The corticotropin-releasing factor (CRF) family of peptides as local modulators of adrenal function

Cellular and Molecular Life Sciences

Volumn 64, Issue 13, 2007, Pages 1638-1655

  Tsatsanis, C ^a   Dermitzaki, E ^a   Venihaki, M ^a   Chatzaki, E ^b   Minas, V ^a   Gravanis, A ^a   Margioris, A N ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

Adrenal; Catecholamine; Corticotropin releasing hormone; CRF receptor; CRF binding protein; Macrophage; Pheochromocytoma; Urocortin

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; BINDING PROTEIN; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR BINDING PROTEIN; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; CYTOCHROME P450C17; PEPTIDE; PRASTERONE; PRASTERONE SULFATE; UNCLASSIFIED DRUG; UROCORTIN; UROCORTIN I; UROCORTIN II; UROCORTIN III;

ADRENAL FUNCTION; ADRENERGIC SYSTEM; CATECHOLAMINE RELEASE; CATECHOLAMINE SYNTHESIS; CELL STRAIN; CENTRAL NERVOUS SYSTEM; CHROMAFFIN CELL; CUSHING SYNDROME; ECTOPIC CORTICOTROPIN PRODUCTION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE DEFICIENCY; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; LOCUS CERULEUS; NONHUMAN; PHEOCHROMOCYTOMA; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; STEROIDOGENESIS;

ADRENAL GLAND DISEASES; ADRENAL GLANDS; ANIMALS; CORTICOTROPIN-RELEASING HORMONE; HUMANS; IMMUNE SYSTEM; PEPTIDES;

EID: 34447123366     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-007-6555-7     Document Type: Review

References (171)

1. Vale, W., Spiess, J., Rivier, C. and Rivier, J. (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213, 1394-1397.
2. Spiess, J., Rivier, J., Rivier, C. and Vale, W. (1981) Primary structure of corticotropin-releasing factor from ovine hypothalamus. Proc. Natl. Acad. Sci. USA 78, 6517-6521.
3. Majzoub, J. A. (2006) Corticotropin-releasing hormone physiology. Eur. J. Endocrinol. 155, S71-S76.
4. Vaughan, J., Donaldson, C., Bittencourt, J., Perrin, M. H., Lewis, K., Sutton, S., Chan, R., Turnbull, A. V., Lovejoy, D. and Rivier, C. (1995) Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor [see comments]. Nature 378, 287-292.
5. Reyes, T. M., Lewis, K., Perrin, M. H., Kunitake, K. S., Vaughan, J., Arias, C. A., Hogenesch, J. B., Gulyas, J., Rivier, J., Vale, W. W. and Sawchenko, P. E. (2001) Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc. Natl. Acad. Sci. USA 98, 2843-2848.
6. Hsu, S. Y. and Hsueh, A. J. (2001) Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat. Med. 7, 605-611.
7. Lewis, K., Li, C., Perrin, M. H., Blount, A., Kunitake, K., Donaldson, C., Vaughan, J., Reyes, T. M., Gulyas, J., Fischer, W., Bilezikjian, L., Rivier, J., Sawchenko, P. E. and Vale, W. W. (2001) Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2receptor. Proc. Natl. Acad. Sci. USA 98, 7570-7575.
8. Xiong, Y., Xie, L. Y. and Abou-Samra, A. B. (1995) Signaling properties of mouse and human corticotropin-releasing factor (CRF) receptors: decreased coupling efficiency of human type II CRF receptor. Endocrinology 136, 1828-1834.
9. Stenzel, P., Kesterson, R., Yeung, W., Cone, R. D., Rittenberg, M. B. and Stenzel-Poore, M. P. (1995) Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart. Mol. Endocrinol. 9, 637-645.
10. Perrin, M. H., Donaldson, C. J., Chen, R., Lewis, K. A. and Vale, W. W. (1993) Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor. Endocrinology 133, 3058-3061.
11. Vita, N., Laurent, P., Lefort, S., Chalon, P., Lelias, J. M., Kaghad, M., Le Fur, G., Caput, D. and Ferrara, P. (1993) Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 335, 1-5.
12. Chen, R., Lewis, K. A., Perrin, M. H. and Vale, W. W. (1993) Expression cloning of a human corticotropin-releasing-factor receptor. Proc. Natl. Acad. Sci. USA 90, 8967-8971.
13. Chalmers, D. T., Lovenberg, T. W., Grigoriadis, D. E., Behan, D. P. and De Souza, E. B. (1996) Corticotrophin-releasing factor receptors: from molecular biology to drug design. Trends Pharmacol. Sci. 17, 166-172.
14. Merchenthaler, I. (1984) Corticotropin releasing factor (CRF)-like immunoreactivity in the rat central nervous system. Extrahypothalamic distribution. Peptides 5 Suppl 1, 53-69.
15. Dautzenberg, F. M. and Hauger, R. L. (2002) The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol. Sci. 23, 71-77.
16. Bale, T. L., Contarino, A., Smith, G. W., Chan, R., Gold, L. H., Sawchenko, P. E., Koob, G. F., Vale, W. W. and Lee, K. F. (2000) Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat. Genet. 24, 410-414.
17. Kishimoto, T., Radulovic, J., Radulovic, M., Lin, C. R., Schrick, C., Hooshmand, F., Hermanson, O., Rosenfeld, M. G. and Spiess, J. (2000) Deletion of crhr2 reveals an anxiolytic role for corticotropin- releasing hormone receptor-2. Nat. Genet. 24, 415-419.
