The β-core fragment of human chorionic gonadotrophin inhibits growth of Kaposi's sarcoma-derived cells and a new immortalized Kaposi's sarcoma cell line

AIDS

Volumn 11, Issue 6, 1997, Pages 713-721

  Albini, Adriana ^a   Paglieri, Isabella ^a   Orengo, Giorgia ^a   Carlone, Sebastiano ^a   Aluigi, Maria Grazia ^a   DeMarchi, Roberto ^a   Matteucci, Cristian ^b   Mantovani, Alberto ^b   Carozzi, Franca ^c   Donini, Silvia ^d   Benelli, Roberto ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d Ist di Ricerca Cesare Serono SpA   (Italy)

Author keywords

Human chorionic gonadotropin; Kaposi's sarcoma; Therapy; core

Indexed keywords

ACRIDINE ORANGE; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN BETA SUBUNIT; ETHIDIUM BROMIDE; SEX HORMONE;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL LINE; CELL NUCLEUS; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; KAPOSI SARCOMA; KARYOTYPE; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; SPINDLE CELL;

EID: 8244221004     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199706000-00003     Document Type: Article

References (42)

1. Lunardi-Iskandai Y, Bryant JI , Zeman RA, et al.: Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone. Nature 1995, 375:64 68.
2. Harris PJ: Treatment of Kaposi's sarcoma and other manifestations of AIDS with human chorionic gonadrotrophin [letter]. Lancet 1995, 346:118 119.
3. Bower M, Fite K, Nelson M, et al.: Human chorionic gonadrotrophin for AIDS-related Kaposi's sarcoma [letter]. Lancet 1995, 346:642 643.
4. von Overbeck J, Perev I, Iten A, Pechere M, Ruffieux P, Hirschel B: Human chorionic gonadrotrophin for AIDS-related Kaposi's sarcoma [letter]. Lancet 1995, 346:642 643.
5. Gill PS, Lunardi-Iskandar Y, Pharm SL, et al.: The effects of preparations of human chorionic gonadrotrophin on AIDS-related Kaposi's sarcoma. N Engl J Med 1996, 335:1261-1269.
6. Braunstien G, Rasor J, Adler D, Danzer H, Wade M: Serum human chorionic gonadotrophin levels throughout normal pregnancy. Am J Obstet Gynecol 1976, 126:678-681.
7. Marshall I, Hammond C, Ross G, Jacobsen A, Rayford P, Odell W: Plasma and urinary chorionic gonadotrophin during early human pregnancy. Obstet Gynecol 1968, 32:760 764.
8. Bagshawe K: Risk and prognostic factors in trophoblastic neoplasia. Cancer 1976, 38:1878 1885.
9. Jacobsen A, Nesland J, Fossa SD, Pelterson FO: Human chorionic gonadotrophin, neuron-specific enolase and deoxyribonucleic acid flow cytometry in patients with high grade bladder cancer. J Urol 1990, 143:706 709.
10. Pierce I, Parsons I : Glycoprotein hormones: structure and function. Annu Rev Biochem 1981, 50:465-495.
11. Schwarz S, Krude H: The human chorionic gonadrotrophin (hCG) receptor: a new class within the family of GTP protein coupled receptors. Epitope mapping of receptor-bound agonistic and antagonistic forms of hCG. Wien Klin Wochenschr 1992, 104:369 390.
12. Gerard C, Gerard NP: The pro-inflammatory seven-transmembrane segment receptors of the leukocyte. Curr Opin Immunol 1994, 6:140-145.
13. de Medeiros SF, Amato I , Matthews CD, Norman RJ: Molecular heterogeneity of the beta-core fragment of human chorionic gonadotrophin. J Endocrinol 1993, 139:519-532.
14. Wehmann R, Nisula B: Characterization of a discrete degradation product of the human chorionic gonadotrophin beta subunit in humans. J Clin Endocrinol Metab 1980, 51:101 105.
15. Fetort G, Stolk J, Nisula B: Renal metabolism of the b-subunit of human choriogonadrotrophin in the rat. Endocrinology 1986, 119:924 931.
16. Krown SI : Kaposi's sarcoma: what's human chorionic gonadrotrophin got to do with it? N Engl J Med 1996, 335:1809 1810.
17. Herndier B, Werner A, Arnstein P, et al.: Characterization fo a human Kaposi's sarcoma cell line that induces angiogenic tumors in animals. AIDS 1994, 8:575 581.
18. Lunardi Iskandac Y, Gill P, Lani V, et al.: Isolation and caharacterization of an immortal neoplastic cell line (KSY-1) from AIDS-associated Kaposi's sarcoma. J Natl Cancer Inst 1995, 87:974 981.
