In vitro cytotoxicity of (-)-catechin gallate, a minor polyphenol in green tea

Toxicology Letters

Volumn 171, Issue 3, 2007, Pages 171-180

  Babich, H ^a   Zuckerbraun, H L ^a   Weinerman, S M ^a  

^a YESHIVA UNIVERSITY   (United States)

Author keywords

Cancer; Catechin gallate; Catechins; Chemoprevention; Green tea; Polyphenol

Indexed keywords

ACRIDINE ORANGE; CASPASE 3; CATALASE; CATECHIN; CATECHIN GALLATE; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; GLUTATHIONE; HYDROGEN PEROXIDE; IRON; POLYPHENOL DERIVATIVE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; EPITHELIOID CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIPID PEROXIDATION; MOUTH CAVITY; NICK END LABELING; OXIDATIVE STRESS; PRIORITY JOURNAL; SALIVARY GLAND CARCINOMA; SQUAMOUS CELL CARCINOMA; TEA; TONGUE CARCINOMA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CATECHIN; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; ELECTROPHORESIS, AGAR GEL; FLAVONOIDS; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; IRON; LIPID PEROXIDATION; MICROSCOPY, FLUORESCENCE; PHENOLS; STEREOISOMERISM; TEA;

EID: 34447332234     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2007.05.125     Document Type: Article

References (55)