18. Dermitzaki, E. Tsatsanis, C., Minas, V., Chatzaki, E., Charalampopoulos, I. Venihaki, M., Androulidaki, A., Lambropoulou, M., Spiess, J., Michalodimitrakis, E., Gravanis, A. and Margioris, A. N. (2007) Corticotropin-Releasing Factor (CRF) and the Urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRFreceptor type-specific manner. Endocrinology 148, 1524-1538.
19. Chatzaki, E., Crowe, P. D., Wang, L., Million, M., Tache, Y. and Grigoriadis, D. E. (2004) CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon. J. Neurochem. 90, 309-316.
20. Coste, S. C., Kesterson, R. A., Heldwein, K. A., Stevens, S. L., Heard, A. D., Hollis, J. H., Murray, S. E., Hill, J. K., Pantely, G. A., Hohimer, A. R., Hatton, D. C., Phillips, T. J., Finn, D. A., Low, M. J., Rittenberg, M. B., Stenzel, P. and Stenzel-Poore, M. P. (2000) Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat. Genet. 24, 403-409.
21. Smith, G. W., Aubry, J. M., Dellu, F., Contarino, A., Bilezikjian, L. M., Gold, L. H., Chen, R., Marchuk, Y., Hauser, C., Bentley, C. A., Sawchenko, P. E., Koob, G. F., Vale, W. and Lee, K. F. (1998) Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20, 1093-1102.
22. Grigoriadis, D. E. (2005) The corticotropin-releasing factor receptor: a novel target for the treatment of depression and anxiety-related disorders. Expert Opin. Ther. Targets 9, 651-684.
23. Kosoyan, H. P., Grigoriadis, D. E. and Tache, Y. (2005) The CRF(1) receptor antagonist, NBI-35965, abolished the activation of locus coeruleus neurons induced by colorectal distension and intracisternal CRF in rats. Brain Res. 1056, 85-96.
24. Cortright, D. N., Goosens, K. A., Lesh, J. S. and Seasholtz, A. F. (1997) Isolation and characterization of the rat corticotropin-releasing hormone (CRH)-binding protein gene: transcriptional regulation by cyclic adenosine monophosphate and CRH. Endocrinology 138, 2098-2108.
25. Behan, D. P., Heinrichs, S. C., Troncoso, J. C., Liu, X. J., Kawas, C. H., Ling, N. and De Souza, E. B. (1995) Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. Nature 378, 284-287.
26. Seasholtz, A. F., Burrows, H. L., Karolyi, I. J. and Camper, S. A. (2001) Mouse models of altered CRH-binding protein expression. Peptides 22, 743-751.
27. Behan, D. P., Maciejewski, D., Chalmers, D. and De Souza, E. B. (1995) Corticotropin releasing factor binding protein (CRF-BP) is expressed in neuronal and astrocytic cells. Brain Res. 698, 259-264.
28. Chatzaki, E., Margioris, A. N. and Gravanis, A. (2002) Expression and regulation of corticotropin-releasing hormone binding protein (CRH-BP) in rat adrenals. J. Neurochem. 80, 81-90.
29. Baigent, S. M. and Lowry, P. J. (2000) mRNA expression profiles for corticotrophin-releasing factor (CRF), urocortin, CRF receptors and CRF-binding protein in peripheral rat tissues. J. Mol. Endocrinol. 25, 43-52.
30. Nicholson, W. E., DeCherney, G. S., Jackson, R. V. and Orth, D. N. (1987) Pituitary and hypothalamic hormones in normal and neoplastic adrenal medullae: biologically active corticotropin-releasing hormone and corticotropin. Regul. Pept. 18, 173-188.
31. Thompson, R. C., Seasholtz, A. F. and Herbert, E. (1987) Rat corticotropin-releasing hormone gene: sequence and tissue-specific expression. Mol. Endocrinol. 1, 363-370.
32. Usui, T., Nakai, Y., Tsukada, T., Jingami, H., Takahashi, H., Fukata, J. and Imura, H. (1988) Expression of adrenocorticotropin-releasing hormone precursor gene in placenta and other nonhypothalamic tissues in man. Mol. Endocrinol. 2, 871-875.
33. Suda, T., Tomori, N., Tozawa, F., Mouri, T., Demura, H. and Shizume, K. (1984) Distribution and characterization of immunoreactive corticotropin- releasing factor in human tissues. J. Clin. Endocrinol. Metab. 59, 861-866.
34. Willenberg, H. S., Bornstein, S. R., Hiroi, N., Path, G., Goretzki, P. E., Scherbaum, W. A. and Chrousos, G. P. (2000) Effects of a novel corticotropin-releasing-hormone receptor type I antagonist on human adrenal function. Mol. Psychiatry 5, 137-141.
35. Seres, J., Bornstein, S. R., Seres, P., Willenberg, H. S., Schulte, K. M., Scherbaum, W. A. and Ehrhart-Bornstein, M. (2004) Corticotropin-releasing hormone system in human adipose tissue. J. Clin. Endocrinol. Metab. 89, 965-970.
36. Bileviciute, I., Ahmed, M., Bergstrom, J., Ericsson-Dahlstrand, A., Kreicbergs, A. and Lundeberg, T. (1997) Expression of corticotropin-releasing factor in the peripheral nervous system of the rat. Neuroreport 8, 3127-3130.
37. Pomerantz, J. E., Li, C., Nathanielsz, P. W. and McDonald, T. J. (1996) Corticotropin-releasing hormone-like axons in the adrenal glands of fetal and postnatal sheep. J. Auton. Nerv. Syst. 59, 87-90.
38. Bruhn, T. O., Engeland, W. C., Anthony, E. L., Gann, D. S. and Jackson, I. M. (1987) Corticotropin-releasing factor in the dog adrenal medulla is secreted in response to hemorrhage. Endocrinology 120, 25-33.
