Vitamin E and Breast Cancer Prevention: Current Status and Future Potential

Journal of Mammary Gland Biology and Neoplasia

Volumn 8, Issue 1, 2003, Pages 91-102

  Kline, Kimberly ^a   Lawson, Karla A ^a   Yu, Weiping ^a   Sanders, Bob G ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Apoptosis; Breast cancer; Chemoprevention; Tocopherols; Tocotrienols; Vitamin E; Vitamin E analogs

Indexed keywords

ALPHA TOCOPHEROL DERIVATIVE; ALPHA TOCOPHEROL SUCCINATE; BIOLOGICAL MARKER; LIPOSOME;

AEROSOL; ANIMAL MODEL; BREAST CARCINOMA; CANCER CELL; CANCER CHEMOTHERAPY; CANCER PREVENTION; CAPSULE FILLING; CELL ACTIVITY; CELL CULTURE; CELL DEATH; CHEMOPROPHYLAXIS; CLINICAL TRIAL; DIET SUPPLEMENTATION; DIETARY INTAKE; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG RETENTION; DRUG STRUCTURE; DRUG UPTAKE; EPIDEMIOLOGICAL DATA; HUMAN; INJECTION; MEDICAL INFORMATION; NEBULIZATION; NONHUMAN; REVIEW; TRANSDERMAL PATCH;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; DIET; HUMANS; MODELS, CHEMICAL; PLANT OILS; TOCOPHEROLS; VITAMIN E;

EID: 1642523463     PISSN: 10833021     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025787422466     Document Type: Review

References (64)

