Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase

Journal of Medicinal Chemistry

Volumn 50, Issue 15, 2007, Pages 3661-3666

  Jütten, Peter ^a   Schumann, Winfried ^a   Härtl, Albert ^a   Dahse, Hans Martin ^a   Gräfe, Udo ^a  

^a HANS KNÖLL INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 FORMYL 6 HYDROXYBENZOIC ACID CYCLOHEXYLTHIOSEMICARBAZONE; 3 (4 CYCLOHEXYLTHIOSEMICARBAZONE)METHYL 2 HYDROXYBENZOIC ACID; 3 (4 CYCLOHEXYLTHIOSEMICARBAZONE)METHYL 4 HYDROXYBENZOIC ACID; 5 (4 CYCLOHEXYLTHIOSEMICARBAZONE)METHYL 2 HYDROXYBENZOIC ACID; BENZO[A]NAPHTHACENEQUINONE; BENZOIC ACID DERIVATIVE; ENZYME INHIBITOR; ESTRONE SULFATASE INHIBITOR; LACTONE DERIVATIVE; MADURAHYDROXYLACTONE; QUINONE DERIVATIVE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CARBON NUCLEAR MAGNETIC RESONANCE; DERIVATIZATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; EGG; ENZYME INHIBITION; HEN; IC 50; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; THIN LAYER CHROMATOGRAPHY;

ACUTE TOXICITY TESTS; ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CHICKENS; FEMALE; HUMANS; MICROSOMES; NEOPLASMS, HORMONE-DEPENDENT; PLACENTA; SALICYLIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFATASES; THIOSEMICARBAZONES;

EID: 34547572121     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0611657     Document Type: Article

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