Activation of AMPK in rat hypothalamus participates in cold-induced resistance to nutrient-dependent anorexigenic signals

Journal of Physiology

Volumn 568, Issue 3, 2005, Pages 993-1001

  Roman, Erika A ^a   Cesquini, Maristela ^a   Stoppa, Graziela R ^a   Carvalheira, José B ^a   Torsoni, Márcio A ^a,b   Velloso, Lício A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b Universidade Braz Cubas   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; INSULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLD EXPOSURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME MECHANISM; FEEDING; FEEDING BEHAVIOR; HYPOTHALAMUS; IMMUNOBLOTTING; INSULIN RESISTANCE; MALE; MOLECULAR INTERACTION; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; COLD TOLERANCE; ENZYME INHIBITION; FOOD INTAKE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANOREXIA; COLD; ENZYME ACTIVATION; FEEDING BEHAVIOR; HYPOTHALAMUS; IMMUNITY, NATURAL; INSULIN RESISTANCE; MALE; MULTIENZYME COMPLEXES; NUTRITION PHYSIOLOGY; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 27844509555     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.095687     Document Type: Article

References (21)

1. Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D & Small CJ (2004). AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 279, 12005-12008.
2. Blundell JE & MacDiarmid JI (1997). Fat as a risk factor for overconsumption: satiation, satiety, and patterns of eating. J Am Diet Assoc 97, S63-S69.
3. Bray GA (2000). Afferent signals regulating food intake. Proc Nutr Soc 59, 373-384.
4. Calegari VC, Bezerra RM, Torsoni MA, Torsoni AS, Franchini KG, Saad MJ & Velloso LA (2003). Suppressor of cytokine signaling 3 is induced by angiotensin II in heart and isolated cardiomyocytes, and participates in desensitization. Endocrinology 144, 4586-4596.
5. Flier JS (2004). Obesity wars: molecular progress confronts an expanding epidemic. Cell 116, 337-350.
6. Friedman JM (2000). Obesity in the new millennium. Nature 404, 632-634.
7. Gasparetti AL, De Souza CT, Pereira-Da-Silva M, Oliveira RL, Saad MJ, Carneiro EM & Velloso LA (2003). Cold exposure induces tissue-specific modulation of the insulin-signalling pathway in Rattus norvegicus. J Physiol 552, 149-162.
8. Hardie DG, Scott JW, Pan DA & Hudson ER (2003). Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 546, 113-120.
9. Jequier E (2002). Pathways to obesity. Int J Obes Relat Metab Disord 26 (Suppl. 2), S12-S17.
10. Kopelman PG (2000). Obesity as a medical problem. Nature 404, 635-643.
11. Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K & Dyck JR (2003). Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J Biol Chem 278, 39422-39427.
12. Michelotto JB, Carvalheira JB, Saad MJ & Gontijo JA (2002). Effects of intracerebroventricular insulin microinjection on renal sodium handling in kidney-denervated rats. Brain Res Bull 57, 613-618.
13. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ, Stuck BJ & Kahn BB (2004). AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428, 569-574.
14. Pereira-Da-Silva M, Torsoni MA, Nourani HV, Augusto VD, Souza CT, Gasparetti AL, Carvalheira JB, Ventrucci G, Marcondes MC, Cruz-Neto AP, Saad MJ, Boschero AC, Carneiro EM & Velloso LA (2003). Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Endocrinology 144, 4831-4840.
15. Roberts SB (2000). High-glycemic index foods, hunger, and obesity: is there a connection? Nutr Rev 58, 163-169.
16. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ & Baskin DG (2000). Central nervous system control of food intake. Nature 404, 661-671.
17. Scott AM, Atwater I & Rojas E (1981). A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans. Diabetologia 21, 470-475.
18. Torsoni MA, Carvalheira JB, Pereira-Da-Silva M, De Carvalho-Filho MA, Saad MJ & Velloso LA (2003). Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. Am J Physiol Endocrinol Metab 285, E216-E223.
19. Trinder P (1969). Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol 22, 158-161.
20. Vallerand AL, Perusse F & Bukowiecki Q (1987). Cold exposure potentiates the effect of insulin on in vivo glucose uptake. Am J Physiol 253, E179-E186.
21. Zabeau L, Lavens D, Peelman F, Eyckerman S, Vandekerckhove J & Tavernier J (2003). The ins and outs of leptin receptor activation. FEBS Lett 546, 45-50.