Vitamin E and Cancer

Vitamins and Hormones

Volumn 76, Issue , 2007, Pages 435-461

  Kline, Kimberly ^a   Lawson, Karla A ^b   Yu, Weiping ^a   Sanders, Bob G ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; DRUG DERIVATIVE;

ANIMAL; APOPTOSIS; CHEMISTRY; DRUG EFFECT; FEMALE; HUMAN; MALE; NEOPLASM; RANDOMIZED CONTROLLED TRIAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; FEMALE; HUMANS; MALE; NEOPLASMS; RANDOMIZED CONTROLLED TRIALS; SIGNAL TRANSDUCTION; VITAMIN E;

EID: 34347387041     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(07)76017-X     Document Type: Review

References (119)

1. Agarwal M.K., Agarwal M.L., Athar M., and Gupta S. Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induced apoptosis independent of cell cycle association. Cell Cycle 3 (2004) 205-211
2. Akazawa A., Nishikawa K., Suzuki K., Asano R., Kumadaki I., Satoh H., Hagiwara K., Shin S.J., and Yano T. Induction of apoptosis in a human breast cancer cell overexpressing ErbB-2 receptor by α-tocopheryloxybutyric acid. Jpn. J. Pharmacol. 89 (2002) 417-421
3. Alleva R., Tomasetti M., Andera L., Gellert N., Borghi B., Weber C., Murphy M.P., and Neuzil J. Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection. FEBS Lett. 503 (2001) 46-50
4. Alleva R., Benassi M.S., Tomasetti M., Gellert N., Ponticelli F., Borghi B., Picci P., and Neuzil J. α-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: The role of E2F1. Biochem. Biophys. Res. Commun. 331 (2005) 1515-1521
5. Anderson K., Simmons-Menchaca M., Lawson K.A., Atkinson J., Sanders B.G., and Kline K. Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E succinate and vitamin E analogue, α-TEA. Cancer Res. 64 (2004) 4263-4269
6. Anderson K., Lawson K.A., Simmons-Menchaca M., Sun L.-Z., Sanders B.G., and Kline K. α-TEA plus cisplatin reduces human cisplatin-resistant ovarian cancer cell tumor burden and metastasis. Exp. Biol. Med. 229 (2004) 1169-1176
7. Arya P., Alibhai N., Quin H., and Burton G.W. Design and synthesis of analogs of vitamin E: Antiproliferative activity against human breast adenocarcinoma cells. Bioorg. Med. Chem. Lett. 8 (1998) 2433-2438
8. ATBC Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 330 (1994) 1029-1035
9. Azzi A., Gysin R., Kempna P., Munteanu A., Villacorta L., Visarius T., and Zingg J.-M. Regulation of gene expression by α-tocopherol. Biol. Chem. 385 (2004) 585-591
10. Bang O.-K., Park J.-H., and Kang S.-S. Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. Biochem. Biophys. Res. Commun. 288 (2001) 789-797
11. Best S.R. α-TEA & Celecoxib in Skin Cancer Prevention & Therapy. Master of Arts Thesis. (2005), University of Texas at Austin
12. Birringer M., EyTina J.H., Salvatore B.A., and Neuzil J. Vitamin E analogues as inducers of apoptosis: Structure-function relation. Br. J. Cancer 88 (2003) 1948-1955
13. Brigelius-Flohe R. Induction of drug metabolizing enzymes by vitamin E. J. Plant Physiol. 162 (2005) 797-802
14. Brigelius-Flohe R., and Traber M.G. Vitamin E: Function and metabolism. FASEB J. 13 (1999) 1145-1155
15. Campbell S.E., Stone W., Whaley S., and Krishnan K. Development of gamma (γ)-tocopherol as a colorectal cancer chemopreventive agent. Crit. Rev. Oncol. Hematol. 47 (2003) 249-259
16. Campbell S.E., Stone W.L., Whaley S.G., Qui M., and Krishnan K. γ-Tocopherol upregulates peroxisome proliferators activated receptor (PPAR) gamma expression in SW480 human colon cancer cell lines. BMC Cancer 3 (2003) 25