1. Ahmad N., Gupta S., and Mukhtar H. Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells. Arch. Biochem. Biophys. 376 (2000) 338-346
2. Anderson M.E. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113 (1981) 548-555
3. Annabi B., Currie J.C., Moghrabi A., and Beliveau R. Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol ECGg. Leuk. Res. (2006) (PubMed-Epub ahead of print)
4. Babich H., Reisbaum A.G., and Zuckerbraun H.L. In vitro response of human gingival epithelial S-G cells to resveratrol. Toxicol. Lett. 114 (2000) 143-153
5. Babich H., Krupka M.E., Nissim H.A., and Zuckerbraun H.L. Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity. Toxicol. In Vitro 19 (2005) 231-242
6. Babich H., Gold T., and Gold T. Mediation of the in vitro cytotoxicity of green and black tea polyphenols by cobalt chloride. Toxicol. Lett. 155 (2005) 195-205
7. Borenfreund E., Babich H., and Martin-Alguacil N. Rapid chemosensitivity assay with human normal and tumor cells in vitro. In Vitro Cell. Dev. Biol. 26 (1990) 1030-1034
8. Chai C., Long L.H., and Halliwell B. Contribution of hydrogen peroxide to the cytotoxicity of green tea and red wines. Biochem. Biophys. Res. Commun. 304 (2003) 54-650
9. Chen Z.P., Schell J.B., Ho C.T., and Chen K.Y. Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts. Cancer Lett. 129 (1998) 173-179
10. Chen C., Shen G., Hebbar V., Hu R., Owuor E.D., and Kong A.N.-T. Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. Carcinogenesis 24 (2003) 1369-1378
11. Chung F.L., Schwartz J., Herzog C.R., and Yang Y.M. Tea and cancer prevention: studies in animals and humans. J. Nutr. 133 (2003) 3268S-3274S
12. Cooper R., Morre D.J., and Morre D.M. Medicinal benefits of green tea: part I review of noncancer health risks. J. Altern. Complement. Med. 11 (2005) 521-528
13. Crespy V., and Williamson G. A review of the health effects of green tea catechins in in vivo animal models. J. Nutr. 134 (2004) 3431S-3440S
14. Fujiki H., Suganuma M., Imai K., and Nakachi K. Green tea: cancer preventive beverage and/or drug. Cancer Lett. 188 (2002) 9-13
15. Gutteridge J.M.C., and Halliwell B. The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem. Sci. 15 (1990) 129-135
16. Horie N., Hirabayashi N., Takahashi Y., Miyauchi Y., Taguchi H., and Takeishi K. Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells. Biol. Pharm. Bull. 28 (2005) 574-579
17. Huddart R.A., Titley J., Robertson D., Williams G.T., Horwich A., and Cooper C.S. Programmed cell death in response to chemotherapeutic agents in human germ cell tumor lines. Eur. J. Cancer A 31 (1995) 739-746
18. Ishino A., Mita S., Watanabe S., and Sakagami H. Effect of anticancer drugs, metals, and antioxidants on cytotoxic activity of epigallocatechin gallate. Anticancer Res. 19 (1999) 4343-4348
19. Kim R., Emi M., and Tanabe K. Caspase-dependent and -independent cell deathpathways after DNA damage. Oncol. Rpts. 14 (2005) 595-599
20. Kroemer G., and Martin S.J. Caspase-independent cell death. Nat. Med. 11 (2005) 725-730
21. Kuzuhara T., Sei Y., Yamaguchi K., Suganuma M., and Fujiki H. DNA and RNA as new binding targets of green tea catechins. J. Biol. Chem. 281 (2006) 17446-17456
22. Lee M.-J., Wang Z.Y., Li H., Chen L., Sun Y., Gobbo S., Balentine D.A., and Yang C.S. Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol. Biomarkers Prev. 4 (1995) 393-399
23. Lee M.-J., Lambert J.D., Prabhu S., Meng X., Lu H., Maliakal P., Ho C.-T., and Yang C.S. Delivery of tea polyphenols to the oral activity by green tea leaves and black tea extract. Cancer Epidemiol. Biomarkers Prev. 13 (2004) 132-137
24. Li N., Sun Z., Han C., and Chen J. The chemopreventive effects of tea on human oral precancerous mucosa lesions. Proc. Soc. Exp. Biol. Med. 220 (1999) 218-224
25. Long L.H., Clement M.V., and Halliwell B. Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. Biochem. Biophys. Res. Commun. 273 (2000) 50-53
26. Mittel A., Pate M.S., Wylie R.C., Tollefsbol T.O., and Katiyar S.K. EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis. Int. J. Oncol. 24 (2004) 703-710
27. Morre D.J., Morre D.M., Sun H., Cooper R., Chang J., and Janle E.M. Tea catechin synergies in inhibition of cancer cell proliferation and of a cancer specific surface oxidase (ECTO-NOX). Pharmacol. Toxicol. 92 (2003) 234-241
28. Nakagawa H., Wachi M., Woo J.-T., Kato M., Kasai S., Takahashi F., Lee I.-S., and Nagai K. Fenton reaction is primarily involved in a mechanism of (-)-epigallocatechin-3-gallate to induce osteoclastic cell death. Biochem. Biophys. Res. Commun. 202 (2002) 94-101
29. Nakagawa H., Hasumi K., Woo J.T., Nagai K., and Wachi M. Generation of hydrogen peroxide primarily contributes to the induction of Fe (II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate. Carcinogenesis 25 (2004) 1567-1574
