Diagnosis of Hodgkin's disease: An update on histopathological and immunophenotypical features

Histology and Histopathology

Volumn 22, Issue 7-9, 2007, Pages 923-935

  Fraga, M ^a   Forteza, Jeronimo ^a  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

Author keywords

Clinical features; Hodgkin lymphoma; Immunophenotype; Molecular studies; Morphology; Reed Sternberg cell

Indexed keywords

CD15 ANTIGEN; CD20 ANTIGEN; CD30 ANTIGEN; CD45 ANTIGEN; CD79A ANTIGEN; EPITHELIAL MEMBRANE ANTIGEN; IMMUNOGLOBULIN D; INTERFERON REGULATORY FACTOR 4; OCTAMER TRANSCRIPTION FACTOR 2; PROTEIN BCL 6; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR PU 1; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIGEN EXPRESSION; B CELL LYMPHOMA; CANCER CLASSIFICATION; CANCER INCIDENCE; CANCER REGRESSION; CANCER SURVIVAL; CLASSICAL HODGKIN LYMPHOMA; CLINICAL FEATURE; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE MARKER; HISTOPATHOLOGY; HODGKIN DISEASE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LYMPH NODE DISSECTION; LYMPHOCYTE DEPLETION HODGKIN LYMPHOMA; LYMPHOCYTE-RICH CLASSICAL HODGKIN LYMPHOMA; MIXED CELLULARITY HODGKIN LYMPHOMA; NODULAR LYMPHOCYTE PREDOMINANT HODGKIN LYMPHOMA; NODULAR SCLEROSIS HODGKIN LYMPHOMA; NONHODGKIN LYMPHOMA; PREVALENCE; REED STERNBERG CELL; REVIEW; ANIMAL; GENETICS; IMMUNOLOGY; LYMPH NODE; PATHOLOGY; POLYMERASE CHAIN REACTION; PROGNOSIS;

ANIMALS; DIAGNOSIS, DIFFERENTIAL; HODGKIN DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LYMPH NODES; LYMPHOMA, NON-HODGKIN; POLYMERASE CHAIN REACTION; PROGNOSIS; RECEPTORS, ANTIGEN; REED-STERNBERG CELLS;

EID: 34447125006     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (122)

1. Abbondanzo S.L. (2003). Thomas Hodgkin. Ann. Diagn. Pathol. 7, 333-334.
2. Abdulkader I., Fraga M., González-Quintela A., Caparrini A., Bello J.L., Galvan C., Varo E. and Forteza J. (2005). Prolonged survival after liver transplantation for Hodgkin's disease-induced fulminant liver failure. Hepatogastroenterology 52, 217-219.
3. Algara P., Martinez P., Sanchez L., Villuendas R., Orradre J.L., Oliva H. and Piris M.A. (1991). Lymphocyte predominance Hodgkin's disease (nodular paragranuloma). A Bcl-2 negative germinal centre lymphoma. Histopathology. 19, 69-75.
4. Alkan S., Ross C.W., Hanson C.A. and Schnitzer B. (1995). Epstein-Barr virus and Bcl-2 protein overexpression are not detected in the neoplastic cells of nodular lymphocyte predominance Hodgkin's disease. Mod. Pathol. 8, 544-547.
5. Anagnostopoulos I., Hansmann M.L., Franssila K., Harris M., Harris N.L., Jaffe E.S., Han J., van Krieken J.M., Poppemna S., Marafioti T., Franklin J., Sextro M., Diehl V. and Stein H. (2000). European Task Force on Lymphoma project on lymphocyte predominance Hodgkin's disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin's disease with a nodular growth pattern and abundant lymphocytes. Blood 96, 1889-1899.
6. Angel C.A., Pringle J.H., Naylor J., West K.P. and Lauder I. (1993a). Analysis of antigen receptor genes in Hodgkin's disease. J. Clin. Pathol. 46, 337-340.
7. Angel C.A., Pringle J.H., Primrose L. and Lauder I. (1993b). Detection of immunoglobulin heavy chain rearrangements in Hodgkin's disease using PCR. J. Clin. Pathol. 46, 940-942.
8. Ashton-Key M., Thorpe P.A., Allen J.P. and Isaacson P.G. (1995). Follicular Hodgkin's disease. Am. J. Surg. Pathol. 19, 1294-1299.