17. Campbell S.E., Stone W.L., Lee S., Whaley S., Yang H., Qui M., Goforth P., Sherman D., HcHaffie D., and Krishnan K. Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines. BMC Cancer 6 (2006) 13
18. Chamras H., Barsky S.H., Ardashian A., Navasartian D., Heber D., and Glaspy J.A. Novel interactions of vitamin E and estrogen in breast cancer. Nutr. Cancer 52 (2005) 43-48
19. Charpentier A., Groves S., Simmons-Menchaca M., Turley J., Zhao B., Sanders B.G., and Kline K. RRR-α-tocopheryl succinate inhibits proliferation and enhances secretion of transforming growth factor-β (TGF-β) by human breast cancer cells. Nutr. Cancer 19 (1993) 225-239
20. Charpentier A., Simmons-Menchaca M., Yu W., Zhao B., Qian M., Heim K., Sanders B.G., and Kline K. RRR-α-tocopheryl succinate enhances TGF-β1, -β2, and -β3 and TGF-βR-II expression by human MDA-MB-435 breast cancer cells. Nutr. Cancer 26 (1996) 237-250
21. Chinery R., Brockman J.A., Peeler M.O., Shyr Y., Beauchamp R.D., and Coffey R.J. Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via c/EBPbeta. Nat. Med. 3 (1997) 1233-1241
22. Cooney R.V., Franke A.A., Harwood P.J., Hatch-Pigott V., Custer L.J., and Mordan L.J. Gamma-tocopherol detoxification of nitrogen dioxide: Superiority to alpha-tocopherol. Proc. Natl. Acad. Sci. USA 90 (1993) 1771-1775
23. Dalen H., and Neuzil J. α-Tocopheryl succinate sensitizes a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-κB activation. Br. J. Cancer 88 (2003) 153-158
24. Donapaty S., Louis S., Horvath E., Kun J., Sebti S.M., and Malafa M. RRR-α-tocopherol succinate down-regulates oncogenic Ras signaling. Mol. Cancer Ther. 5 (2006) 309-316
25. Freemantle S.J., Dragnev K.H., and Dmitrovsky E. The retinoic acid paradox in cancer chemoprevention. J. Natl. Cancer Inst. 98 (2006) 426-427
26. Galli F., Stabile A.M., Betti M., Conte C., Pistilli A., Rende M., Floridi A., and Azzi A. The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation. Arch. Biochem. Biophys. 423 (2004) 97-102
27. Guthrie N., and Carroll K.K. Tocotrienols and cancer. In: Packer L., and Ong A.S.H. (Eds). "Biological Oxidants and Antioxidants: Molecular Mechanisms and Health Effects" (1999), AOCS Press, Champaign 257-264
28. Gysin R., Azzi A., and Visarius T. γ-Tocopherol inhibits human cancer cell cycle progression and cell proliferation by down-regulation of cyclins. FASEB J. 16 (2002) 1952-1954
29. Heinonen O.P., Albanes D., Virtamo J., Taylor P.R., Huttunen J.K., Hartman A.M., Haapakoski J., Malila N., Rautalahti M., Ripatti S., Maenpaa H., Teerenhovi L., et al. Prostate cancer and supplementation with α-tocopherol and β-carotene: Incidence and mortality in a controlled trial. J. Natl Cancer Inst. 90 (1998) 440-446
30. Hensley K., Benaksas E.J., Bolli R., Comp P., Grammas P., Hamdeydari L., Mou S., Pye Q.N., Stoddard M.F., Wallis G., Williamson K.S., West M., et al. New perspectives on vitamin E: Gamma-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine. Free Radic. Biol. Med. 136 (2004) 1-15
31. Hercberg S., Galan P., Preziosi P., Bertrais S., Mennen L., Malvy D., Roussel A.-M., Favier A., and Briancon S. The SU.VI.MAX stduy: A randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch. Intern. Med. 164 (2004) 2335-2342
32. Hope Study Investigators. Effect of long-term vitamin E supplementation on cardiovascular events and cancer. JAMA 293 (2005) 1338-1347
