Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-κB signaling

Molecular Cancer Therapeutics

Volumn 6, Issue 7, 2007, Pages 1983-1992

  Curry, Christine L ^a,b   Reed, Laura L ^a   Broude, Eugenia ^c   Golde, Todd E ^d   Miele, Lucio ^a   Foreman, Kimberly E ^a,b  

^a LOYOLA UNIVERSITY HEALTH SYSTEM   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c ORDWAY RESEARCH INSTITUTE   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINO 4 (4 PHENOXYPHENYLETHYLAMINO)QUINAZOLINE; CELL CYCLE PROTEIN; CYCLIN B1; GAMMA SECRETASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LY 411575; NOTCH RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; KAPOSI SARCOMA; MITOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL LINE;

CDC2 PROTEIN KINASE; CELL EXTRACTS; CELL LINE, TUMOR; CYCLIN B; DNA, NEOPLASM; G2 PHASE; GENES, REPORTER; HUMANS; MICRONUCLEUS TESTS; MITOSIS; NF-KAPPA B; PROTEIN TRANSPORT; RECEPTORS, NOTCH; SARCOMA, KAPOSI; SIGNAL TRANSDUCTION;

EID: 34447320201     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-0093     Document Type: Article

References (53)

1. Struhl G, Adachi A. Nuclear access and action of notch in vivo. Cell 1998;93:649-60.
2. Brou C, Logeat F, Gupta N, et al. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell 2000;5:207-16.
3. Mumm JS, Schroeter EH, Saxena MT, et al. A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1. Mol Cell 2000;5:197-206.
4. Kao HY, Ordentlich P, Koyano-Nakagawa N, et al. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev 1998;12:2269-77.
5. Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A 1999;96:23-8.
6. Zhou S, Fujimuro M, Hsieh JJ, et al. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchICto facilitate NotchIC function. Mol Cell Biol 2000;20:2400-10.
7. Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet 2000;26:484-9.
8. Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999;284:770-6.
9. Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 2003;194:237-55.
10. Moynagh PN. The NF-κB pathway. J Cell Sci 2005;118:4589-92.
11. Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA, Hoffman T. T cell leukemia-associated human Notch/translocation-associated Notch homologue has IκB-like activity and physically interacts with nuclear factor-κB proteins in T cells. J Exp Med 1996;183:2025-32.
12. Wang J, Shelly L, Miele L, Boykins R, Norcross MA, Guan E. Human Notch-1 inhibits NF-κB activity in the nucleus through a direct interaction involving a novel domain. J Immunol 2001;167:289-95.
13. Shin HM, Minter LM, Cho OH, et al. Notch1 augments NF-κB activity by facilitating its nuclear retention. EMBO J 2006;25:129-38.
14. Vilimas T, Mascarenhas J, Palomero T, et al. Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia. Nat Med 2007;13:70-7.
15. Cheng P, Zlobin A, Volgina V, et al. Notch-1 regulates NF-κB activity in hemopoietic progenitor cells. J Immunol 2001;167:4458-67.
16. Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004;23:2919-33.
17. Curry CL, Reed LL, Golde TE, Miele L, Nickoloff BJ, Foreman KE. γ-Secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene 2005;24:6333-44.
18. Herndier BG, Werner A, Arnstein P, et al. Characterization of a human Kaposi's sarcoma cell line that induces angiogenic tumors in animals. AIDS 1994;8:575-81.
19. Albini A, Paglieri I, Orengo G, et al. The h-core fragment of human chorionic gonadotrophin inhibits growth of Kaposi's sarcoma-derived cells and a new immortalized Kaposi's sarcoma cell line. AIDS 1997;11:713-21.
20. Lunardi-Iskandar Y, Gill P, Lam VH, et al. Isolation and characterization of an immortal neoplastic cell line (KS Y-1) from AIDS-associated Kaposi's sarcoma. J Natl Cancer Inst 1995;87:974-81.
21. Foreman KE, Friborg J, Kong W, et al. Propagation of a human herpesvirus from AIDS-associated Kaposi's sarcoma. N Engl J Med 1997;336:163-71.
22. Casalone R, Albini A, Righi R, Granata P, Toniolo A. Nonrandom chromosome changes in Kaposi sarcoma: cytogenetic and FISH results in a new cell line (KS-IMM) and literature review. Cancer Genet Cytogenet 2001;124:16-9.
23. Maier MM, Gessler M. Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes. Biochem Biophys Res Commun 2000;275:652-60.