1. Institute of Medicine, Food and Nutrition Board, Panel on Dietary Antioxidants and Related Compounds (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids, National Academy Press, Washington, DC, p. 1-486.
2. K. N. Prasad and J. Edwards-Prasad (1992). Vitamin E and cancer prevention: Recent advances and future potentials. J. Am. Coll. Nutr. 11:487-500.
3. G. G. Kimmick, R. A. Bell, and R. M. Bostick (1997). Vitamin E and breast cancer: A review. Nutr. Cancer 27:109-117.
4. D. C. Schwenke (2002). Does lack of tocopherols and tocotrienols put women at increased risk of breast cancer? J. Nutr. Biochem. 13:2-20.
5. M. G. Traber and L. Packer (1995). Vitamin E: Beyond antioxidant function. Am. J. Clin. Nutr. 62:1501S-1509S.
6. S. Zimmer, A. Stocker, M. N. Sarbolouki, S. E. Spycher, J. Sassoon, A. Azzi (2000). A novel human tocopherol-associated protein: Cloning, in vitro expression, and characterization. J. Biol. Chem. 275:25672-25680.
7. R. Brigelius-Flohe, F. J. Kelly, J. T. Salonen, J. Neuzil, J.-M. Zingg, and A. Azzi (2002). The European perspective on vitamin E: Current knowledge and future research. Am. J. Clin. Nutr. 76:703-716.
8. H. Weiser and M. Vecchi (1981). Stereoisomers of alpha-tocopheryl acetate. Characterization of the samples by physicochemical methods and determination of biological activities in the rat resorption-gestation test. Int. J. Vitam. Nutr. Res. 51:100-113.
9. Q. Jiang, S. Christen, M. K. Shigenaga, and B. N. Ames (2001). γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am. J. Clin. Nutr. 74:714-722.
10. E. Giovannucci (2001). γ-Tocopherol: A new player in prostate cancer prevention? J. Natl. Cancer Inst. 92:1966-1967.
11. R. Brigelius-Flohe and M. G. Traber (1999). Vitamin E: Function and metabolism. FASEB J. 10:1145-1155.
12. A. Stocker and A. Azzi (2000). Tocopherol-binding proteins: Their function and physiological significance. Antioxid. Redox Signal. 3:397-404.
13. K. Kline, W. Yu, and B. G. Sanders (2001). Vitamin E: Mechanisms of action as tumor cell growth inhibitors. J. Nutr. 131:161S-163S.
14. R. Ricciarelli, J.-M. Zingg, and A. Azzi (2002). The 80th anniversary of vitamin E: Beyond its antioxidant properties. Biol. Chem. 383:457-465.
15. J. Neuzil, K. Kagedal, L. Andera, C. Weber, and U. T. Brunk (2002). Vitamin E analogs: A new class of multiple action agents with anti-neoplastic and anti-atherogenic activity. Apoptosis 7:179-187.
16. J. Neuzil, T. Weber, A. Terman, C. Weber, and U. T. Brunk (2001). Vitamin E analogues as inducers of apoptosis: Implications for their potential antineoplastic role. Redox Rep. 6:143-151.
17. M. G. Traber (1999). Vitamin E. In M. E. Shils, J. A. Olson, M. Shike, and A. C. Ross (eds), Modern Nutrition in Health and Disease, 9th edn., Williams & Wilkins, Baltimore MD, pp. 347-362.
18. M. G. Traber and H. Sies (1996). Vitamin E in humans: Demand and delivery. Annu. Rev. Nutr. 16:321-347.
19. M. G. Traber and H. Arai (1999). Molecular mechanisms of vitamin E transport. Annu. Rev. Nutr. 19:343-355.
20. M. Podda, C. Weber, M. G. Traber, and L. Packer (1996). Simultaneous determination of tissue tocopherols, tocotrienols, ubiquinols and ubiquinones. J. Lipid Res. 37:893-901.
21. A. Stocker, S. Zimmer, S. E. Spycher, and A. Azzi (1999). Identification of a novel cytosolic tocopherol-binding protein: Structure, specificity, and tissue distribution. IUBMB Life 48:49-55.
22. N. Shibata, M. Arita, Y. Misaki, N. Dohmae, K. Takio, T. Ono, K. Inove, and H. Arai (2001). Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. PNAS 98:2244-2249.
23. J. Yamauchi, T. Iwamoto, S. Kida, S. Masushige, K. Yamada, and T. Esashi (2001). Tocopherol-associated protein is a ligand-dependent transcriptional activator. Biochem. Biophys. Res. Commun. 285:295-299.
24. D. K. Singh, V. Mokashi, C. L. Elmore, and T. D. Porter (2003). Phosphorylation of supernatant protein factor enhances its ability to activate microsomal squalene monooxygenase. J. Biol. Chem. 278:5646-5651.