33. Huang H.-Y., and Appel L.J. Supplementation of diets with α-tocopherol reduces serum concentrations of γ- and δ-tocopherol in humans. J. Nutr. 133 (2003) 3137-3140
34. Ikeda S., Tohyama T., and Yamashita K. Dietary sesame seed and its lignans inhibit 2,7,8-trimethyl-2(2′-carboxyethyl)-6-hydroxychroman excretion into urine of rats fed γ-tocopherol. J. Nutr. 132 (2002) 961-966
35. Institute of Medicine, Food and Nutrition Board, Panel on dietary antioxidants and related compounds. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids, (2000), National Academy Press, Washington, DC 1-486
36. Israel K., Yu W., Sanders B.G., and Kline K. Vitamin E succinate induces apoptosis in human prostate cancer cells: Role for Fas in vitamin E succinate-triggered apoptosis. Nutr. Cancer 36 (2000) 90-100
37. Jia L. Proliferation Suppression Activities of α-TEA, a Derivative of RRR-α-Tocopherol, Individually or in Combination with Selenium, in Human Prostate Cancer Cells (2006), University of Texas at Austin Ph.D. Dissertation
38. Jiang Q., Elson-Schwab I., Courtemanche C., and Ames B.N. γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenae activity in macrophages and epithelial cells. Proc. Natl. Acad. Sci. USA 97 (2000) 11494-11499
39. Jiang Q., Christen S., Shigenaga M.K., and Ames B.N. Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am. J. Clin. Nutr. 74 (2001) 714-722
40. Jiang Q., Wong J., Fyrst H., Saba J.D., and Ames B.N. γ-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc. Natl. Acad. Sci. USA 101 (2004) 17825-17830
41. Kelloff G.J., and Boone C.W. Cancer chemopreventive agents: Drug development status and future prospects. J. Cell Biochem. Suppl. 20 (1994) 282-294
42. Kline K., Lawson K.A., Yu W., and Sanders B.G. Vitamin E and breast cancer prevention: Current status and future potential. J. Mammary Gland Biol. Neoplasia 8 (2003) 91-102
43. Kline K., Yu W., and Sanders B.G. Vitamin E and breast cancer. J. Nutr. 134 (2004) 3458S-3462S
44. Landes N., Pfluger P., Kluth D., Birringer M., Ruhl R., Bol G.-F., Glatt H., and Brigelius-Flohe R. Vitamin E activates gene expression via the pregnane X receptor. Biochem. Pharmacol. 65 (2003) 269-273
45. Lawson K.A., Anderson K., Menchaca M., Atkinson J., Sun L., Knight V., Gilbert B.E., Conti C., Sanders B.G., and Kline K. Novel vitamin E analogue decreases syngeneic mouse mammary tumor burden and reduces lung metastasis. Mol. Cancer Ther. 2 (2003) 437-444
46. Lawson K.A., Anderson K., Simmons-Menchaca M., Atkinson J., Sun L.-Z., Sanders B.G., and Kline K. Comparison of vitamin E derivatives α-TEA and VES in reduction of mouse mammary tumor burden and metastasis. Exp. Biol. Med. 229 (2004) 954-963
47. Lawson K.A., Anderson K., Snyder R.M., Simmons-Menchaca M., Atkinson J., Sun L.-Z., Bandyopadhyay A., Knight V., Gilbert B.E., Sanders B.G., and Kline K. Novel vitamin E analogue and 9-nitro-camptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burden and inhibit metastasis. Cancer Chemother. Pharmacol. 54 (2004) 421-431
48. Lee I.-M., Cook N.R., Gaziano J.M., Gordon D., Ridker P.M., Manson J.E., Hennekens C.H., and Buring J.E. Vitamin E in the primary prevention of cardiovascular disease and cancer. The Women's Health Study: A randomized controlled trial. JAMA 294 (2005) 83-88