9. Bellas C., Santon A., Manzanal A., Campo E., Martin C., Acevedo A., Varona C., Forteza J., Morente M. and Montalban C. (1996). Pathological, immunological, and molecular features of Hodgkin's disease associated with HIV infection. Comparison with ordinary hodgkin's disease. Am. J. Surg. Pathol. 20, 1520-1524.
10. Benharroch D., Meguerian-Bedoyan Z., Lament L., Amin C., Brugieres L., Terrier-Lacombe M.J., Haralambieva E., Pulford K., Pileri S., Morris S.W., Mason D.Y. and Delsol G. (1998). ALK-positive lymphoma: a single disease with a broad spectrum of morphology. Blood 91, 2076-2084.
11. Bennett M.H., MacLennan K.A., Easterling M.J., Vaughan Hudson B., Jelliffe A.M. and Vaughan Hudson G. (1983). The prognostic significance of cellular subtypes in nodular sclerosing Hodgkin's disease: an analysis of 271 non-laparotomised cases (BNLI report no. 22). Clin. Radiol. 34, 497-501.
12. Bennett M.H., MacLennan K.A., Vaughan Hudson G. and Vaughan Hudson B. (1991). Non-Hodgkin's lymphoma arising in patients treated for Hodgkin's disease in the BNLI: a 20-year experience. Ann. Oncol. 2 (Suppl 2), S83-S92.
13. Ben-Yehuda-Salz D., Ben-Yehuda A., Polliack A., Ron N. and Okon E. (1990). Syncytial variant of nodular sclerosing Hodgkin's disease. A new clinicopathologic entity. Cancer 65, 1167-1172.
14. Bishop P.W., Harris M., Smith A.P. and Elsam K.J. (1991). Immunophenotypic study of lymphocyte predominance Hodgkin's disease. Histopathology 18, 19-24.
15. Bodis S., Kraus M.D., Pinkus G., Silver B., Kadin M.E., Canellos G.P., Shulman L.N., Tarbell N.J. and Mauch P.M. (1997). Clinical presentation and outcome in lymphocyte-predominant Hodgkin's disease. J. Clin. Oncol. 15, 3060-3066.
16. Bonadonna G. (2000). Historical review of Hodgkin's disease. Br. J. Haematol. 110, 504-511.
17. Boudova L., Torlakovic E., Delabie J., Reimer P., Pfistner B., Wiedenmann S., Diehl V., Muller-Hermelink H.K. and Rudiger T. (2003). Nodular lymphocyte-predominant Hodgkin lymphoma with nodules resembling T-cell/histiocyte-rich B-cell lymphoma: differential diagnosis between nodular lymphocyte-predominant Hodgkin lymphoma and T-cell/ histiocyte-rich B-cell lymphoma. Blood 102, 3753-3758.
18. Braeuninger A., Kuppers R., Strickler J., Wacker H., Rajewski K. and Hansmann M.L. (1997). Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin's disease represent clonal populations of germinal center-derived tumor B-cells. Proc. Natl. Acad. Sci. USA 94, 9337-9342.
19. Brauninger A., Hansmann M.L., Strickler J.G., Dummer R., Burg G., Rajewsky K. Kuppers R. (1999). Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma. N. Engl. J. Med. 340, 1239-1247.
20. Brousset P., Schlaifer D., Meggetto F., Bachmann E., Rothenberger S., Pris J., Delsol G. and Knecht H. (1994). Persistence of the same viral strain in early and late relapses of Epstein-Barr virus-associated Hodgkin's disease. Blood 84, 2447-2451.
21. Brousset P., Vassallo J., Knecht H., Delsol G., Lament L. and Odermatt B.F. (1993). Detection of Epstein-Barr Virus in Hodgkin s disease. Appl. Immunohistochem. 1, 213-219.
22. Browne P., Petrosyan K., Hernandez A. and Chan J.A. (2003). The B-cell transcription factors BSAP, Oct2, and BOB.1 and the Pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am. J. Clin. Pathol. 120, 767-777.
23. Buettner M., Greiner A., Avramidou A., Jäck H.M. and Niedobitek G. (2005). Evidence of abortive plasma cell differentiation in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma. Hematol. Oncol. 23, 127-132.
24. Burns B.F., Colby T.V. and Dorfman R.F. (1984). Differential diagnostic features of nodular L & H Hodgkin's disease, including progressive transformation of germinal centers. Am. J. Surg. Pathol. 8, 253-261.
