R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and β-catenin signaling

Journal of Biological Chemistry

Volumn 282, Issue 21, 2007, Pages 15903-15911

  Wei, Qiou ^a,b,d   Yokota, Chika ^a,b   Semenov, Mikhail V ^a,b   Doble, Brad ^c   Woodgett, Jim ^c   He, Xi ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MOUNT SINAI HOSPITAL   (Canada)

^d The Leukemia & Lymphoma Society   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATENIN SIGNALING; GLYCOGEN SYNTHASE; R-SPONDIN SIGNALING; XENOPUS AXIS;

ENZYME INHIBITION; PHOSPHORYLATION; PROTEINS; SIGNAL TRANSDUCTION; VIRUSES;

LIGANDS;

BETA CATENIN; DICKKOPF 1 PROTEIN; FRIZZLED PROTEIN; FRIZZLED PROTEIN 5; LIGAND; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; PROTEIN; R SPONDIN; THROMBOSPONDIN 1; UNCLASSIFIED DRUG; WNT PROTEIN; DISHEVELLED PROTEINS; DKK1 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LRP6 PROTEIN, HUMAN; PHOSPHOPROTEIN; RSPO1 PROTEIN, HUMAN; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; THROMBOSPONDIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL STRAIN COS7; CELL STRAIN HEK293; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; L CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; XENOPUS LAEVIS; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; DRUG ANTAGONISM; DRUG POTENTIATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BETA CATENIN; CERCOPITHECUS AETHIOPS; COS CELLS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LDL-RECEPTOR RELATED PROTEINS; LIGANDS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; THROMBOSPONDINS; WNT PROTEINS; XENOPUS LAEVIS;

EID: 34447526784     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701927200     Document Type: Article

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