In vivo hypoxic exposure impairs metabolic adaptations to a 48 hour fast in rats

European Respiratory Journal

Volumn 12, Issue 3, 1998, Pages 658-665

  Pison, C M ^a,b,c   Chauvin, C ^a   Perrault, H ^a   Schwebel, C ^a,b   Lafond, J L ^b   Boujet, C ^b   Leverve, X M ^a,b  

^a UNIV GRENOBLE ALPES   (France)

^b HÔPITAL MICHALLON   (France)

^c GRENOBLE UNIVERSITY HOSPITAL   (France)

Author keywords

Fasting; Gluconeogenesis; Hypoxia; Insulin resistance; Lactate; Phosphoenolpyruvate carboxykinase

Indexed keywords

3 HYDROXYBUTYRIC ACID; CATECHOLAMINE; FATTY ACID; INSULIN; LACTIC ACID; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ADAPTATION; AMINO ACID BLOOD LEVEL; ANIMAL MODEL; ARTICLE; CARBOHYDRATE METABOLISM; CATECHOLAMINE BLOOD LEVEL; CONTROLLED STUDY; DIET RESTRICTION; FATTY ACID BLOOD LEVEL; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; HYPOXIA; INSULIN BLOOD LEVEL; LACTATE BLOOD LEVEL; LIPID METABOLISM; LIVER METABOLISM; MALE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; RAT; WEIGHT REDUCTION;

ADAPTATION, PHYSIOLOGICAL; ANALYSIS OF VARIANCE; ANIMALS; ANOXIA; BASAL METABOLISM; BODY MASS INDEX; DISEASE MODELS, ANIMAL; EPINEPHRINE; FASTING; INSULIN; LIVER GLYCOGEN; MALE; NOREPINEPHRINE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); RATS; RATS, WISTAR; TIME FACTORS; WEIGHT LOSS;

EID: 0031691432     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.98.12030658     Document Type: Article

References (38)

