Green tea: Cancer preventive beverage and/or drug

Cancer Letters

Volumn 188, Issue 1-2, 2002, Pages 9-13

  Fujiki, Hirota ^a   Suganuma, Masami ^b   Imai, Kazue ^c   Nakachi, Kei ^c  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b SAITAMA CANCER CENTER   (Japan)

^c RADIATION EFFECTS RESEARCH FOUNDATION   (Japan)

Author keywords

( ) Epigallocatechin gallate; Chemoprevention; Lung cancer; Polyphenols; Sulindac

Indexed keywords

ANTINEOPLASTIC AGENT; COMPLEMENTARY DNA; EPIGALLOCATECHIN GALLATE; FLUOROURACIL; GREEN TEA EXTRACT; SULINDAC;

APOPTOSIS; CANCER; CANCER CELL CULTURE; CANCER CONTROL; CANCER INHIBITION; CANCER PATIENT; CANCER PREVENTION; CANCER RISK; CLINICAL TRIAL; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; ESOPHAGUS CARCINOMA; HEARTBURN; HUMAN; INSOMNIA; IRRITABILITY; NAUSEA; NERVOUSNESS; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; SIDE EFFECT;

EID: 0037114363     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00379-8     Document Type: Review

References (18)

1. Yoshizawa S., Horiuchi T., Fujiki H., Yoshida T., Okuda T., Sugimura T. Antitumor promoting activity of (-)-epigallocatechin gallate, the main constituent of 'Tannin' in green tea. Phytother. Res. 1:1987;44-47.
2. Wang Z.Y., Hong J.-Y., Huang M.-T., Reuhl K.R., Conney A.H., Yang C.S. Inhibition of N-nitrosodiethylamine- and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mice by green tea and black tea. Cancer Res. 52:1992;1943-1947.
3. NCI, DCPC, Chemoprevention Branch and Agent Development Committee . Clinical development plan: tea extracts green tea polyphenols epigallocatechin gallate. J. Cell. Biochem. 26S:1996;236-257.
4. Fujiki H. Two stages of cancer prevention with green tea. J. Cancer Res. Clin. Oncol. 125:1999;589-597.
5. 3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. Carcinogenesis. 19:1998;1771-1776.
6. Imai K., Suga K., Nakachi K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev. Med. 26:1997;769-775.
7. Nakachi K., Matsuyama S., Miyake S., Suganuma M., Imai K. Preventive effects of drinking green tea on cancer and cardiovascular disease: epidemiological evidence for multiple targeting prevention. BioFactors. 13:2000;49-54.
8. Pisters K.M.W., Newman R.A., Coldman B., Shin D.M., Khuri F.R., Hong W.K., Glisson B.S., Lee J.S. Phase I trial of oral green tea extract in adult patients with solid tumors. J. Clin. Oncol. 19:2001;1830-1838.
9. Gao Y.T., McLaughlin J.K., Blot W.J., Ji B.T., Dai Q., Fraumeni J.F. Jr. Reduced risk of esophageal cancer associated with green tea consumption. J. Natl Cancer Inst. 86:1994;855-858.
10. Tsubono Y., Nishino Y., Komatsu S., Hsieh C.C., Kanemura S., Tsuji I., Nakatsuka H., Fukao A., Satoh H., Hisamichi S. Green tea and the risk of gastric cancer in Japan. N. Engl. J. Med. 344:2001;632-636.
11. Kono S., Ikeda M., Tokudome S., Kuratsune M. A case-control study of gastric cancer and diet in northern Kyushu, Japan. Jpn. J. Cancer Res. (Gann). 79:1988;1067-1074.
12. Fujiki H., Suganuma M., Okabe S., Sueoka E., Sueoka N., Fujimoto N., Goto Y., Matsuyama S., Imai K., Nakachi K. Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1. Mutat. Res. 480-481:2001;299-304.
13. Suganuma M., Okabe S., Kai Y., Sueoka N., Sueoka E., Fujiki H. Synergistic effects of (-)-epigallocatechin gallate with (-)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9. Cancer Res. 59:1999;44-47.
14. Suganuma M., Ohkura Y., Okabe S., Fujiki H. Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice. J. Cancer Res. Clin. Oncol. 127:2001;69-72.
15. Masuda M., Suzui M., Weinstein I.B. Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Clin. Cancer Res. 7:2001;4220-4229.
16. Okabe S., Fujimoto N., Sueoka N., Suganuma M., Fujiki H. Modulation of gene expression by (-)-epigallocatechin gallate in PC-9 cells using a cDNA expression array. Biol. Pharm. Bull. 24:2001;883-886.
17. Fujiki H., Suganuma M., Kurusu M., Okabe S., Imayoshi Y., Taniguchi S., Yoshida T. New TNF-α releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen. Mutat. Res. 2002;. (in press).
18. Sueoka N., Suganuma M., Sueoka E., Okabe S., Matsuyama S., Imai K., Nakachi K., Fujiki H. A new function of green tea: prevention of lifestyle-related diseases. Park S.C., Hwang E.S., Kim H.-S., Park W.-Y., Healthy aging for functional longevity, molecular and cellular interactions in senescence. Ann. N. Y. Acad. Sci. 928:2001;274-280.