6-[2-(Adamantylidene)-hydroxybenzoxazole]-O-sulfamate, a steroid sulfatase inhibitor for the treatment of androgen- and estrogen-dependent diseases

Journal of Steroid Biochemistry and Molecular Biology

Volumn 92, Issue 1-2, 2004, Pages 29-37

  Billich, Andreas ^a   Meingassner, Josef G ^a   Nussbaumer, Peter ^a   Desrayaud, Sandrine ^b   Lam, Charles ^a   Winiski, Anthony ^a   Schreiner, Erwin ^a  

^a Novartis Institutes for Biomed Res   (Austria)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Acne; Breast cancer; In vivo inhibition; Steroid sulfatase; Sulfamate

Indexed keywords

6 [2 (ADAMANTYLIDENE)HYDROXYBENZOXAZOLE] O SULFAMATE; ENZYME INHIBITOR; STERYL SULFATASE; STERYL SULFATASE INHIBITOR; UNCLASSIFIED DRUG;

ACNE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG PENETRATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; IC 50; ICHTHYOSIS; MALE; NONHUMAN; RAT; SEBUM SECRETION; SINGLE DRUG DOSE; SKIN PENETRATION; STRATUM CORNEUM; TISSUE HOMOGENATE;

ABSORPTION; ACNE VULGARIS; ADAMANTANE; ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; AGED; ANDROGENS; ANIMALS; CELL LINE; DRUG STABILITY; ENZYME INHIBITORS; ESTROGENS; FEMALE; HUMANS; MALE; MICE; MIDDLE AGED; NEOPLASMS, HORMONE-DEPENDENT; RATS; RATS, WISTAR; SKIN; STERYL-SULFATASE; SWINE;

EID: 8444227178     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2004.06.004     Document Type: Article

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