Specific reduction of hepatic glucose 6-phosphate transporter-1 ameliorates diabetes while avoiding complications of glycogen storage disease

Journal of Biological Chemistry

Volumn 282, Issue 26, 2007, Pages 19113-19121

  Sloop, Kyle W ^a   Showalter, Aaron D ^a   Cox, Amy L ^a   Cao, Julia X C ^a   Siesky, Angela M ^a   Hong, Yan Zhang ^a   Irizarry, Armando R ^a   Murray, Susan F ^b   Booten, Sheri L ^b   Finger, Eleftheria A ^b   McKay, Robert A ^b   Monia, Brett P ^b   Bhanot, Sanjay ^b   Michael, M Dodson ^a  

^a ELI LILLY AND COMPANY   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDES (ASO); GLYCOGEN STORAGE DISEASES; PHOSPHATASE ACTIVITY;

GENE EXPRESSION; GLUCOSE; GLYCOLS; MEDICAL PROBLEMS; RATS;

ENZYME ACTIVITY;

ALANINE AMINOTRANSFERASE; ANTISENSE OLIGONUCLEOTIDE; ASPARTATE AMINOTRANSFERASE; CARBOHYDRATE; ENZYME INHIBITOR; GLUCAGON; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE; GLUCOSE 6 PHOSPHATE TRANSPORTER 1; GLYCOGEN; INSULIN; LACTIC ACID; LIPID; LIVER ENZYME; PHOSPHOROTHIOIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; URIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARBOHYDRATE METABOLISM; CHEMICAL MODIFICATION; CONTROLLED STUDY; DIET RESTRICTION; DRUG SPECIFICITY; ENZYME ACTIVITY; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; GLYCOGEN STORAGE DISEASE; HYPERLIPIDEMIA; HYPOGLYCEMIA; KIDNEY; KNOCKOUT MOUSE; LACTATE BLOOD LEVEL; LIPID METABOLISM; MALE; MOUSE; NEUTROPENIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROVOCATION TEST; REDUCTION KINETICS; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ACIDOSIS, LACTIC; ANIMALS; ANTIPORTERS; BLOOD GLUCOSE; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; GLUCAGON; GLUCOSE-6-PHOSPHATASE; GLYCOGEN; GLYCOGEN STORAGE DISEASE; HYPERLIPIDEMIAS; HYPERURICEMIA; HYPOGLYCEMIA; KIDNEY; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; MONOSACCHARIDE TRANSPORT PROTEINS; OLIGORIBONUCLEOTIDES, ANTISENSE; RNA, MESSENGER;

ANIMALIA; MUS;

EID: 34547098866     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610759200     Document Type: Article

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