49. Lee J.-K., Jung J.C., Chun J.-S., Kang S.-S., and Bang O.-S. Expression of p21Waf1 is dependent on the activation of ERK during vitamin E-succinate-induced monocytic differentiation. Mol. Cells 13 (2002) 125-129
50. Lee R.J. Liposomal delivery as a mechanism to enhance synergism between anticancer drugs. Mol. Cancer Ther. 5 (2006) 1639-1640
51. Lippman S.M., Goodman P.J., Klein E.A., Parnes H.L., Thompson Jr. I.M., Kristal A.R., Santella R.M., Probstfield J.L., Moinpour C.M., Albanes D., Taylor P.R., Minasian L.M., et al. Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). J. Natl. Cancer Inst. 97 (2005) 94-102
52. Malafa M.P., and Neitzel L.T. Vitamin E succinate promotes breast cancer tumor dormancy. J. Surg. Res. 93 (2000) 163-170
53. Malafa M.P., Fokum F.D., Andoh J., Neitzel L.T., Bandyopadhyay S., Zhan R., Iiizumi M., Furuta E., Horvath E., and Watabe K. Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis. Int. J. Cancer 118 (2006) 2441-2447
54. Miyoshi N., Naniwa K., Kumagai T., Uchida K., Osawa T., and Nakamura Y. Alpha-tocopherol-mediated caspase-3 up-regulation enhances susceptibility to apoptotic stimuli. Biochem. Biophys. Res. Commun. 334 (2005) 466-473
55. Nesaretnam K., Stephen R., Dils R., and Darbre P. Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 33 (1998) 461-469
56. Neuzil J., Svensson I., Weber T., Weber C., and Brunk U.T. α-Tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation. FEBS Lett. 445 (1999) 295-300
57. Neuzil J., Weber T., Schroder A., Lu M., Ostermann G., Gellert N., Mayne G.C., Olejnicka B., Negre-Salvayre A., Sticha M., Coffey R.J., and Weber C. Induction of cancer cell apoptosis by α-tocopheryl succinate: Molecular pathways and structural requirements. FASEB J. 15 (2001) 403-415
58. Neuzil J., Weber T., Terman A., Weber C., and Brunk U.T. Vitamin E analogues as inducers of apoptosis: Implications for their potential antineoplastic role. Redox Rep. 6 (2001) 143-151
59. Neuzil J., Zhao M., Ostermann G., Sticha M., Gellert N., Weber C., Eaton J.W., and Brunk U.T. α-Tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability. Biochem. J. 32 (2002) 709-715
60. Neuzil J., Tomasetti M., Mellick A.S., Alleva R., Salvatore B.A., Birringer M., and Fariss M.W. Vitamin E analogues: A new class of inducers of apoptosis with selective anti-cancer effects. Curr. Cancer Drug Targets 4 (2004) 355-372
61. Ni J., Chen M., Zhang Y., Li R., Huang J., and Yeh S. Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. Biochem. Biophys. Res. Commun. 300 (2003) 357-363
62. Nishikawa K., Satoh H., Hirai A., Suzuzki K., Asano R., Kumadaki I., Hagiwara K., and Yano T. Alpha-tocopheryloxybutyric acid enhances necrotic cell death in breast cancer cells treated with chemotherapy agent. Cancer Lett. 201 (2003) 51-56
63. Parker R.S., Sontag T.J., and Swanson J.E. Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin. Biochem. Biophys. Res. Commun. 277 (2000) 531-534
64. Papas A.M. Beyond α-tocopherol: The role of the other tocopherols and tocotrienols. In: Meskin M.S. (Ed). "Phytochemicals in Nutrition and Health" (2002), CRC Press, Boco Raton 61-77
65. Patton J.S. Deep-lung delivery of therapeutic proteins. Chemtech 27 (1997) 34-38
66. Prasad K.N., Kuman B., Yan X.D., Hanson A.J., and Cole W.C. Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: A review. J. Am. Coll. Nutr. 22 (2003) 108-117
67. Ricciarelli R., Zingg J.-M., and Azzi A. Vitamin E 80th anniversary: A double life, not only fighting radicals. IUBMB Life 2 (2001) 71-76
