RRR-α-tocopheryl succinate induces MDA-MB-435 and MCF-7 human breast cancer cells to undergo differentiation

Cell Growth and Differentiation

Volumn 12, Issue 9, 2001, Pages 471-480

  You, H ^a   Yu, W ^a   Sanders, B G ^a   Kline, K ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALPHA TOCOPHEROL SUCCINATE; ANTINEOPLASTIC AGENT; BETA CASEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG INHIBITION; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIBODIES; BETA CATENIN; BIOLOGICAL MARKERS; BREAST NEOPLASMS; CASEINS; CELL DIFFERENTIATION; CYCLIN D1; CYTOSKELETAL PROTEINS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KERATINS; LIPID METABOLISM; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEUTRALIZATION TESTS; RECEPTOR, ERBB-2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; VITAMIN E;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0034799471     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (84)

1. Malignant cell differentiation as a potential therapeutic approach
2. All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia
3. Leukemia cell differentiation: Cellular and molecular interactions of retinoids and vitamin D
4. Complete remission of t(11;17) positive acute promyelocytic leukemia induced by all-trans retinoic acid and granulocyte colony-stimulating factor
5. Clinical development plan: Vitamin E
6. RRR-α-tocopheryl succinate inhibits the proliferation of human prostatic tumor cells with defective cell cycle/differentiation pathways
7. Vitamin E: Mechanisms of action as tumor cell growth inhibitors
8. Vitamin E and cancer prevention: Recent advances and future potentials
9. RRR-α-tocopheryl succinate inhibits proliferation and enhances secretion of transforming growth factor-β (TGF-β) by human breast cancer cells
10. RRR-α-tocopheryl succinate enhances TGF-β1, β2, and -β3 and TGF-β R-II expression by human MDA-MB-435 breast cancer cells
11. The selective cytotoxic effect of carotenoids and α-tocopherol on human cancer cell lines in vitro
12. Growth-inhibitory effects of vitamin E succinate on retrovirus-transformed tumor cells in vitro
13. RRR-α-tocopheryl succinate modulation of human promyelocytic leukemia (HL-60) cell proliferation and differentiation
14. RRR-α-tocopheryl succinate inhibits DNA synthesis and enhances the production and secretion of biologically active transforming growth factor-β by avian retrovirus-transformed lymphoid cells
15. Decreased expressions of c-myc and H-ras oncogenes in vitamin E succinate induced morphologically differentiated murine B-16 melanoma cells in culture
16. Growth inhibition and apoptosis of RL human B lymphoma cells by vitamin E succinate and retinoic acid: Role for transforming growth factor β
17. RRR-α-tocopheryl succinate induces apoptosis in avian retrovirus-transformed lymphoid cells
18. Evidence for role of transforming growth factor-β in RRR-α-tocopheryl succinate-induced apoptosis of human MDA-MB-435 breast cancer cells
19. Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells
20. Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: Role for M, 43,000 Fas in VES-triggered apoptosis
21. Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture
22. Effects of differentiation-inducing agents on maturation of human MCF-7 breast cancer cells
23. Differentiation induction in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A
24. Differentiation of cultured human breast cancer cells (AU-565 and MCF-7) associated with loss of cell surface HER-2/neu antigen
25. Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells
26. Antiprogestins inhibit growth and stimulate differentiation in the normal mammary gland
27. Modulation of normal mammary epithelial cell proliferation, morphogenesis, and functional differentiation by retinoids: A comparison of the retinobenzoic acid derivative RE80 with retinoic acid
28. Prolactin-mediated transcriptional and posttranscriptional control of casein gene expression
29. Rat β-casein cDNA: Sequence analysis and evolutionary comparisons
30. Casein production by human breast cancer
31. Immunohistochemical study of β- and κ-casein in the human breast and breast carcinomas, using monoclonal antibodies
32. Lack of β-casein production by human breast tumours revealed by monoclonal antibodies
33. Tumor-inhibitory monoclonal antibodies to the HER-2/Neu receptor induce differentiation of human breast cancer cells
34. A ligand for the erbB-2 oncogene product (gp30) induces differentiation of human breast cancer cells
35. 20-Epi-vitamin D3 analogues: A novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines
36. Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice
37. Apolipoprotein D gene induction by retinoic acid is concomitant with growth arrest and cell differentiation in human breast cancer cells
38. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
39. The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: From orphanhood to multiple stromal ligands
40. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
41. Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms
42. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
43. Biomarkers of gene expression: Growth factors and oncoproteins
44. Growth factors in breast cancer
45. Molecular mechanisms underlying ErbB2/HER2 action in breast cancer
46. Modulation of breast cancer progression and differentiation by the gp30/heregulin [correction of neuregulin]
47. Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit
48. Isolation of the neu/HER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells
49. Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis
50. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
51. Cyclin D1 provides a link between development and oncogenesis in the retina and breast
52. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
53. Dysregulated expression of cyclin D1 in normal human mammary epithelial cells inhibits all-trans-retinoic acid-mediated G0/G1-phase arrest and differentiation in vitro
54. Upregulation of cytokeratin 8 and 18 in human breast cancer T47D cells is retinoid-specific and retinoic acid receptor-dependent
55. Loss of epithelial markers and acquisition of vimentin expression in Adriamycin- and vinblastine-resistant human breast cancer cell lines
56. E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture
57. Elevated keratin 18 protein expression indicates a favorable prognosis in patients with breast cancer
58. A subclone of the aggressive breast cancer cell line MDA-MB-231 with strongly increased expression of the cytoskeletal protein keratin 18 shows dramatically reduced tumorigenicity and invasiveness
59. An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4
60. Neu differentiation factor (heregulin) induces expression of intercellular adhesion molecule 1: Implications for mammary tumors
61. Effects of differentiation inducers on cell phenotypes of cultured nontransformed and immortalized mammary epithelial cells: A comparative immunocytochemical analysis
62. All-trans retinoic acid inhibits the growth of breast cancer cells by up-regulating ICAM-1 expression
63. Expression of intercellular adhesion molecule-1 in invasive breast cancer reflects low growth potential, negative lymph node involvement, and good prognosis
64. 5
65. Retinoids increase cell-cell adhesion strength, β-catenin protein stability, and localization to the cell membrane in a breast cancer cell line: A role for serine kinase activity
66. Regulation of milk protein gene expression
67. Composite response elements mediate hormonal and developmental regulation of milk protein gene expression
68. Terminal differentiation of human breast cancer through PPARγ
69. Ligands for peroxisome proliferator-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
70. Vitamin E: Mechanisms of action as tumor cell growth inhibitors
71. Vitamin E succinate promotes breast cancer tumor dormancy
72. Growth inhibition of MCF-7 and MCF-10A human breast cells by α-tocopheryl hemisuccinate, cholesteryl hemisuccinate and their ether analogs
73. Selective cancer cell killing by α-tocopheryl succinate
74. Induction of cancer cell apoptosis by α-tocopheryl succinate: Molecular pathways and structural requirements
75. Effect of vitamin E succinate and a cAMP-stimulating agent on the expression of c-myc and N-myc and H-ras in murine neuroblastoma cells
76. Involvement of activator protein-1 (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells
77. RRR-α-tocopheryl succinate induction of prolonged activation of c-jun amino-terminal kinase and c-jun during induction of apoptosis in human MDA-MB-435 breast cancer cells
78. Possible role for vitamin D in controlling breast cancer cells proliferation
79. In vitro study of effects of 1,25-dihydroxyvitamin D3 on the morphology of human breast cancer cell line BT.20
80. The transforming growth factor-β family
81. Molecular and cell biology of TGF-β
82. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain