Immobilization of malarial (Plasmodium falciparum) dihydrofolate reductase for the selection of tight-binding inhibitors from combinatorial library

Analytical Chemistry

Volumn 79, Issue 13, 2007, Pages 5006-5012

  Thongpanchang, Chawanee ^a   Taweechai, Supannee ^a   Kamchonwongpaisan, Sumalee ^a   Yuthavong, Yongyuth ^a   Thebtaranonth, Yodhathai ^a  

^a NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

COMBINATORIAL LIBRARIES; DIHYDROFOLATE REDUCTASES; GUANIDINE HYDROCHLORIDE; TIGHT-BINDING INHIBITORS;

ENZYME INHIBITION; GELS; LIGANDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ENZYME IMMOBILIZATION;

CYSTEINE; DIHYDROFOLATE REDUCTASE; GUANIDINE; LIGAND; SEPHAROSE; SULFUR; TRIMETHOPRIM DERIVATIVE;

ARTICLE; BINDING AFFINITY; CALCULATION; CARBOXY TERMINAL SEQUENCE; COMBINATORIAL LIBRARY; ENZYME IMMOBILIZATION; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATHEMATICAL ANALYSIS; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; CYSTEINE; ENZYMES, IMMOBILIZED; FOLIC ACID ANTAGONISTS; GUANIDINE; LIGANDS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PLASMODIUM FALCIPARUM; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEPHAROSE; SULFHYDRYL COMPOUNDS; SULFIDES; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 34447315305     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac070215s     Document Type: Article

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