19. Benelli R, Albini A, Parravicini C, et al.: Isolation of spindle-shaped cell populations from primary cultures of Kaposi's sarcoma of different stage. Cancer Lett 1996, 100:125 132.
20. Aluigi M, Albini A, Carlone S, et al.: KSHV sequences in biopsies and cultured spindle cells of epidemic, iatrogenic and mediterranean forms of Kaposi's sarcoma. Res Virol 1996, 147:267 273.
21. Albini A, Repetto L, Carlone S, et al.: Characterization of Kaposi's sarcoma-derived cell cultures from an epidemic and a classic case. Int J Oncol 1992, 1:723 730.
22. Benelli R, Repetto I, Carlone S, Parravicini C, Albini A: Establishment and characterization of two new Kaposi's sarcoma cell cultures from an AIDS and a non-AIDS patient. Res Virol 1994, 145:251 259.
23. Seabright M: A rapid banding technique for human chromosomes. Lancet 1971, ii:971 972.
24. Biondi A, Rossing IH, Bennett J, Iodd RE: Surface membrane heterogeneity among human mononuclear phagocytes. J Immunol 1984, 132:1237 1243.
25. Uccini S, Sitianni MC, Vincenzi, et al.: Kaposi's sarcoma (KS) cells express the macrophage associated antigen mannose receptor and develop in peripheral blood cultures of KS patients. Am J Pathol 1997, 150:929 938.
26. Peri GC, Milanese C, Matteucci C, et al.: A new monoclonal antibody (5D3-F7) which recognizes human monocyte-chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells. J Immunol Methods 1994, 174:249 257.
27. Sironi M, Bioviario F, Proserpio P, et al.: IL-1 stimulates IL-6 production in endothelial cells. J Immunol 1989, 142:549 553.
28. Introna M, Alles VV, Castellano M, et al.: Cloning of mouse plx3, a new member of the pentraxin gene family expressed at extrahepatic sites. Blood 1996, 87:1862 1872.
29. Carmichael J, Degrait WG, Gazdai AI, Minna JD, Mitchell JB: Evaluation of a tetrazolium-based semi-automated colorimetric assay: assessment of chemotherapy testing. Cancer Res 1987, 47:936 943.
30. Ken JER, Wintertord CM, Harmon BV: Apoptosis. Its significance in cancer and cancer therapy. Cancer 1994, 73:2013 2026.
31. Thompson L, Nakamura S, Shima L, et al.: Supernatants of acquired immunodeficiency syndrome-related Kaposi's sarcoma cells induce endothelial cell chemotaxis and invasiveness. Cancer Res 1991, 51:2670 2671.
32. Alles VV, Bottazzi B, Peri G, Golay J, Introna M, Mantovani A: Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes. Blood 1994, 84:3483 3493.
33. Armes J: A review of Kaposi's sarcoma. Adv Cancer Res 1989, 53:73 87.
34. Sciaoca H, Bussolino F, Sironi M, et al.: Expression of adhesion molecules, platelet-activating factor and chemoattractant cytokines by Kaposi's sarcoma cells. J Immunol 1994, 153:4816-4825.
35. Yang J, Xu Y, Zhu C, Hagan MK, Lawley L, Otteimann MK: Regulation of adhesion molecule expression in Kaposi's sarcoma cells. J Immunol 1994, 152:361 373.
36. Miles SA, Rezai AR, Salazar GJ, et al.: AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6. Proc Natl Acad Sci USA 1990, 87:4068-4072.
37. Nakamura S, Salahuddin SZ, Biberfeld P, et al.: Kaposi's sarcoma cells: long-term culture with growth factor from retrovirus-infected CD4+ T cells. Science 1988, 242:426-429.
38. Mantovani A, Bussolino L, Dejana E: Cytokine regulation of endothelial cell function. FASEB J 1992, 6:2591 2599.
39. Sunderkotter C, Stienbrink K, Goebeler M, Bhardwaj R, Sorg C: Macrophages and angiogenesis. J Leukocyte Biol 1994, 55:410 422.
40. Bourinbaiar A, Lee-Huang S: Anti-HIV effect of beta subunit of human chorionic gonadrotrophin (bhCG) in vitro. Immunol Lett 1995, 44:13-18.
41. Gillot D, Iles R, Chard T: The effects of beta-human chorionic gonadotrophin on the in vitro growth of bladder cancer cell lines. Br J Cancer 1996, 73:323-326.
42. Russo J, Russo IH: Hormonally induced differentiation: a novel approach to breast cancer prevention. J Cell Biochem 1995, 22:58-64.