Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease

Blood

Volumn 87, Issue 2, 1996, Pages 465-471

  Falini, Brunangelo ^a   Bigerna, Barbara ^b   Pasqualucci, Laura ^b   Fizzotti, Marco ^b   Martelli, Massimo F ^b   Pileri, Stefano ^b   Pinto, Antonio ^b   Carbone, Antonino ^b   Venturi, Stefanie ^b   Pacini, Roberta ^b   Cattoretti, Giorgio ^b   Pescarmona, Edoardo ^b   Lo Coco, Francesco ^b   Pelicci, Pier Giuseppe ^b   Anagnastopoulos, Ioannis ^b   Dalla Favera, Riccardo ^b   Flenghi, Leonardo ^b  

^a Istituto di Ematologia   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; ZINC FINGER PROTEIN;

ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; CARCINOGENESIS; CELL NUCLEUS; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LYMPH FOLLICLE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS REGULATION; REED STERNBERG CELL;

EID: 13344283429     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.2.465.bloodjournal872465     Document Type: Article

References (44)

1. Offit K, Jhanwar S, Ebrahim SA, Filippa D, Clarkson BD, Chaganti RSK. t(3;22) (q27,q11): A novel translocation associated with diffuse non-Hodgkin's lymphoma Blood 74:1876, 1989
2. Bastard C, Tilly H, Lenormand B, Bigorgne C, Boulet D, Kunlin A, Moncond M, Piguet H: Translocations involving hand 3q27 and Ig gene regions in non-Hodgkin's lymphomas. Blood 79:2527, 1992
3. Ye BH, Rao PH, Chaganti RSK, Dalla-Favera R: Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma. Cancer Res 53:2732, 1993
4. Baron BW, Nucifora G, McCabe N, Espinosa R III, Le Beau MM, McKeithan TW: Identification of the gene associated with the recurring chromosomal translocations t(3; 14)(q27:q32) and t(3; 22)(q27;q11) in B-cell lymphomas. Proc Natl Acad Sci USA 90:5262, 1992
5. Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RSK, Dalla Favera R: Alterations of a zinc finger-encoding gene. BCL6, in diffuse large-cell lymphoma. Science 262:747, 1993
6. Offit K, Lo Coco F, Louie DC, Parsa NZ, Leung D, Portlock C, Ye BH, Lista F, Filippa D, Rosenbaum A, Ladanyi M, Jhanwar S, Dalla Favera R, Shaganti RSK: Rearrangement of the BCL6 gene as a prognostic marker in diffuse large cell lymphoma. N Engl J Med 331:74, 1994
7. El-Baradi T, Pieler T: Zinc finger proteins: What we know and what we would like to know. Mech Dev 35:155, 1991
8. Chen Z, Brand NJ. Chen A, Chen SJ, Tong JH, Wang ZY Waxman S, Zelent A: Fusion between a novel Kruppel-like finger gene and the retinoic acid receptor-α locus due to a variant t(11;17) translocation associated with acute promyelocytic leukemia. EMBO J 12:1161, 1993
9. Cattoretti G, Chang C-C, Cechova K, Zhang J, Ye BH, Falini B, Louie DC, Offit K, Chaganti RSK, Dalla Favera R: The BCL-6 protein is expressed in germinal-center B cells. Blood 86:45, 1995
10. Onizuka T, Moriyama M, Yamochi T, Kuroda T, Kazama A, Kanazawa N, Sato K, Kato H, Mori S: BCL-6 gene product, a 92-to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood 86:28, 1995
11. Flenghi L, Ye BH, Fizzotti M, Bigerna B, Cattoretti G, Venturi S, Pacini R, Pileri S, Lo Coco F, Pescarmona Li, Pelicci P-G Dalla Favera R, Falini B: A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells Am J Pathol 147:405, 1995
12. Ye BH, Chaganti S, Chang C-C, Niu H, Corradini P, Chaganti RSK, Dalla Favera R: Chromosomal translocations cause deregulated BCL-6 expression by promoter substitution in B-cell lymphoma. EMBO J (in press)
13. Mason DY, Banks PM, Chan JKC, Cleary ML, Delsol G, De Wolf Peeters C, Falini B, Gatter KC, Grogan TM, Harris NL, Isaacson P, Jaffe E, Knowles DM, Muller-Hermelink HK, Pileri SA, Pins MA, Ralfkier E, Stein H, Warnke RA: Nodular lymphocyte predominance Hodgkin's disease. A distinct clinicopathologic entity Am J Surg Pathol 18:526, 1994
14. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, De Wolf Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson P, Knowles DM, Mason DY, Muller-Hermelink HK, Pileri SA, Piris MA, Ralfkier E, Warnke RA: A revised European American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 84:1361, 1994
15. Haluska F, Brufsky AM, Canellos GF: The cellular biology of the Reed-Sternberg cells. Blood 84:1005, 1994
16. Flenghi L, Fizzotti M, Bigerna B, Cattoretti G, Venturi S, Pasqualucci L, Pacini R, Pileri S, Gambacorta M, Baroni C, Pescarmona E, Pelicci P-G, Dalla-Favera R, Falini B: Monoclonal antibodies PG-B6a and PG-B6p recognize respectively a highly evolutionary conserved and formol-resistant epitope on the aminoterminal region of the human BCL-6 protein. Am J Pathol (in press)
17. Mason DY, Comans-Bitter WM, Cordell JL, Verhoeven MJ, van Dongen JJM: Antibody L26 recognizes an intracellular epitope on the B-cell associated antigen CD20. Am J Pathol 136:1215, 1990
18. Mason DY, Cordell JL, Tse AGD, Van Dongen JJM, Van Noesel CJM, Micklem K, Pulford K, Valensi F, Comans-Bitter WM, Borst J, Gatter KC: The IgM associated protein mb-I as a marker of normal and neoplastic B cells. J Immunol 147:2474, 1991
