Rescue of defective T cell development and function in Atm(-/-) mice by a functional TCRαβ transgene

Journal of Immunology

Volumn 164, Issue 1, 2000, Pages 345-349

  Chao, Connie ^a   Yang, Eva Marie ^a   Xu, Yang ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; ATAXIA TELANGIECTASIA; EMBRYO; GENE EXPRESSION; HYPOPLASIA; IMMUNE DEFICIENCY; IMMUNE RESPONSE; LYMPHATIC SYSTEM TUMOR; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 0033970851     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.1.345     Document Type: Article

References (27)

1. Lehmann, A. R. 1982. Ataxia-telangiectasia. In A cellular and Molecular Link Between Cancer, Neuropathology and Immune Deficiency. B. A. Bridges and D. G. Harnden, eds. Wiley, Chichester, U.K., p.83.
2. Peterson, R. D. A., and R. A. Good. 1968. Ataxia-telangiectasia. In Birth Defects: Immunologic Deficiency Disease in Man. D. Bergsma and R. A. Good, eds. National Foundation, March of Dimes, New York, NY., p. 370.
3. Meyn, M. S. 1996. Chromsomal instability syndromes: lessons for carcinogenesis. Curr. Top. Microbiol. Immunol. 221:71.
4. Kojis, T. L., R. A. Gatti, and R. S. Sparkes. 1991. The cytogenetics of ataxia telangiectasia. Cancer Genet. Cytogenet. 56:143.
5. T. Savitsky, K., A. Bar-Shira, S. Gilad, G. Rotman, Y. Ziv, L. Vanagaite, D. A. Tagle, S. Smith, T. Uziel, S. Sfez, et al. 1995. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268:1749.
6. Zakian, V. A. 1995. ATM-related genes: what do they tell us about functions of the human gene? Cell 82:685
7. Blunt, T., N. J. Finnie, G. E. Taccioli, G. C. Smith, J. Demengeot, T. M. Gottlieb, R. Mizuta, A. J. Varghese, F.W. Alt, P. A. Jeggo, et al. 1995. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80:813.
8. Hartley, K. O., D. Gell, G. C. Smith, H. Zhang, N. Divecha, M. A. Connelly, A. Admon, S. P. Lees-Miller, C. W. Anderson, and S. P. Jackson. 1995. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82:849.
9. Meyn, M. S. 1995. Alaxia-telangiectasia and cellular responses to DNA damage. Cancer Res. 55:5991.
10. Shiloh, Y., and G. Rotman. 1996. Ataxia-telangiectasia and the ATM gene: linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints. J. Clin. Immunol. 16:254.
11. Xu, Y., and D. Baltimore. 1996. Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev. 10:2401.
12. Barlow, C., S. Hirotsune, R. Paylor, M. Liyanage, M. Eckhaus, F. Collins, Y. Shiloh, J. N. Crawley, T. Ried, D. Tagle, and A. Wynshaw-Boris. 1996. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86:159.
13. Elson, A., Y. Wang, C. J. Daugherty, C. C. Morton, F. Zhou, J. Campos-Torres, and P. Leder. 1996. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc. Natl. Acad. Sci. USA 93:13084.
14. Shinkai, Y., S. Koyasu, K. Nakayama, K. M. Murphy, D. Y. Loh, E. L. Reinherz, and F. W. Alt. 1993. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 259:822.
15. Mombaerts, P., A. R. Clarke, M. A. Rudnicki, J. Iacomini, S. Itohara, J. J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M. L. Hooper, et al. 1992. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360:225.
16. von Boehmer, H. 1994. Positive selection of lymphocytes. Cell 76:219.
17. Lafaille, J. J., K. Nagashima, M. Katsuki, and S. Tonegawa. 1994. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78:399.
18. Xu, Y., T. Ashley, E. E. Brainerd, R. T. Bronson, M. S. Meyn, and D. Baltimore. 1996. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10:2411.
19. Field, S. J., F. Y. Tsai, F. Kuo, A. M. Zubiaga, W. G. Kaelin, Jr., D. M. Livingston, S. H. Orkin, and M. E. Greenberg. 1996. E2F-I functions in mice to promote apoptosis and suppress proliferation. Cell 85:549.
20. Goverman, J., A. Woods, L. Larson, L. P. Weiner, L. Hood, and D. M. Zaller. 1993. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72:551.
21. Baskaran, R., L. D. Wood, L. L. Whitaker, C. E. Canman, S. E. Morgan, Y. Xu, C. Barlow, D. Baltimore, A. Wynshaw-Boris, M. B. Kastan, and J. Y. Wang. 1997. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 387:516.
22. Schlissel, M., A. Constantinescu, T. Morrow, M. Baxter, and A. Peng. 1993. Double-strand signal sequence breaks in V(D)J recombination are blunt. 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7:2520.
23. Lin, W. C., and S. Desiderio. 1995. V(D)J recombination and the cell cycle. Immunol. Today 16:279.
24. Barlow, C., M. Liyanage, P. B. Moens, C. X. Deng, T. Ried, and A. Wynshaw-Boris. 1997. Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles. Nat. Genet. 17:462.
25. -/- mice. Mol. Cell. Biol. 18:4385.
26. + cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353:180.
27. Sperling, A. I., and J. A. Bluestone. 1996. The complexities of T-cell co-stimulation: CD28 and beyond Immunol. Rev: 153:154.