39. Edwards, A. V. and Jones, C. T. (1988) Secretion of corticotrophin releasing factor from the adrenal during splanchnic nerve stimulation in conscious calves. J. Physiol. 400, 89-100.
40. Jones, C. T. and Edwards, A. V. (1992) The role of corticotrophin releasing factor in relation to the neural control of adrenal function in conscious calves. J. Physiol. 447, 489-500.
41. Fukuda, T., Takahashi, K., Suzuki, T., Saruta, M., Watanabe, M., Nakata, T. and Sasano, H. (2005) Urocortin 1, urocortin 3/stresscopin, and corticotropin-releasing factor receptors in human adrenal and its disorders. J. Clin. Endocrinol. Metab. 90, 4671-4678.
42. Takahashi, K., Totsune, K., Saruta, M., Fukuda, T., Suzuki, T., Hirose, T., Imai, Y., Sasano, H. and Murakami, O. (2006) Expression of urocortin 3/stresscopin in human adrenal glands and adrenal tumors. Peptides 27, 178-82.
43. Leavitt, M. G., Albrecht, E. D. and Pepe, G. J. (1999) Development of the baboon fetal adrenal gland: regulation of the ontogenesis of the definitive and transitional zones by adrenocorticotropin. J. Clin. Endocrinol. Metab. 84, 3831-3835.
44. Wilburn, L. A. and Jaffe, R. B. (1988) Quantitative assessment of the ontogeny of met-enkephalin, norepinephrine and epinephrine in the human fetal adrenal medulla. Acta Endocrinol. (Copenh) 118, 453-459.
45. Bocian-Sobkowska, J., Malendowicz, L. K. and Wozniak, W. (1997) Comparative stereological studies on zonation and cellular composition of adrenal glands of normal and anencephalic human fetuses. II. Cellular composition of the gland. Histol. Histopathol. 12, 391-399.
46. Dotzler, S. A., Digeronimo, R. J., Yoder, B. A. and Siler-Khodr, T. M. (2004) Distribution of corticotropin releasing hormone in the fetus, newborn, juvenile, and adult baboon. Pediatr. Res. 55, 120-125.
47. Karteris, E., Randeva, H. S., Grammatopoulos, D. K., Jaffe, R. B. and Hillhouse, E. W. (2001) Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals. J. Clin. Endocrinol. Metab. 86, 4512-4519.
48. Crespi, E. J. and Denver, R. J. (2005) Ancient origins of human developmental plasticity. Am. J. Hum. Biol. 17, 44-54.
49. Sirianni, R., Rehman, K. S., Carr, B. R., Parker, C. R. Jr. and Rainey, W. E. (2005) Corticotropin-releasing hormone directly stimulates cortisol and the cortisol biosynthetic pathway in human fetal adrenal cells. J. Clin. Endocrinol. Metab. 90, 279-285.
50. Hillhouse, E. W., Grammatopoulos, D., Milton, N. G. and Quartero, H. W. (1993) The identification of a human myometrial corticotropin-releasing hormone receptor that increases in affinity during pregnancy. J. Clin. Endocrinol. Metab. 76, 736-741.
51. Jahn, O., Tezval, H., vanWerven, L., Eckart, K. and Spiess, J. (2004) Three-amino acid motifs of urocortin II and III determine their CRF receptor subtype selectivity. Neuropharmacology 47, 233-242.
52. Dave, J. R., Eiden, L. E. and Eskay, R. L. (1985) Corticotropin-releasing factor binding to peripheral tissue and activation of the adenylate cyclase-adenosine 3′,5′-monophosphate system. Endocrinology 116, 2152-2159.
53. Minamino, N., Uehara, A. and Arimura, A. (1988) Biological and immunological characterization of corticotropin-releasing activity in the bovine adrenal medulla. Peptides 9, 37-45.
54. Habib, K. E., Weld, K. P., Rice, K. C., Pushkas, J., Champoux, M., Listwak, S., Webster, E. L., Atkinson, A. J., Schulkin, J., Contoreggi, C., Chrousos, G. P., McCann, S. M., Suomi, S. J., Higley, J. D. and Gold, P. W. (2000) Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. Proc. Natl. Acad. Sci. USA 97, 6079-6084.
55. Millan, M. A., Samra, A. B., Wynn, P. C., Catt, K. J. and Aguilera, G. (1987) Receptors and actions of corticotropinreleasing hormone in the primate pituitary gland. J. Clin. Endocrinol. Metab. 64, 1036-1041.
56. Udelsman, R., Harwood, J. P., Millan, M. A., Chrousos, G. P., Goldstein, D. S., Zimlichman, R., Catt, K. J. and Aguilera, G. (1986) Functional corticotropin releasing factor receptors in the primate peripheral sympathetic nervous system. Nature 319, 147-150.
57. Palchaudhuri, M. R., Wille, S., Mevenkamp, G., Spiess, J., Fuchs, E. and Dautzenberg, F. M. (1998) Corticotropin-releasing factor receptor type 1 from Tupaia belangeri-cloning, functional expression and tissue distribution. Eur. J. Biochem. 258, 78-84.
58. Venihaki, M., Gravanis, A. and Margioris, A. N. (1997) Comparative study between normal rat chromaffin and PC12 rat pheochromocytoma cells: production and effects of corticotropin-releasing hormone. Endocrinology 138, 698-704.
59. Mazzocchi, G., Malendowicz, L. K., Rebuffat, P., Gottardo, G. and Nussdorfer, G. G. (1997) Neurotensin stimulates CRH and ACTH release by rat adrenal medulla in vitro. Neuropeptides 31, 8-11.
60. Oki, Y., Iwabuchi, M., Masuzawa, M., Watanabe, F., Ozawa, M., Iino, K., Tominaga, T. and Yoshimi, T. (1998) Distribution and concentration of urocortin, and effect of adrenalectomy on its content in rat hypothalamus. Life Sci. 62, 807-812.
