Responses to acute exercise in type 2 diabetes, with an emphasis on metabolism and interaction with oral hypoglycemic agents and food intake

Applied Physiology, Nutrition and Metabolism

Volumn 32, Issue 3, 2007, Pages 567-575

  Galbo, Henrik ^a   Tobin, Lillan ^a   Van Loon, Luc J C ^b  

^a BISPEBJERG HOSPITAL   (Denmark)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Clearance; Diet; Exertion; Hormones; Lipid; Metabolic rate; Metabolism; NIDDM; Non insulin diabetes mellitus; Sulfonylurea

Indexed keywords

ANTIDIABETIC AGENT;

CALORIC INTAKE; CONFERENCE PAPER; DIET; ENDURANCE; ENERGY METABOLISM; EXERCISE; FAT INTAKE; FOOD; GLUCOSE BLOOD LEVEL; HUMAN; LIPID METABOLISM; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY;

BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIET; DIETARY FATS; ENERGY INTAKE; ENERGY METABOLISM; EXERCISE; FOOD; HUMANS; HYPOGLYCEMIC AGENTS; LIPID METABOLISM; PHYSICAL ENDURANCE;

EID: 34547416213     PISSN: 17155312     EISSN: None     Source Type: Journal    
DOI: 10.1139/H07-029     Document Type: Conference Paper

References (53)