68. Ricciarelli R., Zingg J.-M., and Azzi A. The 80th anniversary of vitamin E: Beyond its antioxidant properties. Biol. Chem. 383 (2002) 457-465
69. Rowland J., Mariotto A., Aziz N., Tesauro G., Feuer E.J., Blackman D., Thompson P., and Pollack L.A. Cancer survivorship-U.S. 1971-2001. Morb. Mortal. Wkly. Rep. 53 (2004) 526-529
70. Salih H.R., Starling G.C., Knauff M., Llewellyn M.-B., Davis P.M., Pitts W.J., Aruffo A., and Kiener P.A. Retinoic acid and vitamin E modulate expression and release of CD178 in carcinoma cells: Consequences for induction of apoptosis in CD95-sensitive cells. Exp. Cell Res. 270 (2001) 248-258
71. Sen C.K., Khasnna S., and Roy S. Tocotrienols: Vitamin E beyond tocopherols. Life Sci. 78 (2006) 2088-2098
72. Schindler R., and Mentlein R. Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells. J. Nutr. 136 (2006) 1477-1482
73. Shiau C.-W., Huang J.-W., Wang D.-S., Weng J.-R., Yang C.-C., Lin C.-H., Li C., and Chen C.-S. α-Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function. J. Biol. Chem. 281 (2006) 11819-11825
74. Shun M.-C. Investigation of the Molecular Mechanisms of Apoptosis Induced by a Novel Vitamin E Derivative (α-TEA) in Human Breast and Ovarian Cancer Using Cell Culture (2005), University of Texas at Austin Ph.D. Dissertation
75. Shun M.-C., Yu W., Gapor A., Parsons R., Atkinson J., Sanders B.G., and Kline K. Pro-apoptotic mechanisms of action of a novel vitamin E analog (α-TEA) and a naturally occurring form of vitamin E (δ-tocotrienol) in MDA-MB-435 human breast cancer cells. Nutr. Cancer 48 (2004) 95-105
76. Siler U., Barella L., Spitzer V., Schnorr J., Lein M., Goralczyk R., and Wertz K. Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. FASEB J. 18 (2004) 1019-1021
77. Snyder R. (2005), University of Texas at Austin Ph.D. Dissertation
78. Stapelberg M., Tomasetti M., Alleva R., Gellert N., Procopio A., and Neuzil J. α-Tocopheryl succinate inhibits prolideration of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Biochem. Biophys. Res. Commun. 318 (2004) 636-641
79. Stapelberg M., Gellert N., Swettenham E., Tomasetti M., Witting P.K., Procopio A., and Neuzil J. α-Tocopheryl succinate inhibits malignant mesothelioma by distrupting the fibroblast growth factor autocrine loop. J. Biol. Chem. 280 (2005) 25369-25376
80. Stone W.L., Krishnan K., Campbell S.E., Qui M., Whaley S.G., and Yang H. Tocopherols and the treatment of colon cancer. Ann. NY Acad. Sci. 1031 (2004) 223-233
81. Swettenham E., Witting P.K., Salvatore B.A., and Neuzil J. α-Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells; potential therapy of malignancies of the nervous system. J. Neurochem. 94 (2005) 144-1456
82. Takahashi K., and Loo G. Disruption of mitochondria during tocotrienol-induced apoptosis in MDA-MB-231 human breast cancer cells. Biochem. Pharmacol. 67 (2004) 315-324
83. Thompson T.A., and Wilding G. Androgen antagonist activity by the antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol in human prostate cancer cells. Mol. Cancer Ther. 2 (2003) 797-803
84. Tomasetti M., Rippo M.R., Alleva R., Moretti S., Andera L., Neuzil J., and Procopio A. α-Tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells. Br. J. Cancer 90 (2004) 1644-1653