61. Yamauchi, N., Otagiri, A., Nemoto, T., Sekino, A., Oono, H., Kato, I., Yanaihara, C. and Shibasaki, T. (2005) Distribution of urocortin 2 in various tissues of the rat. J. Neuroendocrinol. 17, 656-663.
62. Takahashi, K., Totsune, K., Murakami, O. and Shibahara, S. (2004) Urocortins as cardiovascular peptides. Peptides 25, 1723-1731.
63. Takagi, M., Egawa, T., Motomura, T., Sakuma-Mochizuki, J., Nishimoto, N., Kasayama, S., Hayashi, S., Koga, M., Yoshizaki, K., Yoshioka, T., Okuyama, A. and Kishimoto, T. (1997) Interleukin-6 secreting phaeochromocytoma associated with clinical markers of inflammation. Clin. Endocrinol. (Oxf) 46, 507-509.
64. Gadient, R. A., Lachmund, A., Unsicker, K. and Otten, U. (1995) Expression of interleukin-6 (IL-6) and IL-6 receptor mRNAs in rat adrenal medulla. Neurosci. Lett. 194, 17-20.
65. Marz, P., Herget, T., Lang, E., Otten, U. and Rose-John, S. (1997) Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation. Eur. J. Neurosci. 9, 2765-2773.
66. Umegaki, H., Yamada, K., Naito, M., Kameyama, T., Iguchi, A. and Nabeshima, T. (1996) Protective effect of interleukin-6 against the death of PC12 cells caused by serum deprivation or by the addition of a calcium ionophore. Biochem. Pharmacol. 52, 911-916.
67. Jezova, D., Ochedalski, T., Glickman, M., Kiss, A. and Aguilera, G. (1999) Central corticotropin-releasing hormone receptors modulate hypothalamic-pituitary-adrenocortical and sympathoadrenal activity during stress. Neuroscience 94, 797-802.
68. Lehnert, H., Schulz, C. and Dieterich, K. (1998) Physiological and neurochemical aspects of corticotropin-releasing factor actions in the brain: the role of the locus coeruleus. Neurochem. Res. 23, 1039-1052.
69. Koob, G. F. and Heinrichs, S. C. (1999)Arole for corticotropin releasing factor and urocortin in behavioral responses to stressors. Brain Res. 848, 141-152.
70. Reyes, B. A., Valentino, R. J., Xu, G. and VanBockstaele, E. J. (2005) Hypothalamic projections to locus coeruleus neurons in rat brain. Eur. J. Neurosci. 22, 93-106.
71. Reyes, B. A., Fox, K., Valentino, R. J. and Van Bockstaele, E. J. (2006) Agonist-induced internalization of corticotropin-releasing factor receptors in noradrenergic neurons of the rat locus coeruleus. Eur. J. Neurosci. 23, 2991-2998.
72. Traver, S., Marien, M., Martin, E., Hirsch, E. C. and Michel, P. P. (2006) The phenotypic differentiation of locus ceruleus noradrenergic neurons mediated by brain-derived neurotrophic factor is enhanced by corticotropin releasing factor through the activation of a cAMP-dependent signaling pathway. Mol. Pharmacol. 70, 30-40.
73. VanBockstaele, E. J., Bajic, D., Proudfit, H. and Valentino, R. J. (2001) Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleus. Physiol. Behav. 73, 273-283.
74. Lejeune, F. and Millan, M. J. (2003) The CRF1 receptor antagonist, DMP695, abolishes activation of locus coeruleus noradrenergic neurones by CRF in anesthetized rats. Eur. J. Pharmacol. 464, 127-133.
75. Fisher, L. A., Kikkawa, D. O., Rivier, J. E., Amara, S. G., Evans, R. M., Rosenfeld, M. G., Vale, W. W. and Brown, M. R. (1983) Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide. Nature 305, 534-536.
76. Kurosawa, M., Sato, A., Swenson, R. S. and Takahashi, Y. (1986) Sympatho-adrenal medullary functions in response to intracerebroventricularly injected corticotropin-releasing factor in anesthetized rats. Brain Res. 367, 250-257.
77. Yokotani, K., Murakami, Y., Okada, S. and Hirata, M. (2001) Role of brain arachidonic acid cascade on central CRF1 receptor-mediated activation of sympatho-adrenomedullary outflow in rats. Eur. J. Pharmacol. 419, 183-189.
78. Andreis, P. G., Neri, G. and Nussdorfer, G. G. (1991) Corticotropin-releasing hormone (CRH) directly stimulates corticosterone secretion by the rat adrenal gland. Endocrinology 128, 1198-1200.
79. Hoheisel, G., Schauer, J., Scherbaum, W. A. and Bornstein, S. R. (1998) The effect of corticotropin-releasing hormone (CRH) on the adrenal medulla in hypophysectomized rats. Histol. Histopathol. 13, 81-87.
80. Robinson, B. G., Emanuel, R. L., Frim, D. M. and Majzoub, J. A. (1988) Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Proc. Natl. Acad. Sci. USA 85, 5244-5248.
81. Smith, R., Mesiano, S., Chan, E. C., Brown, S. and Jaffe, R. B. (1998) Corticotropin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells. J. Clin. Endocrinol. Metab. 83, 2916-2920.
82. Jaffe, R. B., Mesiano, S., Smith, R., Coulter, C. L., Spencer, S. J. and Chakravorty, A. (1998) The regulation and role of fetal adrenal development in human pregnancy. Endocr. Res. 24, 919-926.