19. Schwarting R, Gerdes J, Durkop H, Falini B, Pileri S, Stein H: Ber-H2: A new anti Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope Blood 74:1678, 1989
20. Gerdes J, Li L, Schlueter C, Duchrow M, Wohlenberg C, Gerlach C, Stahmer I, Kloth S, Brandt E, Flad HD: Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am J Pathol 138:1359, 1993
21. Lukes RJ, Butler JJ: The pathology and nomenclature of Hodgkin's disease. Cancer Res 26:1063, 1966
22. Falini B, Pileri S, Martelli MF: Histological and immunohistological analysis of human lymphomas. Crit Rev Oncol Hematol 9:305, 1989
23. Mason DY, Erber MN, Falini B, Stein H, Gatter KC: Immunoenzymatic labelling of hematological samples with monoclonal antibodies, in Beverley PCL (ed): Methods in Haematology, vol 13. London, UK, Churchill-Livingstone, 1989, p 145
24. Morgan JM, Navabi H, Schmid KW, Jasaiu B. Possible role of tissue-bound calcium ions in citrate-mediated high-temperature antigen retrieval. J Pathol 174:301, 1994
25. Cordell JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, MacDonald S, Pulford KAF, Stein H, Mason DY: Immunoenzymatic labelling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 32:219, 1984
26. Flenghi L, Fagioli M, Tomassoni L, Pileri S, Gambacorta M, Pacini R, Grignani F, Casini T, Ferrucci PF, Martelli MF, Pelicci PG, Falini B: Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: Immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia. Blood 85:1871, 1995
27. Ponder BA, Wilkinson WN: Inhibition of endogenous tissue alkaline phosphatase with the use of alkaline phosphatase conjugates in immunohistochemistry. J Histochem Cytochem 29:981, 1981
28. Falini B, Abdulaziz Z, Gerdes J, Canino S, Ciani C, Cordell JL, Knight PM, Stein H, Grignani F, Martelli MF, Mason DY: Description of a sequential staining procedure for double immunoenzymatic staining of pairs of antigens using monoclonal antibodies. J Immunol Methods 93:265, 1986
29. Carbone A, Gloghini A, Gattei V, Aldinucci D, Degan M, De Paoli P, Zagonei V, Pinto A: Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines. Blood 85:780, 1995
30. Lane P, Traunecker A, Hubele S, Inui S, Lanzavecchia A, Gray D: Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes. Eur J Immunol 22:2573, 1992
31. Carbone A, Gloghini A, Gruss HJ, Pinto A: CD40 ligand is constitutively expressed in a subset of T-cell lymphomas and on the microenvironmental reactive T-cells of follicular lymphomas and Hodgkin's disease. Am J Pathol 147:912, 1995
32. Timens W, Visser L, Poppema S: Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma. Lab Invest 54:457, 1986
33. Poppema S, Kaiserling E, Lennert K: Nodular paragranuloma and progressively transformed germinal centers: Ultrastructural and immunohistological findings. Virchows Arch Cell Pathol 31:211, 1979
34. Stein H, Hansmann M-L, Lennert K, Brandtzaeg P, Gatter KC, Mason DY: Reed-Sternberg and Hodgkin cells in lymphocyte predominance Hodgkin's disease of nodular subtype contain J chain. Am J Clin Pathol 86:292, 1986
35. Pinkus GS, Said JW: Hodgkin's disease, lymphocyte predominance type, nodular: Further evidence for a B cell derivation, L & H variants of Reed-Sternberg cells express L26, a pan B cell marker. Am J Pathol 133:211, 1988
36. Korkolopoulou P, Cordell J, Jones M, Kaklamanis L, Tsenga A. Gatter KC, Mason DY: The expression of the B-cell marker mb-1 (CD79a) in Hodgkin's disease. Histopathology 24:511, 1994
37. Falini B, Pileri S, Pizzolo G, Durkop H, Flenghi L, Stirpe F, Martelli MF, Stein H: CD30 (Ki-1) molecule: A new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy. Blood 85:1, 1995
38. Poppema S: The nature of the lymphocytes surrounding Reed-Sternberg cells in nodular lymphocyte predominance and other types of Hodgkin's disease. Am J Pathol 135:351, 1989
39. Poppema S, Visser L, De Leij L: Reactivity of presumed antinatural killer cell antibody Leu 7 with intrafollicular T lymphocytes. Clin Exp Immunol 54:834, 1983
40. Kuppers R, Rajewsky K, Zhao M, Simons G, Laumann R, Fisher R, Hansmann M-L: Hodgkin's disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci USA 91:10962, 1994
41. Delabie J, Tierens A, Wu G, Weisenburger DD, Chan WC: Lymphocyte predominance Hodgkin's disease: Lineage and clonality determination using a single-cell assay. Blood 84:3291, 1994
42. Migliazza A, Martinotti S, Chen W, Fusco C, Ye BH, Knowles DM, Offit K, Chaganti RSK, Dalla-Favera R: Frequent somatic hypermutation of the 5′ non-coding region of the BCL-6 gene in B-cell lymphoma in the absence of linkage to immunoglobulin genes. Proc Natl Acad Sci USA (in press)
43. Kamel O, Gelb AB, Shibuya RB, Warnke RA: Leu 7 (CD57) reactivity distinguishes nodular lymphocyte predominance Hodgkin's disease from nodular sclerosing Hodgkin's disease, T-cell-rich B-cell lymphoma and follicular lymphoma. Am J Pathol 142:541, 1993
44. Liu Y-J, Johnson GD, Gordon J, MacLennan I: Germinal centers in T-cell-dependent antibody responses. Immunol Today 17:17, 1992