Effects of a novel corticotropin-releasing-hormone receptor type I antagonist on human adrenal function

Molecular Psychiatry

Volumn 5, Issue 2, 2000, Pages 137-141

  Willenberg, H S ^a   Bornstein, S R ^b   Hiroi, N ^b   Path G ^a   Goretzki, P E ^a   Scherbaum, W A ^a   Chrousos, G P ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Adrenal; CRH; CRH receptor antagonist; Human

Indexed keywords

ANTALARMIN; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR; HYDROCORTISONE; MESSENGER RNA;

ADRENAL CORTEX CELL; ADRENAL FUNCTION; ADRENAL MEDULLA; ADRENERGIC SYSTEM; ALZHEIMER DISEASE; ARTICLE; CELL CULTURE; CHROMAFFIN CELL; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DEPRESSION; HUMAN; HUMAN CELL; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOHISTOCHEMISTRY; MENTAL DISEASE; MESSENGER RNA SYNTHESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADRENAL CORTEX; ADRENAL MEDULLA; ADRENOCORTICOTROPIC HORMONE; ADULT; ANIMALS; CELL LINE; CELLS, CULTURED; CHROMAFFIN CELLS; COCULTURE TECHNIQUES; CORTICOTROPIN-RELEASING HORMONE; GENE EXPRESSION REGULATION; HAPLORHINI; HUMANS; HYDROCORTISONE; PITUITARY GLAND; PYRIMIDINES; PYRROLES; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

EID: 0034092839     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000720     Document Type: Article

References (40)