25. Carbone A., Gloghini A., Gaidano G., Franceschi S., Capello D., Drexler H.G., Falini B. and Dalla-Favera. R. (1998). Expression status of BCL-6 and syndecan-1 identifies distinct histogenetic subtypes of Hodgkin's disease. Blood 92, 2220-2228.
26. Carbone A., Gloghini A., Aldinucci D., Gattei V., Dalla-Favera R. and Gaidano G. (2002). Expression pattern of MUM1/IRF4 in the spectrum of pathology of Hodgkin's disease. Br. J. Haematol. 117, 366-372.
27. Chadburn A. and Frizzera G. (1999). Mediastinal large B-cell lymphoma vs classic Hodgkin lymphoma. Am. J. Clin. Pathol. 112, 155-158.
28. Chittal S.M., Caveriviere P., Schwarting R., Gerdes J., Al Saati T., Rigal-Huget F., Stein H. and Desol G. (1988). Monoclonal antibodies in the diagnosis of Hodgkin's disease. The search for a rational panel. Am. J. Surg. Pathol. 1, 274-285.
29. Chittal S., Al Saati T. and Delsol G. (1997). Epithelial membrane antigen in hematolymphoid neoplasms. A review. Appl. Immunohistochem. 5, 203-215.
30. Chittal S.M., Alard C., Rossi J.F., al Saati T., Le Tourneau A., Diebold J. and Delsol G. (1990). Further phenotypic evidence that nodular, lymphocyte-predominant Hodgkin's disease is a large B-cell lymphoma in evolution. Am. J. Surg. Pathol. 14, 1024-1035.
31. Chittal S.M., Brousset P., Voigt J.J. and Delsol G. (1991). Large B-cell lymphoma rich in T-cells and simulating Hodgkin's disease. Histopathology 19, 211-220.
32. Colby T.V., Hoppe R.T. and Warnke R.A. (1982). Hodgkin's disease: a clinicopathologic study of 659 cases. Cancer 49, 1848-1858.
33. Coles F.B., Cartun R.W. and Pastuszak W.T. (1988). Hodgkin's disease, lymphocyte-predominant type: immunoreactivity with B-cell antibodies. Mod Pathol. 1, 274-285.
34. Copie-Bergman C., Gaulard P., Maouche-Chretien L., Briere J., Haioun C., Alonso, M.A., Romeo P.H. and Leroy K.(1999). The MAL gene is expressed in primary mediastinal large B-cell lymphoma. Blood 94, 3567-3575.
35. Dallenbach F.E. and Stein H. (1989). Expression of T-cell-receptor beta chain in Reed-Sternberg cells. Lancet 2, 828-830.
36. d'Amore E.S., Lee C.K., Aeppli D.M., Levitt S.H. and Frizzera G. (1992). Lack of prognostic value of histopathologic parameters in Hodgkin's disease, nodular sclerosis type. A study of 123 patients with limited stage disease who had undergone laparotomy and were treated with radiation therapy. Arch. Pathol. Lab. Med. 116, 856-861.
37. De Jong D., Van Gorp J., Sie-Go D. and Van Heerde P. (1996). T-cell rich b-cell non-hodgkin's lymphoma: a progressed form of follicle centre cell lymphoma and lymphocyte predominance hodgkin's disease. Histopthology 28, 15-24.
38. Delabie J., Vandenberghe E., Kennes C., Verhoef G., Foschini M.P., Stul M., Cassiman J.J. and De Wolf-Peeters C. (1992). Histiocyle-rich B-cell lymphoma. A distinct clinicopathologic entity possibly related to lymphocyte predominant Hodgkin's disease, paragranuloma subtype. Am. J. Surg. Pathol. 16, 37-48.
39. Delsol G., Brousset P., Chittal S. and Rigal-Huguet F. (1992). Correlation of the expression of Epstein-Barr virus latent membrane protein and in situ hybridization with biotinylated BamHI-W probes in Hodgkin's disease. Am. J. Pathol. 140, 247-253.
40. Delsol G., Gatter K.C., Stein H., Erber W.N., Pulford K.A., Zinne K. and Mason D.Y. (1984). Human lymphoid cells express epithelial membrane antigen. Implications for diagnosis of human neoplasms. Lancet 2, 1124-1129.
