Relating ligand binding to activation gating in CNGA2 channels

Nature

Volumn 446, Issue 7134, 2007, Pages 440-443

  Biskup, Christoph ^a   Kusch, Jana ^a   Schulz, Eckhard ^b   Nache, Vasilica ^a   Schwede, Frank ^c   Lehmann, Frank ^d   Hagen, Volker ^e   Benndorf, Klaus ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b University of Applied Sciences Schmalkalden   (Germany)

^c BIOLOG Life Science Institute   (Germany)

^d Dyomics GmbH   (Germany)

^e LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; CYCLIC NUCLEOTIDE; ION CHANNEL;

FLUORESCENCE; LIGAND; OLFACTION; OLFACTORY CUE; PHOTORECEPTION; PROTEIN;

ARTICLE; BINDING SITE; CONCENTRATION (PARAMETERS); LIGAND BINDING; MEMBRANE TRANSPORT; OLFACTORY SYSTEM; PHOTORECEPTOR; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEADY STATE;

ANIMALS; CYCLIC GMP; ION CHANNEL GATING; ION CHANNELS; LIGANDS; MODELS, BIOLOGICAL; OOCYTES; PATCH-CLAMP TECHNIQUES; XENOPUS LAEVIS;

EID: 33947501708     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05596     Document Type: Article

References (30)

1. Körschen, H. G. et al. A 240 kDa protein represents the complete β subunit of the cyclic nucleotide-gated channel from rod photoreceptor. Neuron 15, 627-636 (1995).
2. Bönigk, W. et al. The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits. J. Neurosci. 19, 5332-5347 (1999).
3. Zhong, H., Molday, L. L., Molday, R. S. & Yau, K.-W. The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry. Nature 420, 193-198 (2002).
4. Zheng, J. & Zagotta, W. N. Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels. Neuron 42, 411-421 (2004).
5. Kaupp, U. B. & Seifert, R. Cyclic nucleotide-gated ion channels. Physiol. Rev. 82, 769-824 (2002).
6. Dhallan, R. S., Yau, K.-W., Schrader, K. A. & Reed, R. R. Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature 347, 184-187 (1990).
7. Nache, V. et al. Activation of olfactory-type cyclic nucleotide-gated channels is highly cooperative. J. Physiol. (Lond.) 569, 91-102 (2005).
8. Kaupp, U. B. et al. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature 342, 762-766 (1989).
9. Goulding, E. H., Tibbs, G. R. & Siegelbaum, S. A. Molecular mechanism of cyclic-nucleotide-gated channel activation. Nature 372, 369-374 (1994).
10. Liu, D. T., Tibbs, G. R., Paoletti, P. & Siegelbaum, S. A. Constraining ligand-binding site stoichiometry suggests that a cyclic nucleotide-gated channel is composed of two functional dimers. Neuron 21, 235-248 (1998).
11. Liu, D. T. & Siegelbaum, S. A. Change of pore helix conformational state upon opening of cyclic nucleotide-gated channels. Neuron 28, 899-909 (2000).
12. Zagotta, W. N. et al. Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature 425, 200-205 (2003).
13. Colquhoun, D. Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br. J. Pharmacol. 125, 924-947 (1998).
14. Colquhoun, D. Agonist-activated ion channels. Br. J. Pharmacol. 147, S17-S26 (2006).
15. Edsall, J. T. & Wyman, J. Biophysical Chemistry. (Academic Press, New York, 1958).
16. Wyman, J. & Gill, S. J. Binding and Linkage. Functional Chemistry of Biological Macromolecules. (Univ. Science Books, Mill Valley, 1990).
17. Li, J., Zagotta, W. N. & Lester, H. A. Cyclic-nucleotide gated channels: structural basis of ligand efficacy and allosteric modulation. Q. Rev. Biophys. 30, 177-193 (1997).
18. Picones, A. & Korenbrot, J. I. Spontaneous ligand-independent activity of the cGMP-gated ion channels in cone photoreceptors in fish. J. Physiol. (Lond.) 485, 699-714 (1995).
19. Tibbs, G. R., Goulding, E. H. & Siegelbaum, S. A. Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels. Nature 386, 612-615 (1997).
20. Monod, J., Wyman, J. & Changeux, J. P. On the nature of allosteric transitions: a plausible model. J. Mol. Biol. 12, 88-118 (1965).
21. Li, J. & Lester, H. A. Single-channel kinetics of the rat olfactory cyclic nucleotide-gated channel expressed in Xenopus oocytes. Mol. Pharmacol. 55, 883-893 (1999).
22. Zheng, J. & Zagotta, W. N. Patch-clamp fluorometry recording of conformational rearrangements of ion channels. Sci. STKE 10.1126/stke.2003.176.pl7 (2003).
23. 2+- calmodulin-dependent inhibition of rod cyclic nucleotide-gated channels measured by patch-clamp fluorometry. J. Gen. Physiol. 124, 211-223 (2004).
24. Craven, K. B. & Zagotta, W. N. Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels. J. Gen. Physiol. 124, 663-677 (2004).
25. Ruiz, M. L. & Karpen, J. W. Single cyclic nucleotide-gated channels locked in different ligand-bound states. Nature 389, 389-392 (1997).
26. Ruiz, M. L. & Karpen, J. W. Opening mechanism of a cyclic nucleotide-gated channel based on analysis of single channels locked in each liganded state. J. Gen. Physiol. 113, 873-895 (1999).
27. Brejc, K. et al. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature 411, 269-276 (2001).
28. Beato, M., Groot-Kormelink, P. J., Colquhoun, D. & Sivilotti, L. G. The activation mechanism of α1 homomeric glycine receptors. J. Neurosci. 24, 895-906 (2004).
29. Burzomato, V., Beato, M., Groot-Kormelink, P. J., Colquhoun, D. & Sivilotti, L. G. Single-channel behaviour of heteromeric α1β glycine receptors: An attempt to detect a conformational change before the channel opens. J. Neurosci. 24, 10924-10940 (2004).
30. Bradley, J., Bönigk, W., Yao, K.-W.&Frings, S. Calmodulin permanently associates with rat olfactory CNG channels under native conditions. Nature Neurosci. 7, 705-710 (2004).