85. Tomasetti M., Andera L., Alleva R., Borghi B., Nuezil J., and Procopio A. α-Tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: Implication for sensitization of resistant cancer cells to TRAIL apoptosis. FEBS Lett. 580 (2006) 1925-1931
86. Tomic-Vatic A., EyTina J., Chapman J., Mahdavian E., Neuzil J., and Salvatore B.A. Vitamin E amides, a new class of vitamin E analogues with enhanced proapoptotic activity. Int. J. Cancer 117 (2005) 188-193
87. Traber M.G., and Arai H. Molecular mechanisms of vitamin E transport. Annu. Rev. Nutr. 19 (1999) 343-355
88. Turley J.M., Ruscetti F.W., Kim S.-J., Fu T., Gou F.V., and Birchenall-Roberts M.C. Vitamin E succinate inhibits proliferation of BT-20 human breast cancer cells: Increased binding of cyclin A negatively regulates E2F transactivation activity. Cancer Res. 57 (1997) 2668-2675
89. Turley J.M., Fu T., Ruscetti F.W., Mikovits J.A., Bertolette D.C., and Birchenall-Roberts M.C. Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells. Cancer Res. 57 (1997) 881-890
90. Venkateswaran V., Fleshner N.E., and Klotz L.H. Modulation of cell proliferation and cell cycle regulators by vitamin E in human prostate carcinoma cell lines. J. Urol. 168 (2002) 1578-1582
91. Venkateswaran V., Fleshner N.E., Sugar L.M., and Klotz L.H. Antioxidants block prostate cancer in Lady transgenic mice. Cancer Res. 54 (2004) 5891-5896
92. Wagner K.H., Kamal-Eldin A., and Elmadfa I. Gamma-tocopherol: An underestimated vitamin?. Ann. Nutr. Metab. 48 (2004) 169-188
93. Wang P. Studies of the Antitumor Activity of α-TEA in Human Breast Cancer Cells (2006), University of Texas at Austin Ph.D. Dissertation
94. Wang X.-F., Dong L., Zhao Y., Tomasetti M., Wu K., and Neuzil J. Vitamin E analogues as anticancer agents: Lessons from studies with α-tocopheryl succinate. Mol. Nutr. Food Res. 50 (2006) 675-685
95. Waters D.D., Alderman E.L., Hsia J., Howard B.V., Cobb F.R., Rogers W.J., Ouyang P., Thompson P., Tardif J.C., Higginson L., Bittner V., Steffes M., et al. Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: A randomized controlled trial. JAMA 288 (2002) 2432-2440
96. Weber T., Lu M., Andera L., Lahm H., Gellert N., Fariss M.W., Korinek V., Sattler W., Ucker D.S., Terman A., Schroder A., Erl W., et al. Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Clin. Cancer Res. 8 (2002) 863-869
97. Weber T., Dalen H., Andera L., Negre-Salvayre A., Auge N., Sticha M., Lloret A., Terman A., Witting P.K., Higuchi M., Plasilova M., Zivny J., et al. Mitochondria play a central role in apoptosis induced by α-tocopheryl succinate, an agent with antineoplastic activity: Comparison with receptor-mediated pro-apoptotic signaling. Biochemistry 42 (2003) 4277-4291
98. Wu K., Liu B.H., Zhao D.Y., and Zhao Y. Effects of vitamin E succinate on expression of TGF-β1, c-Jun and JNK1 in human gastric cancer SGC-7901 cells. World J. Gastroenterol. 7 (2001) 83-87
99. Wu K., Li Y., Zhao Y., Shan Y.-J., Xia W., Yu W.-P., and Zhao L. Roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. World J. Gastroenterol. 8 (2002) 982-986
100. Wu K., Zhao Y., Li G.C., and Yu W.P. c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells. World J. Gastroenterol. 10 (2004) 1110-1114
101. You H., Yu W., Sanders B.G., and Kline K. RRR-α-tocopheryl succinate induces MDA-MB-435 and MCF-7 human breast cancer cells to undergo differentiation. Cell Growth Differ. 12 (2001) 471-480