41. Diehl V., Sextro M., Franklin J., Hansmann M.L., Harris N., Jaffe E., Poppema S., Harris M., Franssila K., van Krieken J., Marafioti T., Anagnostopoulos I. and Stein H. (1999). Clinical presentation, course, and prognostic factors in lymphocyte-predominant Hodgkin's disease and lymphocyte-rich classical Hodgkin's disease: report from the European Task Force on Lymphoma Project on Lymphocyte-Predominant Hodgkin's Disease. J. Clin. Oncol. 17, 776-783.
42. Doggett R.S., Colby T.V. and Dorfman R.F. (1983). Interfollicular Hodgkin's disease. Am. J. Surg. Pathol. 7, 145-149.
43. Emmerich F., Meiser M., Hummel M., Demel G., Foss H.D., Jundt F., Mathes S., Krappmann D., Scheidereit C., Stein H. and Dorken B. (1999). Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells. Blood 94, 3129-3134.
44. Falini B., Stein H., Pileri S., Canino S., Farabbi R., Martelli M.F., Grignani F., Fagioli M. Minelli O. and Clani C. (1987). Expression of lymphoid-associated antigens on Hodgkin's and Reed-Sternberg cells of Hodgkin's disease. An immunocytochemical study on lymph node cytospins using monoclonal antibodies. Histopathology 12, 1229-1242.
45. Falini B., Bigerna B., Fizzotti M., Pulford K., Pileri S.A., Delsol G., Carbone A., Paulli M., Magrini U., Menestrina F., Giardini R., Pilotti S., Mezzelani A., Ugolini B., Billi M., Pucciarini A., Pacini R., Pelicci P.G. and Flenghi L. (1998). ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum. Am. J. Pathol. 153, 875-886.
46. Falini B., Bigerna B., Pasqualucci L., Fizzotti M., Martelli M.F., Pileri S., Pinto A., Carbone A., Venturi S., Pacini R., Cattoretti G., Pescarmona E., Lo Coco F., Pelicci P.G., Anagnastopoulos I., Dalla-Favera R. and Flenghi L. (1996). Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease. Blood 87, 465-471.
47. Falini B., Fizzotti M., Pileri S., Liso A., Pasqualucci L. and Flenghi L. (1997). Bcl-6 protein expression in normal and neoplastic lymphoid tissues. Ann. Oncol. 8 (Suppl 2), 101-104.
48. Falini B., Fizzotti M., Pucciarini A., Bigerna B., Marafioti T., Gambacorta M., Pacini R., Alunni C., Natali-Tanci L., Ugolini B., Sebastiani C., Cattoretti G., Pileri S., Dalla-Favera R. and Stein H. (2000). A monoclonal antibody (MUM1p) detects expression of the MUM1/ IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood 95, 2084-2092.
49. Fan Z., Natkunam Y., Bair E., Tibshirani R. and Warnke R.A. (2003). Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation. Am. J. Surg. Pathol. 27, 1346-1356.
50. Ferry J.A., Linggood R.M., Convery K.M., Efird J.T., Eliseo R. and Harris N. L. (1993). Hodgkin disease, nodular sclerosis type. Implications of histologic subclassification. Cancer 71, 457-463.
51. Fleming M.D., Shahsafei A. and Dorfman D.M. (1998). Absence of dendritic reticulum cell staining is helpful for distinguishing T-cell-rich-B-cell lymphoma from lymphocyte predominance Hodgkin's disease. Appl. Immunohistochem. 6, 16-22.
52. Fraga M., García-Rivero A., Sánchez-Verde L., Forteza J. and Piris M.A. (2002). T-cell/histiocyte-rich large B-cell lymphoma is a disseminated aggressive neoplasm. Differential diagnosis with Hodgkin's lymphoma. Histopathology 41, 1-14.
53. Franco V., Tripodo C., Rizzo A., Stella M. and Florena A.M. (2004). Bone marrow biopsy in Hodgkin's lymphoma. Eur. J. Haematol. 73, 149-155.
54. Garcia J.F., Mollejo M., Fraga M., Forteza J., Muniesa J.A., Perez-Guillermo M., Perez-Seoane C., Rivera T., Ortega P., Piris M.A. (2005). Large B-cell lymphoma with Hodgkin's features. Histopathology 47, 101-110.
55. Garcia-Cosio M., Santon A., Martin P., Camarasa N., Montalban C., Garcia J.F. and Bellas C. (2004). Analysis of transcription factor OCT.1, OCT.2 and BOB.1 expression using tissue arrays in classical Hodgkin's lymphoma. Mod. Pathol. 17, 1531-1538.
