Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 10, 2004, Pages 2759-2772

  Hejaz, Hatem A M ^a   Woo, L W Lawrence ^a   Purohit, Atul ^b   Reed, Michael J ^b   Potter, Barry V L ^a  

^a UNIVERSITY OF BATH   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

(1,3 ADAMANTANEDIYL)DIPHENYL 4,4' O,O BIS SULFAMATE; 1 CYCLOHEXYL 1,1 BIS(4 SULFAMOYLOXYPHENYL)METHANOL; 2 HYDROXYANTHRAQUINONE 6 O SULFAMATE; 4 SULFAMOYLOXY 4' HYDROXYDIPHENYLMETHANE; 4' HYDROXY (1,3 ADAMANTANEDIYL)DIPHENYL 4 O SULFAMATE; 4' HYDROXYBENZOPHENONE 4 O SULFAMATE; 4' HYDROXYTHIODIPHENYL 4 O SULFAMATE; 4,4' BIS(SULFAMOYLOXYDIPHENYLMETHANE); ANTHRAQUINONE 2,6 O,O BIS SULFAMATE; BENZO[B]NAPHTHO[2,3 D ]FURAN 6,11 3 O SULFAMATE; BENZOPHENONE; BENZOPHENONE 3,3' O,O BIS SULFAMATE; BENZOPHENONE 4 O SULFAMATE; BENZOPHENONE 4,4' O,O BIS SULFAMATE; CHALCONE 4 O SULFAMATE; CHALCONE 4' O SULFAMATE; DIBENZOFURAN 2 O SULFAMATE; ENZYME INHIBITOR; STERYL SULFATASE; SULFONYLDIPHENYL 4,4' O,O BIS SULFAMATE; THIODIPHENYL 4,4' O,O BIS SULFAMATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROSOME; NONHUMAN; RAT; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOPHENONES; CELL LINE, TUMOR; ENZYME INHIBITORS; FEMALE; HUMANS; LIVER; RATS; RATS, WISTAR; STERYL-SULFATASE;

MINK CELL FOCUS-FORMING VIRUS; RODENTIA;

EID: 2142760056     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.02.040     Document Type: Article

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