83. Sirianni, R., Mayhew, B. A., Carr, B. R., Parker, C. R. Jr. and Rainey, W. E. (2005) Corticotropin-releasing hormone (CRH) and urocortin act through type 1 CRH receptors to stimulate dehydroepiandrosterone sulfate production in human fetal adrenal cells. J. Clin. Endocrinol. Metab. 90, 5393-5400.
84. Rainey, W. E., Rehman, K. S. and Carr, B. R. (2004) The human fetal adrenal: making adrenal androgens for placental estrogens. Semin. Reprod. Med. 22, 327-336.
85. Margioris, A. N., Brockmann, G., Bohler, H. C. Jr., Grino, M., Vamvakopoulos, N. and Chrousos, G. P. (1990) Expression and localization of growth hormone-releasing hormone messenger ribonucleic acid in rat placenta: in vitro secretion and regulation of its peptide product. Endocrinology 126, 151-158.
86. Power, M. L. and Schulkin, J. (2006) Functions of corticotropin-releasing hormone in anthropoid primates: from brain to placenta. Am. J. Hum. Biol. 18, 431-447.
87. Laatikainen, T., Virtanen, T., Kaaja, R. and Salminen-Lappalainen, K. (1991) Corticotropin-releasing hormone in maternal and cord plasma in pre-eclampsia. Eur. J. Obstet. Gynecol. Reprod. Biol. 39, 19-24.
88. Venihaki, M., Ain, K., Dermitzaki, E., Gravanis, A. and Margioris, A. N. (1998) KAT45, a noradrenergic human pheochromocytoma cell line producing corticotropin-releasing hormone. Endocrinology 139, 713-722.
89. Nanmoku, T., Takekoshi, K., Fukuda, T., Isobe, K., Shibuya, S. and Kawakami, Y. (2005) Urocortin stimulates tyrosine hydroxylase activity via the cAMP/protein kinase a pathway in rat Pheochromocytoma PC12 cells. Neurosci. Lett. 382, 124-127.
90. Nemoto, T., Mano-Otagiri, A. and Shibasaki, T. (2005) Urocortin 2 induces tyrosine hydroxylase phosphorylation in PC12 cells. Biochem. Biophys. Res. Commun. 330, 821-831.
91. Kvetnansky, R., Pacak, K., Fukuhara, K., Viskupic, E., Hiremagalur, B., Nankova, B., Goldstein, D. S., Sabban, E. L. and Kopin, I. J. (1995) Sympathoadrenal system in stress. Interaction with the hypothalamic-pituitary- adrenocortical system. Ann. N Y Acad. Sci. 771, 131-158.
92. Lima, L. and Sourkes, T. L. (1987) Effect of corticotropin-releasing factor on adrenal DBH and PNMT activity. Peptides 8, 437-441.
93. Dermitzaki, E., Tsatsanis, C., Gravanis, A. and Margioris, A. N. (2002) Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. J. Biol. Chem. 277, 12280-12287.
94. Dermitzaki, I., Tsatsanis, C., Alexaki, V. I., Castanas, E. and Margioris, A. N. (2004) Roles of protein kinase A (PKA) and PKC on Corticotropin-releasing hormone (CRH)-induced elevation of cytosolic calcium from extra-and intra-cellular sources. Hormones (Athens) 3, 252-258.
95. Dermitzaki, E., Tsatsanis, C., Charalampopoulos, I., Androulidaki, A., Alexaki, V. I., Castanas, E., Gravanis, A. and Margioris, A. N. (2005) Corticotropin-releasing hormone activates protein kinase C in an isoenzyme-specific manner. Biochem. Biophys. Res. Commun. 327, 828-836.
96. Lujan, H. J., Mathews, H. L., Gamelli, R. L. and Jones, S. B. (1998) Human immune cells mediate catecholamine secretion from adrenal chromaffin cells. Crit. Care. Med. 26, 1218-1224.
97. Raber, J., Sorg, O., Horn, T. F., Yu, N., Koob, G. F., Campbell, I. L. and Bloom, F. E. (1998) Inflammatory cytokines: putative regulators of neuronal and neuro-endocrine function. Brain Res. Brain Res. Rev. 26, 320-326.
98. McCann, S. M., Kimura, M., Karanth, S., Yu, W. H., Mastronardi, C. A. and Rettori, V. (2000) The mechanism of action of cytokines to control the release of hypothalamic and pituitary hormones in infection. Ann. N Y Acad. Sci. 917, 4-18.
99. Minghetti, L., Ajmone-Cat, M. A., De Berardinis, M. A. and De Simone, R. (2005) Microglial activation in chronic neurodegenerative diseases: roles of apoptotic neurons and chronic stimulation. Brain Res. Brain Res. Rev. 48, 251-256.
100. Marx, C., Ehrhart-Bornstein, M., Scherbaum, W. A. and Bornstein, S. R. (1998) Regulation of adrenocortical function by cytokines - relevance for immune-endocrine interaction. Horm. Metab. Res. 30, 416-420.
101. Nussdorfer, G. G. and Mazzocchi, G. (1998) Immune-endocrine interactions in the mammalian adrenal gland: facts and hypotheses. Int. Rev. Cytol. 183, 143-184.
102. Currie, K. P., Zhou, Z. and Fox, A. P. (2000) Evidence for paracrine signaling between macrophages and bovine adrenal chromaffin cell Ca(2+) channels. J. Neurophysiol. 83, 280-287.
103. Gonzalez-Hernandez, J. A., Bornstein, S. R., Ehrhart-Bornstein, M., Geschwend, J. E., Adler, G. and Scherbaum, W. A. (1994) Macrophages within the human adrenal gland. Cell Tissue Res. 278, 201-205.