56. Grossman D.M., Hanson C.A. and Schnitzer B. (1991). Simultaneous lymphocyte predominant Hodgkin's disease and large-cell lymphoma. Am. J. Surg. Pathol. 15, 668-676.
57. Hansmann M.L., Zwingers T., Boske A., Loffler H. and Lennert K. (1984). Clinical features of nodular paragranuloma (Hodgkin's disease, lymphocyte predominance type, nodular). J. Cancer Res. Clin. Oncol. 108, 321-330.
58. Hansmann M.L., Fellbaum C., Hui P.K. and Zwingers T. (1988). Correlation of content of B cells and Leu7-positive cells with subtype and stage in lymphocyte predominance type Hodgkin's disease. J. Cancer Res. Clin. Oncol. 119, 405-410.
59. Hansmann M.L., Stein H., Fellbaum C., Hui P.K., Parwaresch M.R. and Lannert K. (1989). Nodular paragranuloma can transform into high-grade malignant lymphoma of B type. Hum. Pathol. 20, 1169-1175.
60. Hansmann M.L., Fellbaum C., Hui P.K. and Moubayed P. (1990). Progressive transformation of germinal centers with and without association to Hodgkin's disease. Am. J. Clin. Pathol. 93, 219-226.
61. Hansmann M.L., Stein H., Dallenbach F. and Felibaum C. (1991). Diffuse lymphocyte-predominant Hodgkin's disease (diffuse paragranuloma). A variant of the B-cell-derived nodular type. Am. J. Pathol. 138, 29-36.
62. Harris N.L., Jaffe E.S., Stein H., Banks P.M., Chan J.K., Cleary M.L., Delsol G., De Wolf-Peeters C., Falini B. and Gatter K.C. (1994). A revised european-american classification of lymphold neoplasms: A proposal from the International lymphoma study group. Blood 5, 1361-1392.
63. Hess J.L., Bodis S., Pinkus G., Silver B. and Mauch P. (1994). Histopathologic grading of nodular sclerosis Hodgkin's disease. Lack of prognostic significance in 254 surgically staged patients. Cancer 74, 708-714.
64. Hummel M., Marafioti T. and Stein H. (1999). Clonality of Reed-Sternberg cells in Hodgkin's disease. N. Engl. J. Med. 340, 394-395.
65. Jackson H. and Parker F. (1947). Hodgkin's disease and allied disorders. Oxford University Press. New York.
66. Jaffe E., Lee Harris N., Stein H. and Vardiman J.W. (2001). World Health Organization Classification of Tumours. Pathology and genetics of tumors of haematopoietic and lymphoid tissues. IARC Press. Lyon. pp 238-253.
67. Josting A., Wolf J. and Diehl V. (2000). Hodgkin disease: prognostic factors and treatment strategies. Curr. Opin. Oncol. 12, 403-411.
68. Kamel O.W., Gelb A.B., Shibuya A.B. and Warnke R.A. (1993). Leu 7 (CD57) reactivity distinguishes nodular lymphocyte predominance Hodgkin's disease from nodular sclerosing Hodgkin's disease, T-cell-rich B-cell lymphoma and follicular lymphoma. Am. J. Pathol. 142, 541-546.
69. Kant J.A., Hubbard S.M., Longo D.L., Simon A.M., DeVita V.T. and Jaffe E.S. (1986). The pathologic and clinical heterogeneity of lymphocyte-depleted Hodgkin's disease. J. Clin. Oncol. 4, 284-294.
70. Karayalcin G., Behm F.G., Gieser P.W., Kung F., Weiner M., Tebbi C.K., Ferree C., Marcus R., Constine L., Mendenhall N.P., Chauvenet A. and Murphy S.B. (1997). Lymphocyte predominant Hodgkin's disease: clinico-pathologic features and results of treatment. The Pediatric Oncology Group experience. Med. Pediat. Oncol. 29, 519-525.
71. Kraus M.D. and Haley J. (2000). Lymphocyte predominance Hodgkin's disease: the use of bcl-6 and CD57 in diagnosis and differential diagnosis. Am. J. Surg. Pathol. 24, 1068-1078.
72. Kuppers R., Klein U., Hansmann M.L. and Rajewsky K. (1999). Cellular origin of human B-cell lymphomas. N. Engl. J. Med. 341, 1520-1529.
