Cytotoxicity of diacetoxyscirpenol is associated with apoptosis by activation of caspase-8 and interruption of cell cycle progression by down-regulation of cdk4 and cyclin B1 in human Jurkat T cells

Toxicology and Applied Pharmacology

Volumn 222, Issue 2, 2007, Pages 190-201

  Jun, Do Youn ^a,b   Kim, Jun Seok ^a   Park, Hae Sun ^a   Song, Woo Sun ^a   Bae, Young Seuk ^a   Kim, Young Ho ^a  

^a Kyungpook National University   (South Korea)

^b Kyungpook National University   (South Korea)

Author keywords

Apoptosis; Bid; Caspase cascade; Caspase 8; Cell cycle arrest; Diacetoxyscirpenol; Mitochondrial cytochrome c release; T cell toxicity; Trichothecene mycotoxin

Indexed keywords

BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 9; CYCLIN B1; CYCLIN DEPENDENT KINASE 4; CYCLOSPORIN A; CYTOCHROME C; DIACETOXYSCIRPENOL; DNA FRAGMENT; FAS ANTIBODY; FAS ANTIGEN; FAS LIGAND; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NEUTRALIZING ANTIBODY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL XL; PROTEIN BID;

APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; FUSARIUM; GROWTH RETARDATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NECROSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; CASPASE 8; CELL CYCLE; CELL CYCLE PROTEINS; CELL SURVIVAL; CYCLIN B; CYCLIN-DEPENDENT KINASE 4; CYCLOSPORINE; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROMES C; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME ACTIVATION; HUMANS; JURKAT CELLS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OLIGOPEPTIDES; PHYTOHEMAGGLUTININS; T-LYMPHOCYTES; TRICHOTHECENES;

GIBBERELLA PULICARIS;

EID: 34447624511     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.04.011     Document Type: Article

References (40)

