The human fetal adrenal: Making adrenal androgens for placental estrogens

Seminars in Reproductive Medicine

Volumn 22, Issue 4, 2004, Pages 327-336

  Rainey, William E ^a,b   Rehman, Khurram S ^a   Carr, Bruce R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

ACTH; Cortisol; CRH; DHEA; Fetal adrenal

Indexed keywords

ANDROGEN; CORTICOTROPIN RELEASING FACTOR; ESTROGEN; PRASTERONE SULFATE;

ADRENAL FUNCTION; ADRENAL GLAND; ANALYTIC METHOD; ANDROGEN RELEASE; BIOSYNTHESIS; DNA FLANKING REGION; DNA MICROARRAY; ESTROGEN RELEASE; FETUS; GENE FUNCTION; HORMONAL REGULATION; HORMONE SYNTHESIS; HUMAN; PREGNANCY; PROTEIN EXPRESSION; REVIEW; STEROID RELEASE; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ANDROGENS; CORTICOTROPIN-RELEASING HORMONE; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; ENZYMES; ESTROGENS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; HYDROCORTISONE; PREGNANCY; STEROIDS; STEROLS;

EID: 11144343250     PISSN: 15268004     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-861549     Document Type: Review

References (56)

1. Carr BR, Simpson ER. Lipoprotein utilization and cholesterol synthesis by the human fetal adrenal gland. Endocr Rev 1981;2:306-326
2. Elliott JR, Armour RG: The development of the cortex in the human suprarenal gland and its condition in hemicephaly. J Pathol 1911;15:481-496
3. Mesiano S, Jaffe RB. Developmental and functional biology of the primate fetal adrenal cortex. Endocr Rev 1997;18:378-403
4. Pepe GJ, Albrecht ED. Regulation of the primate fetal adrenal cortex. Endocr Rev 1990;11:151-176
5. Narasaka T, Suzuki T, Moriya T, Sasano H. Temporal and spatial distribution of corticosteroidogenic enzymes immunoreactivity in developing human adrenal. Mol Cell Endocrinol 2001;174:111-120
6. Mesiano S, Coulter CL, Jaffe RB. Localization of cytochrome P450 cholesterol side-chain cleavage, cytochrome P45017-α-hydroxylase/17,20- lyase, and 3-β-hydroxysteroid dehydrogenase isomerase steroidogenic enzymes in human and rhesus monkey fetal adrenal glands: reappraisal of functional zonation. J Clin Endocrinol Metab 1993;77:1184-1189
7. Coulter CL, Goldsmith PC, Mesiano S, et al. Functional maturation of the primate fetal adrenal in vivo. II. Ontogeny of corticosteroid synthesis is dependent upon specific zonal expression of 3β-hydroxysteroid dehydrogenase/isomerase. Endocrinology 1996;137:4953-4959
8. Suzuki T, Sasano H, Takeyama J, et al. Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. Clin Endocrinol (Oxf) 2000;53:739-747
9. Doody KM, Carr BR, Rainey WE, et al. β-hydroxysteroid dehydrogenase/isomerase in the fetal zone and neocortex of the human fetal adrenal gland. Endocrinology 1990;126: 2487-2492
10. Rehman KS, Carr BR, Rainey WE. Profiling the steroidogenic pathway in human fetal and adult adrenals. J Soc Gynecol Investig 2003;10:372-380
11. Rainey WE, Carr BR, Wang ZN, Parker CR Jr. Gene profiling of human fetal and adult adrenals. J Endocrinol 2001;171:209-215
12. Rainey WE, Parker CR Jr, Rehman K, Carr BR. The adrenal genetic puzzle: how do the fetal and adult pieces differ? Endocr Res 2002;28:611-622
13. Han VK, Lund PK, Lee DC, D'Ercole AJ. Expression of somatomedin/insulin- like growth factor messenger ribonucleic acids in the human fetus: identification, characterization, and tissue distribution. J Clin Endocrinol Metab 1988;66: 422-429
14. Mesiano S, Katz SL, Lee JY, Jaffe RB. Insulin-like growth factors augment steroid production and expression of steroidogenic enzymes in human fetal adrenal cortical cells: implications for adrenal androgen regulation. J Clin Endocrinol Metab 1997;82:1390-1396
