Protective effect of interleukin-6 against the death of PC12 cells caused by serum deprivation or by the addition of a calcium ionophore

Biochemical Pharmacology

Volumn 52, Issue 6, 1996, Pages 911-916

  Umegaki, Hiroyuki ^a   Yamada, Kiyofumi ^a   Naito, Michitaka ^a   Kameyama, Tsutomu ^b   Iguchi, Akihisa ^a   Nabeshima, Toshitaka ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b MEIJO UNIVERSITY   (Japan)

Author keywords

apoptosis; calcium ionophore; cell death; interleukin 6; PC12 cells; serum deprivation

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; AURINTRICARBOXYLIC ACID; CALCIMYCIN; CALCIUM IONOPHORE; CYCLOHEXIMIDE; DNA FRAGMENT; INTERLEUKIN 6 ANTIBODY; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NERVE GROWTH FACTOR; RECOMBINANT INTERLEUKIN 1ALPHA; RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT INTERLEUKIN 2; RECOMBINANT INTERLEUKIN 6;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DNA CLEAVAGE; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; SERUM;

EID: 0030603959     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00422-4     Document Type: Article

References (22)

1. 1. Oppenheim RW, Cell death during development of the nervous system. Annu Rev Neurosci 14: 453-501, 1991.
2. 2. Green LA, Nerve growth factor prevents the death and stimulates neuronal differentiation of clonal PC 12 phenochromocytoma cells in serum-free medium. J Cell Biol 78: 747-755, 1978.
3. 3. Batistatou A and Green LA, Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: Correlation with suppression of endonuclease activity. J Cell Biol 115: 461-471, 1991.
4. 4. Wyllie AH, Morris RG, Smith AL and Dunlop D, Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence of macromolecular synthesis. J Pathol 142: 67-77, 1984.
5. 5. Rukenstein A, Rydel RE and Greene LA, Multiple agents rescue PC12 cells from serum-free cell death by translationand transcription-independent mechanisms. J Neurosci 11: 2552-2563, 1991.
6. 6. Mesner PW, Winters TR and Green SH, Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons. J Cell Biol 119: 1669-1680, 1992.
7. 7. Koike T, Molecular and cellular mechanism of neuronal degeneration caused by nerve growth factor deprivation approached through PC12 cell culture. Prog Neuropsychopharmacol Biol Psychiatry 16: 95-106, 1992.
8. 8. Pittman RN, Wang S, DiBenedetto AJ and Mills JC, A system for characterizing cellular and molecular events in programmed neuronal cell death. J Neurosci 13: 3669-3680, 1993.
9. 9. Joseph R, Li W and Han E, Neuronal death, cytoplasmic calcium and internucleosomal DNA fragmentation: Evidence for DNA fragments being released from cells. Mol Brain Res 17: 70-76, 1993.
10. 10. Mah SP, Zhong LT, Liu Y, Roghani A, Edwards RH and Bredesen DE, The protooncogene bcl-2 inhibits apoptosis in PC12 cells. J Neurochem 60: 1183-1186, 1993.
11. 11. Rydel RE and Green LA, Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells. J Neurosci 7: 3639-3653, 1987.
12. 12. Giulian D, Young DG, Woodward J, Brown DC and Lachman LB, Interleukin-1 is an astroglial growth factor in the developing brain. J Neurosci 8: 709-714, 1988.
13. 13. Brenneman DE, Schultzberg M, Barfai T and Gozes I, Cytokine regulation of neuronal survival. J Neurochem 58: 454-460, 1992.
14. 14. Shimojo M, Imai Y, Nakajima K, Mizushima S, Uemura A and Kohsaka S, Interleukin-2 enhances the viability of primary cultured rat neocortical neurons. Neurosci Lett 151: 170-173, 1993.
15. 15. Satoh T, Nakamura S, Taga T, Matsuda T, Hirano T, Kishimoto T and Kaziro Y, Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6. Mol Cell Biol 8: 3546-3549, 1988.
16. 16. Hama T, Kushima Y, Miyamoto M, Kubota M, Takei N and Hatanaka H, Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures. Neuroscience 40: 445-452, 1991.
17. 17. Hama T, Miyamoto M, Tsukui H, Nishio C and Hatanaka H, Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats. Neurosci Lett 104: 340-344, 1989.
18. 18. Yamada M and Hatanaka H, Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death. Brain Res 643: 173-180, 1994.
19. 19. Mosmann T, Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.
20. 20. Schwartzman RA and Cidlowski JA, Apoptosis: The biochemistry and molecular biology of programmed cell death. Endocrinol Rev 14: 133-151, 1993.
21. 21. Zhong LT, Sarafian T, Kane DJ, Charles AC, Mah SP, Edwards RH and Bredesen DE, bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Nad Acad Sci USA 90: 4533-4537, 1993.
22. 22. Batistatou A and Green LA, Internucleosomal DNA cleavage and neuronal cell survival/death. J Cell Biol 122: 523-532, 1993.