1. Wong ML, Licinio J, Pasternak KI, Gold PW. Localization of corticotropin-releasing hormone (CRH) receptor mRNA in adult rat brain by in situ hybridization histochemistry. Endocrinology 1994; 135: 2275-2278.
2. Vale W, Spiess J, Rivier C, Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 1981; 213: 1394-1397.
3. Vita N, Laurent P, Lefort S, Chalon P, Lelias JM, Kaghad M et al. Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett 1993; 335: 1-5.
4. Liaw CW, Lovenberg TW, Barry G, Oltersdorf T, Grigoriadis DE, de Souza EB. Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid. Endocrinology 1996; 137: 72-77.
5. Andreis PG, Neri G, Belloni AS, Mazzocchi G, Kasprzak A, Nussdorfer GG. Interleukin-1 beta enhances corticosterone secretion by acting directly on the rat adrenal gland. Endocrinology 1991; 129: 53-57.
6. Smith R, Mesiano S, Chan EC, Brown S, Jaffe RB. Corticotropin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cells. J Clin Endocrinol Metab 1998; 83: 2916-2920.
7. Chakravorty A, Mesiano S, Jaffe RB. Corticotropin-releasing hormone stimulates P450 17alpha-hydroxylase/17,20-lyase in human fetal adrenal cells via protein kinase C. J. Clin Endocrinol Metab 1999; 84: 3732-3738.
8. Raadsheer FC, van Heerikhuize JJ, Lucassen PJ, Hoogendijk WJ, Tilders FJ, Swaab DF. Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression. Am J Psychiarty 1995; 152: 1372-1376.
9. Luger A, Deuster PA, Kyle SB, Gallucci WT, Montgomery LC, Gold PW et al. Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptions to physical training. N Engl J Med 1987; 316: 1309-1315.
10. Gold PW, Pigott TA, Kling MA, Kalogeras K, Chrousos GP. Basic and clinical studies with corticotropin-releasing hormone. Implications for a possible role in panic disorder. Psychiatr Clin North Am 1988; 11: 327-334.
11. Bornstein SR, Webster EL, Tropy DJ, Richman SJ, Mitsiades N, Igel M et al. Chronic effects of a nonpeptide corticotropin-releasing hormone type 1 receptor antagonist on pituitary-adrenal function, body weight, and metabolic regulation. Endocrinology 1998; 139: 1546-1555.
12. Wong ML, Webster EL, Spokes H, Phu P, Ehrhart-Bornstein M, Bornstein SR et al. Chronic administration of the non-peptide CRH type 1 receptor antagonist antalarmin does not blunt hypothalamic-pituitary-adrenal axis responses to acute immobilization stress. Life Sci 1999; 65: PL53-58.
13. Deak T, Nguyen KT, Ehrlich AL, Watkins LR, Spencer RL, Maier SF et al. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. Endocrinology 1999; 140: 79-86.
14. Willenberg HS, Stratakis CA, Marx C, Ehrhart-Bornstein M, Chrousos GP, Bornstein SR. Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. N Engl J Med 1998; 339: 27-31.
15. Haidan A, Bornstein SR, Glasow A, Uhlmann K, Lubke C, Ehrhart-Bornstein M. Basal steroidogenic activity of adrenocortical cells is increased 10-fold by coculture with chromaffin cells. Endocrinology 1998; 139: 772-780.
16. Webster EL, Lewis DB, Torpy DJ, Zachman EK, Rice KC, Chrousos GP. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: Suppression of pituitary ACTH release and peripheral inflammation. Endocrinology 1996; 137: 5747-5750.
17. Nussdorfer, Mazzocchi G. Immune-endocrine interactions in the mammalian adrenal gland: Facts and hypotheses. Int Rev Cytol 1998; 183: 143-184.
18. Suda T, Tomori N, Tozawa F, Mouri T, Demura H, Shizume K. Distribution and characterization of immunoreactive corticotropin-releasing factor in human tissues. J Clin Endocrinol Metab 1984; 58: 861-866.
19. Suda T, Tomori N, Tozawa F, Demura H, Shizume K, Mouri T et al. Immunoreactive corticotropin and corticotropin-releasing factor in human hypothalamus, adrenal, lung cancer, and pheochromocytoma. J Clin Endocrinol Metab 1984; 58: 919-924.
20. Bruhn TO, Engeland WC, Anthony ELP, Gann DS, Jackson IMD. Corticotropin-releasing factor in the dog adrenal medulla is secreted in response to hemorrhage. Endocrinology 1987; 120: 25-33.
21. Edwards AV, Jones CT. Secretion of corticotropin releasing factor from the adrenal during splanchnic nerve stimulation in conscious calves. J Physiol 1988; 400: 89-100.
22. McDonald TJ, Nathanielsz PW. The involvement of innervation in the regulation of fetal adrenal steroidogenesis. Horm Metab Res 1998; 30: 297-302.
23. Venihaki M, Gravanis A, Margioris AN. Comparative study between normal rat chromaffin and PC12 rat pheochromocytoma cells: Production and effects of corticotropin-releasing hormone. Endocrinology 1997; 138: 698-704.
24. Ehrhart-Bornstein M, Hinson JP, Bornstein SR, Scherbaum WA, Vinson GP. Intraadrenal interactions in the regulation of adrenocortical steroidogenesis. Endocr Rev 1998; 19: 101-143.
25. Pignatelli D, Magalhães MM, Magalhães MC. Direct effects of stress on adrenocortical function. Horm Metab Res 1998; 30: 464-474.
26. Bagdy G, Calogero AE, Szemeredi K, Chrousos GP, Gold PW. Effects of cortisol treatment on brain and adrenal corticotropin-releasing hormone (CRH) content and other parameters regulated by CRH. Regul Pept 1990; 31: 83-92.
27. Mazzocchi G, Malendowicz LK, Markowska A, Nussdorfer GG. Effect of hypophysectomy on corticotropin-releasing hormone and adrenocorticotropin immunoreactivities in the rat adrenal gland. Mol Cell Neurosci 1994; 5: 345-349.
28. Bornstein SR, Vaudry H. Paracrine and neuroendocrine regulation of the adrenal gland - basic and clinical aspects. Horm Metab Res 1998; 30: 292-296.
29. Grigoriadis DE, Lovenberg TW, Chalmers D, Liaw C, DeSouza EB. Characterization of corticotropin-releasing factor receptor subtypes. Ann NY Acad Sci 1996; 780: 60-80.
30. Stenzel P, Kesterson R, Yeung W, Cone RD, Rittenberg MB, Stenzel-Pooro MP. Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart. Mol Endocrinol 1995; 9: 637-645.
31. Kishimoto T, Pearse RV, Lin CR, Rosenfeld MG. A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc Natl Acad Sci USA 1995; 92: 1108-1112.
32. Chen R, Lewis KA, Perrin MH, Vale WW. Expression cloning of a human corticotropin-releasing factor receptor. Proc Natl Acad Sci USA 1993; 90: 8967-8971.
33. Lovenberg TW, Liaw CW, Grigoriadis DE, Clevenger W, Chalmers DT, DeSouza EB et al. Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc Natl Acad Sci USA 1995; 92: 836-840.
34. Chang CP, Pearse RV, O'Connell S, Rosenfeld MG. Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Neuron 1993; 133: 3058-3061.
35. Perrin MH, Donaldson CJ. Chen R, Lewis KA, Vale WW. Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor. Endocrinology 1993; 133: 3058-3061.
36. Bornstein SR, Gonzalez-Hernandez JA, Ehrhart-Bornstein M, Adler G, Scherbaum WA. Intimate contact of chromaffin and cortical cells within the human adrenal gland forms the cellular basis for important intraadrenal interactions. J Clin Endocrinol Metab 1994; 78: 225-232.
37. Marx C, Ehrhart-Bornstein M, Scherbaum WA, Bornstein SR. Regulation of adrenocortical function by cytokines-relevance for immune-endocrine interaction. Horm Metab Res 1998; 30: 416-420.
38. Path G, Bornstein SR, Ehrhart-Bornstein M, Scherbaum WA. Interleukin-6 and the interleukin-6 receptor in the human adrenal gland: Expression and effects on steroidogenesis. J Clin Endocrinol Metab 1997; 82: 2343-2349.
39. Karalis K, Sano H, Redwine J, Listwak S, Wilder RL, Chrousos GP. Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone in vivo. Science 1991; 254: 421-423.
40. Webster EL, Torpy DJ, Elenkov IJ, Chrousos GP. Corticotropin-releasing hormone and inflammation. Ann N Y Acad Sci 1998; 840: 21-32.