104. Schober, A., Huber, K., Fey, J. and Unsicker, K. (1998) Distinct populations of macrophages in the adult rat adrenal gland: a subpopulation with neurotrophin-4-like immunoreactivity. Cell Tissue Res. 291, 365-373.
105. + mobilization in single bovine adrenal chromaffin cells by digital image microscopy. J. Neurochem. 56, 531-540.
106. Agelaki, S., Tsatsanis, C., Gravanis, A. and Margioris, A. N. (2002) Corticotropin-releasing hormone augments proinflammatory cytokine production from macrophages in vitro and in lipopolysaccharide-induced endotoxin shock in mice. Infect. Immun. 70, 6068-6074.
107. Tsatsanis, C., Androulidaki, A., Dermitzaki, E., Charalampopoulos, I., Spiess, J., Gravanis, A. and Margioris, A. N. (2005) Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2. FEBS Lett. 579, 4259-4264.
108. Tsatsanis, C., Androulidaki, A., Alissafi, T., Dermitzaki, E., Charalampopoulos, I., Roger, T., Gravanis, A. and Margioris, A. N. (2006) Corticotropin releasing factor and the Urocortins induce TLR4 expression in macrophages via activation of PU. 1 and AP. 1. J. Immunol. 176, 1869-1877.
109. Call, G. B., Husein, O. F., McIlmoil, C. J., Adams, A., Heckmann, R. A. and Judd, A. M. (2000) Bovine adrenal cells secrete interleukin-6 and tumor necrosis factor in vitro. Gen. Comp. Endocrinol. 118, 249-261.
110. Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F. and Besedovsky, H. (1987) Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 238, 524-526.
111. Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P. and Vale, W. (1987) Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238, 522-524.
112. Tsagarakis, S., Gillies, G., Rees, L. H., Besser, M. and Grossman, A. (1989) Interleukin-1 directly stimulates the release of corticotrophin releasing factor from rat hypothalamus. Neuroendocrinology 49, 98-101.
113. Suda, T., Tozawa, F., Ushiyama, T., Sumitomo, T., Yamada, M. and Demura, H. (1990) Interleukin-1 stimulates corticotropin-releasing factor gene expression in rat hypothalamus. Endocrinology 126, 1223-1228.
114. Nicholson, R. C., King, B. R. and Smith, R. (2004) Complex regulatory interactions control CRH gene expression. Front. Biosci. 9, 32-39.
115. King, B. R., Smith, R. and Nicholson, R. C. (2002) Novel glucocorticoid and cAMP interactions on the CRH gene promoter. Mol. Cell. Endocrinol. 194, 19-28.
116. Seth, K. A. and Majzoub, J. A. (2001) Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. J. Biol. Chem. 276, 13917-13923.
117. Singh, L. K., Boucher, W., Pang, X., Letourneau, R., Seretakis, D., Green, M. and Theoharides, T. C. (1999) Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors. J. Pharmacol. Exp. Ther. 288, 1349-1356.
118. Theoharides, T. C., Singh, L. K., Boucher, W., Pang, X., Letourneau, R., Webster, E. and Chrousos, G. (1998) Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Endocrinology 139, 403-413.
119. Sashinami, H., Kageyama, K., Suda, T. and Nakane, A. (2005) Urocortin 2 suppresses host resistance to Listeria monocytogenes infection via up-regulation of interleukin-10. Endocrinology 146, 5003-5011.
120. Venihaki, M., Zhao, J. and Karalis, K. P. (2003) Corticotropin-releasing hormone deficiency results in impaired splenocyte response to lipopolysaccharide. J. Neuroimmunol. 141, 3-9.
121. Zhao, J. and Karalis, K. P. (2002) Regulation of nuclear factor-kappaB by corticotropin-releasing hormone in mouse thymocytes. Mol. Endocrinol. 16, 2561-2570.
122. Kokkotou, E., Torres, D., Moss, A. C., O'Brien, M., Grigoriadis, D. E., Karalis, K. and Pothoulakis, C. (2006) Corticotropin-releasing hormone receptor 2-deficient mice have reduced intestinal inflammatory responses. J. Immunol. 177, 3355-3361.
123. Tsatsanis, C., Androulidaki, A., Dermitzaki, E., Gravanis, A. and Margioris, A. N. (2007) Corticotropin releasing factor receptor 1 (CRF(1)) and CRF(2) agonists exert an antiinflammatory effect during the early phase of inflammation suppressing LPS-induced TNF-alpha release from macrophages via induction of COX-2 and PGE(2). J. Cell. Physiol. 210, 774-783.
124. Cao, J., Papadopoulou, N., Kempuraj, D., Boucher, W. S., Sugimoto, K., Cetrulo, C. L. and Theoharides, T. C. (2005) Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J. Immunol. 174, 7665-7675.
125. Makrigiannakis, A., Zoumakis, E., Margioris, A. N., Stournaras, C., Chrousos, G. P. and Gravanis, A. (1996) Regulation of the promoter of the human corticotropin-releasing hormone gene in transfected human endometrial cells. Neuroendocrinology 64, 85-92.
126. Wang, Y. D., Wang, L., Li, D. J. and Wang, W. J. (2006) Dehydroepiandrosterone inhibited the bone resorption through the upregulation of OPG/RANKL. Cell. Mol. Immunol. 3, 41-45.
127. Kim, S. K., Shin, M. S., Jung, B. K., Shim, J. Y., Won, H. S., Lee, P. R. and Kim, A. (2006) Effect of dehydroepiandrosterone on lipopolysaccharide- induced interleukin-6 production in DH82 cultured canine macrophage cells. J. Reprod. Immunol. 70, 71-81.
128. Dhingra, V. K., Uusaro, A., Holmes, C. L. and Walley, K. R. (2001) Attenuation of lung inflammation by adrenergic agonists in murine acute lung injury. Anesthesiology 95, 947-953.