15. L'Allemand D, Penhoat A, Lebrethon MC, et al. Insulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor messenger ribonucleic acid levels and corticotropin steroidogenic responsiveness in cultured human adrenocortical cells. J Clin Endocrinol Metab 1996;81: 3892-3897
16. Latinkic BV, Mo FE, Greenspan JA, et al. Promoter function of the angiogenic inducer Cyr61gene in transgenic mice: tissue specificity, inducibility during wound healing, and role of the serum response element. Endocrinology 2001;142: 2549-2557
17. Carr BR, Simpson ER. Cholesterol synthesis in human fetal tissues. J Clin Endocrinol Metab 1982;55:447-452
18. Waterham HR, Koster J, Romeijn GJ, et al. Mutations in the 3β-hydroxysterol delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Am J Hum Genet 2001;69:685-694
19. Parker CR Jr, Carr BR, Winkel CA, et al. Hypercholesterolemia due to elevated low density lipoprotein-cholesterol in newborns with anencephaly and adrenal atrophy. J Clin Endocrinol Metab 1983;57:37-43
20. Parker CR Jr, MacDonald PC, Carr BR, Morrison JC. The effects of dexamethasone and anencephaly on newborn serum levels of apolipoprotein A-1. J Clin Endocrinol Metab 1987;65:1098-1101
21. Parker CR Jr. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids 1999;64:640-647
22. Voutilainen R, Ilvesmaki V, Miettinen PJ. Low expression of 3β-hydroxy-5-ene steroid dehydrogenase gene in human fetal adrenals in vivo; adrenocorticotropin and protein kinase C-dependent regulation in adrenocortical cultures. J Clin Endocrinol Metab 1991;72:761767
23. Ebert SN, Balt SL, Hunter JP, et al. Egr-1 activation of rat adrenal phenylethanolamine N-methyltransferase gene. J Biol Chem 1994;269:20885-20898
24. Wilson TE, Mouw AR, Weaver CA, Milbrandt J, Parker KL. The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol Cell Biol 1993;13:861-868
25. Davis IJ, Lau LF. Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands. Mol Cell Biol 1994;14:3469-3483
26. Bassett MH, Suzuki T, Sasano H, et al. The orphan nuclear receptor NGFIB regulates transcription of 3β-hydroxysteroid dehydrogenase: implications for the control of adrenal functional zonation. J Biol Chem 2004;279: 37622-37630
27. Parker CR Jr, Stankovic AM, Goland RS. Corticotropin-releasing hormone stimulates steroidogenesis in cultured human adrenal cells. Mol Cell Endocrinol 1999;155:19-2S
28. Hillhouse EW, Grammatopoulos DK. Role of stress peptides during human pregnancy and labour. Reproduction 2002;124: 323-329
29. McGrath S, Smith R. Corticotrophin-releasing hormone and parturition. Clin Endocrinol (Oxf) 2001;55:593-595
30. Rehman KS, Sirianni R, Carr B, Rainey WE, Parker CR. Endocrine controls of human parturition: corticotropin-releasing hormone (CRH) directly stimulates cortisol and the cortisol biosynthetic pathway in the human fetal adrenal. J Soc Gynecol Investig 2004;11:80A-80A
31. McLean M, Bisits A, Davies J, et al. Predicting risk of preterm delivery by second-trimester measurement of maternal plasma corticotropin-releasing hormone and alpha-fetoprotein concentrations. Am J Obstet Gynecol 1999;181: 207-215
32. Campbell EA, Linton EA, Wolfe CD, et al. Plasma corticotropin-releasing hormone concentrations during pregnancy and parturition. J Clin Endocrinol Metab 1987;64: 1054-1059
33. Petraglia F, Sawchenko P, Rivier J, Vale W. Evidence for local stimulation of ACTH by corticotropin-releasing hormone in human placenta. Nature 1987;328:717-719
34. Robinson BG, Emanuel RL, Frim DM, Majzoub JA. Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Proc Natl Acad Sci USA 1988;85:5244-5248
35. Jones SA, Brooks AN, Challis JR. Steroids modulate corticotropin- releasing hormone production in human fetal membranes and placenta. J Clin Endocrinol Metab 1989;68: 825-830
36. Karalis K, Majzoub JA. Regulation of placental corticotropin-releasing hormone by steroids. Possible implications in labor initiation. Ann N Y Acad Sci 1995;771:551-555