1. Alam M.M., Nagase M., Yoshizawa T., and Sakato N. Thymocyte apoptosis by T-2 toxin in vivo in mice is independent of Fas/Fas ligand system. Biosci. Biotechnol. Biochem. 64 (2000) 210-213
2. Ali N.S., Yamashita A., and Yoshizawa T. Natural co-occurrence of aflatoxins and Fusarium mycotoxins (fumonisins, deoxynivalenol, nivalenol and zearalenone) in corn from Indonesia. Food Addit. Contam. 15 (1998) 377-384
3. Anto R.j., Mukhopadhyay A., Denning K., and Aggarwal B.B. Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 23 (2002) 143-150
4. Bondy G.S., and Pestka J.J. Immunomodulation by fungal toxins. J. Toxicol. Environ. Health, Part B. Crit. Rev. 3 (2000) 109-143
5. Broekemeier K.M., Dempsey M.E., and Pfeiffer D.R. Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria. J. Biol. Chem. 264 (1989) 7826-7830
6. Cole R.J., and Cox R.H. Handbook of Toxic Fungal Metabolites (1981), Academic Press, New York
7. Desagher S., Osen-Sand A., Nichols A., Eskes R., Montessuit S., Lauper S., Maundrell K., Antonsson B., and Martinou J.C. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J. Cell Biol. 144 (1999) 891-901
8. Fornelli F., Minervini F., and Logrieco A. Cytotoxicity of fungal metabolites to lepidopteran (Spodoptera frugiperda) cell line (SF-9). J. Invertebr. Pathol. 85 (2004) 74-79
9. Friesen C., Herr I., Krammer P.H., and Debatin K.M. Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat. Med. 2 (1996) 574-578
10. Guillouf C., Grana X., Selvakumaran M., De Luca A., Giordano A., Hoffman B., and Liebermann D.A. Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest. Blood 85 (1995) 2691-2698
11. Huang D.C.S., Hahne M., Schroeter M., Frei K., Fontana A., Villunger A., and Newton K. Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L). Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 14871-14876
12. Hyer M.L., Voelkel-Johnson C., Rubinchik S., Dong J., and Norris J.S. Intracellular Fas ligand expression causes Fas-mediated apoptosis in human prostate cancer cells resistant to monoclonal antibody-induced apoptosis. Mol. Ther. 2 (2000) 348-358
13. Islam Z., Nagase M., Yoshizawa T., Yamauchi K., and Sakato N. T-2 toxin induces thymic apoptosis in vivo in mice. Toxicol. Appl. Pharmacol. 148 (1998) 205-214
14. Jun D.Y., Kim J.S., Park H.S., Han C.R., Fang Z., Woo M.H., Rhee I.K., and Kim Y.H. Apoptogenic activity of auraptene of Zanthoxylum schinifolium toward human acute leukemia Jurkat T cells is associated with ER stress-mediated caspase-8 activation that stimulates mitochondria-dependent or -independent caspase cascade. Carcinogenesis 28 (2007) 10.1093/carcin/bgm028
15. Jun D.Y., Rue S.W., Han K.H., Taub D., Lee Y.S., Bae Y.H., and Kim Y.H. Mechanism underlying cytotoxicity of lysine analog, thialysine, toward human acute leukemia Jurkat T cells. Biochem. Pharmacol. 66 (2003) 2291-2300
16. Kim Y.H., Proust J.T., Buchholz M.J., Chrest F.J., and Nordin A.A. Expression of the murine homologue of the cell cycle control protein p34cdc2 in T lymphocytes. J. Immunol. 149 (1992) 17-23
17. Kluck R.M., Bossy-Wetzel E., Green D.R., and Newmeyer D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275 (1997) 1132-1136
18. Lauraite S., Rio B., Guinard J., and Parent-Massin D. In vitro effects of diacetoxyscirpenol (DAS) on human and rat granulo-monocytic progenitors. Mycopathologia 140 (1997) 59-64
19. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirer G.G., and Earnshaw W.C. Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371 (1994) 346-347
20. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-489
21. Li H., Zhu H., Xu C., and Yuan J. Cleavage of Bid by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
22. Liu B., and Fan Z. The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway. Oncogene 20 (2001) 3726-3734
23. McDonnell M.A., Wang D., Khan S.M., Vander Heiden M.G., and Kelekar A. Caspase-9 is activated in a cytochrome c-independent manner early during TNFα-induced apoptosis in murine cells. Cell Death Differ. 10 (2003) 1005-1015
24. Muller M., Strand S., Hug H., Heinemann E.M., Walczak H., Hofmann W.J., Stremmel W., Krammer P.H., and Galle P.R. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J. Clin. Invest. 99 (1997) 403-413
25. Nagarkatti N., and Davis B.A. Tamoxifen induces apoptosis in Fas+ tumor cells by upregulating the expression of Fas ligand. Cancer Chemother. Phamarcol. 51 (2003) 284-290
26. Nagase M., Alam M.M., Tsushima A., Yoshizawa T., and Sakato N. Apoptosis induction by T-2 toxin: activation of caspase-9, caspase-3, and DFF-40/CAD through cytosolic release of cytochrome c in HL-60 cells. Biosci. Biotechnol. Biochem. 65 (2001) 1741-1747
27. Nasri T., Bosch R.R., Voorde S., and Fink-Gremmels J. Differential induction of apoptosis by type A and B trichothecenes in Jurkat T-lymphocytes. Toxicol. In Vitro 20 (2006) 832-840
28. Rocha O., Ansari K., and Doohan F.M. Effects of trichothecene mycotoxins on eukaryotic cells: a review. Food Addit. Contam. 22 (2005) 369-378
29. Rosenstein Y., Lafarge-Frayssinet C., Lespinats G., Loisillier F., Lafont P., and Frayssinet C. Immunosuppressive activity of Fusarium toxins: effects on antibody synthesis and skin grafts of crude extracts, T2-toxin and diacetoxyscirpenol. Immunology 36 (1979) 111-117
30. Sato N., Ito T., Kumada H., Ueno Y., Asano K., Saito M., Ohtsubo K., Ueno I., and Hatanaka Y. Toxicological approaches to the metabolites of Fusaria. XIII. Hematological changes in mice by a single and repeated administrations of trichothecenes. J. Toxicol. Sci. 3 (1978) 335-356
31. Shifrin V.I., and Anderson P. Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis. J. Biol. Chem. 274 (1999) 13985-13992
32. Slee E.A., Zhu H., Chow S.C., MacFarlane M., Nicholson D.W., and Cohen G.M. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (z-VAD-fmk) inhibits apoptosis by blocking the processing CPP32. Biochem. J. 315 (1996) 21-24
33. Takizawa T., Tatematsu C., Ohashi K., and Nakanishi Y. Recruitment of apoptotic cysteine proteases (caspases) in influenza virus-induced cell death. Microbiol. Immunol. 43 (1999) 245-252
34. Taylor M.J., Reddy R.V., and Sharma R.P. Immunotoxicity of repeated low level of exposure to T-2 toxin, a trichthecene mycotoxin, in CD-1 mice. Mycotoxin Res. 1 (1985) 57-64
35. Ueno Y. Toxicological features of T-2 toxin and related trichothecenes. Fundam. Appl. Toxicol. 4 (1984) S124-S132
36. Ueno Y. The toxicology of mycotoxins. Crit. Rev. Toxicol. 14 (1985) 99-132
37. Yang J., Liu X., Bhalla K., Kim C.N., Ibrado A.M., Cai J., Peng T.I., Jones D.P., and Wang X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275 (1997) 1129-1132
38. Yarom R., Sherman Y., More R., Ginsburg I., Borinski R., and Yagen B. T-2 toxin effect on bacterial infection and leukocyte functions. Toxicol. Appl. Pharmacol. 75 (1984) 60-68
39. Yim D., Singh R.P., Agarwal C., Lee S., Chi H., and Agarwal R. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res. 65 (2005) 1035-1044
40. Yu Z., Li W., and Liu F. Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett. 215 (2004) 159-166