24. Qin JZ, Chaturvedi V, Denning MF, Choubey D, Diaz MO, Nickoloff BJ. Role of NF-κB in the apoptotic-resistant phenotype of keratinocytes. J Biol Chem 1999;274:37957-64.
25. Curry CL, Reed LL, Nickoloff BJ, Miele L, Foreman KE. Notch-independent regulation of Hes-1 expression by c-Jun N-terminal kinase (JNK) signaling in human endothelial cells. Lab Invest 2006;86:842-52.
26. Kinsella TM, Nolan GP. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther 1996;7:1405-13.
27. Swanson PE, Carroll SB, Zhang XF, Mackey MA. Spontaneous premature chromosome condensation, micronucleus formation, and nonapoptotic cell death in heated HeLa S3 cells. Ultrastructural observations. Am J Pathol 1995;146:963-71.
28. Roninson IB, Broude EV, Chang BD. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat 2001;4:303-13.
29. Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G. Cell death by mitotic catastrophe: a molecular definition. Oncogene 2004;23:2825-37.
30. Dalal SN, Schweitzer CM, Gan J, DeCaprio JA. Cytoplasmic localization of human cdc25Cduring interphase requires an intact 14-3-3 binding site. Mol Cell Biol 1999;19:4465-79.
31. Hirao A, Kong YY, Matsuoka S, et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 2000;287:1824-7.
32. Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001;15:2177-96.
33. Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. 14 - 3-3-σ is required to prevent mitotic catastrophe after DNA damage. Nature 1999;401:616-20.
34. Huang TS, Shu CH, Chao Y, Chen SN, Chen LL. Activation of MAD 2 checkprotein and persistence of cyclin B1/CDC 2 activity associate with paclitaxel-induced apoptosis in human nasopharyngeal carcinoma cells. Apoptosis 2000;5:235-41.
35. Courvalin JC, Segil N, Blobel G, Worman HJ. The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase. J Biol Chem 1992;267:19035-8.
36. Nikolakaki E, Meier J, Simos G, Georgatos SD, Giannakouros T. Mitotic phosphorylation of the lamin B receptor by a serine/arginine kinase and p34(cdc2). J Biol Chem 1997;272:6208-13.
37. Eom YW, Kim MA, Park SS, et al. Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype. Oncogene 2005;24:4765-77.
38. Radtke F, Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 2003;3:756-67.
39. Nickoloff BJ, Osborne BA, Miele L. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents. Oncogene 2003;22:6598-608.
40. Leong KG, Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood 2006;107:2223-33.
41. 2 DNA damage checkpoint. Mol Cancer Ther 2003;2:543-8.
42. Heald R, McLoughlin M, McKeon F. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell 1993;74:463-74.
43. Fotedar R, Flatt J, Gupta S, et al. Activation-induced T-cell death is cell cycle dependent and regulated by cyclin B. Mol Cell Biol 1995;15:932-42.
44. Niida H, Tsuge S, Katsuno Y, Konishi A, Takeda N, Nakanishi M. Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe. J Biol Chem 2005;280:39246-52.
45. Park SS, Eom YW, Choi KS. Cdc2 and Cdk2 play critical roles in low dose doxorubicin-induced cell death through mitotic catastrophe but not in high dose doxorubicin-induced apoptosis. Biochem Biophys Res Commun 2005;334:1014-21.
46. Lopez-Schier H, St. Johnston D. Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis. Genes Dev 2001;15:1393-405.
47. Deng WM, Althauser C, Ruohola-Baker H. Notch-Delta signaling induces a transition from mitotic cell cycle to endocycle in Drosophila follicle cells. Development 2001;128:4737-46.
48. Schaeffer V, Althauser C, Shcherbata HR, Deng WM, Ruohola-Baker H. Notch-dependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transition in Drosophila follicle cells. Curr Biol 2004;14:630-6.
49. 1 cell-cycle transitions. Development 2004;131:3169-81.
50. Sun J, Deng WM. Notch-dependent downregulation of the homeo-domain gene cut is required for the mitotic cycle/endocycle switch and cell differentiation in Drosophila follicle cells. Development 2005;132:4299-308.
51. Sarmento LM, Huang H, Limon A, et al. Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation. J Exp Med 2005;202:157-68.
52. Ronchini C, Capobianco AJ. Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol 2001;21:5925-34.
53. Qi R, An H, Yu Y, et al. Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res 2003;63:8323-9.