30. Nakazato T., Ito k., miyakawa Y., Kinjo K., yamada Y., hozumi N., Ikeda Y., and Kizaki M. Catechin, green tea component, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo. Haematologica 90 (2005) 317-325
31. Oikawa S., Furukawa A., Asada H., Hiraawa K., and Kawanishi S. Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species. Free Rad. Res. 37 (2003) 881-890
32. Ratan R.R., Murphy T.H., and Baraban J.M. Oxidative stress induces apoptosis in embryonic cortical neurons. J. Neurochem. 62 (1994) 376-379
33. Raza H., and John A. Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments. Toxicol. Appl. Pharmacol. 207 (2005) 212-220
34. Sakagami H., Arakawa H., Maeda M., Satoh K., Kadofuku T., Fukuchi K., and Gomi K. Production of hydrogen peroxide and methionine sulfoxide by epigallocatechin gallate and antioxidants. Anticancer Res. 21 (2001) 2633-2642
35. Sartippour M.R., Heber D., Ma J., Li Q., Go V.L., and Nguyen M. Green tea and its catechins inhibit breast cancer xenografts. Nutr. Cancer 40 (2001) 149-156
36. Sartippour M.R., Pietras R., Marquez-Garban D.C., Chen H.-W., Heber D., Henning S.M., Sartippour G., Zhang L., Lu M., Weinberg D., Rao J.Y., and Brooks M.N. The combination of green tea and tamoxifen is effective against breast cancer. Carcinogenesis 27 (2006) 2424-2433
37. Schwartz J.L., Baker V., Larios E., and Chung F.-L. Molecular and cellular effects of green tea on oral cells of smokers: a pilot study. Mol. Nutr. Food Res. 49 (2005) 43-51
38. Seeram N.P., Zhang Y., and Nair M.G. Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. Nutr. Cancer 46 (2003) 101-106
39. Shanafelt T.D., Lee Y.K., Call T.G., Nowakowski D., Dingli D., Zent C.S., and Kay N.E. Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies. Leuk. Res. 30 (2006) 707-712
40. Solovyan V.T. Characterization of apoptotic pathway associated with caspases-independent excision of DNA loop domains. Exp. Cell Res. 313 (2007) 1947-1960
41. Strobel P., Allard C., Perez-Acle T., Calderon R., Aldunate R., and Leighton F. Myricetin, quercetin, and catechin gallate inhibit glucose uptake in isolated rat adipocytes. Biochem. J. 386 (2005) 471-478
42. Suganuma M., Okabe S., Kai Y., Sueoka N., Suoeka E., and Fujiki H. Synergistic effects of (-)-epigallocatechin gallate with (-)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human ling cancer cell line PC-9. Cancer Res. 59 (1999) 44-47
43. Susin S.A., Daugas E., Ravagnan L., Samejima K., Zamzami N., Loeffler M., Constantini P., Ferri K.F., Irinopoulou T., Prevost M.-C., Brothers G., Mak T.W., Penninger J., Earnshaw W.C., and Kroemer G. Two distinct pathways leading to nuclear apoptosis. J. Exp. Med. 192 (2000) 571-579
44. Thangagazham R.L., Singh A.K., Sharma A., Warren J., Gaddipati J.P., and Maheshwari R.K. Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo. Cancer Lett. 245 (2007) 232-342
45. Wan S.B., Chen D., Duo Q.P., and Chan T.H. Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors. Bioorg. Med. Chem. 12 (2004) 3521-3527
46. Weisburg J., Weissman D.R., Sedaghat T., and Babich H. In vitro cytotoxicity of epigallocatechin gallate and tea extracts to cancerous and normal cells from the human oral cavity. Basic Clin. Pharmacol. Toxicol. 95 (2004) 191-200
47. Yamamoto T., Hsu S.D., Lewis J., Wataha J., Dickinson D., Singh B., Bollag W.B., Lockwood P., Ueta E., Osaki T., and Schuster G. Green tea polyphenol causes differential oxidative environments in tumor vs. normal epithelial cells. J. Pharmacol. Exp. Ther. 307 (2003) 230-236
48. Yamamoto T., Lewis J., Wahata J., Dickinson D., Singh B., Bollag W.B., Ueta E., Osaki T., Athar M., Schuster G., and Hsu S. Roles of catalase and hydrogen peroxide in green tea polyphenol-induced chemopreventive effects. J. Pharmacol. Exp. Ther. 308 (2004) 317-323
49. Yang C.S., Chen L., Lee M.J., Balentine D., Kuo M.C., and Schantz S.P. Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers. Cancer Epidemiol. Biomarkers Prev. 7 (1998) 351-354
50. Yang C.S., Lee M.J., and Chen L. Human salivary tea catechin levels and catechin esterase activities: implications in human cancer prevention studies. Cancer Epidemiol. Biomarkers Prev. 8 (1999) 83-89
51. Yang C.S., Lambert J.D., Hou Z., Ju J., Lu G., and Hao X. Molecular target for cancer preventive activity of tea polyphenols. Mol. Carcinog. 45 (2006) 431-535
52. 2 production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction. Carcinogenesis 21 (2004) 2035-2039
53. Zaveri N.T. Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. Life Sci. 78 (2006) 2073-2080
54. Zeeb D.J., Nelson B.C., Albert K., and Dalluge J.J. Separation and identification of twelve catechins in tea using liquid chromatographic/atmospheric pressure chemical ionization-mass spectrometry. Anal. Chem. 72 (2000) 5020-5026
55. Zhang G., Miura Y., and Yagaski K. Induction of apoptosis and cell cycle arrest in cancer cells by in vivo metabolites of teas. Nutr. Cancer 38 (2000) 265-273