129. Deng, J., Muthu, K., Gamelli, R., Shankar, R. and Jones, S. B. (2004) Adrenergic modulation of splenic macrophage cytokine release in polymicrobial sepsis. Am. J. Physiol. Cell. Physiol. 287, C730-736.
130. Newell-Price, J., Bertagna, X., Grossman, A. B. and Nieman, L. K. (2006) Cushing's syndrome. Lancet 367, 1605-1617.
131. Isidori, A. M., Kaltsas, G. A., Pozza, C., Frajese, V., Newell-Price, J., Reznek, R. H., Jenkins, P. J., Monson, J. P., Grossman, A. B. and Besser, G. M. (2006) The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up. J. Clin. Endocrinol. Metab. 91, 371-377.
132. Biller, B. M. (1994) Pathogenesis of pituitary Cushing's syndrome. Pituitary versus hypothalamic. Endocrinol. Metab. Clin. North Am. 23, 547-554.
133. Becker, M. and Aron, D. C. (1994) Ectopic ACTH syndrome and CRH-mediated Cushing's syndrome. Endocrinol. Metab. Clin. North Am. 23, 585-606.
134. Zarate, A., Kovacs, K., Flores, M., Moran, C. and Felix, I. (1986) ACTH and CRF-producing bronchial carcinoid associated with Cushing's syndrome. Clin. Endocrinol. (Oxf) 24, 523-529.
135. Muller, O. A. and von Werder, K. (1992) Ectopic production of ACTH and corticotropin-releasing hormone (CRH). J. Steroid Biochem. Mol. Biol. 43, 403-408.
136. Boon, E. S., Leers, M. P. and Tjwa, M. K. (1994) Ectopic Cushing's syndrome in a patient with squamous cell carcinoma of the lung due to CRF-like production. Monaldi Arch. Chest Dis. 49, 19-21.
137. Eng, P. H., Tan, L. H., Wong, K. S., Cheng, C. W., Fok, A. C. and Khoo, D. H. (1999) Cushing's syndrome in a patient with a corticotropin-releasing hormone-producing pheochromocytoma. Endocr. Pract. 5, 84-87.
138. Orth, D. N. (1992) Corticotropin-releasing hormone in humans. Endocr. Rev. 13, 164-191.
139. Austin, M. C., Janosky, J. E. and Murphy, H. A. (2003) Increased corticotropin-releasing hormone immunoreactivity in monoamine-containing pontine nuclei of depressed suicide men. Mol. Psychiatry 8, 324-332.
140. Tsigos, C. and Chrousos, G. P. (2002) Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J. Psychosom. Res. 53, 865-871.
141. Strohle, A. and Holsboer, F. (2003) Stress responsive neurohormones in depression and anxiety. Pharmacopsychiatry 36 Suppl 3, S207-214.
142. Schteingart, D. E., Lloyd, R. V., Akil, H., Chandler, W. F., Ibarra-Perez, G., Rosen, S. G. and Ogletree, R. (1986) Cushing's syndrome secondary to ectopic corticotropinreleasing hormone-adrenocorticotropin secretion. J. Clin. Endocrinol. Metab. 63, 770-775.
143. Adams, E. F., Skrabal, F., Carroll, D., Loizou, M., White, M. C., Biggins, J. A. and Mashiter, K. (1987) Ectopic corticotrophin-releasing-factor and growth hormone releasing factor secretion: diagnosis using human pituitary cell culture. Horm. Res. 25, 80-87.
144. Tourniaire, J., Rebattu, B., Conte-Devolx, B., Trouillas, J., Grino, M., Berger-Dutrieux, N., Peix, J. L. and Pugeat, M. (1988) Cushing's syndrome caused by ectopic production of CRF by a medullary carcinoma of the thyroid body. Ann. Endocrinol. (Paris) 49, 61-67.
145. Gerl, H., Knappe, G., Rohde, W., Stahl, F., Wolff, H. and Martin, H. (1990) Cushing's syndrome in CRF-producing mediastinal carcinoid. Dtsch. Med. Wochenschr. 115, 332-336.
146. Preeyasombat, C., Sirikulchayanonta, V., Mahachokelertwattana, P., Sriphrapradang, A. and Boonpucknavig, S. (1992) Cushing's syndrome caused by Ewing's sarcoma secreting corticotropin releasing factor-like peptide. Am. J. Dis. Child 146, 1103-1105.
147. Saeger, W., Reincke, M., Scholz, G. H. and Ludecke, D. K. (1993) Ectopic ACTH- or CRH-secreting tumors in Cushing's syndrome. Zentralbl. Pathol. 139, 157-163.
148. Auchus, R. J., Mastorakos, G., Friedman, T. C. and Chrousos, G. P. (1994) Corticotropin-releasing hormone production by a small cell carcinoma in a patient with ACTH-dependent Cushing's syndrome. J Endocrinol. Invest. 17, 447-452.
149. Suda, T. (1994) Synthesis and release of CRF and ACTH in ectopic CRF/ACTH-producing tumors. Nippon Naibunpi Gakkai Zasshi 70, 17-24.
150. Asa, S. L., Kovacs, K., Hammer, G. D., Liu, B., Roos, B. A. and Low, M. J. (1992) Pituitary corticotroph hyperplasia in rats implanted with a medullary thyroid carcinoma cell line transfected with a corticotropin-releasing hormone complementary deoxyribonucleic acid expression vector. Endocrinology 131, 715-720.
151. Hammer, G. D., Mueller, G., Liu, B., Petrides, J. S., Roos, B. A. and Low, M. J. (1992) Ectopic corticotropin-releasing hormone produced by a transfected cell line chronically activates the pituitary-adrenal axis in transkaryotic rats. Endocrinology 130, 1975-1985.