73. Küppers R., Rajewsky K., Zhao M., Simons G., Laumann R., Fisher R. and Hansmann M.L. (1994). Hodgkin and Reed-Sternberg cell picked from histological sections show clonal immunoglobulin rearrangements and appear to be derived from B cells at various stages of development. Proc. Natl. Acad. Sci. USA 91, 10962-10966.
74. Linden M.D., Fishleder A.J., Katzin W.E. and Tubbs R.R. (1988). Absence of B-cell or T-cell clonal expansion in nodular, lymphocyte predominant Hodgkin's disease. Hum. Pathol. 19, 591-594.
75. Lukes R.J. (1971). Criteria for involvement of lymph node, bone marrow, spleen and liver in Hodgkin's disease. Cancer Res. 31, 1755-1767.
76. Lukes R.J. and Butler J.J. (1966). The pathology and nomenclature of Hodgkin's disease. Cancer Res. 26, 1063-1081.
77. MacLennan K.A., Bennett M.H., Vaughan Hudson B. and Vaughan Hudson G. (1992). Diagnosis and grading of nodular sclerosing Hodgkin's disease: a study of 2190 patients. Int. Rev. Exp. Pathol. 33, 27-51.
78. Maheswaran P.R., Ramsay A.D., Norton A.J. and Roche W.R. (1991). Hodgkin's disease presenting with the histological features of Castleman's disease. Histopathology 18, 249-253.
79. Manzanal A.I., Santon A., Acevedo A., Aguilera B., Oliva H. and Belles C. (1997). Molecular analysis of the IgH gene in 212 cases of Hodgkin's disease. Correlation of IgH clonality with the histologic and the immunohistochemical features. Mod. Pathol. 10, 679-685.
80. Marafioti T., Hummel M., Anagnostopoulos I., Foss H.D., Falini B., Delsol G., Isaacson P.G., Pileri S. and Stein H. (1997). Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells. N. Engl. J. Med. 337, 453-458.
81. Marafioti T., Hummel M., Foss H.D., Laumen H., Korbjuhn P., Anagnostopoulos I., Lammert H., Demel G., Theil J., Wirth T. and Stein H. (2000). Hodgkin and reed-sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood 95, 1443-1450.
82. Marafioti T., Jabri L., Pulfor K., Brousset P., Mason D.Y. and Delsol G. (2003). Leucocyte-specific protein (LSP1) in malignant lymphoma and Hodgkin's disease. Br. J. Haematol. 120, 671-678.
83. Marafioti T., Mancini C., Ascani S., Sabattini E., Zinzani P.L., Pozzobon M., Pulford K., Falini B., Jaffe E.S., Müller-Hermelink H.-K., Mason D.Y. and Pileri S.A. (2004). Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich lymphoma from lymphocyte-predominant Hodgkin's disease. Haematologica 89, 957-964.
84. Mason Y.D., Banks P.M., Chan J., Cleary M.L., Delsol G., de Wolf Peeters C., Falini B., Gatter K., Grogan T.M., Harris N.L., Isaacson P.G., Jaffe E.S., Knowles D.M., Müller-Hermelink H.K., Pileri S., Ralfkiaer E., Stein H. and Warnke R. (1994). Nodular lymphocyte predominance Hodgkin's disease. A distinct clinicopathological entity. Am. J. Surg. Pathol. 18, 526-530.
85. McBride J.A., Rodriguez J., Luthra R., Ordóñez N.G., Cabanillas F. and Pugh W.C. (1996). T-cell-rich B large-cell lymphoma simulating lymphocyte-rich Hodgkin's disease. Am. J. Surg. Pathol. 20, 193-201.
86. Nicholas D.S., Harris S. and Wright D.H. (1990). Lymphocyte predominance Hodgkin's disease. An immunohistochemical study. Histopathology 16, 157-165.
87. Ohno T., Stribley J.A., Wu G., Hinrichs S.H., Weisenburger D.D. and Chan W.C. (1997). Clonality in nodular lymphocyte-predominant Hodgkin's disease. N. Engl. J. Med. 337, 459-465.
88. Osborne B.M. and Butler J.J. (1984). Clinical implications of progressive transformation of germinal centers. Am. J. Surg. Pathol. 8, 725-733.
89. Osborne B.M., Butler J.J. and Gresik M.V. (1993). Progressive transformation of germinal centers: comparison of 23 pediatric patients to the adult population. Mod. Pathol. Mod. Pathol. 5, 135-140.