1. West JB, Boyer SJ, Graber DJ, et al. Maximal exercise at extreme altitudes on Mount Everest. J Appl Physiol 1983; 70: 1129-1136.
2. Boyer SJ, Blume D. Weight loss and changes in body composition at high altitude. J Appl Physiol 1984; 57: 1580-1585.
3. Rose MS, Houston CS, Fulco CS, Coates G, Sutton JR, Cymerman A. Operation Everest II: nutrition and body composition. J Appl Physiol 1988; 65: 2545-2551.
4. Kreher P, Kériel C, Leverve X. Action potentials in right and left ventriculs from chronic hypoxic rats: effects of almitrine. Am J Physiol (Heart Circ Physiol 40) 1996; 271: H1856-H1863.
5. Pison CM, Chauvin C, Fontaine E, et al. Mechanism of gluconeogenesis inhibition in rat hepatocytes isolated after in vivo hypoxia. Am J Physiol (Endocrinol Netab 31) 1995; 268: E965-E973.
6. Schols AMWJ, Soeters PB, Saris WHM, Wouters EFM. Energy balance in chronic obstructive pulmonary disease. Am Rev Respir Dis 1991; 143: 1248-1252.
7. Jones DP. Cellular energetics and biochemistry of hypoxia. In: Haddad GG, Lister G, eds. Tissue Oxygen Deprivation. From Molecular to Integrated Function. New York, Marcel Dekker, 1996; pp. 25-50.
8. Hochachka PW. ATP supply and demand: models and insights. In: Haddad GG, Lister G, Eds. Tissue Oxygen Deprivation. From Molecular to Integrated Function. New York, Marcel Dekker, 1996; pp. 51-80.
9. Wilson DO, Rogers RM, Wright EC, Anthonisen NR. Body weight in chronic obstructive pulmonary disease. Am Rev Respir Dis 1989; 139: 1435-1438.
10. Chailleux E, Fauroux B, Binet F, Dautzenberg B, Polu JM. Predictors of survival in patients receiving domiciliary oxygen therapy or mechanical ventilation. A 10-year analysis of ANTADIR observatory. Chest 1996; 109: 741-749.
11. Graydonald K, Gibbons L, Shapiro SH, Macklem PT, Martin JG. Nutritional status and mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996; 153: 961-966.
12. Gold AJ, Johnson TF, Cosiello EC. Effects of altitude stress on mitochondrial function. Am J Physiol 1973; 224: 946-949.
13. Krzywicki HJ, Consolazio CF, Matoush LL, Jonhson HL, Barnhart RA. Body composition changes during exposure to altitude. Fedn Proc 1969; 28: 1190-1194.
14. Butterfield GE, Gates J, Fleming S, Brooks GA, Sutton JR, Reeves JT. Increased energy intake minimizes weight loss in men at high altitude. J Appl Phvsiol 1992; 72: 1741-1748.
15. De Fronzo R, Ferrannini E. Regulation of hepatic glucose metabolism in humans. Diabetes/Metab Rev 1987; 3: 415-459.
16. Gerich J. Control of glycaemia. Baillière's Clin Endocrinol Metab 1993; 7: 551-586.
17. Pilkis SJ, Granner DK. Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 1992; 54: 885-909.
18. Kietzmann T, Schmidt H, Probst I, Jungerman K. Modulation of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures. Evidence for a heme protein as oxygen sensor. FEBS Lett 1992; 311: 251-255.
19. Bergmeyer HU. Methods of Enzymatic Analysis. 3rd Edn. New York, Academic Press, 1974.
20. Da Prada M, Zürcher G. Simultaneous radioenzymatic determination of plasma, tissue adrenaline and dopamine within the fentamole range. Life Sci 1971; 19: 1161-1174.
21. Passon PG, Peuler JD. A simplified radiometric assay for plasma norepinephrine and epinephrine. Anal Biochem 1973; 51: 618-631.
22. Jomain-Baum M, Schramm VL, Hanson RW. Mechanism of 3-mercaptopicolinic acid inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP). J Biol Chem 1976; 251: 37-44.
23. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
24. Feinberg AP, Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 1984; 137: 266-267.
25. Yoo-Warren H, Monahan JE, Short JM. et al. Isolation and characterization of the gene coding for cytosolic phosphoenolpyruvate carboxykinase (GTP) from the rat. Proc Natl Acad Sci USA 1984; 80: 3656-3660.
26. Kayser B. Nutrition and high altitude exposure. Int J Sports Ned 1992; 13: S129-S132.
27. Mortola JP, Matsuoka T, Saiki C, Naso L. Metabolism and ventilation in hypoxic rats: effect of body mass. Respir Physiol 1994; 97: 225-234.
28. Cahill GF. Starvation in man. N Engl J Med 1970; 282: 668-675.
29. Sreja DJ, Steiner G, Marliss EB, Vranic M. Turn-over and recycling of glucose in man during prolonged starvation. Metabolism 1977; 26: 1089-1098.
30. Morrison WL, Gibson JNA, Scrimegeour C, Rennie MJ. Muscle wasting in emphysema. Clin Sci 1988; 75: 415-420.
31. Felig P. The glucose-alanine cycle. Metabolism 1973; 22: 179-207.
32. Gutierrez G, Hurtado FJ, Gutierrez AM, Fernandez H. Net uptake of lactate by rabbit hindlimb during hypoxia. Am Rev Respir Dis 1993; 148: 1204-1209.
33. Weissman C. The metabolic response to stress: an overview and update. Anesthesiology 1990; 73: 308-327.
34. Moldawer LL, Lowry SF. Interactions among pro-inflammatory cytokines and the classical macro-endocrine system in sepsis and inflammation. In: Kinney JM, Tucker HN, eds. Organ Metabolism and Nutrition. Ideas for Future Critical Care. New York, Raven Press, 1994; pp. 119-136.
35. Roberts AC, Reeves JT, Butterfield GE, et al. Altitude and β-blockade augment glucose utilization during submaximal exercise. J Appl Physiol 1996; 80: 605-615.
36. Hempel SL, Monick MM, Hunninghake GW. Effect of hypoxia on release of IL-1 and TNF by human alveolar macrophages. Am J Respir Cell Mol Biol 1996; 14: 170-176.
37. Lemaigre FP, Rousseau GR. Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver. Biochem J 1994; 303: 1-14.
38. Ebert BL, Gleadle JM, O'Rourke JF, Bartlett SM, Poulton J, Ratcliffe PJ. Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoeitin. Biochem J 1996; 313: 809-814.