25. A. Stocker, T. Tomizaki, C. Schulze-Briese, and U. Baumann (2002). Crystal structure of the human supernatant protein factor. Structure 10:1533-1540.
26. J. L. Hess (1993). Vitamin E: α-Tocopherol. In R. G. Alscher and J. L. Hess (eds.), Antioxidants in Higher Plants, CRC Press, Boca Raton, FL, pp. 111-134.
27. D. Shintani and D. DellaPenna (1998). Elevating the vitamin E content of plants through metabolic engineering. Science 282:2098-2100.
28. L. J. Machlin (ed). (1984). Handbook of Vitamins: Nutritional, Biochemical and Clinical Aspects, Marcel Dekker, New York.
29. G. J. Kelloff, J. A. Crowell, C. W. Boone, V. E. Steele, R. A. Lubet, P. Greenwald, et al. (1994). Clinical development plans for cancer chemopreventive agents. J. Cell Biochem. Suppl. 20:282-294.
30. C. Ip (1985). Attenuation of the anticarcinogenic action of selenium by vitamin E deficiency. Cancer Lett. 25:325-331.
31. C. Ip and G. White (1987). Mammary cancer chemoprevention by inorganic and organic selenium: Single agent treatment or in combination with vitamin E and their effects on in vitro immune functions. Carcinogenesis 8:1763-1766.
32. C. Ip (1988). Feasibility of using lower doses of chemopreventive agents in a combination regimen for cancer protection. Cancer Lett. 39:239-246.
33. P. M. Horvath and C. Ip (1983). Synergistic effect of vitamin E and selenium in the chemoprevention of mammary carcinogenesis in rats. Cancer Res. 43:5335-5341.
34. S. Cognault, M. L. Jourdan, E. Germain, R. Pitavy, E. Morel, G. Durand, P. Bougnoux, and C. Lhuillery (2000). Effect of an α-linolenic acid-rich diet on rat mammary tumor growth depends on the dietary oxidative status. Nutr. Cancer 36:33-41.
35. M. Beth, M. R. Berger, M. Aksoy, and D. Scmahl (1987). Effects of vitamin A and E supplementation to diets containing two different fat levels on methylnitrosourea-induced mammary carcinogenesis in female SD-rats. Br. J. Cancer 56:445-449.
36. M. Hirose, A. Masuda, T. Inoue, S. Fukushima, and N. Ito (1986). Modification by antioxidants and p,p′-diaminodiphenylmethane of 7,12-dimethylbenz[a]anthracene-induced carcinogenesis of the mammary gland and ear duct in CD rats. Carcinogenesis 7:1155-1159.
37. M. N. Gould, J. D. Haag, W. S. Kennan, M. A. Tanner, and C. E. Elson (1991). A comparison of tocopherol and tocotrienol for the chemoprevention of chemically induced rat mammary tumors. Am. J. Clin. Nutr. 53:1068S-1070S.
38. H. Takada, T. Hirooka, T. Hatano, Y. Hamanda, and M. Yamamoto (1992). Inhibition of 7,12-dimethylbenz[a] anthracene-induced lipid peroxidation and mammary tumor development in rats by vitamin E in conjunction with selenium. Nutr. Cancer 17:115-122.
39. A. Charpentier, S. Groves, M. Simmons-Menchaca, J. Turley, B. Zhao, B. G. Sanders, and K. Kline (1993). RRR-α-tocopheryl succinate inhibits proliferation and enhances secretion of transforming growth factor-β (TGF-β) by human breast cancer cells. Nutr. Cancer 19:225-239.
40. N. Guthrie, A. Gapor, A. F. Chambers, and K. K. Carroll (1997). Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination. J. Nutr. 127:544S-548S.
41. J. M. Turley, T. Fu, F. W. Ruscetti, J. A. Mikovits, D. C. Bertolette, and M. C. Birchenall-Roberts (1997). Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells. Cancer Res. 57:881-890.
42. Z. Djuric, L. K. Heilbrun, S. Lababidi, C. K. Everett-Bauer, and M. W. Fariss (1997). Growth inhibition of MCF-7 and MCF-10A human breast cells by α-tocopheryl hemisuccinate, cholesteryl hemisuccinate and their ether analogs. Cancer Lett. 111:133-139.
43. K. Nesaretnam, R. Stephen, R. Dils, and P. Darbre (1998). Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 33:461-469.
44. W. Yu, M. Simmons-Menchaca, A. Gapor, B. G. Sanders, and K. Kline (1999). Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr. Cancer 33:26-32.