37. Goland RS, Wardlaw SL, Stark RI, Brown LS Jr, Frantz AG. High levels of corticotropin-releasing hormone immunoactivity in maternal and fetal plasma during pregnancy. J Clin Endocrinol Metab 1986;63:1199-1203
38. Stalla GK, Bost H, Stalla J, et al. Human corticotropin-releasing hormone during pregnancy. Gynecol Endocrinol 1989;3:1-10
39. Lockwood CJ, Radunovic N, Nastic D, et al. Corticotropin-releasing hormone and related pituitary-adrenal axis hormones in fetal and maternal blood during the second half of pregnancy. J Perinat Med 1996;24:243-251
40. Perkins AV, Wolfe CD, Eben F, Soothill P, Linton EA. Corticotrophin- releasing hormone-binding protein in human fetal plasma. J Endocrinol 1995;146:395-401
41. Florio P, Woods RJ, Genazzani AR, Lowry PJ, Petraglia F. Changes in amniotic fluid immunoreactive corticotropin-releasing factor (CRF) and CRF-binding protein levels in pregnant women at term and during labor. J Clin Endocrinol Metab 1997;82:835-838
42. Goland RS, Jozak S, Warren WB, et al. Elevated levels of umbilical cord plasma corticotropin-releasing hormone in growth-retarded fetuses. J Clin Endocrinol Metab 1993;77: 1174-1179
43. Goland RS, Tropper PJ, Warren WB, et al. Concentrations of corticotrophin-releasing hormone in the umbilical-cord blood of pregnancies complicated by pre-eclampsia. Reprod Fertil Dev 1995;7:1227-1230
44. Petraglia F, Aguzzoli L, Florio P, et al. Maternal plasma and placental immunoreactive corticotrophin-releasing factor concentrations in infection-associated term and pre-term delivery. Placenta 1995;16:157-164
45. Ruth V, Hallman M, Laatikainen T. Corticotropin-releasing hormone and cortisol in cord plasma in relation to gestational age, labor, and fetal distress. Am J Perinatol 1993;10:115-118
46. Petraglia F, Florio P, Benedetto C, et al. High levels of corticotropin-releasing factor (CRF) are inversely correlated with low levels of maternal CRF-binding protein in pregnant women with pregnancy-induced hypertension. J Clin Endocrinol Metab 1996;81:852-856
47. Hobel CJ, Arora CP, Korst LM. Corticotrophin-releasing hormone and CRH-binding protein. Differences between patients at risk for preterm birth and hypertension. Ann N Y Acad Sci 1999;897:54-65
48. Murphy BE. Human fetal serum cortisol levels related to gestational age: evidence of a midgestational fall and a steep late gestational rise, independent of sex or mode of delivery. Am J Obstet Gynecol 1982;144:276-282
49. Goland RS, Jozak S, Conwell I. Placental corticotropin-releasing hormone and the hypercortisolism of pregnancy. Am J Obstet Gynecol 1994;171:1287-1291
50. Falkenberg ER, Davis RO, DuBard M, Parker CR Jr. Effects of maternal infections on fetal adrenal steroid production. Endocr Res 1999;25:239-249
51. Bolte E, Wiqvist N, Diczfalusy E. Metabolism of dehydroepiandrosterone and dehydroepiandrosterone sulphate by the human foetus at midpregnancy. Acta Endocrinol 1966;52: 583-597
52. Kirschner MA, Wiqvist N, Diczfalusy E. Studies on oestriol synthesis from dehydroepiandrosterone sulphate in human pregnancy. Acta Endocrinol 1966;53:584-597
53. Siiteri PK, MacDonald PC. Placental estrogen biosynthesis during human pregnancy. J Clin Endocrinol Metab 1966;26: 751-761
54. Ryan KJ. Metabolism of C-16-oxygenated steroids by human placenta: the formation of estriol. J Biol Chem 1959;234:2006
55. MacDonald PC, Siiteri PK. Origin of estrogen in women pregnant with an anencephalic fetus. J Clin Invest 1965;44: 465
56. Cantineau R, Kremers P, De Graeve J, Gielen JE, Lambotle R. 15- and 16-hydroxylations of androgens and estrogens in the human fetal liver: a critical step in estetrol biosynthesis. J Steroid Biochem 1985;22:195-201