Hypoxic stimulus alters hypothalamic AMP-activated protein kinase phosphorylation concomitant to hypophagia

Journal of Applied Physiology

Volumn 102, Issue 6, 2007, Pages 2135-2141

  Simler, N ^a   Malgoyre, A ^a   Koulmann, N ^a   Alonso, A ^a   Peinnequin, A ^a   Bigard, A X ^a  

^a CENTRE DE RECHERCHES   (France)

Author keywords

Acetyl coenzyme A carboxylase; Altitude; Insulin; Leptin; Neuropeptide Y

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; MESSENGER RNA; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FOOD INTAKE; HYPOBARISM; HYPOPHAGIA; HYPOTHALAMUS; HYPOXIA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUTRIENT; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; RAT STRAIN;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANOXIA; EATING DISORDERS; FEEDING BEHAVIOR; HYPOTHALAMUS; MALE; MULTIENZYME COMPLEXES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR;

EID: 34447558469     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01150.2006     Document Type: Article

References (43)

1. Ahima RS, Flier JS. Leptin. Annu Rev Physiol 62: 413-437, 2000.
2. Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJ. AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 279: 12005-12008, 2004.
3. Baum D, Porte D Jr. Stress hyperglycemia and the adrenergic regulation of pancreatic hormones in hypoxia. Metabolism 29: 1176-1185, 1980.
4. Bi S, Robinson BM, Moran TH. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am J Physiol Regul Integr Comp Physiol 285: R1030-R1036, 2003.
5. Bigard AX, Douce P, Merino D, Lienhard F, Guezennec CY. Changes in dietary protein intake fail to prevent decrease in muscle growth induced by severe hypoxia in rats. J Appl Physiol 80: 208-215, 1996.
6. Boyer SJ, Blume FD. Weight loss and changes in body composition at high altitude. J Appl Physiol 57: 1580-1585, 1985.
7. Carling D. The AMP-activated protein kinase cascade - a unifying system for energy control. Trends Biochem Sci 29: 18-24, 2004.
8. Grosfeld A, André J, Haugel-de Mouzon S, Berra E, Pouysségur J, Guerre-Millo M. Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J Biol Chem 45: 42953-42957, 2002.
9. Grosfeld A, Zilberfarb V, Turban S, André J, Guerre-Millo M, Issad T. Hypoxia increases leptin expression in human PAZ6 adipose cells. Diabetologia 45: 527-530, 2002.
10. Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase - development of the energy sensor concept. J Physiol 574: 7-15, 2006.
11. Hawley SA, Davison M, Woods A, Davies SP, Beri KK, Carling D, Hardie DG. Characterization of the AMP-activated protein kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem 271: 27879-27887, 1996.
12. Jones RM, Terhaard C, Zullo J, Tenney SM. Mechanism of reduced water intake in rats at high altitude. Am J Physiol Regul Integr Comp Physiol 240: R187-R191, 1981.
13. Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metabolism 1: 15-25, 2005.
14. Kayser B. Nutrition and high altitude exposure. Int J Sports Med 13: S129-S132, 1992.
15. Kim EK, Miller I, Aja S, Landree LE, Pinn M, McFadden J, Kuhajda FP, Moran TH, Ronnett GV. C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. J Biol Chem 279: 19970-19976, 2004.
16. Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Youn JH, Lee HK, Lee KU. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 10: 727-733, 2004.
17. Koritzinsky M, Seigneuric R, Magagnin MG, van den Beucken T, Lambin P, Wouters BG. The hypoxic proteome is influenced by gene-specific changes in mRNA translation. Radiother Oncol 76: 177-186, 2005.
18. Lee K, Li B, Xi X, Suh Y, Martin RJ. Role of neuronal energy status in the regulation of adenosine 5′-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. Endocrinology 146: 3-10, 2005.
19. Levin BE, Dunn-Meynell AA, Routh VH. Brain glucose sensing and body energy homeostasis: role in obesity and diabetes. Am J Physiol Regul Integr Comp Physiol 276: R1223-R1231, 1999.
20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2[-ΔΔC(T)] method. Methods 25: 402-408, 2001.
21. Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB. Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem 281: 18933-18941, 2006.
22. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum M, Stuck B, Kahn BB. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569-574, 2004.
23. Munday MR. Regulation of mammalian acetyl-CoA carboxylase. Biochem Soc Trans 30: 1059-1064, 2002.
24. Namkoong C, Kim MS, Jang PG, Han SM, Park HS, Koh EH, Lee WJ, Kim JY, Park IS, Lee KU. Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats. Diabetes 54: 63-68, 2005.
25. Obici S, Rossetti L. Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinology 144: 5172-5178, 2003.
26. Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51: 271-275, 2002.
27. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates (2nd ed.). San Diego, CA: Academic, 1986.
28. Peinnequin A, Mouret C, Birot O, Alonso A, Mathieu J, Clarencon D, Agay D, Chancerelle Y, Multon E. Rat pro-inflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green. BMC Immunol 5: 3-8, 2004.
29. Pison CM, Chauvin C, Perrault H, Schwebel C, Lafond JL, Boujet C, Leverve XM. In vivo hypoxic exposure impairs metabolic adaptations to a 48 hour fast in rats. Eur Respir J 12: 658-665, 1998.
30. Purshottam T, Kaveeshwar U, Brahmachari HD. Changes in tissue glycogen stores of rats under acute and chronic hypoxia and their relationship to hypoxia tolerance. Aviat Space Environ Med 48: 351-355, 1977.
31. Ramamurthy S, Ronnett GV. Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain. J Physiol 574: 85-93, 2006.
32. Roman EA, Cesquini M, Stoppa GR, Carvalheira JB, Torsoni MA, Velloso LA. Activation of AMPK in rat hypothalamus participates in cold-induced resistance to nutrient-dependent anorexigenic signals. J Physiol 568: 993-1001, 2005.
33. Rose MS, Houston CS, Fulco CS, Coates G, Sutton JR, Cymerman A. Operation Everest II: nutrition and body composition. J Appl Physiol 65: 2545-2551, 1988.
34. Sahu A, Kalra PS, Kalra SP. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 9: 83-86, 1988.
35. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 404: 661-671, 2000.
36. Simler N, Grosfeld A, Peinnequin A, Guerre-Millo M, Bigard AX. Leptin receptor deficient obese Zucker rats reduce their food intake in response to hypobaric hypoxia. Am J Physiol Endocrinol Metab 290: E591-E597, 2006.
37. Singh SB, Sharma A, Sharma KM, Selvamurthy W. Effect of high altitude hypoxia on feeding responses and hedonic matrix in rats. J Appl Physiol 80: 1133-1137, 1996.
38. Steinberg CR, Watt MJ, Fam BC, Proietto J, Andrikopoulos S, Allen AM, Febbraio MA, Kemp BE. Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin resistant obese mice. Endocrinology 147: 3906-3914, 2006.
39. Westerterp-Plantenga MS, Westerterp KR, Rubbens M, Verwegen CRT, Richalet JP, Gardette B. Appetite at "high altitude" [Operation Everest III (Comex-'97)]: a simulated ascent of Mount Everest. J Appl Physiol 87: 391-399, 1999.
40. Westerterp-Plantenga MS. Effects of extreme environments on food intake in human subjects. Proc Nutr Soc 58: 791-798, 1999.
41. Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LGD, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13: 2004-2008, 2003.
42. Woods SC, Seeley RJ, Porte D Jr, Schwartz MW. Signals that regulate food intake and energy homeostasis. Science 280: 1378-1380, 1998.
43. Xue B, Kahn BB. AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol 574: 73-83, 2006.