Pig islet xenografts are susceptible to 'anti-pig' but not Galα(1,3)Gal antibody plus complement in Gal o/o mice

Journal of Immunology

Volumn 161, Issue 10, 1998, Pages 5116-5119

  McKenzie, Ian F C ^a   Koulmanda, Maria ^b   Mandel, Tom E ^b   Sandrin, Mauro S ^a  

^a AUSTIN RESEARCH INSTITUTE   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTOSYLTRANSFERASE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; GENE EXPRESSION REGULATION; GRAFT REJECTION; IMMUNOPATHOGENESIS; MOUSE; NONHUMAN; PANCREAS BLOOD FLOW; PANCREAS ISLET TRANSPLANTATION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; SWINE; XENOTRANSPLANTATION;

EID: 0032533468     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Sandrin, M. S., and I. F. C. McKenzie. 1994. Galα(1,3)Gal, the major xenoantigen(s) recognized in pigs by human natural antibodies. Immunol. Rev. 141:169.
2. McKenzie, I. F. C., M. Koulmanda, T. E. Mandel, P.-X. Xing, and M. S. Sandrin. 1995. Pig-to-human xenotransplantation: the expression of Galα(1,3)Gal epitopes on pig islet cells. Xenotransplantation 2:1.
3. Koulmanda, M., I. F. C. McKenzie, M. S. Sandrin, and T. E. Mandel. 1995. Fetal pig islet xenografts in NOD/Lt mice: the effects of peritransplant anti-CD4 monoclonal antibody and graft immunomodulation on graft survival and lack of expression of Galα(1,3)Gal on endocrine cells. Xenotransplantation 2:295.
4. McKenzie, I. F. C., M. Koulmanda, T. E. Mandel, and M. S. Sandrin. 1995. The expression of Galα(1,3)Gal by porcine islet cells and its relevance to xenotransplantation. Xenotransplantation 2:139.
5. Groth, C. G., O. Korsgren, A. Tibell, J. Tollemar, E. Moller, J. Bolinder, J. Ostman, F. P. Reinholt, C. Hellerstrom, and A. Andreson. 1994. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 344:1402.
6. Galili, U. A., A. Tibell, B. Samuelson, L. Rydberg, and C. G. Groth. 1995. Increased anti-Gal activity in diabetic patients transplanted with fetal porcine islet cell clusters. Transplantation 59:1549.
7. Thall, A. D., P. Maly, and J. B. Lowe. 1995. Oocyte Galα(1,3)Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse. J. Biol. Chem. 270:21437.
8. Tearle, R. G., M. J. Tange, Z. L. Zannettino, M. Katerelos, T. A. Shinkel, B. J. W. Van Denderen, A. J. Lonie, I. Lyons, M. B. Nottle, T. Cox, et al. 1996. The α-1,3-galactosyltransferase knockout mouse: implications for xenotransplantation. Transplantation 61:13.
9. Winn, H. J., C. A. Baldmus, S. V. Jooste, and P. S. Russell. 1973. Acute destruction by humoral antibody of rat skin grafted to mice: the role of complement and polymorphonuclear granulocytes. J. Exp. Med. 137:893.
10. McKenzie, I. F. C., Y. Q. Li, K. Patton, A. Thall, and M. S. Sandrin. 1998. A murine model for antibody-mediated hyperacute rejection due to anti-Galα(1,3)Gal antibodies in Gal o/o mice. Transplantation, In press.
11. Galili, U., A. E. Rachmilewitz, A. Peleg and I. Flechner. 1984. A unique natural human IgG antibody with anti-α-galactosyl specificity. J. Exp. Med. 160:1519.
12. Vaughan, H. A., K. R. Oldenburg, M. A. Gallop, J. D. Atkin, I. F. C. McKenzie, and M. S. Sandrin. 1995. Recognition of an octapeptide sequence by multiple Galα(1,3)Gal-binding proteins. Xenotransplantation 3:18.
13. Mandel, T. E., and M. Koulmanda. 1994. Islet isolation from the fetal pancreas. In Pancreatic Islet Transplantation, Vol. 1. R. P. Lanza and W. I. Chick, eds. R.G. Landes, Austin, Texas, p. 107-124.
14. Dialynas, D. P., Z. S. Quan, K. A. Wall, A. Pierres, J. Quintans, M. R. Loken, and F. W. Fitch. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J. Immunol. 131:2445.
15. Stenberger, L. A. 1979. Immunocytochemistry, 2nd Ed. John Wiley, New York.
16. Mandel, T. E., and M. Koulmanda. 1993. Effect of immunosuppression with anti-T cell mAbs on the survival of organ-cultured fetal pig xenografts in NOD mice. Transplant. Proc. 25:2928.
17. McKenzie, I. F. C., H. A. Vaughan, and M. S. Sandrin. 1994. How important are anti-Galα(1,3)Gal antibodies in pig-to-human xenotransplants? Xeno 2:107.
18. Sandrin, M. S., H. A. Vaughan, P. L. Dabkowski, and I. F. C. McKenzie. 1993. Anti-pig IgM antibodies in human serum react predominantly with Galα1-3Gal epitopes. Proc. Natl. Acad. Sci. USA 90:11391.
19. Mandel, T. E., M. Koulmanda, E. Cozzi, P. Waterworth, M. Tolan, G. Langford, and D. J. G. White. 1997. Transplantation of normal and DAF-transgenic fetal pig pancreas into cynomologous monkeys. Transplant. Proc. 29:940.
20. + T cells and B cells. Transplantation 61:1678.