1. 2 difference in type 2 diabetes. J. Appl. Physiol. 94: 1033-1038. PMID:12571134.
2. 3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise. Diabetes, 52: 1926-1934. doi:10.2337/diabetes.52.8.1926. PMID:12882907.
3. Blaak, E.E., van Aggel-Leijssen, D.P.C., Wagenmakers, A.J.M., Saris, W.H.M., and van Baak, M.A. 2000. Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise. Diabetes, 49: 2102-2107. doi:10.2337/diabetes.49.12.2102. PMID:11118013.
4. Boon, H., Blaak, E.E., Saris, W.H.M., Keizer, H.A., Wagenmakers, A.J.M., and van Loon, L.J.C. 2007. Substrate source utilization in long-term diagnosed type 2 diabetes patients at rest, during exercise and subsequent recovery. Diabetologia, 50: 103-112. PMID:17131144.
5. Borghouts, L.B., Wagenmakers, A.J., Goyens, P.L., and Keizer, H.A. 2002. Substrate utilization in non-obese type II diabetic patients at rest and during exercise. Clin. Sci. 103: 559-566. PMID:12444908.
6. Boule, N.G., Haddad, E., Kenny, G.P., Wells, G.A., and Sigal, R.J. 2001. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA, 286: 1218-1227. doi:10.1001/jama.286.10.1218. PMID:11559268.
7. Brozinick, J.T., Jr., Etgen, G.J., Jr., Yaspelkis, B.B., III, and Ivy, J.L. 1992. Contraction-activated glucose uptake is normal in insulin-resistant muscle of the obese Zucker rat. J. Appl. Physiol. 73: 382-387. PMID:1506395.
8. Ceriello, A. 2005. Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabetes, 54: 1-7. doi:10.2337/diabetes.54.1.1. PMID:15616004.
9. Christ-Roberts, C.Y., Pratipanawatr, T., Pratipanawatr, W., Berria, R., Belfort, R., and Mandarino, L.J. 2003. Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action. J. Appl. Physiol. 95: 2519-2529. PMID:12909611.
10. Colberg, S.R., Hagberg, J.M., McCole, S.D., Zmuda, J.M., Thompson, P.D., and Kelley, D.E. 1996. Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise. J. Appl. Physiol. 81: 2027-2033. PMID:8941525.
11. Colberg, S.R., Swain, D.P., and Vinik, A.L. 2003. Use of heart rate reserve and rating of perceived exertion to prescribe exercise intensity in diabetic autonomic neuropathy. Diabetes Care, 26: 986-990. doi:10.2337/diacare.26.4.986. PMID:12663561.
12. The Diabetes Control and Complications Trial Research Group. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329: 977-986. doi:10.1056/NEJM199309303291401. PMID:8366922.
13. Dalgaard, M., Thomsen, C., and Hermansen, K. 2004. Effects of one single bout of low-intensity exercise on postprandial lipaemia in type 2 diabetic men. Br. J. Nutr. 92: 469-476. doi:10.1079/BJN20041227. PMID:15469650.
14. Dela, F., Mikines, K.J., Larsen, J.J., and Galbo, H. 1999. Glucose clearance in aged trained skeletal muscle during maximal insulin with superimposed exercise. J. Appl. Physiol. 87: 2059-2067. PMID:10601150.
15. Fang, Z.Y., Sharman, J., Prins, J.B., and Marwick, T.H. 2005. Determinants of exercise capacity in patients with type 2 diabetes. Diabetes Care, 28: 1643-1648. doi:10.2337/diacare.28.7.1643. PMID:15983314.
16. Fragasso, G., Piatti, M.P.M., Monti, L., Palloshi, A., Setola, E., Puccetti, P., et al. 2003. Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy. Am. Heart J. 146: E18. PMID:14597947.
17. Galbo, H. 1983. Hormonal and metabolic adaptation to exercise. Georg Thieme, New York.
18. Galbo, H., and Richter, E.A. 2004. Exercise. In International textbook of diabetes mellitus. 3rd ed. Edited by R.A. DeFronzo, E. Ferrannini, H. Keen, and P. Zimmet. John Wiley & Sons Ltd., England, pp. 771-794.
19. Giacca, A., Groenewoud, Y., Tsui, E., McClean, P., and Zinman, B. 1998. Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. Diabetes, 47: 1763-1770. doi:10.2337/diabetes.47.11.1763. PMID:9792546.
20. Gregg, E.W., Gerzoff, R.B., Caspersen, C.J., Williamson, D.F., and Narayan, K.M. 2003. Relationsship of walking to mortality among US adults with diabetes. Arch. Intern. Med. 163: 1440-1447. doi:10.1001/archinte.163.12. 1440. PMID:12824093.
21. Heine, R.J., Balkau, B., Ceriello, A., Del Prato, S., Horton, E.S., and Taskinen, M.R. 2004. What does postprandial hyperglycaemia mean? Diabet. Med. 21: 208-213. doi:10.1111/j.1464-5491. 2004.01149.x. PMID:15008828.
22. Hu, F.B., Stampfer, M.J., Solomon, C., Liu, S., Colditz, G.A., Speizer, P.E., et al. 2001. Physical activity and risk for cardiovascular events in diabetic women. Ann. Intern. Med. 134: 96-105. PMID:11177312.
23. Jenkins, A.B., Furier, S.M., Bruce, D.G., and Chisholm, D.J. 1988. Regulation of hepatic glucose output during moderate exercise in non-insulin-dependent diabetes. Metabolism, 37: 966-972. doi:10.1016/0026-0495(88)90154-0. PMID:3050368.
24. Kang, J., Kelley, D.E., Robertson, R.J., Goss, F.L., Suminski, R.R., Utter, A.C., et al. 1999. Substrate utilization and glucose turnover during exercise of varying intensities in individuals with NIDDM. Med. Sci. Sports Exerc. 31: 82-89. PMID:9927014.
25. Kelley, D.E., He, J., Menshikova, E.V., and Ritov, V.B. 2002. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes, 51: 2944-2950. doi:10.2337/diabetes.51.10. 2944. PMID:12351431.
26. Kennedy, J.W., Hirshman, M.F., Gervino, E.V., Ocel, J.V., Forse, R.A., Hoenig, S.J., et al. 1999. Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes. Diabetes, 48: 1192-1197. doi:10.2337/diabetes.48.5.1192. PMID:10331428.
27. Kingwell, B.A., Formosa, M., Muhlmann, M., Bradley, S.J., and McConell, G.K. 2002. Nitric oxide synthase inhibition reduces glucose uptake during exercise in individuals with type 2 diabetes more than in control subjects. Diabetes, 51: 2572-2580. doi:10.2337/diabetes.51.8.2572. PMID:12145173.
28. Kingwell, B.A., Formosa, M., Muhlmann, M., Bradley, S.J., and McConell, G.K. 2003. Type 2 diabetic individuals have impaired leg blood flow responses to exercise: role of endothelium-dependent vasodilation. Diabetes Care, 26: 899-904. doi:10.2337/diacare.26.3.899. PMID:12610056.