102. You H., Yu W., Munoz-Medellin D., Brown P.H., Sanders B.G., and Kline K. Role of extracellular signal-regulated kinase pathway in RRR-α-tocopheryl succinate-induced differentiation of human MDA-MB-435 breast cancer cells. Mol. Carcinog. 33 (2002) 228-236
103. Yu W., Heim K., Qian M., Simmons-Menchaca M., Sanders B.G., and Kline K. Evidence for role of transforming growth factor-β in RRR-α-tocopheryl succinate-induced apoptosis of human MDA-MB-435 breast cancer cells. Nutr. Cancer 27 (1997) 267-278
104. Yu W., Simmons-Menchaca M., You H., Brown P., Birrer M.J., Sanders B.G., and Kline K. RRR-α-tocopheryl succinate induction of prolonged activation of c-jun amino-terminal kinase and c-jun during induction of apoptosis in human MDA-MB-435 breast cancer cells. Mol. Carcinog. 22 (1998) 247-257
105. Yu W., Israel K., Liao Q.Y., Aldaz C.M., Sanders B.G., and Kline K. Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: Role for Mr 43,000 Fas in VES-triggered apoptosis. Cancer Res. 59 (1999) 953-961
106. Yu W., Simmons-Menchaca M., Gapor A., Sanders B.G., and Kline K. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr. Cancer 33 (1999) 26-32
107. Yu W., Liao Q.Y., Hantash F.M., Sanders B.G., and Kline K. Activation of extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells. Cancer Res. 61 (2001) 6569-6576
108. Yu W., Sanders B.G., and Kline K. RRR-α-tocopheryl succinate induction of DNA synthesis arrest of human MDA-MB-435 cells involves TGF-β-independent activation of p21Waf1/Cip1. Nutr. Cancer 43 (2002) 227-236
109. Yu W., Sanders B.G., and Kline K. RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria. Cancer Res. 63 (2003) 2483-2491
110. Yu W., Shun M.-C., Anderson K., Chen H., Sanders B.G., and Kline K. α-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells. Apoptosis 11 10 (2006) 1813-1823
111. Zhang Y., Ni J., Messing E.M., Chang E., Yang C.-R., and Yeh S. Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells. Proc. Natl. Acad. Sci. 99 (2002) 7408-7413
112. Zhang M., Altuwaijri S., and Yeh S. RRR-α-tocopheryl succinate inhibits human prostate cancer cell invasiveness. Oncogene 23 (2004) 3080-3088
113. Zhang S., Lawson K.A., Simmons-Menchaca M., Sun L.-Z., Sanders B.G., and Kline K. Vitamin E analog α-TEA and celecoxib alone and together reduce human MDA-MB-435-FL-GFP breast cancer burden and metastasis in nude mice. Breast Cancer Res. Treat. 87 (2004) 111-121
114. Zhao B., Yu W., Qian M., Simmons-Menchaca M., Brown P., Birrer M.J., Sanders B.G., and Kline K. Involvement of activator protein (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells. Mol. Carcinog. 19 (1997) 180-190
115. Zhao Y., Wu K., Xia W., Shan Y.-J., Wu L.-J., and Yu W.-P. The effects of vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells. World J. Gastroenterol. 8 (2002) 782-786
116. Zhao Y., Zhao X., Yang B., Neuzil J., and Wu K. Alpha-tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner. Cancer Lett. 247 2 (2006) 345-352
117. Zhou C., Tabb M.M., Sadatrafiei A., Grun F., and Blumberg B. Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. Drug Metab. Dispos. 32 (2004) 1075-1082
118. Zingg J.-M., and Azzi A. Non-antioxidant activities of vitamin E. Curr. Med. Chem. 11 (2004) 1113-1133
119. Zu K., Hawthorn L., and Ip C. Up-regulation of c-Jun-NH2-kinase pathway contributes to the induction of mitochondria-mediated apoptosis by α-tocopheryl succinate in human prostate cancer cells. Mol. Cancer Ther. 4 (2005) 43-50