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Volumn 111, Issue 28, 2007, Pages 8335-8341

Rational design of hetero-ring-expanded guanine analogs with enhanced properties for modified DNA building blocks

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; DENSITY FUNCTIONAL THEORY; DERIVATIVES; GENETIC ENGINEERING;

EID: 34547520602     PISSN: 15206106     EISSN: None     Source Type: Journal    
DOI: 10.1021/jp073592h     Document Type: Article
Times cited : (33)

References (60)
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    • Other strategies include (i) exploring covalently linked base pairs; (ii) exploring compounds without hydrogen-bonding functionalities, which might nevertheless act as substrates for DNA polymerases and self-pair in DNA; and the mixed strategies that exploit several of these key features
    • Other strategies include (i) exploring covalently linked base pairs; (ii) exploring compounds without hydrogen-bonding functionalities, which might nevertheless act as substrates for DNA polymerases and self-pair in DNA; and the mixed strategies that exploit several of these key features.
  • 31
    • 84906401224 scopus 로고    scopus 로고
    • Frisch, M. J, Trucks, G. W, Schlegel, H. B, Scuseria, G. E, Robb, M. A, Cheeseman, J. R, Montgomery, J. A, Jr, Vreven, T, Kudin, K. N, Burant, J. C, Millam, J. M, Iyengar, S. S, Tomasi, J, Barone, V, Mennucci, B, Cossi, M, Scalmani, G, Rega, N, Petersson, G. A, Nakatsuji, H, Hada, M, Ehara, M, Toyota, M, Fukuda, R, Hasegawa, J, Ishida, M, Nakajima, T, Honda, Y, Kitao, O, Nakai, H, Klene, M, Li, X, Knox, J. E, Hratchian, H. P, Cross, J. B, Adamo, C, Jaramillo, J, Gomperts, R, Stratmann, R. E, Yazyev, O, Austin, A. J, Cammi, R, Pomelli, C, Ochterski, J. W, Ayala, P. Y, Morokuma, K, Voth, G. A, Salvador, P, Dannenberg, J. J, Zakrzewski, V. G, Dapprich, S, Daniels, A. D, Strain, M. C, Farkas, O, Malick, D. K, Rabuck, A. D, Raghavachari, K, Foresman, J. B, Ortiz, J. V, Cui, Q, Baboul, A. G, Clifford, S, Cioslowski, J, Stefanov, B. B, Liu, G, Liashenko, A, Piskorz, P, Komaromi, I, Martin, R. L, Fox, D. J, Keith, T, Al-La
    • Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Montgomery, J. A., Jr.; Vreven, T.; Kudin, K. N.; Burant, J. C.; Millam, J. M.; Iyengar, S. S.; Tomasi, J.; Barone, V.; Mennucci, B.; Cossi, M.; Scalmani, G.; Rega, N.; Petersson, G. A.; Nakatsuji, H.; Hada, M.; Ehara, M.; Toyota, M.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Klene, M.; Li, X.; Knox, J. E.; Hratchian, H. P.; Cross, J. B.; Adamo, C.; Jaramillo, J.; Gomperts, R.; Stratmann, R. E.; Yazyev, O.; Austin, A. J.; Cammi, R.; Pomelli, C.; Ochterski, J. W.; Ayala, P. Y.; Morokuma, K.; Voth, G. A.; Salvador, P.; Dannenberg, J. J.; Zakrzewski, V. G.; Dapprich, S.; Daniels, A. D.; Strain, M. C.; Farkas, O.; Malick, D. K.; Rabuck, A. D.; Raghavachari, K.; Foresman, J. B.; Ortiz, J. V.; Cui, Q.; Baboul, A. G.; Clifford, S.; Cioslowski, J.; Stefanov, B. B.; Liu, G.; Liashenko, A.; Piskorz, P.; Komaromi, I.; Martin, R. L.; Fox, D. J.; Keith, T.; Al-Laham, M. A.; Peng, C. Y.; Nanayakkara, A.; Challacombe, M.; Gill, P. M. W.; Johnson, B.; Chen, W.; Wong, M. W.; Gonzalez, C.; Pople, J. A. Gaussian 03; Gaussian, Inc.: Pittsburgh, PA, 2003.
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    • (a) Ratner, M. Nature 1999, 397, 480-481.
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    • Ratner, M.1
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    • In general, three important factors that are prerequisites for designing real DNA nanowires may be outlined as (i) a highly ordered π-stacking array, ii) low oxidation potential, and (iii) suppressed oxidative degradation. See ref 5 and Baik, M.-H, Silverman, J. S, Yang, I. V, Ropp, P. A, Szalai, V. A, Yang, W. T, Thorp, H. H. J. Phys. Chem. B 2001, 105, 6437-6444
    • In general, three important factors that are prerequisites for designing real DNA nanowires may be outlined as (i) a highly ordered π-stacking array, (ii) low oxidation potential, and (iii) suppressed oxidative degradation. See ref 5 and Baik, M.-H.; Silverman, J. S.; Yang, I. V.; Ropp, P. A.; Szalai, V. A.; Yang, W. T.; Thorp, H. H. J. Phys. Chem. B 2001, 105, 6437-6444.
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    • 8 however, the fluorescence mechanism may be different. The exploration of the detailed fluorescence mechanism is still underway.
    • 8 however, the fluorescence mechanism may be different. The exploration of the detailed fluorescence mechanism is still underway.
  • 60
    • 84906401225 scopus 로고    scopus 로고
    • 52, their major grooves are reduced, so quadruplex formation or protein interactions may, in fact, be less favored. However, their minor grooves are enlarged, favoring the interaction of helices with proteins. This is a qualitative prediction, and the details should be explored by combining the actual amino acids, peptides, or proteins. We plan to examine the details of all these bindings, including quadruplex formation, protein interactions, and others.
    • 52, their major grooves are reduced, so quadruplex formation or protein interactions may, in fact, be less favored. However, their minor grooves are enlarged, favoring the interaction of helices with proteins. This is a qualitative prediction, and the details should be explored by combining the actual amino acids, peptides, or proteins. We plan to examine the details of all these bindings, including quadruplex formation, protein interactions, and others.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.