45. A. Theriault, J.-T. Chao, Q. Wang, A. Gapor, and K. Adeli (1999). Tocotrienol: A review of its therapeutic potential. Clin. Biochem. 32:309-319.
46. M. P. Malafa and L. T. Neitzel (2000). Vitamin E succinate promotes breast cancer tumor dormancy. J. Surg. Res. 93:163-170.
47. K. J. Helzlsouer, H.-Y. Huang, A. J. Alberg, S. Hoffman, A. Burke, E. P. Norkus, J. S. Morris, and G. W. Comstock (2000). Association between α-tocopherol, γ-tocopherol, selenium, and subsequent prostate cancer. J. Natl. Cancer Inst. 92:2018-2023.
48. R. K. Chopra and H. N. Bhagavan (1999). Relative bioavailabilities of natural and synthetic vitamin E formulations containing mixed tocopherol in human subjects. Int. J. Vitam. Nutr. Res. 69:92-95.
49. W. Yu, K. Israel, Q. Y. Liao, C. M. Aldaz, B. G. Sanders, and K. Kline (1999). Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: Role for Mr 43,000 Fas in VES-triggered apoptosis. Cancer Res. 59:953-961.
50. J. E. Green, M.-A. Shibata, E. Shibata, R. C. Moon, M. R. Anver, G. Kelloff, and R. Lubet (2001). 2-Difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)SV40T/t-antigen transgenic mice. Cancer Res. 61:7449-7455.
51. A. Calvo, A. L. Feldman, S. K. Libutti, and J. E. Green (2002). Adenovirus-mediated endostatin delivery results in inhibition of mammary gland tumor growth in C3(1)/SV40 T-antigen transgenic mice. Cancer Res. 62:3934-3938.
52. D. L. Dankort and W. J. Muller (2000). Signal transduction in mammary tumorigenesis: A transgenic perspective. Oncogene 19:1038-1044.
53. V. N. Anisimov, V. K. H. Khavinson, M. Provinciali, I. Alimova, I. N. Baturin, D. A. Popovich, et al. (2002). Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in Her-2/Neu transgenic mice. Int. J. Cancer 101:7-10.
54. J. Neuzil, T. Weber, A. Schroder, M. Lu, G. Ostermann, N. Gellert, et al. (2001). Induction of cancer cell apoptosis by α-tocopheryl succinate: Molecular pathways and structural requirements. FASEB J. 15:403-415.
55. K. T. Barnett, F. D. Fokum, and M. P. Malafa (2002). Vitamin E succinate inhibits colon cancer liver metastases. J. Surg. Res. 106:292-298.
56. M. P. Malafa, F. D. Fokum, A. Mowlavi, M. Abusief, and M. King (2002). Vitamin E inhibits melanoma growth in mice. Surgery 131:85-91.
57. M. W. Fariss, M. B. Fortuna, C. K. Everett, J. D. Smith, D. F. Trent, and Z. Djuric (1994). The selective antiproliferative effects of α-tocopheryl hemisuccinate and cholesteryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds. Cancer Res. 54:3346-3351.
58. K. Wu, Y. J. Shan, Y. Zhao, J. W. Yu, and B. H. Liu (2001). Inhibitory effects of RRR-α-tocopheryl succinate on benzo(a)pyrene (B(a)P)-induced forestomach carcinogenesis in female mice. World J. Gastroenterol 7:60-65.
59. B. G. Sanders, K. Kline, L. Hurley, R. Gardner, M. Menchaca, W. Yu, P. N. Ramanan, S. Liu, and K. Israel (2002). Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof. US Patent 6,417,223.
60. P. Arya, N. Alibhai, H. Qin, and G. W. Burton (1998). Design and synthesis of analogs of vitamin E: Antiproliferative activity against human breast adenocarcinoma cells. Bioorg. Med. Lett. 8:2433-2438.
61. W. Yu, Q. Y. Liao, F. M. Hantash, B. G. Sanders, and K. Kline (2001). Activation of extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells. Cancer Res 61:6569-6576.
62. H. You, W. Yu, B. G. Sanders, and K. Kline (2001). RRR-α- tocopheryl succinate induces MDA-MB-435 and MCF-7 human breast cancer cells to undergo differentiation. Cell Growth Differ. 12:471-480.
63. H. You, W. Yu, D. Munoz-Medellin, P. H. Brown, B. G. Sanders, and K. Kline (2002). Role of extracellular signal-regulated kinase pathway in RRR-α-tocopheryl succinate-induced differentiation of human MDA-MB-435 breast cancer cells. Mol. Carcinogensis 4:228-236.
64. W. Yu, B. G. Sanders, and K. Kline (2002). RRR-α-tocopheryl succinate-induction of DNA synthesis arrest of human MDA-MB-435 cells involves TGF-β independent activation of p21 (Waf1/Cip1). Nutr. Cancer 43:227-236.