90. Pan L.X., Diss T.C., Peng H.Z., Norton A.J. and Isaacson P.G. (1996). Nodular lymphocyte predominance Hodgkin's disease: a monoclonal or polyclonal B-cell disorder? Blood 87, 2428-2434.
91. Patsouris E., Noel H. and Lennert K. (1989). Cytohistologic and immunohistochemical findings in Hodgkin's disease, mixed cellularity type, with a high content of epithelioid cells. Am. J. Surg. Pathol. 13, 1014-1022.
92. Pinkus G. and Said J. (1985). Hodgkin's disease, lymphocyte predominance type, nodular--a distinct entity? Unique staining profile for L & H variants of Reed-Sternberg cells defined by monoclonal antibodies to leukocyte common antigen, granulocyte-specific antigen, and B-cell-specific antigen. Am J. Pathol. 116, 1-6.
93. Pinkus G. and Said J. (1988). Hodgkin's disease, lymphocyte predominance type, nodular--further evidence for a B cell derivation. L & H variants of Reed-Sternberg cells express L26, a pan B cell marker. Am. J. Pathol. 133, 211-217.
94. Pinkus G.S., Thomas P. and Said J.W. (1985). Leu-M1--a marker for Reed-Sternberg cells in Hodgkin's disease. An immunoperoxidase study of paraffin-embedded tissues. Am. J. Pathol. 119,
95. Pileri S.A., Ascani S., Leoncini L., Sabattini E., Zinzani P.L., Piccaluga P.P., Pileri A. Jr., Giunti M., Falini B., Bolis G.B. and Stein H. (2002). Hodgkin's lymphoma: the pathologist's viewpoint. J. Clin. Pathol. 55, 162-176.
96. Poppema S. (1980). The diversity of the immunohistological staining pattern of Sternberg-Reed cells. J. Histochem. Cytochem. 20, 788-791.
97. Poppema S. (1989). The nature of the lymphocytes surrounding Reed-Sternberg cells in nodular lymphocyte predominance and in other types of Hodgkin's disease. Am. J. Pathol. 135, 351-357.
98. Poppema S. (1996). Nodular lymphocyte predominance type of Hodgkin's disease. In: Pathology of lymph nodes. Weiss L.M. Churchill-Livingstone Press. New York. pp 215-228.
99. Poppema S., Kaiserling E. and Lennert K. (1979a). Epidemiology of nodular paragranuloma (Hodgkin's disease with lymphocytic predominance, nodular). J. Cancer. Res. Clin. Oncol. 95, 57-63.
100. Poppema S., Kaiserling E. and Lennert K. (1979b). Hodgkin's disease with lymphocytic predominance, nodular type (nodular paragranuloma) and progressively transformed germinal centres. A cytohistological study. Histopathology 3, 295-308.
101. Poppema S., Kaiserling E. and Lennert K. (1979c). Nodular paragranuloma and progressively transformed germinal centers. Ultrastructural and immunohistologic findings. Virchows Arch. 31, 211-225.
102. Prakash S., Fountaine T., Raffeld M., Jaffe E.S. and Pittaluga S. (2006). IgD positive L & H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphoma. Am. J. Surg. Pathol. 30, 585-592.
103. Rappaport H., Berard C.W., Butler J.J., Dorfman R.F., Lukes R.J. and Thomas L.B. (1971). Report on the committee on histopathological criteria contributing to staging in Hodgkin's disease. Cancer Res. 31, 1864-1865.
104. Regula D.P., Hoppe R.T. and Weiss L.M. (1988). Nodular and diffuse types of lymphocyte predominance Hodgkin's disease. N. Engl. J. Med. 318, 214-219.
105. Rüdiger T., Ott G., Ott M.M., Müller-Deubert S.M. and Müller-Hermelink H.K. (1998). Differential diagnosis between classic Hodgkin's lymphoma, T-cell-rich B-cell lymphoma and paragranuloma by paraffin immunohistochemistry. Am. J. Surg. Pathol. 22, 1184-1191.
106. Said H., Sasoon A., Shintaku I., Kurtin P. and Pinkus G. (1991). Absence of bcl-2 major breakpoint region and Jh gene rearrangement in lymphocyte predominant Hodgkin's disease. Results of Southern blot analysis and polymerase chain reaction study. Am. J. Pathol. 138, 261-264.
