Dubnau, D., and Sheetz, M.P. (2004) DNA transport into Bacillus subtilis requires proton motive force to generate large molecular forces. Nat Struct Mol Biol 11: 643-649.
21. Nester, E.W., and Stocker, B.A. (1963) Biosynthetic latency in early stages of deoxyribonucleic acidtransformation in Bacillus Subtilis. J Bacteriol 86: 785-796.
22. Ogura, M., Yamaguchi, H., Kobayashi, K., Ogasawara, N., Fujita, Y., and Tanaka, T. (2002) Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK. J Bacteriol 184: 2344-2351.
23. Rao, C.V., Wolf, D.M., and Arkin, A.P. (2002) Control, exploitation and tolerance of intracellular noise. Nature 420: 231-237.
24. Ratnayake-Lecamwasam, M., Serror, P., Wong, K.W., and Sonenshein, A.L. (2001) Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels. Genes Dev 15: 1093-1103.
25. Serror, P., and Sonenshein, A.L. (1996) Interaction of CodY, a novel Bacillus subtilis DNA-binding protein, with the dpp promoter region. Mol Microbiol 20: 843-852.
26. Smits, W.K., Eschevins, C.C., Susanna, K.A., Bron, S., Kuipers, O.P., and Hamoen, L.W. (2005) Stripping Bacillus: comK auto-stimulation is responsible for the bistable response in competence development. Mol Microbiol 56: 604-614.
27. Smits, W.K., Kuipers, O.P., and Veening, J.W. (2006) Phenotypic variation in bacteria: the role of feedback regulation. Nat Rev Microbiol 4: 259-271.
28. Suel, G.M., Garcia-Ojalvo, J., Liberman, L.M., and Elowitz, M.B. (2006) An excitable gene negulatory circuit induces transient cellular differentiation. Nature 440: 545-550.
29. Turgay, K., Hahn, J., Burghoorn, J., and Dubnau, D. (1998) Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor. EMBO J 17: 6730-6738.
30. Veening, J.W., Smits, W.K., Hamoen, L.W., and Kuipers, O.P. (2006) Single cell analysis of gene expression patterns of competence development and initiation of sporulation in Bacillus subtilis grown on chemically defined media. J Appl Microbiol 101: 531-541.
31. Wolf, D.M., and Arkin, A.P. (2003) Motifs, modules and games in bacteria. Curr Opin Microbiol 6: 125-134.