152. Venihaki, M., Gravanis, A. and Margioris, A. N. (1998) KAT45 human pheochromocytoma cell line. A new model for the in vitro study of neuro-immuno-hormonal interactions. Ann. N Y Acad. Sci. 840, 425-433.
153. Willenberg, H. S., Haase, M., Papewalis, C., Schott, M., Scherbaum, W. A. and Bornstein, S. R. (2005) Corticotropin-releasing hormone receptor expression on normal and tumorous human adrenocortical cells. Neuroendocrinology 82, 274-281.
154. Jessop, D. S., Cunnah, D., Millar, J. G., Neville, E., Coates, P., Doniach, I., Besser, G. M. and Rees, L. H. (1987) A phaeochromocytoma presenting with Cushing's syndrome associated with increased concentrations of circulating corticotrophin-releasing factor. J. Endocrinol. 113, 133-138.
155. O'Brien, T., Young, W. F. Jr., Davila, D. G., Scheithauer, B. W., Kovacs, K., Horvath, E., Vale, W. and van Heerden, J. A. (1992) Cushing's syndrome associated with ectopic production of corticotrophin-releasing hormone, corticotrophin and vasopressin by a phaeochromocytoma. Clin. Endocrinol. (Oxf) 37, 460-467.
156. Liu, J., Heikkila, P., Voutilainen, R., Karonen, S. L. and Kahri, A. I. (1994) Pheochromocytoma expressing adrenocorticotropin and corticotropin- releasing hormone; regulation by glucocorticoids and nerve growth factor. Eur. J. Endocrinol. 131, 221-228.
157. Bayraktar, F., Kebapcilar, L., Kocdor, M. A., Asa, S. L., Yesil, S., Canda, S., Demir, T., Saklamaz, A., Secil, M., Akinci, B., Yener, S. and Comlekci, A. (2006) Cushing's syndrome due to ectopic CRH secretion by adrenal pheochromocytoma accompanied by renal infarction. Exp. Clin. Endocrinol. Diabetes 114, 444-447.
158. Zangeneh, F., Young, W. F. Jr., Lloyd, R. V., Chiang, M. and Kurczynski, E. (2003) Cushing's syndrome due to ectopic production of corticotropin- releasing hormone in an infant with ganglioneuroblastoma. Endocr. Pract. 9, 394-399.
159. Majzoub, J. A. and Muglia, L. J. (1996) Knockout mice. N. Engl. J. Med. 334, 904-907.
160. Muglia, L., Jacobson, L., Dikkes, P. and Majzoub, J. A. (1995) Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 373, 427-432.
161. Muglia, L. J., Jenkins, N. A., Gilbert, D. J., Copeland, N. G. and Majzoub, J. A. (1994) Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells. J. Clin. Invest. 93, 2066-2072.
162. Venihaki, M., Carrigan, A., Dikkes, P. and Majzoub, J. A. (2000) Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency. Proc. Natl. Acad. Sci. USA 97, 7336-7341.
163. Weninger, S. C., Dunn, A. J., Muglia, L. J., Dikkes, P., Miczek, K. A., Swiergiel, A. H., Berridge, C. W. and Majzoub, J. A. (1999) Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH. Proc. Natl. Acad. Sci. USA 96, 8283-8288.
164. Weninger, S. C., Peters, L. L. and Majzoub, J. A. (2000) Urocortin expression in the Edinger-Westphal nucleus is upregulated by stress and corticotropin-releasing hormone deficiency. Endocrinology 141, 256-263.
165. Muglia, L. J., Jacobson, L., Luedke, C., Vogt, S. K., Schaefer, M. L., Dikkes, P., Fukuda, S., Sakai, Y., Suda, T. and Majzoub, J. A. (2000) Corticotropin-releasing hormone links pituitary adrenocorticotropin gene expression and release during adrenal insufficiency. J. Clin. Invest. 105, 1269-1277.
166. Viskupic, E., Kvetnansky, R., Sabban, E. L., Fukuhara, K., Weise, V. K., Kopin, I. J. and Schwartz, J. P. (1994) Increase in rat adrenal phenylethanolamine N-methyltransferase mRNA level caused by immobilization stress depends on intact pituitary-adrenocortical axis. J. Neurochem. 63, 808-814.
167. Bruhn, T. O., Engeland, W. C., Anthony, E. L., Gann, D. S. and Jackson, I. M. (1987) Corticotropin-releasing factor in the adrenal medulla. Ann. N Y Acad. Sci. 512, 115-128.
168. Jeong, K. H., Jacobson, L., Pacak, K., Widmaier, E. P., Goldstein, D. S. and Majzoub, J. A. (2000) Impaired basal and restraint-induced epinephrine secretion in corticotropin-releasing hormone-deficient mice. Endocrinology 141, 1142-1150.
169. Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J. M., Stalla, G. K., Blanquet, V., Steckler, T., Holsboer, F. and Wurst, W. (1998) Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat. Genet. 19, 162-166.
170. Yoshida-Hiroi, M., Bradbury, M. J., Eisenhofer, G., Hiroi, N., Vale, W. W., Novotny, G. E., Hartwig, H. G., Scherbaum, W. A. and Bornstein, S. R. (2002) Chromaffin cell function and structure is impaired in corticotropin-releasing hormone receptor type 1-null mice. Mol. Psychiatry 7, 967-974.
171. Preil, J., Muller, M. B., Gesing, A., Reul, J. M., Sillaber, I., van Gaalen, M. M., Landgrebe, J., Holsboer, F., Stenzel-Poore, M. and Wurst, W. (2001) Regulation of the hypothalamicpituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2. Endocrinology 142, 4946-4955.