Substrate utilization in non-obese Type II diabetic patients at rest and during exercise

Clinical Science

Volumn 103, Issue 6, 2002, Pages 559-566

  Borghouts, L B ^a   Wagenmakers, A J M ^a   Goyens, P L L ^a   Keizer, Hans A ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Free fatty acids; Glucose turnover; Muscle glycogen; Muscle triacylglycerols; Stable isotopes; Type II diabetes

Indexed keywords

ACETIC ACID; FATTY ACID; GLUCOSE; GLYCOGEN; PALMITIC ACID; TRIACYLGLYCEROL;

ADULT; ARTICLE; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; EXERCISE; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; GLYCOGEN METABOLISM; HUMAN; MALE; MUSCLE METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REST; SKELETAL MUSCLE;

EID: 0036911624     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs1030559     Document Type: Article

References (22)

1. Blaak, E. E., Wagenmakers, A. J., Glatz, J. F., Wolffenbuttel, B. H., Kemerink, G. J., Langenberg, C. J., Heidendal, G. A. and Saris, W. H. (2000) Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle. Am. J. Physiol. Endocrinol. Metab. 279, E146-E154
2. Kelley, D. E. and Simoneau, J. A. (1994) Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. J. Clin. Invest. 94, 2349-2356
3. Blaak, E. E., van Aggel-Leijssen, D. P., Wagenmakers, A. J., Saris, W. H. and van Baak, M. A. (2000) Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise. Diabetes 49, 2102-2107
4. Porte, D. and Sherwin, R. S. (1998) Ellenberg and Rifkin's Diabetes Mellitus: Theory and Practice, McGraw-Hill, Seattle
5. Schneider, S. H., Khachadurian, A. K., Amorosa, L. F., Gavras, H., Fineberg, S. E. and Ruderman, N. B. (1987) Abnormal glucoregulation during exercise in type II (non-insulin-dependent) diabetes. Metabolism 36, 1161-1166
6. Martin, I. K., Katz, A. and Wahren, J. (1995) Splanchnic and muscle metabolism during exercise in NIDDM patients. Am. J. Physiol. 269, E583-E590
7. Minuk, H. L., Vranic, M., Marliss, E. B., Hanna, A. K., Albisser, A. M. and Zinman, B. (1981) Glucoregulatory and metabolic response to exercise in obese non-insulin-dependent diabetes. Am. J. Physiol. 240, E458-E464
8. Colberg, S. R., Hagberg, J. M., McCole, S. D., Zmuda, J. M., Thompson, P. D. and Kelley, D. E. (1996) Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise. J. Appl. Physiol. 81, 2027-2033
9. Seidell, J. C., Verschuren, W. M. and Kromhout, D. (1995) Prevalence and trends of obesity in The Netherlands 1987-1991. Int. J. Obes. Relat. Metab. Disord. 19, 924-927
10. Durnin, J. V. and Womersley, J. (1974) Body fat assessed from total body density and its estimation from skinfold thickness: Measurements on 481 men and women aged from 16 to 72 years. Br. J. Nutr. 32, 77-97
11. Sidossis, L. S., Coggan, A. R., Gastaldelli, A. and Wolfe, R. R. (1995) A new correction factor for use in tracer estimations of plasma fatty acid oxidation. Am. J. Physiol. 269, E649-E656
12. Sidossis, L. S., Coggan, A. R., Gastaldelli, A. and Wolfe, R. R. (1995) Pathway of free fatty acid oxidation in human subjects. Implications for tracer studies. J. Clin. Invest. 95, 278-284
13. 13C]palmitate oxidation rates in humans. J. Physiol. (London) 513, 215-223
14. Gutmann, I. and Wahlefeld, A. W. (1974) L-(+)-Lactate, determination with lactate dehydrogenase and NAD. In Methods in Enzymatic Analysis (Bergmeyer, H. U., ed.), pp. 1464-1468, Academic Press, New York
15. Andersen, L., Dinesen, B., Jorgensen, P. N., Poulsen, F. and Roder, M. E. (1993) Enzyme immunoassay for intact human insulin in serum or plasma. Clin. Chem. 39, 578-582
16. Peronnet, F. and Massicotte, D. (1991) Table of nonprotein respiratory quotient: An update. Can. J. Sport. Sci. 16, 23-29
17. Van der Vusse, G. J. and Reneman, R. S. (1996) Lipid metabolism in muscle. In Exercise: Regulation and Integration of Multiple Systems, vol. 12, (Rowell, L. B. and Shepherd, J. T., eds), pp. 953-994, Oxford University Press, Oxford
18. Steele, R. (1959) Influences of glucose loading and of injected insulin on hepatic glucose output. Ann. NY. Acad. Sci. 82, 420-430
19. Wolfe, R. R. (1992) Radioactive and stable isotope tracers. In Biomedicine: Principles and Practice of Kinetic Analysis, Wiley-Liss, New York
20. Jeukendrup, A. E., Raben, A., Gijsen, A., Stegen, J. H., Brouns, F., Saris, W. H. and Wagenmakers, A. J. (1999) Glucose kinetics during prolonged exercise in highly trained human subjects: Effect of glucose ingestion. J. Physiol. (London) 515, 579-589
21. Regensteiner, J. G., Sippel, J., McFarling, E. T., Wolfel, E. E. and Hiatt, W. R. (1995) Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise. Med. Sci. Sports Exerc. 27, 875-881
22. Romijn, J. A., Coyle, E. F., Sidossis, L. S., Gastaldelli, A., Horowitz, J. F., Endert, E. and Wolfe, R. R. (1993) Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am. J. Physiol. 265, E380-E391