29. Kjaer, M., Hollenbeck, C., Frey-Hewitt, B., Galbo, H., Haskell, W., and Reaven, G. 1990. Glucoregulation and hormonal responses to maximal exercise in non-insulin-dependent diabetes. J. Appl. Physiol. 68: 2067-2074. PMID:2193907.
30. Krotkiewski, M., and Gorski, J. 1986. Effect of muscular exercise on plasma C-peptide and insulin in obese non-diabetics and diabetics, type II. Clin. Physiol. 6: 499-506. PMID:3539463.
31. Larsen, J.J., Dela, F., Kjaer, M., and Galbo, H. 1997. The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients. Diabetologia, 40: 447-453. doi:10.1007/s001250050699. PMID:9112022.
32. Larsen, J.J., Dela, F., Madsbad, S., and Galbo, H. 1999a. The effect of intense exercise on postprandial glucose homeostasis in type II diabetic patients. Diabetologia, 42: 1282-1292. doi:10.1007/ s001250051440. PMID:10550411.
33. Larsen, J.J., Dela, F., Madsbad, S., Vibe-Petersen, J., and Galbo, H. 1999b. Interaction of sulfonylureas and exercise on glucose homeostasis in type 2 diabetic patients. Diabetes Care, 22: 1647-1654. doi:10.2337/diacare.22.10.1647. PMID:10526729.
34. Lau, A.C., Lo, M.K., Leung, G.T., Choi, P.P., Yam, L.Y., and Wasserman, K. 2004. Altered exercise gas exchange as related to microalbuminuria in type 2 diabetic patients. Chest, 125: 1292-1298. doi:10.1378/chest.125.4.1292. PMID:15078737.
35. LeBrasseur, N.K., and Ruderman, N.B. 2005. Why might thiazolidinediones increase exercise capacity in patients with type 2 diabetes? Diabetes Care, 28: 2975-2977. doi:10.2337/diacare.28.12. 2975. PMID:16306565.
36. MacDonald, A.L., Philip, A., Harrison, M., Bone, A.J., and Watt, P.W. 2006. Monitoring exercise-induced changes in glycemic control in type 2 diabetes. Med. Sci. Sports Exerc. 38: 201-207. doi:10.1249/01.mss. 0000183852.31164.5a. PMID:16531885.
37. Martin, I.K., Katz, A., and Wahren, J. 1995. Splanchnic and muscle metabolism during exercise in NIDDM patients. Am. J. Physiol. 269: E583-E590. PMID:7573437.
38. Massi-Benedetti, M., Herz, M., and Pfeiffer, C. 1996. The effects of acute exercise on metabolic control in type II diabetic patients treated with glimepiride or glibenclamide. Horm. Metab. Res. 28: 451-455. PMID:8911982.
39. McIntyre, E.A., Halse, R., Yeaman, S.J., and Walker, M. 2004. Cultured muscle cells from insulin-resistant type 2 diabetes patients have impaired insulin, but normal 5-amino-4-imidazole-carboxamide riboside-stimulated, glucose uptake. J. Clin. Endocrinol. Metab. 89: 3440-3448. doi:10.1210/jc.2003- 031919. PMID:15240629.
40. Minuk, H.L., Vranic, M., Marliss, E.B., Hanna, A.K., Albisser, A.M., and Zinman, B. 1981. Glucoregulatory and metabolic response to exercise in obese noninsulin-dependent diabetes. Am. J. Physiol. 240: E458-E464. PMID:7015876.
41. Mootha, V.K., Lindgren, C.M., Eriksson, K.F., Subramanian, A., Sihag, S., Lehar, J., et al. 2003. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34: 267-273. doi:10.1038/ng1180. PMID:12808457.
42. Musi, N., Fujii, N., Hirshman, M.F., Ekberg, I., Froberg, S., Ljungqvist, O., et al. 2001. AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes. 50: 921-927. doi:10.2337/diabetes.50. 5.921. PMID:11334434.
43. Patti, M.E., Butte, A.J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., et al. 2003. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. U.S.A. 100: 8466-8471. doi:10.1073/pnas. 1032913100. PMID:12832613.
44. Petrofsky, J.S., and Lee, S. 2006. The impact of rosiglitazone on cardiovascular responses and endurance during isometric exercise in patients with type 2 diabetes. Med. Sci. Monit. 12: CR21-CR26. PMID:16369466.
45. Petrofsky, J.S., Stewart, B., Patterson, C., Cole, M., Al Malty, A., and Lee, S. 2005. Cardiovascular responses and endurance during isometric exercise in patients with type 2 diabetes compared to control subjects. Med. Sci. Monit. 11: CR470-CR477. PMID:16192898.
46. Poirier, P., Mawhinney, S., Grondin, L., Tremblay, A., Broderick, T., Cleroux, J., et al. 2001. Prior meal enhances the plasma glucose lowering effect of exercise in type 2 diabetes. Med. Sci. Sports Exerc. 33: 1259-1264. PMID:11474324.
47. Praet, S.F.E., Manders, R.J.F., Lieverse, A.G., Kuipers, H., Stehouwer, C.D.A., Keizer, H.A., et al. 2006. Influence of acute exercise on hyperglycemia in insulin-treated type 2 diabetes. Med. Sci. Sports Exerc. 38: 2037-2044. PMID:17146308.
48. Regensteiner, J.G., Bauer, T.A., and Reusch, J.E. 2005. Rosiglitazone improves exercise capacity in individuals with type 2 diabetes. Diabetes Care, 28: 2877-2883. doi:10.2337/diacare.28.12. 2877. PMID:16306548.
49. Riddle, M.C., McDaniel, P.A., and Tive, L.A. 1997. Glipizide-GITS does not increase the hypoglycemic effect of mild exercise during fasting in NIDDM. Diabetes Care, 20: 992-994. doi:10.2337/diacare.20.6.992. PMID:9167112.
50. Simonsen, L., Henriksen, O., Enevoldsen, L.H., and Billow, J. 2004. The effect of exercise on regional adipose tissue and sphlachnic lipid metabolism in overweight type 2 diabetic subjects. Diabetologia, 47: 652-659. PMID:15298342.
51. UKPDS. 1998. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet, 352: 837-853. doi:10.1016/S0140-6736(98)07019-6. PMID:9742976.
52. van Loon, L.J.C., Manders, R.J.F., Koopman, R., Kaastra, B., Stegen, J.H.C.H., Gijsen, A.P., et al. 2005. Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients. Diabetologia, 48: 2097-2107. doi:10.1007/s00125-005-1889-x. PMID:16096823.
53. Wei, M., Gibbons, L.W., Kampert, J.B., Nichaman, M.Z., and Blair, S.N. 2000. Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes. Ann. Intern. Med. 132: 605-611. PMID:10766678.