107. Schmid C., Sargent C. and Isaacson P. (11991). L and H cells of nodular lymphocyte predominant Hodgkin's disease show immunoglobulin light-chain restriction. Am. J. Pathol. 139, 1281-1289.
108. Seitz V., Hummel M., Marafioti T., Anagnostopoulos I., Assaf C. and Stein H. (2000). Detection of clonal T-cell receptor gamma-chain gene rearrangements in Reed-Sternberg cells of classic Hodgkin disease. Blood 95, 3020-3024.
109. Sherrod A.E., Felder B., Levy N., Epstein A., Marder R., Lukes R.J. and Taylor C.R. (1986). Immunohistologic identification of phenotypic antigens associated with Hodgkin and Reed-Sternberg cells. Cancer. 57, 2135-2140.
110. Stein H., Hansmann M.L., Lennert K., Brandtzaeg P., Getter K.C. and Mason D.Y. (1986). Reed-Sternberg and Hodgkin cells in lymphocyte-predominant Hodgkin's disease of nodular subtype contain J chain. Am. J. Clin. Pathol. 86, 292-297.
111. Stein H., Mason D.Y., Gerdes J., O'Connor N., Wainscoat J., Pallesen G., Getter K., Falini B., Delsol G., Lemke H., Schwarting R. and Lennert K. (1985). The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 66, 848-858.
112. Stein H., Marafioti T., Foss H.D., Laumen H., Hummel M., Anagnostopoulos I., Wirth T., Demel G. and Falini B. (2001). Down-regulation of BOB.1/ OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription. Blood 97, 496-501.
113. Strickler J.G., Michie S.A., Warnke R.A. and Dorfman R.F. (1986). The "syncytial variant" of nodular sclerosing Hodgkin's disease. Am. J. Surg. Pathol. 10, 470-477.
114. Sundeen J.T., Cossman J. and Jaffe E.S. (1988). Lymphocyte predominant Hodgkin's disease nodular subtype with coexistent "large cell lymphoma". Histological progression or composite malignancy? Am. J. Surg. Pathol. 12, 599-606.
115. Torlakovic E., Tierens A., Deng H.D. and Delabie J. (2001). The transcription factor PU.1, necessary for B-cell development is expressed in lymphocyte predominance, but not classical Hodgkin's disease. Am. J. Pathol. 159, 1807-1814.
116. Traverse-Glehen A., Pittaluga S., Gaulard P., Sorbara L., Alonso M.A., Raffeld M. and Jaffe E.S. (2005). Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. Am. J. Surg. Pathol. 29, 1411-1421.
117. Tzankov A., Zimpfer A., Pehrs A.C., Lugli A., Went P., Maurer R., Pileri S. and Dirhofer S. (2003). Expression of B-cell markers in classical Hodgkin lymphoma: a tissue microarray analysis of 330 cases. Mod. Pathol. 16, 1141-1147.
118. van Spronsen D.J., Vrints L.W., Hofstra G., Crommelin M.A., Coebergh J.W. and Breed W.P. (1997). Disappearance of prognostic significance of histopathological grading of nodular sclerosing Hodgkin's disease for unselected patients, 1972-92. Br. J. Haematol. 96, 322-327.
119. von Wasielewski R., Mengel M., Fischer R., Hansmann M.L., Hubner K., Franklin J., Tesch H., Paulus U., Werner M., Diehl V. and Georgii A. (1997a). Classical Hodgkin's disease. Clinical impact of the immunophenotype. Am. J. Pathol. 151, 1123-1130.
120. von Wasielewski R., Werner M., Fischer R., Hansmann M.L., Hubner K., Hasenclever D., Franklin J., Sextro M., Diehl V. and Georgii A. (1997b). Lymphocyte-predominant Hodgkin's disease. An immunohistochemical analysis of 208 reviewed Hodgkin's disease cases from the German Hodgkin Study Group. Am. J. Pathol. 150, 793-803.
121. Weiss L., Chen Y., Liu X. and Shibata D. (1991). Epstein-Barr virus and Hodgkin's disease: a correlative in situ hybridization and polymerase chain reaction study. Am. J. Pathol. 139, 1259-1265.
122. Wickert R.S., Weisenburger D.D., Tierens A., Greiner T.C. and Chan W.C. (1995). Clonal relationship between lymphocytic predominance Hodgkin's disease and concurrent or subsequent large-cell lymphoma of B lineage. Blood 86, 2312-2320.